{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T17:06:52Z","timestamp":1782320812557,"version":"3.54.5"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.tice.2021.101502","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T11:23:56Z","timestamp":1611919436000},"page":"101502","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Structural and chemical role of mesenchymal stem cells and resveratrol in regulation of apoptotic -induced genes in Bisphenol-A induced uterine damage in adult female albino rats"],"prefix":"10.1016","volume":"70","author":[{"given":"Hanan","family":"Fouad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman Mohamed","family":"Faruk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wardah Abdullah","family":"Alasmari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8963-790X","authenticated-orcid":false,"given":"Eman Hassan","family":"Nadwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usama Fouad Ahmed","family":"Ebrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2021.101502_bib0005","first-page":"438","article-title":"Histological study on the role of bone marrowderived mesenchymal stem cells on the sciatic nerve and the gastrocnemius muscle in a model of sciatic nerve crush injury in albino rats","volume":"38","author":"Abd El Samad","year":"2015","journal-title":"EJH"},{"issue":"11","key":"10.1016\/j.tice.2021.101502_bib0010","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1177\/1933719114525271","article-title":"Resveratrol and endometrium: a closer look at an active ingredient of red wine using in vivo and in vitro models","volume":"21","author":"Amaya","year":"2014","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.tice.2021.101502_bib0015","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/jcb.25193","article-title":"N-acetyl cysteine has both gastro-protective and anti-inflammatory effects in experimental rat models: its gastro-protective effect is related to its in vivo and in vitro antioxidant properties","volume":"117","author":"Atalay","year":"2016","journal-title":"J. Cell. Biochem."},{"issue":"3","key":"10.1016\/j.tice.2021.101502_bib0020","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.repbio.2017.07.001","article-title":"Dose dependent effect of resveratrol in preventing cisplatin-induced ovarian damage in rats: an experimental study","volume":"17","author":"Atli","year":"2017","journal-title":"Reprod. Biol."},{"issue":"3","key":"10.1016\/j.tice.2021.101502_bib0025","first-page":"208","article-title":"Isolation, differentiation, and characterization of mesenchymal stem cells from human bone marrow","volume":"10","author":"Baghaei","year":"2017","journal-title":"Gastroenterol. Hepatol. Bed Bench"},{"issue":"August (8)","key":"10.1016\/j.tice.2021.101502_bib0030","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1007\/s10815-019-01461-6","article-title":"Effects of resveratrol on VEGF & HIF1 genes expression in granulosa cells in the angiogenesis pathway and laboratory parameters of polycystic ovary syndrome: a triple-blind randomized clinical trial","volume":"36","author":"Bahramrezaie","year":"2019","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.tice.2021.101502_bib0035","series-title":"Bancroft\u2019s Theory and Practice of Histological Techniques","first-page":"153","article-title":"Connective tissue and other mesenchymal tissues with their stains","author":"Bancroft","year":"2019"},{"key":"10.1016\/j.tice.2021.101502_bib0040","series-title":"Bancroft\u2019s Theory and Practice of Histological Techniques","first-page":"126","article-title":"The hematoxylin and eosin","author":"Bancroft","year":"2019"},{"issue":"December","key":"10.1016\/j.tice.2021.101502_bib0045","article-title":"Bisphenol A impairs reproductive fitness in zebrafish ovary: potential involvement of oxidative\/nitrosative stress, inflammatory and apoptotic mediators","volume":"267","author":"Biswas","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tice.2021.101502_bib0050","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1477-7827-12-37","article-title":"Bisphenol A and the female reproductive tract: an overview of recent laboratory evidence and epidemiological studies","volume":"12","author":"Caserta","year":"2014","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"4","key":"10.1016\/j.tice.2021.101502_bib0055","article-title":"Natural Antioxidant Resveratrol Suppresses Uterine Fibroid Cell Growth and Extracellular Matrix Formation in Vitro and in Vivo","volume":"8","author":"Chen","year":"2019","journal-title":"Antioxidants (Basel)"},{"issue":"6","key":"10.1016\/j.tice.2021.101502_bib0060","doi-asserted-by":"crossref","first-page":"748","DOI":"10.2174\/0929867324666171009121001","article-title":"Bisphenol A in reproduction: epigenetic effects","volume":"25","author":"Chianese","year":"2018","journal-title":"Curr. Med. Chem."