{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T10:44:59Z","timestamp":1794048299258,"version":"4.8.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.tice.2022.101912","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T11:10:36Z","timestamp":1662030636000},"page":"101912","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Caffeic acid abrogates amyloidosis, hypospermatogenesis and cell membrane alterations in the testes and epididymis of fructose-diabetic rats by upregulating steroidogenesis, PCNA and Nrf2 expression"],"prefix":"10.1016","volume":"79","author":[{"given":"Victor Okoliko","family":"Ukwenya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelakun Sunday","family":"Aderemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olutayo Margaret","family":"Alese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olabiyi Ayodeji","family":"Augustine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2022.101912_bib1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ejphar.2019.01.033","article-title":"Dietary protocatechuic acid abrogates male reproductive dysfunction in streptozotocin-induced diabetic rats via suppression of oxidative damage, inflammation and caspase-3 activity","volume":"849","author":"Adedara","year":"2019","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.tice.2022.101912_bib2","doi-asserted-by":"crossref","DOI":"10.1111\/and.12839","article-title":"Co-administration of caffeine and caffeic acid alters some key enzymes linked with reproductive function in male rats","volume":"50","author":"Akomolafe","year":"2018","journal-title":"Andrologia"},{"key":"10.1016\/j.tice.2022.101912_bib3","doi-asserted-by":"crossref","first-page":"4543","DOI":"10.2147\/DMSO.S270783","article-title":"The beneficial role of anchomanes difformis in STZ-induced reproductive dysfunction in male wistar rats","volume":"13","author":"Alabi","year":"2020","journal-title":"Diabetes, Metab. Syndr. Obes.: Targets Ther."},{"key":"10.1016\/j.tice.2022.101912_bib4","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/S0015-0282(03)00984-1","article-title":"Streptozotocin-induced diabetic effects on spermatogenesis with proliferative cell nuclear antigen immunostaining of adult rat testis","volume":"80","author":"Altay","year":"2003","journal-title":"Fertil. Steril."},{"issue":"2","key":"10.1016\/j.tice.2022.101912_bib5","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.pbb.2012.09.006","article-title":"Effects of caffeic acid on behavioral parameters and on the activity of acetylcholinesterase in different tissues from adult rats","volume":"103","author":"Anwar","year":"2012","journal-title":"Pharmacol. Biochem. Behav. 1"},{"issue":"7","key":"10.1016\/j.tice.2022.101912_bib6","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1177\/0960327108092293","article-title":"Caffeic acid phenethyl ester modulates methotrexate-induced oxidative stress in testes of rat","volume":"27","author":"Armagan","year":"2008","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.tice.2022.101912_bib7","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.smallrumres.2007.09.002","article-title":"Effect of anti-oxidants and oxidative stress parameters on ram semen after the freeze\u2013thawing process","volume":"75","author":"Bucak","year":"2008","journal-title":"Small Rumin. Res."},{"issue":"10","key":"10.1016\/j.tice.2022.101912_bib8","doi-asserted-by":"crossref","first-page":"382","DOI":"10.3389\/fphar.2019.00382","article-title":"Nrf2 as a potential mediator of cardiovascular risk in metabolic diseases","volume":"12","author":"da Costa","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.tice.2022.101912_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13000-017-0646-z","article-title":"Localized amyloidosis of the epididymis: a previously unreported phenomenon","volume":"12","author":"D\u00edaz-Flores","year":"2017","journal-title":"Diagn. Pathol."},{"issue":"2","key":"10.1016\/j.tice.2022.101912_bib10","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1007\/s12011-020-02082-2","article-title":"Co-administration of selenium nanoparticles and metformin abrogate testicular oxidative injury by suppressing redox imbalance, augmenting sperm quality and Nrf2 protein expression in streptozotocin-induced diabetic rats","volume":"198","author":"Ebokaiwe","year":"2020","journal-title":"Biol. Trace Elem. Res."