{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T08:09:48Z","timestamp":1794211788040,"version":"4.8.0"},"reference-count":126,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.tice.2022.101992","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T11:10:29Z","timestamp":1669633829000},"page":"101992","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"special_numbering":"C","title":["Challenges in osteoarthritis treatment"],"prefix":"10.1016","volume":"80","author":[{"given":"Asrin","family":"Emami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haideh","family":"Namdari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzad","family":"Parvizpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohreh","family":"Arabpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.tice.2022.101992_bib1","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1093\/rheumatology\/keaa745","article-title":"Potential efficacy of dendritic cell immunomodulation in the treatment of osteoarthritis","volume":"60","author":"Alahdal","year":"2021","journal-title":"Rheumatology"},{"key":"10.1016\/j.tice.2022.101992_bib2","series-title":"A Study of Bone Quality in Femoral Neck of Osteoarthritis","author":"Alousaimi","year":"2018"},{"key":"10.1016\/j.tice.2022.101992_bib3","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.2165\/11592550-000000000-00000","article-title":"Topical Therapies for Osteoarthritis","volume":"71","author":"Altman","year":"2011","journal-title":"Drugs"},{"issue":"10","key":"10.1016\/j.tice.2022.101992_bib4","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1002\/jbm.a.36742","article-title":"Design and characterization of biodegradable multi layered electrospun nanofibers for corneal tissue engineering applications","volume":"107","author":"Arabpour","year":"2019","journal-title":"J. Biomed. Mater. Res. Part A"},{"issue":"11","key":"10.1016\/j.tice.2022.101992_bib5","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1089\/ten.tea.2007.0264","article-title":"Macrophage phenotype as a determinant of biologic scaffold remodeling","volume":"14","author":"Badylak","year":"2008","journal-title":"Tissue Eng. Part A"},{"issue":"4","key":"10.1016\/j.tice.2022.101992_bib6","doi-asserted-by":"crossref","first-page":"582","DOI":"10.3390\/life12040582","article-title":"Epigenetic regulation of chondrocytes and subchondral bone in osteoarthritis","volume":"12","author":"Ball","year":"2022","journal-title":"Life"},{"issue":"01","key":"10.1016\/j.tice.2022.101992_bib7","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2217\/rme-2020-0045","article-title":"Adipose tissue-derived mesenchymal stem cells for breast tissue regeneration","volume":"16","author":"Banani","year":"2021","journal-title":"Regen. Med."},{"issue":"22","key":"10.1016\/j.tice.2022.101992_bib8","doi-asserted-by":"crossref","first-page":"10764","DOI":"10.1073\/pnas.90.22.10764","article-title":"Intraarticular expression of biologically active interleukin 1-receptor-antagonist protein by ex vivo gene transfer","volume":"90","author":"Bandara","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"4","key":"10.1016\/j.tice.2022.101992_bib9","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3390\/biology9040065","article-title":"Osteoarthritis and toll-like receptors: When innate immunity meets chondrocyte apoptosis","volume":"9","author":"Barreto","year":"2020","journal-title":"Biology"},{"issue":"1","key":"10.1016\/j.tice.2022.101992_bib10","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1177\/1947603509360044","article-title":"Autologous matrix-induced chondrogenesis (AMIC): combining microfracturing and a collagen i\/iii matrix for articular cartilage resurfacing","volume":"1","author":"Benthien","year":"2010","journal-title":"Cartilage"},{"issue":"10","key":"10.1016\/j.tice.2022.101992_bib11","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1177\/0363546517704842","article-title":"Clinical outcome after arthroscopic debridement and microfracture for osteochondritis dissecans of the capitellum","volume":"45","author":"Bexkens","year":"2017","journal-title":"Am. J. Sports Med"},{"issue":"1\u20132","key":"10.1016\/j.tice.2022.101992_bib12","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.cellimm.2013.08.005","article-title":"Constitutive expression of ligand for natural killer cell NKp44 receptor (NKp44L) by normal human articular chondrocytes","volume":"285","author":"Bia\u0142oszewska","year":"2013","journal-title":"Cell. Immunol."