},{"issue":"12","key":"10.1016\/j.tice.2021.101502_bib0065","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1007\/s11064-007-9368-z","article-title":"Mesenchymal stem cells from rat bone marrow downregulate caspase-3-mediated apoptotic pathway after spinal cord injury in rats","volume":"32","author":"Dasari","year":"2007","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.tice.2021.101502_bib0070","series-title":"NTP Research Report on the CLARITY-BPA Core Study: A Perinatal and Chronic Extended-Dose-Range Study of Bisphenol A in Rats","author":"Delclos","year":"2018"},{"issue":"22","key":"10.1016\/j.tice.2021.101502_bib0075","first-page":"3477","article-title":"Investigation of Bisphenol A as an endocrine disruptor, total thiol, malondialdehyde, and C-reactive protein levels in chronic obstructive pulmonary disease","volume":"18","author":"Erden","year":"2014","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.tice.2021.101502_bib0080","first-page":"442","article-title":"Do exosomes derived bone marrow mesenchymal stem cells restore ovarian function by promoting stem cell survival on experimentally induced polycystic ovary in adult female albino rats? (Histological and immunohisto-chemical study)","volume":"8","author":"Faruk","year":"2018","journal-title":"Stem Cell Res. Ther."},{"issue":"3","key":"10.1016\/j.tice.2021.101502_bib0085","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1177\/1933719118799201","article-title":"Bone marrow mesenchymal stem cells (BMSCs) restore functional endometrium in the rat model for severe asherman syndrome","volume":"26","author":"Gao","year":"2019","journal-title":"Reprod. Sci."},{"issue":"2","key":"10.1016\/j.tice.2021.101502_bib0090","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/em.22072","article-title":"Induction of oxidative stress by bisphenol A and its pleiotropic effects","volume":"58","author":"Gassman","year":"2017","journal-title":"Environ. Mol. Mutagen."},{"issue":"2","key":"10.1016\/j.tice.2021.101502_bib0095","doi-asserted-by":"crossref","first-page":"250","DOI":"10.15283\/ijsc16010","article-title":"Transplantation of autologous bone marrow mesenchymal stem cells into the testes of infertile male rats and new germ cell formation","volume":"9","author":"Ghasemzadeh-Hasankolaei","year":"2016","journal-title":"Int. J. Stem Cells"},{"key":"10.1016\/j.tice.2021.101502_bib0100","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.envpol.2019.01.127","article-title":"Male exposure to bisphenol a impairs spermatogenesis and triggers histone hyperacetylation in zebrafish testes","volume":"248","author":"Gonz\u00e1lez-Rojo","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tice.2021.101502_bib0105","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/s13287-018-1008-9","article-title":"The therapeutic potential of bone marrow mesenchymal stem cells in premature ovarian failure","volume":"9","author":"He","year":"2018","journal-title":"Stem Cell Res. Ther."},{"issue":"18","key":"10.1016\/j.tice.2021.101502_bib0110","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20184382","article-title":"Maternal exposure to bisphenol a combined with high-fat diet-induced programmed hypertension in adult male rat offspring: effects of resveratrol","volume":"20","author":"Hsu","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"18","key":"10.1016\/j.tice.2021.101502_bib0115","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20184382","article-title":"Maternal exposure to bisphenol a combined with high-fat diet-induced programmed hypertension in adult male rat offspring: effects of resveratrol","volume":"20","author":"Hsu","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"October (7)","key":"10.1016\/j.tice.2021.101502_bib0120","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.acthis.2019.07.003","article-title":"Chronic valproate treatment influences folliculogenesis and reproductive hormones with possible ameliorating role for folic acid in adult albino rats","volume":"121","author":"Ibrahim","year":"2019","journal-title":"Acta Histochem."},{"key":"10.1016\/j.tice.2021.101502_bib0125","series-title":"Theory and Practice of Histological Techniques","first-page":"381","article-title":"Immunohistochemical techniques","author":"Jackson","year":"2013"},{"key":"10.1016\/j.tice.2021.101502_bib0130","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.reprotox.2015.08.001","article-title":"Strain-specific induction of endometrial periglandular fibrosis in mice exposed during adulthood to the endocrine disrupting chemical bisphenol A","volume":"58","author":"Kendziorski","year":"2015","journal-title":"Reprod. Toxicol."