{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:40:04Z","timestamp":1758588004513,"version":"3.44.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"Fapesp","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.tice.2017.03.003","type":"journal-article","created":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T15:46:35Z","timestamp":1489074395000},"page":"203-208","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"PB","title":["Dose dependent treatment with isotretinoin induces more changes in the ileum than in the duodenum and jejunum in Wistar rats"],"prefix":"10.1016","volume":"49","author":[{"given":"B.F.","family":"Thomazini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.A.H.","family":"Dolder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.tice.2017.03.003_bib0005","first-page":"32","article-title":"Isotretinoin-associated Croh\u0144s disease-like \u00edleo-colitis in a renal transplanted patient: case report","volume":"20","author":"\u00dcnal","year":"2013","journal-title":"Turklye Klinikleri J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.tice.2017.03.003_bib0010","first-page":"1","article-title":"Isotretinoin in acne: how much and for how long?","volume":"25","author":"Akhtar","year":"2015","journal-title":"J. Pakistan Assoc. Dermatol."},{"issue":"2","key":"10.1016\/j.tice.2017.03.003_bib0015","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.pnpbp.2007.07.001","article-title":"The neurobiology of retinoic acid in affective disorders","volume":"32","author":"Bremmer","year":"2008","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"5","key":"10.1016\/j.tice.2017.03.003_bib0020","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1002\/ar.22890","article-title":"Paneth cell identification in the small intestine of guinea pig offsprings (Caviaporcellus)","volume":"297","author":"Cachay","year":"2014","journal-title":"Anat. Rec."},{"key":"10.1016\/j.tice.2017.03.003_bib0025","doi-asserted-by":"crossref","first-page":"59","DOI":"10.6000\/1929-5634.2013.02.02.1","article-title":"Use of vitamins and their derivates in the treatment of cutaneous disorders","volume":"2","author":"Chiricozzi","year":"2013","journal-title":"J. Nutr. Therapeutica"},{"issue":"6","key":"10.1016\/j.tice.2017.03.003_bib0030","first-page":"470","article-title":"Serum levels of albumin, triglycerides, total protein and glucose in rats are altered after oral treatment with low doses of 13-cis-retinoic acid or all-trans-retinoic acid","volume":"25","author":"Cisneros","year":"2005","journal-title":"J. Appl. Pharmacol."},{"issue":"10","key":"10.1016\/j.tice.2017.03.003_bib0035","doi-asserted-by":"crossref","DOI":"10.1590\/S0103-84782010005000160","article-title":"\u00d3leo de aroeira-vermelha sobre o desempenho e a morfometria intestinal de frangos de corte","volume":"40","author":"da Silva","year":"2010","journal-title":"Cienc Rural"},{"issue":"02","key":"10.1016\/j.tice.2017.03.003_bib0040","first-page":"85","article-title":"An\u00e1lise morfom\u00e9trica da parede intestinal do \u00edleo de ratos submetidos a intensa car\u00eancia de prote\u00ednas","volume":"10","author":"de Azevedo","year":"2007","journal-title":"Ci\u00eanc. Vet. Zool. Unipar."},{"issue":"2","key":"10.1016\/j.tice.2017.03.003_bib0045","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/toxsci\/kfi262","article-title":"Chronic oral treatment with 13-cis-retinoic acid (isotretinoin) or all-trans-retinoic acid does not alter depression-like behavior in rats","volume":"87","author":"Ferguson","year":"2005","journal-title":"Toxicol. Sci."},{"issue":"June (6)","key":"10.1016\/j.tice.2017.03.003_bib0050","first-page":"838","article-title":"Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells","volume":"2","author":"Forster","year":"2014","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.tice.2017.03.003_bib0055","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/BF00317001","article-title":"Fiber: effect on bacterial translocation and intestinal mucin content","volume":"19","author":"Frankel","year":"1995","journal-title":"World J. Surg."},{"key":"10.1016\/j.tice.2017.03.003_bib0060","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1136\/gut.12.10.773","article-title":"Endocrine tumour in kidney affecting small bowel structure, motility, and absorptive function","volume":"12","author":"Gleeson","year":"1971","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.tice.2017.03.003_bib0065","first-page":"357","article-title":"Changes in the intestinal mucosa structure of rats caused by pollen administration in the diet","volume":"47","author":"Hajkov\u00e1","year":"2014","journal-title":"J. Anim. Sci. Biotechnol."},{"issue":"1","key":"10.1016\/j.tice.2017.03.003_bib0070","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1136\/gut.44.1.26","article-title":"The effect of epidermal growth factor on brush border surface area and function in the distal remnant following resection in the rabbit","volume":"44","author":"Hardin","year":"1999","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.tice.2017.03.003_bib0075","first-page":"33","article-title":"Morphometric and histopathological evaluation of a probiotic and its synergism with vaccination against coccidiosis in broilers","volume":"1","author":"Hayakawa","year":"2014","journal-title":"Anim. Sci. Lett."