},{"issue":"237","key":"10.1016\/j.tice.2022.101912_bib11","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jep.2019.03.039","article-title":"Raffia palm (Raphia hookeri G. Mann & H. Wendl) wine modulates glucose homeostasis by enhancing insulin secretion and inhibiting redox imbalance in a rat model of diabetes induced by high fructose diet and streptozotocin.","volume":"12","author":"Erukainure","year":"2019","journal-title":"J. Ethnopharmacol."},{"issue":"21","key":"10.1016\/j.tice.2022.101912_bib12","doi-asserted-by":"crossref","first-page":"9350","DOI":"10.1128\/MCB.25.21.9350-9359.2005","article-title":"Nuclear dynamics of PCNA in DNA replication and repair","volume":"25","author":"Essers","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.tice.2022.101912_bib13","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1007\/s001250050707","article-title":"Alteration of Na,K-ATPase isoenzymes in diabetic cardiomyopathy: effect of dietary supplementation with \ufb01sh oil (n-3 fatty acids) in rats","volume":"40","author":"Gerbi","year":"1997","journal-title":"Diabetologia"},{"key":"10.1016\/j.tice.2022.101912_bib14","article-title":"Sorbitol, phosphoinositides, and sodium-potassium ATPase in the pathogenesis of diabetic complications","volume":"316","author":"Greene","year":"1987","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.tice.2022.101912_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-44358-1","article-title":"Activation of the unfolded protein response in high glucose treated endothelial cells is mediated by methylglyoxal","volume":"9","author":"Irshad","year":"2019","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.tice.2022.101912_bib16","doi-asserted-by":"crossref","first-page":"5321","DOI":"10.18632\/oncotarget.23915","article-title":"Hyperglycemia induced testicular damage in type 2 diabetes mellitus rats exhibiting microcirculation impairments associated with vascular endothelial growth factor decreased via PI3K\/Akt pathway","volume":"9","author":"Long","year":"2018","journal-title":"Oncotarget"},{"issue":"4","key":"10.1016\/j.tice.2022.101912_bib17","first-page":"3404","article-title":"Protective effects of amifostine, curcumin and caffeic acid phenethyl ester against cisplatin-induced testis tissue damage in rats","volume":"15","author":"Mercantepe","year":"2018","journal-title":"Exp. Ther. Med."},{"issue":"4\u20135","key":"10.1016\/j.tice.2022.101912_bib18","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1046\/j.1439-0272.2000.00391.x","article-title":"Sertoli cells as a target for reproductive hazards","volume":"32","author":"Monsees","year":"2000","journal-title":"Andrologia"},{"key":"10.1016\/j.tice.2022.101912_bib19","first-page":"2015","article-title":"Immunohistochemical study of Nrf2-antioxidant response element as indicator of oxidative stress induced by cadmium in developing rats","author":"Montes","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.tice.2022.101912_bib20","series-title":"Clinically Oriented Anatomy","author":"Moore","year":"2017"},{"key":"10.1016\/j.tice.2022.101912_bib21","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/145342","article-title":"Caffeic acid phenethyl ester and therapeutic potentials","volume":"2014","author":"Murtaza","year":"2014","journal-title":"BioMed. Res. Int."},{"issue":"1","key":"10.1016\/j.tice.2022.101912_bib22","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/0003-2697(77)90315-3","article-title":"A high sensitive method for the measurement of ATPase activity","volume":"77","author":"Muszbek","year":"1977","journal-title":"Anal. Biochem"},{"key":"10.1016\/j.tice.2022.101912_bib23","first-page":"E243","article-title":"Alterations in levels of Na(+)-K(+)-ATPase isoforms in heart, skeletal muscle, and kidney of diabetic rats","volume":"265","author":"Ng","year":"1993","journal-title":"Am. J. Physiol."