},{"issue":"3","key":"10.1016\/j.tice.2022.101992_bib13","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.rh.2020.06.001","article-title":"Efficacy of magnetotherapy in hand erosive osteoarthritis. A clinical trial","volume":"55","author":"Boada-Pladellorens","year":"2021","journal-title":"Rehabil. (Madr. )"},{"issue":"6","key":"10.1016\/j.tice.2022.101992_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/ar2099","article-title":"The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis","volume":"8","author":"Bondeson","year":"2006","journal-title":"Arthritis Res. Ther."},{"issue":"3","key":"10.1016\/j.tice.2022.101992_bib15","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/art.27290","article-title":"The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis","volume":"62","author":"Bondeson","year":"2010","journal-title":"Arthritis Rheum. -Arthritis Care Res."},{"issue":"3","key":"10.1016\/j.tice.2022.101992_bib16","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1177\/0954411917751560","article-title":"Simple geometry tribological study of osteochondral graft implantation in the knee","volume":"232","author":"Bowland","year":"2018","journal-title":"Proc. Inst. Mech. Eng., Part H: J. Eng. Med."},{"key":"10.1016\/j.tice.2022.101992_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.645842","article-title":"New trends in pharmacological treatments for osteoarthritis","volume":"12","author":"Cai","year":"2021","journal-title":"Front Pharm."},{"issue":"1","key":"10.1016\/j.tice.2022.101992_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-018-1047-2","article-title":"Exosomes derived from mature chondrocytes facilitate subcutaneous stable ectopic chondrogenesis of cartilage progenitor cells","volume":"9","author":"Chen","year":"2018","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.tice.2022.101992_bib19","first-page":"261","article-title":"Macrophages in osteoarthritis: pathophysiology and therapeutics","volume":"12","author":"Chen","year":"2020","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.tice.2022.101992_bib20","first-page":"1063","article-title":"Molecular mechanisms of chondrocyte proliferation and differentiation","author":"Chen","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.tice.2022.101992_bib21","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1111\/j.1526-4637.2012.01394.x","article-title":"Evidence-based knee injections for the management of arthritis","volume":"13","author":"Cheng","year":"2012","journal-title":"Pain. Med."},{"key":"10.1016\/j.tice.2022.101992_bib22","doi-asserted-by":"crossref","first-page":"n2321","DOI":"10.1136\/bmj.n2321","article-title":"Effectiveness and safety of non-steroidal anti-inflammatory drugs and opioid treatment for knee and hip osteoarthritis: network meta-analysis","volume":"375","author":"da Costa","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.tice.2022.101992_bib23","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.bone.2016.01.010","article-title":"Proinflammatory T cells and IL-17 stimulate osteoblast differentiation","volume":"84","author":"Croes","year":"2016","journal-title":"Bone"},{"issue":"391 Suppl","key":"10.1016\/j.tice.2022.101992_bib24","doi-asserted-by":"crossref","first-page":"S90","DOI":"10.1097\/00003086-200110001-00009","article-title":"Impact of mechanical trauma on matrix and cells","author":"D'Lima","year":"2001","journal-title":"Clin. Orthop. Relat. Res"},{"issue":"1","key":"10.1016\/j.tice.2022.101992_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep17622","article-title":"TLR-3 stimulation improves anti-tumor immunity elicited by dendritic cell exosome-based vaccines in a murine model of melanoma","volume":"5","author":"Damo","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2022.101992_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108179","article-title":"Crosstalk between immune cells and bone cells or chondrocytes","volume":"101","author":"Deng","year":"2021","journal-title":"Int. Immunopharmacol."},{"issue":"10","key":"10.1016\/j.tice.2022.101992_bib27","article-title":"Complete loss of the MHC II pathway in an anglerfish","volume":"15","author":"Dubin","year":"2019","journal-title":"Lophius piscatorius. Biol. Lett."