},{"key":"10.1016\/j.tice.2017.03.003_bib0080","first-page":"137","article-title":"A formaldehyde-glutaraldehyde fixative of high osmolality for use in eletron microscopy","volume":"27","author":"Karnovsky","year":"1965","journal-title":"J. Cell Biol."},{"year":"2011","series-title":"Histology and Cell Biology: An Introduction to Pathology","author":"Kierszenbaum","key":"10.1016\/j.tice.2017.03.003_bib0085"},{"issue":"8","key":"10.1016\/j.tice.2017.03.003_bib0090","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.2478\/s11756-014-0409-1","article-title":"Morphological changes in basement membrane associated with jejuna graft injury","volume":"69","author":"Koval\u010dinov\u00e1","year":"2014","journal-title":"Biologia"},{"issue":"June (1)","key":"10.1016\/j.tice.2017.03.003_bib0095","first-page":"55","article-title":"Histological architecture and histochemistry of jejunum of sheep (Ovisaries)","volume":"53","author":"Kumar","year":"2014","journal-title":"Haryana V\u00e9t."},{"issue":"3","key":"10.1016\/j.tice.2017.03.003_bib0100","doi-asserted-by":"crossref","first-page":"162","DOI":"10.4161\/derm.1.3.9364","article-title":"The use of isotretinoin in acne","volume":"1","author":"Layton","year":"2009","journal-title":"Dermato Endocrinol."},{"issue":"10\u201311","key":"10.1016\/j.tice.2017.03.003_bib0105","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1080\/00498250701704819","article-title":"Intestinal permeability and its relevance for absorption and elimination","volume":"37","author":"Lennern\u00e4s","year":"2007","journal-title":"Xenobiotica"},{"key":"10.1016\/j.tice.2017.03.003_bib0110","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1677\/joe.0.0450315","article-title":"The effects of hormones on the absorptive, metabolic and digestive functions of the small intestine","volume":"45","author":"Levin","year":"1969","journal-title":"J. Endocrinol."},{"issue":"2","key":"10.1016\/j.tice.2017.03.003_bib0115","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1016\/S0190-9622(98)70444-X","article-title":"The role of Isotretinoin in the treatment of acne: personal observations","volume":"39","author":"Leyden","year":"1998","journal-title":"J. Am. Acad. Dermatol."},{"issue":"1","key":"10.1016\/j.tice.2017.03.003_bib0120","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ad.2012.05.004","article-title":"Acne relapse rate and predictors of relapse following treatment with oral Isotretinoin","volume":"104","author":"Morales-Cardona","year":"2013","journal-title":"Actas Dermo-Sifiliogr\u00e1ficas"},{"issue":"2","key":"10.1016\/j.tice.2017.03.003_bib0125","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0378-5173(94)00390-Q","article-title":"Effect of lipid vehicle on intestinal lymphatic transport of isotretinoin in the rat","volume":"119","author":"Nankervis","year":"1995","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.tice.2017.03.003_bib0130","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1038\/sj.npp.1300998","article-title":"Chronic administration of 13-cis-retinoic acid increases depression-related behavior in mice","volume":"31","author":"O\u2019Reilly","year":"2006","journal-title":"Neuropsychopharmacology"},{"issue":"4","key":"10.1016\/j.tice.2017.03.003_bib0135","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jpag.2007.07.004","article-title":"Adolescent female acne: etiology and management","volume":"21","author":"Olutunmbi","year":"2008","journal-title":"J. Pediatr. Adolesc. Gynecol."},{"issue":"October","key":"10.1016\/j.tice.2017.03.003_bib0140","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1177\/1098612X14520811","article-title":"A morphological and immunohistochemical study of the effects of prednisolone or ursodeoxycholic acid on liver histology in feline lymphocytic cholangitis","volume":"16","author":"Otte","year":"2014","journal-title":"J. Feline Med. Surg."},{"issue":"547","key":"10.1016\/j.tice.2017.03.003_bib0145","first-page":"125","article-title":"Morfometria e ultra-estrutura da mucosa intestinal de frangos de corte alimentados com dietas contendo diferentes probi\u00f3ticos","volume":"98","author":"Pelicano","year":"2003","journal-title":"Ver. Port. Ci\u00eanc. Vet."},{"issue":"04","key":"10.1016\/j.tice.2017.03.003_bib0150","first-page":"329","article-title":"Estudo morfom\u00e9trico e estereol\u00f3gico digital da mucosa do intestino delgado de crian\u00e7as eutr\u00f3ficas e desnutridas com diarr\u00e9ia persistente","volume":"79","author":"Pires","year":"2003","journal-title":"J. Pediatr."