{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:43:54Z","timestamp":1787168634788,"version":"build-2736575974"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.tice.2021.101680","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T08:08:06Z","timestamp":1637309286000},"page":"101680","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Propofol enhances the lethality of cisplatin on liver cancer cells by up-regulating miR-195-5p"],"prefix":"10.1016","volume":"74","author":[{"given":"Lan","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiufeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.tice.2021.101680_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2019.188314","article-title":"Challenges in liver cancer and possible treatment approaches","volume":"1873","author":"Anwanwan","year":"2020","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"issue":"2","key":"10.1016\/j.tice.2021.101680_bib0010","doi-asserted-by":"crossref","first-page":"104","DOI":"10.2174\/1568009619666191023100046","article-title":"Anti-tumor activity of propofol: a focus on microRNAs","volume":"20","author":"Ashrafizadeh","year":"2020","journal-title":"Curr. Cancer Drug Targets"},{"key":"10.1016\/j.tice.2021.101680_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2020.109871","article-title":"Lung cancer cells and their sensitivity\/resistance to cisplatin chemotherapy: role of microRNAs and upstream mediators","volume":"78","author":"Ashrafizadeh","year":"2021","journal-title":"Cell. Signal."},{"issue":"2","key":"10.1016\/j.tice.2021.101680_bib0020","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/ijc.30669","article-title":"The role of exosomes and miRNAs in drug-resistance of cancer cells","volume":"141","author":"Bach","year":"2017","journal-title":"Int. J. Cancer"},{"issue":"1","key":"10.1016\/j.tice.2021.101680_bib0025","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s10555-017-9724-7","article-title":"miR-155 in cancer drug resistance and as target for miRNA-based therapeutics","volume":"37","author":"Bayraktar","year":"2018","journal-title":"Cancer Metastasis Rev."},{"issue":"9","key":"10.1016\/j.tice.2021.101680_bib0030","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21093233","article-title":"Mechanisms of multidrug resistance in cancer chemotherapy","volume":"21","author":"Bukowski","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"17","key":"10.1016\/j.tice.2021.101680_bib0035","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20174136","article-title":"New insights into mechanisms of cisplatin resistance: from tumor cell to microenvironment","volume":"20","author":"Chen","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"38","key":"10.1016\/j.tice.2021.101680_bib0040","doi-asserted-by":"crossref","first-page":"63986","DOI":"10.18632\/oncotarget.19256","article-title":"miR-195-5p is critical in REG\u03b3-mediated regulation of wnt\/\u03b2-catenin pathway in renal cell carcinoma","volume":"8","author":"Chen","year":"2017","journal-title":"Oncotarget"},{"issue":"7","key":"10.1016\/j.tice.2021.101680_bib0045","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s40263-015-0259-6","article-title":"Propofol: a review of its role in pediatric anesthesia and sedation","volume":"29","author":"Chidambaran","year":"2015","journal-title":"CNS Drugs"},{"issue":"24","key":"10.1016\/j.tice.2021.101680_bib0050","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20246249","article-title":"Deciphering miRNAs\u2019 action through miRNA editing","volume":"20","author":"Correia de Sousa","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.tice.2021.101680_bib0055","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s12967-019-1932-1","article-title":"Overexpression of microRNA-195-5p reduces cisplatin resistance and angiogenesis in ovarian cancer by inhibiting the PSAT1-dependent GSK3\u03b2\/\u03b2-catenin signaling pathway","volume":"17","author":"Dai","year":"2019","journal-title":"J. Transl. Med."},{"issue":"2","key":"10.1016\/j.tice.2021.101680_bib0060","doi-asserted-by":"crossref","first-page":"285","DOI":"10.2174\/157489206777442287","article-title":"Recent developments in the field of anticancer platinum complexes","volume":"1","author":"Galanski","year":"2006","journal-title":"Recent Pat. Anticancer Drug Discov."},{"issue":"7","key":"10.1016\/j.tice.2021.101680_bib0065","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1038\/bjc.2014.426","article-title":"Prostate cancer cell malignancy via modulation of HIF-1\u03b1 pathway with isoflurane and propofol alone and in combination","volume":"111","author":"Huang","year":"2014","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.tice.2021.101680_bib0070","article-title":"Propofol improves sensitivity of lung cancer cells to cisplatin and its mechanism","volume":"26","author":"Huang","year":"2020","journal-title":"Med. Sci. Monit."},{"issue":"4","key":"10.1016\/j.tice.2021.101680_bib0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0033856","article-title":"Characterization of cyclin E expression in multiple myeloma and its functional role in seliciclib-induced apoptotic cell death","volume":"7","author":"Josefsberg Ben-Yehoshua","year":"2012","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.tice.2021.101680_bib0080","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/modpathol.3800593","article-title":"Comprehensive analysis of 19q12 amplicon in human gastric cancers","volume":"19","author":"Leung","year":"2006","journal-title":"Mod. Pathol."},{"issue":"2","key":"10.1016\/j.tice.2021.101680_bib0085","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.canlet.2015.07.018","article-title":"Heterogeneity of liver cancer and personalized therapy","volume":"379","author":"Li","year":"2016","journal-title":"Cancer Lett."},{"key":"10.1016\/j.tice.2021.101680_bib0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2019.109462","article-title":"A novel long non-coding RNA LINC00355 promotes proliferation of lung adenocarcinoma cells by down-regulating miR-195 and up-regulating the expression of CCNE1","volume":"66","author":"Liang","year":"2020","journal-title":"Cell. Signal."},{"issue":"9","key":"10.1016\/j.tice.2021.101680_bib0095","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a021535","article-title":"Treatment of liver cancer","volume":"5","author":"Liu","year":"2015","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.tice.2021.101680_bib0100","article-title":"Propofol reduces epithelial to mesenchymal transition, invasion and migration of gastric cancer cells through the microRNA-195-5p\/Snail axis","volume":"26","author":"Liu","year":"2020","journal-title":"Med. Sci. Monit."