{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:17:07Z","timestamp":1792513027932,"version":"4.5.0"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["NSC 101-2314-B-075B-005"],"award-info":[{"award-number":["NSC 101-2314-B-075B-005"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011913","name":"Kaohsiung Veterans General Hospital","doi-asserted-by":"publisher","award":["108-108"],"award-info":[{"award-number":["108-108"]}],"id":[{"id":"10.13039\/501100011913","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011913","name":"Kaohsiung Veterans General Hospital","doi-asserted-by":"publisher","award":["VGHKS 109-86"],"award-info":[{"award-number":["VGHKS 109-86"]}],"id":[{"id":"10.13039\/501100011913","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.tice.2021.101699","type":"journal-article","created":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T01:57:31Z","timestamp":1637891851000},"page":"101699","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Kidney bioengineering by using decellularized kidney scaffold and renal progenitor cells"],"prefix":"10.1016","volume":"74","author":[{"given":"Chih-Yang","family":"Hsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Ling","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Hsiang","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang-Ju","family":"Chou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Chang","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Liang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Wei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzung-Yo","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Tsang","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2021.101699_bib0005","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.actbio.2015.11.026","article-title":"Repopulation of porcine kidney scaffold using porcine primary renal cells","volume":"29","author":"Abolbashari","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.tice.2021.101699_bib0010","first-page":"6526","article-title":"Whole organ decellularization - a tool for bioscaffold fabrication and organ bioengineering","author":"Baptista","year":"2009","journal-title":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society"},{"key":"10.1016\/j.tice.2021.101699_bib0015","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1186\/s13287-015-0241-8","article-title":"Progenitor-like cells derived from mouse kidney protect against renal fibrosis in a remnant kidney model via decreased endothelial mesenchymal transition","volume":"6","author":"Chen","year":"2015","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.tice.2021.101699_bib0020","doi-asserted-by":"crossref","first-page":"8001","DOI":"10.1038\/s41598-019-44393-y","article-title":"Engineering the vasculature of decellularized rat kidney scaffolds using human induced pluripotent stem cell-derived endothelial cells","volume":"9","author":"Ciampi","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2021.101699_bib0025","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1002\/adhm.201600120","article-title":"Functional kidney bioengineering with pluripotent stem-cell-derived renal progenitor cells and decellularized kidney scaffolds","volume":"5","author":"Du","year":"2016","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.tice.2021.101699_bib0030","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1172\/JCI22593","article-title":"Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells","volume":"115","author":"Duffield","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tice.2021.101699_bib0035","doi-asserted-by":"crossref","first-page":"150","DOI":"10.5301\/ijao.5000564","article-title":"Towards a bioengineered kidney: recellularization strategies for decellularized native kidney scaffolds","volume":"40","author":"Fedecostante","year":"2017","journal-title":"Int. J. Artif. Organs"},{"issue":"Suppl 2","key":"10.1016\/j.tice.2021.101699_bib0040","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/ajt.13666","article-title":"Kidney","volume":"16","author":"Hart","year":"2016","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.tice.2021.101699_bib0045","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1002\/jbm.a.36407","article-title":"Biocompatibility and hemocompatibility of efficiently decellularized whole porcine kidney for tissue engineering","volume":"106","author":"Hussein","year":"2018","journal-title":"J. Biomed. Mater. Res. A."},{"key":"10.1016\/j.tice.2021.101699_bib0050","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1172\/JCI17856","article-title":"Bone marrow stem cells contribute to repair of the ischemically injured renal tubule","volume":"112","author":"Kale","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tice.2021.101699_bib0055","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1056\/NEJMc1213779","article-title":"HLA-mismatched renal transplantation without maintenance immunosuppression","volume":"368","author":"Kawai","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tice.2021.101699_bib0060","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.biomaterials.2014.11.027","article-title":"Bioengineered transplantable porcine livers with re-endothelialized vasculature","volume":"40","author":"Ko","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.tice.2021.101699_bib0065","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/stem.310","article-title":"Mouse kidney progenitor cells accelerate renal regeneration and prolong survival after ischemic injury","volume":"28","author":"Lee","year":"2010","journal-title":"Stem Cells"},{"key":"10.1016\/j.tice.2021.101699_bib0070","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1111\/ajt.15200","article-title":"Vascular bioengineering of scaffolds derived from human discarded transplant kidneys using human pluripotent stem cell-derived endothelium","volume":"19","author":"Leuning","year":"2019","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.tice.2021.101699_bib0075","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","article-title":"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study","volume":"380","author":"Lozano","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.tice.2021.101699_bib0080","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/SLA.0b013e31825a02ab","article-title":"Production and implantation of renal extracellular matrix scaffolds from porcine kidneys as a platform for renal bioengineering investigations","volume":"256","author":"Orlando","year":"2012","journal-title":"Ann. Surg."},{"key":"10.1016\/j.tice.2021.101699_bib0085","doi-asserted-by":"crossref","first-page":"43502","DOI":"10.1038\/srep43502","article-title":"Experimental evaluation of kidney regeneration by organ scaffold recellularization","volume":"7","author":"Remuzzi","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2021.101699_bib0090","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/nm.3154","article-title":"Regeneration and experimental orthotopic transplantation of a bioengineered kidney","volume":"19","author":"Song","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.tice.2021.101699_bib0095","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s13770-019-00197-9","article-title":"Induced intermediate mesoderm combined with decellularized kidney scaffolds for functional engineering kidney","volume":"16","author":"Zhang","year":"2019","journal-title":"Tissue Eng. Regen. Med."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816621002159?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816621002159?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:35:23Z","timestamp":1777455323000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816621002159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":19,"alternative-id":["S0040816621002159"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2021.101699","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Kidney bioengineering by using decellularized kidney scaffold and renal progenitor cells","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2021.101699","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101699"}}