},{"issue":"1","key":"10.1016\/j.tice.2022.101992_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12967-020-02525-3","article-title":"Synergic effects of decellularized bone matrix, hydroxyapatite, and extracellular vesicles on repairing of the rabbit mandibular bone defect model","volume":"18","author":"Emami","year":"2020","journal-title":"J. Transl. Med."},{"issue":"11","key":"10.1016\/j.tice.2022.101992_bib29","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1021\/acs.biomac.6b01235","article-title":"Smart polymeric hydrogels for cartilage tissue engineering: a review on the chemistry and biological functions","volume":"17","author":"Eslahi","year":"2016","journal-title":"Biomacromolecules"},{"issue":"1","key":"10.1016\/j.tice.2022.101992_bib30","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1089\/hum.2017.181","article-title":"Gene delivery to joints by intra-articular injection","volume":"29","author":"Evans","year":"2018","journal-title":"Hum. Gene Ther."},{"issue":"8","key":"10.1016\/j.tice.2022.101992_bib31","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1002\/art.40515","article-title":"Emerging treatment models in rheumatology: challenges for osteoarthritis trials","volume":"70","author":"Felson","year":"2018","journal-title":"Arthritis Rheumatol."},{"issue":"2011","key":"10.1016\/j.tice.2022.101992_bib32","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2478\/v10078-011-0076-z","article-title":"Application of platelet rich plasma in sports medicine","volume":"30","author":"Ficek","year":"2011","journal-title":"J. Hum. Kinet."},{"issue":"11","key":"10.1016\/j.tice.2022.101992_bib33","doi-asserted-by":"crossref","first-page":"8962","DOI":"10.1002\/jcp.26832","article-title":"Time\u2010dependent contribution of BMP, FGF, IGF, and HH signaling to the proliferation of mesenchymal stroma cells during chondrogenesis","volume":"233","author":"Fischer","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"3","key":"10.1016\/j.tice.2022.101992_bib34","first-page":"156","article-title":"Synthesis and optimization of chitosan nanoparticles: potential applications in nanomedicine and biomedical engineering","volume":"5","author":"Ghadi","year":"2014","journal-title":"Casp. J. Intern Med"},{"key":"10.1016\/j.tice.2022.101992_bib35","article-title":"In situ casting of platelet rich plasma\/SiO2\/alginate for bone tissue engineering application in rabbit mandible defect model","author":"Gholijani","year":"2022","journal-title":"J. Dent."},{"issue":"4","key":"10.1016\/j.tice.2022.101992_bib36","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1177\/1947603516638901","article-title":"Matrix-associated autologous chondrocyte implantation: a clinical follow-up at 15 years","volume":"7","author":"Gille","year":"2016","journal-title":"Cartilage"},{"issue":"5","key":"10.1016\/j.tice.2022.101992_bib37","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1080\/08923973.2018.1523927","article-title":"Suppressive oligodeoxynucleotide-induced dendritic cells rein the aggravation of osteoarthritis in mice","volume":"40","author":"Guo","year":"2018","journal-title":"Immunopharmacol. Immunotoxicol."},{"issue":"3","key":"10.1016\/j.tice.2022.101992_bib38","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.clim.2012.12.011","article-title":"Immunopathogenesis of osteoarthritis","volume":"146","author":"Haseeb","year":"2013","journal-title":"Clin. Immunol."},{"issue":"Suppl 120","key":"10.1016\/j.tice.2022.101992_bib39","first-page":"3","article-title":"Osteoarthritis is a serious disease","volume":"37","author":"Hawker","year":"2019","journal-title":"Clin. Exp. Rheuma"},{"issue":"1","key":"10.1016\/j.tice.2022.101992_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-020-01781-w","article-title":"Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis","volume":"11","author":"He","year":"2020","journal-title":"Stem Cell Res. Ther."},{"issue":"315","key":"10.1016\/j.tice.2022.101992_bib41","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aac5608","article-title":"Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis","volume":"7","author":"Headland","year":"2015","journal-title":"Sci. Transl. Med."},{"issue":"3","key":"10.1016\/j.tice.2022.101992_bib42","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.clim.2011.04.008","article-title":"Induction of type B synoviocyte-like cells from plasmacytoid dendritic cells of the bone marrow in rheumatoid arthritis and osteoarthritis","volume":"140","author":"Hirohata","year":"2011","journal-title":"Clin. Immunol."