},{"issue":"3","key":"10.1016\/j.tice.2021.101680_bib0105","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.jpainsymman.2010.07.001","article-title":"Propofol","volume":"40","author":"Lundstr\u00f6m","year":"2010","journal-title":"J. Pain Symptom Manage."},{"issue":"8","key":"10.1016\/j.tice.2021.101680_bib0110","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26082382","article-title":"Elucidating role of reactive oxygen species (ROS) in cisplatin chemotherapy: a focus on molecular pathways and possible therapeutic strategies","volume":"26","author":"Mirzaei","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.tice.2021.101680_bib0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105575","article-title":"Nrf2 signaling pathway in cisplatin chemotherapy: potential involvement in organ protection and chemoresistance","volume":"167","author":"Mirzaei","year":"2021","journal-title":"Pharmacol. Res."},{"issue":"4","key":"10.1016\/j.tice.2021.101680_bib0120","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s10585-018-9903-0","article-title":"The challenge of drug resistance in cancer treatment: a current overview","volume":"35","author":"Nikolaou","year":"2018","journal-title":"Clin. Exp. Metastasis"},{"issue":"1","key":"10.1016\/j.tice.2021.101680_bib0125","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0305-7372(79)80057-2","article-title":"Cisplatin (cis-diamminedichloroplatinum II)","volume":"6","author":"Prestayko","year":"1979","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.tice.2021.101680_bib0130","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/3461251","article-title":"H-ferritin affects cisplatin-induced cytotoxicity in ovarian cancer cells through the modulation of ROS","volume":"2019","author":"Salatino","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"9","key":"10.1016\/j.tice.2021.101680_bib0135","doi-asserted-by":"crossref","first-page":"3761","DOI":"10.1073\/pnas.1014835108","article-title":"Cyclin E amplification\/overexpression is a mechanism of trastuzumab resistance in HER2+ breast cancer patients","volume":"108","author":"Scaltriti","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.tice.2021.101680_bib0140","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"issue":"7","key":"10.1016\/j.tice.2021.101680_bib0145","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1080\/1061186X.2017.1307379","article-title":"LncRNA PVT1 epigenetically silences miR-195 and modulates EMT and chemoresistance in cervical cancer cells","volume":"25","author":"Shen","year":"2017","journal-title":"J. Drug Target."},{"key":"10.1016\/j.tice.2021.101680_bib0150","series-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","author":"Sung","year":"2021"},{"issue":"2","key":"10.1016\/j.tice.2021.101680_bib0155","doi-asserted-by":"crossref","first-page":"696","DOI":"10.18632\/oncotarget.2673","article-title":"Cyclin E1 and RTK\/RAS signaling drive CDK inhibitor resistance via activation of E2F and ETS","volume":"6","author":"Taylor-Harding","year":"2015","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.tice.2021.101680_bib0160","doi-asserted-by":"crossref","first-page":"266","DOI":"10.2174\/1568009617666170630142725","article-title":"MicroRNA key to angiogenesis regulation: MiRNA biology and therapy","volume":"18","author":"Tiwari","year":"2018","journal-title":"Curr. Cancer Drug Targets"},{"issue":"13","key":"10.1016\/j.tice.2021.101680_bib0165","first-page":"1722","article-title":"Propofol inhibits invasion and enhances paclitaxel- induced apoptosis in ovarian cancer cells through the suppression of the transcription factor slug","volume":"17","author":"Wang","year":"2013","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"14","key":"10.1016\/j.tice.2021.101680_bib0170","doi-asserted-by":"crossref","first-page":"e141","DOI":"10.1093\/nar\/gkt464","article-title":"Chromosomal deletions and inversions mediated by TALENs and CRISPR\/Cas in zebrafish","volume":"41","author":"Xiao","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tice.2021.101680_bib0175","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1186\/s12967-014-0279-x","article-title":"Propofol exerts anti-hepatocellular carcinoma by microvesicle-mediated transfer of miR-142-3p from macrophage to cancer cells","volume":"12","author":"Zhang","year":"2014","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.tice.2021.101680_bib0180","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s13046-017-0528-y","article-title":"Exosomal transfer of tumor-associated macrophage-derived miR-21 confers cisplatin resistance in gastric cancer cells","volume":"36","author":"Zheng","year":"2017","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"14","key":"10.1016\/j.tice.2021.101680_bib0185","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.2174\/1871520617666170713151149","article-title":"Recent progress of nano-drug delivery system for liver cancer treatment","volume":"17","author":"Zhou","year":"2018","journal-title":"Anticancer Agents Med. Chem."},{"issue":"2","key":"10.1016\/j.tice.2021.101680_bib0190","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1620\/tjem.245.89","article-title":"Microarray expression profiling of microRNAs reveals potential biomarkers for hepatocellular carcinoma","volume":"245","author":"Zhu","year":"2018","journal-title":"Tohoku J. Exp. Med."},{"issue":"1","key":"10.1016\/j.tice.2021.101680_bib0195","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/hep.21224","article-title":"Expression of a cyclin E1 isoform in mice is correlated with the quiescent cell cycle status of hepatocytes in vivo","volume":"44","author":"Zschemisch","year":"2006","journal-title":"Hepatology"}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816621001968?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816621001968?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:21:07Z","timestamp":1758572467000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816621001968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":39,"alternative-id":["S0040816621001968"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2021.101680","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Propofol enhances the lethality of cisplatin on liver cancer cells by up-regulating miR-195-5p","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2021.101680","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101680"}}