},{"issue":"1","key":"10.1016\/j.tice.2021.101502_bib0135","first-page":"10","article-title":"Effect of transplantation of bone marrow stromal cell- conditioned medium on ovarian function, morphology and cell death in cyclophosphamide-treated rats","volume":"20","author":"Khanmohammadi","year":"2018","journal-title":"Cell J."},{"issue":"7","key":"10.1016\/j.tice.2021.101502_bib0140","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1080\/15592294.2016.1182272","article-title":"Bisphenol A causes reproductive toxicity, decreases dnmt1 transcription, and reduces global DNA methylation in breeding zebrafish (Danio rerio)","volume":"11","author":"Laing","year":"2016","journal-title":"Epigenetics"},{"key":"10.1016\/j.tice.2021.101502_bib0145","series-title":"Bancroft\u2019s Theory and Practice of Histological Techniques","first-page":"176","article-title":"Carbohydrates","author":"Layton","year":"2019"},{"issue":"5","key":"10.1016\/j.tice.2021.101502_bib0150","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1210\/en.2015-2031","article-title":"Chronic exposure to Bisphenol A affects uterine function during early pregnancy in mice","volume":"157","author":"Li","year":"2016","journal-title":"Endocrinology"},{"issue":"9","key":"10.1016\/j.tice.2021.101502_bib0155","doi-asserted-by":"crossref","first-page":"14455","DOI":"10.1002\/jcb.28705","article-title":"Human umbilical cord mesenchymal stem cells derived exosomes exert antiapoptosis effect via activating PI3K\/Akt\/mTOR pathway on H9C2 cells","volume":"120","author":"Liu","year":"2019","journal-title":"J. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.tice.2021.101502_bib0160","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1186\/s13287-019-1315-9","article-title":"Human amniotic mesenchymal stem cells improve the follicular microenvironment to recover ovarian function in premature ovarian failure mice","volume":"10","author":"Liu","year":"2019","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.tice.2021.101502_bib0165","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1080\/0886022X.2019.1605296","article-title":"Resveratrol inhibits parathyroid hormone-induced apoptosis in human aortic smooth muscle cells by upregulating sirtuin 1","volume":"41","author":"Liu","year":"2019","journal-title":"Ren. Fail."},{"issue":"6","key":"10.1016\/j.tice.2021.101502_bib0170","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1007\/s10517-011-1242-y","article-title":"Angiogenesis in rat uterine cicatrix after injection of autologous bone marrow mesenchymal stem cells","volume":"150","author":"Maiborodin","year":"2011","journal-title":"Bull. Exp. Biol. Med."},{"issue":"1","key":"10.1016\/j.tice.2021.101502_bib0175","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/cyto.a.22205","article-title":"Human mesenchymal stem cells: from immunophenotyping by flow cytometry to clinical applications","volume":"83","author":"Nery","year":"2013","journal-title":"Cytometry A."},{"issue":"August (8)","key":"10.1016\/j.tice.2021.101502_bib0180","doi-asserted-by":"crossref","first-page":"4019","DOI":"10.1210\/en.2012-1385","article-title":"Resveratrol reduces steroidogenesis in rat ovarian theca-interstitial cells: the role of inhibition of Akt\/PKB signaling pathway","volume":"153","author":"Ortega","year":"2012","journal-title":"Endocrinology"},{"issue":"October","key":"10.1016\/j.tice.2021.101502_bib0185","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.neuropharm.2015.04.017","article-title":"The effect of trans-resveratrol on post-stroke depression via regulation of hypothalamus\u2013pituitary\u2013adrenal axis","volume":"97","author":"Pang","year":"2015","journal-title":"Neuropharmacology"},{"issue":"June (6)","key":"10.1016\/j.tice.2021.101502_bib0190","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.bbadis.2015.01.014","article-title":"The pharmacology of resveratrol in animals and humans","volume":"1852","author":"Park","year":"2015","journal-title":"Biochimica et Biophysica Acta (BBA)-Mol. Basis Dis."