},{"issue":"1","key":"10.1016\/j.tice.2022.101992_bib43","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/art.41486","article-title":"Synergistic roles of macrophages and neutrophils in osteoarthritis progression","volume":"73","author":"Hsueh","year":"2021","journal-title":"Arthritis Rheumatol."},{"issue":"12","key":"10.1016\/j.tice.2022.101992_bib44","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.1002\/art.27751","article-title":"Synovial tissue\u2013infiltrating natural killer cells in osteoarthritis and periprosthetic inflammation","volume":"62","author":"Huss","year":"2010","journal-title":"Arthritis Rheum."},{"issue":"3","key":"10.1016\/j.tice.2022.101992_bib45","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.bbrc.2004.06.029","article-title":"Growth factor combination for chondrogenic induction from human mesenchymal stem cell","volume":"320","author":"Indrawattana","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"10","key":"10.1016\/j.tice.2022.101992_bib46","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1016\/j.joca.2017.06.007","article-title":"CD56+\/CD16\u2212 Natural Killer cells expressing the inflammatory protease granzyme A are enriched in synovial fluid from patients with osteoarthritis","volume":"25","author":"Jaime","year":"2017","journal-title":"Osteoarthr. Carti."},{"key":"10.1016\/j.tice.2022.101992_bib47","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3389\/fimmu.2020.00363","article-title":"Dendritic cell-restricted progenitors contribute to obesity-associated airway inflammation via Adam17-p38 MAPK-dependent pathway","volume":"11","author":"Jaiswal","year":"2020","journal-title":"Front. Immunol."},{"issue":"Pt B","key":"10.1016\/j.tice.2022.101992_bib48","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.ijsu.2017.08.557","article-title":"Hip arthroscopy: indications, outcomes and complications","volume":"54","author":"Jamil","year":"2018","journal-title":"Int J. Surg."},{"issue":"6","key":"10.1016\/j.tice.2022.101992_bib49","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nm.4324","article-title":"Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment","volume":"23","author":"Jeon","year":"2017","journal-title":"Nat. Med"},{"key":"10.1016\/j.tice.2022.101992_bib50","first-page":"3","article-title":"Platelet-rich plasma application in chondrogenesis","author":"Kabiri","year":"2014","journal-title":"Adv. Biomed. Res."},{"issue":"1","key":"10.1016\/j.tice.2022.101992_bib51","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1089\/humc.2017.249","article-title":"A multicenter, double-blind, phase iii clinical trial to evaluate the efficacy and safety of a cell and gene therapy in knee osteoarthritis patients","volume":"29","author":"Kim","year":"2018","journal-title":"Hum. Gene Ther. Clin. Dev."},{"issue":"5","key":"10.1016\/j.tice.2022.101992_bib52","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1242\/dev.105536","article-title":"A pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturation","volume":"142","author":"Kozhemyakina","year":"2015","journal-title":"Development"},{"issue":"9","key":"10.1016\/j.tice.2022.101992_bib53","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.3390\/ijms19092700","article-title":"Challenges in fabrication of tissue-engineered cartilage with correct cellular colonization and extracellular matrix assembly","volume":"19","author":"Lammi","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"1\u20132","key":"10.1016\/j.tice.2022.101992_bib54","first-page":"95","article-title":"Effects of shear stress on articular chondrocyte metabolism","volume":"37","author":"Lane Smith","year":"2000","journal-title":"Biorheology"},{"key":"10.1016\/j.tice.2022.101992_bib55","first-page":"76","article-title":"Cartilage repair by mesenchymal stem cells: clinical trial update and perspectives","volume":"9","author":"Lee","year":"2017","journal-title":"J. Orthop. Transl."},{"issue":"33","key":"10.1016\/j.tice.2022.101992_bib56","doi-asserted-by":"crossref","first-page":"36938","DOI":"10.1021\/acsami.0c10458","article-title":"Chondrocyte-targeted microRNA delivery by engineered exosomes toward a cell-free osteoarthritis therapy","volume":"12","author":"Liang","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"18","key":"10.1016\/j.tice.2022.101992_bib57","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202005513","article-title":"Recent progress in cartilage lubrication","volume":"33","author":"Lin","year":"2021","journal-title":"Adv. Mater."