{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:59:36Z","timestamp":1793296776156,"version":"4.5.0"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.tice.2020.101346","type":"journal-article","created":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T11:44:43Z","timestamp":1581680683000},"page":"101346","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Limonin suppresses the progression of oral tongue squamous cell carcinoma via inhibiting YAP transcriptional regulatory activity"],"prefix":"10.1016","volume":"65","author":[{"given":"Guangsheng","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.tice.2020.101346_bib0005","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/jop.12317","article-title":"LATS2 induced by TNF-alpha and inhibited cell proliferation and invasion by phosphorylating YAP in oral squamous cell carcinoma","volume":"44","author":"Dong","year":"2015","journal-title":"J. Oral Pathol. Med."},{"issue":"2\u20133","key":"10.1016\/j.tice.2020.101346_bib0010","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ejphar.2009.09.040","article-title":"Inhibition of P-glycoprotein activity by limonin and other secondary metabolites from Citrus species in human colon and leukaemia cell lines","volume":"626","author":"El-Readi","year":"2010","journal-title":"Eur. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.tice.2020.101346_bib0015","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1002\/cncr.22492","article-title":"A phase II study of the safety and efficacy of the multidrug resistance inhibitor VX-710 combined with doxorubicin and vincristine in patients with recurrent small cell lung cancer","volume":"109","author":"Gandhi","year":"2007","journal-title":"Cancer"},{"key":"10.1016\/j.tice.2020.101346_bib0020","doi-asserted-by":"crossref","DOI":"10.1039\/C9FO01274E","article-title":"The gastrointestinal fate of limonin and its effect on gut microbiota in mice","author":"Gu","year":"2019","journal-title":"Food Funct."},{"issue":"5","key":"10.1016\/j.tice.2020.101346_bib0025","first-page":"3024","article-title":"Antitumor activity of the plant extract morin in tongue squamous cell carcinoma cells","volume":"40","author":"Ji","year":"2018","journal-title":"Oncol. Rep."},{"issue":"1","key":"10.1016\/j.tice.2020.101346_bib0030","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3892\/ijmm.2017.2992","article-title":"hsa-miR-485-5p reverses epithelial to mesenchymal transition and promotes cisplatin-induced cell death by targeting PAK1 in oral tongue squamous cell carcinoma","volume":"40","author":"Lin","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.tice.2020.101346_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105768","article-title":"Limonin ameliorates ulcerative colitis by regulating STAT3\/miR-214 signaling pathway","volume":"75","author":"Liu","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.tice.2020.101346_bib0040","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.ejphar.2014.06.010","article-title":"Limonin attenuates hepatocellular injury following liver ischemia and reperfusion in rats via toll-like receptor dependent pathway","volume":"740","author":"Mahmoud","year":"2014","journal-title":"Eur. J. Pharmacol."},{"issue":"9","key":"10.1016\/j.tice.2020.101346_bib0045","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.1002\/hed.25772","article-title":"Survival of oral tongue squamous cell carcinoma in young adults","volume":"41","author":"Oliver","year":"2019","journal-title":"Head Neck"},{"key":"10.1016\/j.tice.2020.101346_bib0050","article-title":"Oral cancer: prevention, early detection, and treatment","volume":"3","author":"Sankaranarayanan","year":"2015"},{"issue":"1","key":"10.1016\/j.tice.2020.101346_bib0055","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3164\/jcbn.15-28","article-title":"Suppression of intestinal carcinogenesis in Apc-mutant mice by limonin","volume":"57","author":"Shimizu","year":"2015","journal-title":"J. Clin. Biochem. Nutr."},{"issue":"18","key":"10.1016\/j.tice.2020.101346_bib0060","doi-asserted-by":"crossref","first-page":"3198","DOI":"10.1002\/cncr.32199","article-title":"Early squamous cell carcinoma of the oral tongue with histologically benign lymph nodes: A model predicting local control and vetting of the eighth edition of the American Joint Committee on Cancer pathologic T stage","volume":"125","author":"Sridharan","year":"2019","journal-title":"Cancer"},{"key":"10.1016\/j.tice.2020.101346_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.108699","article-title":"Limonin attenuates the stemness of breast cancer cells via suppressing MIR216A methylation","volume":"112","author":"Su","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.tice.2020.101346_bib0070","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1155\/2012\/926703","article-title":"Resistance\/response molecular signature for oral tongue squamous cell carcinoma","volume":"32","author":"Suresh","year":"2012","journal-title":"Dis. Markers"},{"issue":"4","key":"10.1016\/j.tice.2020.101346_bib0075","first-page":"3561","article-title":"The effect of YAP expression in tumor cells and tumor stroma on the prognosis of patients with squamous cell carcinoma of the oral cavity floor and oral surface of the tongue","volume":"18","author":"Szelachowska","year":"2019","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.tice.2020.101346_bib0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109051","article-title":"Limonin provokes hepatocellular carcinoma cells with stemness entry into cycle via activating PI3K\/Akt signaling","volume":"117","author":"Tang","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"29","key":"10.1016\/j.tice.2020.101346_bib0085","doi-asserted-by":"crossref","first-page":"8538","DOI":"10.1002\/anie.201503794","article-title":"Total synthesis of limonin","volume":"54","author":"Yamashita","year":"2015","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.tice.2020.101346_bib0090","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.2147\/OTT.S165220","article-title":"By blocking hexokinase-2 phosphorylation, limonin suppresses tumor glycolysis and induces cell apoptosis in hepatocellular carcinoma","volume":"11","author":"Yao","year":"2018","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.tice.2020.101346_bib0095","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jep.2015.06.019","article-title":"Developing an activity and absorption-based quality control platform for Chinese traditional medicine: application to Zeng-Sheng-Ping(Antitumor B)","volume":"172","author":"Yin","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.tice.2020.101346_bib0100","doi-asserted-by":"crossref","first-page":"5924","DOI":"10.12659\/MSM.905035","article-title":"Identification of Key Genes and Pathways in Tongue Squamous Cell Carcinoma Using Bioinformatics Analysis","volume":"23","author":"Zhang","year":"2017","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.tice.2020.101346_bib0105","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.fct.2019.02.011","article-title":"Limonin attenuates the stemness of cervical carcinoma cells by promoting YAP nuclear-cytoplasmic translocation","volume":"125","author":"Zhao","year":"2019","journal-title":"Food Chem. Toxicol."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816619305440?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816619305440?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:18:00Z","timestamp":1758572280000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816619305440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":21,"alternative-id":["S0040816619305440"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2020.101346","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Limonin suppresses the progression of oral tongue squamous cell carcinoma via inhibiting YAP transcriptional regulatory activity","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2020.101346","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101346"}}