},{"key":"10.1016\/j.tice.2017.03.003_bib0155","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/nature12972","article-title":"Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging","volume":"507","author":"Ritsma","year":"2014","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.tice.2017.03.003_bib0160","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.jad.2009.09.005","article-title":"Psychiatric reactions to Isotretinoin in patients with bipolar disorder","volume":"122","author":"Schaffer","year":"2009","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.tice.2017.03.003_bib0165","first-page":"425","article-title":"A study of proximal and distal intestinal structure and absorptive function in idiopathic steatorrhoea","volume":"143","author":"Stewart","year":"1967","journal-title":"Q. J. Med."},{"issue":"9","key":"10.1016\/j.tice.2017.03.003_bib0170","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.nurpra.2014.07.005","article-title":"Isotretinoin: reconsidering manageent of acne vulgaris in primary care","volume":"10","author":"Studer-Heikenfeld","year":"2014","journal-title":"J. Nurse Pract."},{"issue":"3","key":"10.1016\/j.tice.2017.03.003_bib0175","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.stem.2014.02.011","article-title":"Ballroom dancing with stem cells: placement and displacement in the intestinal crypt","volume":"14","author":"Tajbakhsh","year":"2014","journal-title":"Cell Stem Cell"},{"issue":"1","key":"10.1016\/j.tice.2017.03.003_bib0180","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1046\/j.1523-1747.2002.01816.x","article-title":"High albumin levels restrict the kinetics of 13-cis retinoic acid uptake and intracellular isomerization to all-trans retinoic acid and inhibit its anti-proliferative effect on SZ95 sebocytes","volume":"119","author":"Tsukada","year":"2002","journal-title":"J. Investig. Dermatol."},{"issue":"1","key":"10.1016\/j.tice.2017.03.003_bib0185","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1590\/S0044-59672014000100013","article-title":"Histologia e histoqu\u00edmica do tubo digest\u00f3rio de Phrynops geoffroanus (Testudines, Chelidae)","volume":"44","author":"Vieira-Lopes","year":"2014","journal-title":"Acta Amazon"},{"issue":"9","key":"10.1016\/j.tice.2017.03.003_bib0190","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.prp.2011.08.001","article-title":"Clinical value of duodenal biopsies\u2013beyond the diagnosis of coeliac disease","volume":"207","author":"Walker","year":"2011","journal-title":"Pathol. Res. Pract."},{"issue":"1","key":"10.1016\/j.tice.2017.03.003_bib0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/path.4370","article-title":"Location, location, location! The reality of life for an intestinal stem cell in the crypt","volume":"234","author":"Walther","year":"2014","journal-title":"J. Pathol."},{"issue":"7","key":"10.1016\/j.tice.2017.03.003_bib0200","first-page":"1297","article-title":"Retinoic acid stimulates early cellular proliferation in the adpting remmant rat small intestine after partial resection","volume":"127","author":"Wang","year":"1997","journal-title":"Am. Soc. Nutr. Serv."},{"issue":"8","key":"10.1016\/j.tice.2017.03.003_bib0205","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0011-5029(99)90008-1","article-title":"Acne therapy","volume":"45","author":"White","year":"1999","journal-title":"Dis. Mon."},{"year":"1962","series-title":"Intestinal Absorption","author":"Wilson","key":"10.1016\/j.tice.2017.03.003_bib0210"},{"key":"10.1016\/j.tice.2017.03.003_bib0215","series-title":"Systemic Retinoids. Comprehensive Dermatologic Drug Therapy","first-page":"275","author":"Wolverton","year":"2007"},{"issue":"June (7404)","key":"10.1016\/j.tice.2017.03.003_bib0220","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/nature11163","article-title":"mTORC 1 in the Paneth cell niche couples intestinal stem cell function to calorie intake","volume":"486","author":"Yilmaz","year":"2012","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.tice.2017.03.003_bib0225","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1093\/carcin\/18.11.2119","article-title":"Prevention by retinoids of azoxymethane-induced tumors and aberrant crypt foci and their modulation of cell proliferation in the colon of rats","volume":"18","author":"Zheng","year":"1997","journal-title":"Carcinogenesis"}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004081661630297X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004081661630297X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:14:45Z","timestamp":1758572085000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004081661630297X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["S004081661630297X"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2017.03.003","relation":{},"ISSN":["0040-8166"],"issn-type":[{"type":"print","value":"0040-8166"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dose dependent treatment with isotretinoin induces more changes in the ileum than in the duodenum and jejunum in Wistar rats","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2017.03.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}