},{"issue":"1","key":"10.1016\/j.tice.2021.101502_bib0195","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1093\/toxsci\/kfq319","article-title":"Bisphenol A impairs follicle growth, inhibits steroidogenesis, and downregulates rate-limiting enzymes in the estradiol biosynthesis pathway","volume":"119","author":"Peretz","year":"2011","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tice.2021.101502_bib0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2019.117149","article-title":"Investigation of the effect for bisphenol A on oxidative stress in human hepatocytes and its interaction with catalase","volume":"221","author":"Piao","year":"2019","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"issue":"1","key":"10.1016\/j.tice.2021.101502_bib0205","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12958-019-0558-8","article-title":"Bisphenol A: an emerging threat to female fertility","volume":"18","author":"Pivonello","year":"2020","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.tice.2021.101502_bib0210","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.reprotox.2014.08.005","article-title":"Presence and bioavailability of bisphenol A in the uterus of rats and mice following single and repeated dietary administration at low doses","volume":"49","author":"Pollock","year":"2014","journal-title":"Reprod. Toxicol."},{"issue":"12","key":"10.1016\/j.tice.2021.101502_bib0215","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1002\/ptr.6175","article-title":"Bisphenol A vascular toxicity: protective effect of Vitis vinifera (grape) seed extract and resveratrol","volume":"32","author":"Rameshrad","year":"2018","journal-title":"Phytother. Res."},{"issue":"5","key":"10.1016\/j.tice.2021.101502_bib0220","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.tjog.2017.08.015","article-title":"The role of resveratrol on full - Thickness uterine wound healing in rats","volume":"56","author":"Sayin","year":"2017","journal-title":"Taiwan J. Obstet. Gynecol."},{"issue":"6","key":"10.1016\/j.tice.2021.101502_bib0225","first-page":"889","article-title":"Effects of resveratrol on inflammation and apoptosis after experimental spinal cord injury","volume":"28","author":"Senturk","year":"2018","journal-title":"Turk. Neurosurg."},{"issue":"August","key":"10.1016\/j.tice.2021.101502_bib0230","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.reprotox.2018.06.005","article-title":"Effects of bisphenol A and its analogs on reproductive health: a mini review","volume":"79","author":"Siracusa","year":"2018","journal-title":"Reprod. Toxicol."},{"issue":"July(1)","key":"10.1016\/j.tice.2021.101502_bib0235","first-page":"21","article-title":"Efficient generation of hypothalamic neurons from human pluripotent stem cells","volume":"90","author":"Wang","year":"2016","journal-title":"Curr. Protoc. Hum. Genet."},{"key":"10.1016\/j.tice.2021.101502_bib0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109182","article-title":"Bisphenol A induces apoptosis, oxidative stress and inflammatory response in colon and liver of mice in a mitochondria-dependent manner","volume":"117","author":"Wang","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.tice.2021.101502_bib0245","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/3585394","article-title":"Antioxidative and anti-inflammatory effects of water extract of Acrostichum aureum Linn. Against ethanol-induced gastric ulcer in rats","volume":"2018","author":"Wu","year":"2018","journal-title":"Evid. Based Complement. Altern. Med."},{"issue":"1","key":"10.1016\/j.tice.2021.101502_bib0250","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13287-018-1101-0","article-title":"Endometrial mesenchymal stem cells isolated from menstrual blood repaired epirubicin-induced damage to human ovarian granulosa cells by inhibiting the expression of Gadd45b in cell cycle pathway","volume":"10","author":"Yan","year":"2019","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.tice.2021.101502_bib0255","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1186\/s13287-017-0718-8","article-title":"Vitamin C plus hydrogel facilitates bone marrow stromal cell-mediated endometrium regeneration in rats","volume":"8","author":"Yang","year":"2017","journal-title":"Stem Cell Res. Ther."},{"issue":"4","key":"10.1016\/j.tice.2021.101502_bib0260","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.fertnstert.2016.06.027","article-title":"Evidence for bisphenol A-induced female infertility - Review (2007\u20132016)","volume":"106","author":"Ziv-Gal","year":"2016","journal-title":"Fertil. Steril."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816621000185?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816621000185?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:20:27Z","timestamp":1758572427000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816621000185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":52,"alternative-id":["S0040816621000185"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2021.101502","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structural and chemical role of mesenchymal stem cells and resveratrol in regulation of apoptotic -induced genes in Bisphenol-A induced uterine damage in adult female albino rats","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2021.101502","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101502"}}