},{"issue":"10","key":"10.1016\/j.tice.2022.101912_bib24","first-page":"465","article-title":"Oxidative stress, NF-\u03baB-mediated inflammation and apoptosis in the testes of streptozotocin-induced diabetic rats: combined protective effects of malaysian propolis and metformin","volume":"8","author":"Nna","year":"2019","journal-title":"Antioxid. (Basel, Switz.)"},{"issue":"4","key":"10.1016\/j.tice.2022.101912_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2020.e03817","article-title":"Possible therapeutic effects of vindoline on testicular and epididymal function in diabetes-induced oxidative stress male Wistar rats","volume":"6","author":"Oguntibeju","year":"2020","journal-title":"Heliyon"},{"key":"10.1016\/j.tice.2022.101912_bib26","doi-asserted-by":"crossref","DOI":"10.1177\/2515690X18796053","article-title":"Effects of L-carnitine on the follicle-stimulating hormone, luteinizing hormone, testosterone, and testicular tissue oxidative stress levels in streptozotocin-induced diabetic rats","volume":"23","author":"Rezaei","year":"2018","journal-title":"J. Evid. -Based Integr. Med."},{"issue":"2","key":"10.1016\/j.tice.2022.101912_bib27","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3109\/01485019808987932","article-title":"Impact of aging and diabetes mellitus on the expression of the proliferating cell nuclear antigen in rat testicular tissue","volume":"40","author":"Salama","year":"1998","journal-title":"Arch. Androl."},{"issue":"1","key":"10.1016\/j.tice.2022.101912_bib28","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0090-4295(99)00369-6","article-title":"Testicular amyloid deposition as a cause of secondary azoospermia","volume":"55","author":"Schrepferman","year":"2000","journal-title":"Urology"},{"issue":"7","key":"10.1016\/j.tice.2022.101912_bib29","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1046\/j.1432-1327.2000.01211.x","article-title":"Effect of streptozotocin\u2010induced diabetes on rat liver Na+\/K+\u2014ATPase","volume":"267","author":"Sennoune","year":"2000","journal-title":"Eur. J. Biochem."},{"issue":"2","key":"10.1016\/j.tice.2022.101912_bib30","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0092-8674(92)90416-A","article-title":"Proliferating cell nuclear antigen is required for DNA excision repair","volume":"69","author":"Shivji","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.tice.2022.101912_bib31","first-page":"72","article-title":"Evaluation of antioxidant potential of methanolic leaf extract of Anacardium occidentale (Linn) on the testes of streptozotocin-induced diabetic wistar rats","volume":"17","author":"Ukwenya","year":"2013","journal-title":"Eur. J. Anat."},{"issue":"2","key":"10.1016\/j.tice.2022.101912_bib32","first-page":"92","article-title":"Cytoprotective activities of Anacardium occidentale (linn) on the testis of streptozotocin-induced diabetic rats","volume":"17","author":"Ukwenya","year":"2013","journal-title":"Eur. J. Anat."},{"issue":"1","key":"10.1016\/j.tice.2022.101912_bib33","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S1734-1140(12)70739-9","article-title":"Fructose-fed streptozotocin-injected rat: an alternative model for type 2 diabetes","volume":"64","author":"Wilson","year":"2012","journal-title":"Pharm. Rep."},{"key":"10.1016\/j.tice.2022.101912_bib34","doi-asserted-by":"crossref","first-page":"396","DOI":"10.2337\/diab.36.3.396","article-title":"Does a common mechanism induce the diverse complications of diabetes?","volume":"36","author":"Winegrad","year":"1986","journal-title":"Diabetes"}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816622001847?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816622001847?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:24:30Z","timestamp":1758572670000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816622001847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":34,"alternative-id":["S0040816622001847"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2022.101912","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Caffeic acid abrogates amyloidosis, hypospermatogenesis and cell membrane alterations in the testes and epididymis of fructose-diabetic rats by upregulating steroidogenesis, PCNA and Nrf2 expression","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2022.101912","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101912"}}