},{"key":"10.1016\/j.tice.2022.101992_bib58","doi-asserted-by":"crossref","first-page":"757","DOI":"10.3389\/fphar.2020.00757","article-title":"The bone extracellular matrix in bone formation and regeneration","volume":"11","author":"Lin","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.tice.2022.101992_bib59","first-page":"356","article-title":"T cells in osteoarthritis: alterations and beyond","volume":"8","author":"Li","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tice.2022.101992_bib60","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.intimp.2018.09.038","article-title":"B-cell-specific mammalian target of rapamycin complex 1 activation results in severe osteoarthritis in mice","volume":"65","author":"Lin","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.tice.2022.101992_bib61","series-title":"Seminars in cell & developmental biology","article-title":"Transcriptional Control of Chondrocyte Specification and Differentiation","author":"Liu","year":"2017"},{"key":"10.1016\/j.tice.2022.101992_bib62","article-title":"The immune microenvironment in cartilage injury and repair","author":"Li","year":"2021","journal-title":"Acta Biomater."},{"issue":"1","key":"10.1016\/j.tice.2022.101992_bib63","first-page":"149","article-title":"Nanoparticle-cartilage interaction: pathology-based intra-articular drug delivery for osteoarthritis therapy","volume":"13","author":"Li","year":"2021","journal-title":"Nanomicro Lett."},{"issue":"2","key":"10.1016\/j.tice.2022.101992_bib64","doi-asserted-by":"crossref","first-page":"137","DOI":"10.2340\/16501977-0134","article-title":"A randomized controlled trial of aquatic and land-based exercise in patients with knee osteoarthritis","volume":"40","author":"Lund","year":"2008","journal-title":"J. Rehabil. Med"},{"issue":"6","key":"10.1016\/j.tice.2022.101992_bib65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-021-03792-8","article-title":"TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca2+\/CaMKII\/Nrf2 signaling pathway","volume":"12","author":"Lv","year":"2021","journal-title":"Cell death Dis."},{"issue":"1","key":"10.1016\/j.tice.2022.101992_bib66","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrrheum.2014.157","article-title":"Repair and tissue engineering techniques for articular cartilage","volume":"11","author":"Makris","year":"2015","journal-title":"Nat. Rev. Rheumatol."},{"issue":"12","key":"10.1016\/j.tice.2022.101992_bib67","article-title":"Emerging therapies for cartilage regeneration in currently excluded \u2018red knee\u2019 populations","volume":"4","author":"Mart\u00edn","year":"2019","journal-title":"npj Regen. Med"},{"issue":"11","key":"10.1016\/j.tice.2022.101992_bib68","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1002\/jcp.25969","article-title":"Osteoblast role in osteoarthritis pathogenesis","volume":"232","author":"Maruotti","year":"2017","journal-title":"J. Cell. Physiol."},{"issue":"2","key":"10.1016\/j.tice.2022.101992_bib69","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/aa9ef1","article-title":"Automated 3D bioassembly of micro-tissues for biofabrication of hybrid tissue engineered constructs","volume":"10","author":"Mekhileri","year":"2018","journal-title":"Biofabrication"},{"issue":"4","key":"10.1016\/j.tice.2022.101992_bib70","doi-asserted-by":"crossref","first-page":"e400","DOI":"10.1111\/sms.12330","article-title":"Trends in arthroscopy-documented cartilage injuries of the knee and repair procedures among 15-60-year-old patients","volume":"25","author":"Mor","year":"2015","journal-title":"Scand. J. Med Sci. Sports"},{"issue":"11","key":"10.1016\/j.tice.2022.101992_bib71","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/nrrheum.2016.162","article-title":"The danger from within: alarmins in arthritis","volume":"12","author":"Nefla","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"issue":"1","key":"10.1016\/j.tice.2022.101992_bib72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41413-020-0100-9","article-title":"Exosomes: roles and therapeutic potential in osteoarthritis","volume":"8","author":"Ni","year":"2020","journal-title":"Bone Res."},{"key":"10.1016\/j.tice.2022.101992_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116920","article-title":"Dendritic cells aggregate inflammation in experimental osteoarthritis through a toll-like receptor (TLR)-dependent machinery response to challenges","volume":"238","author":"Nie","year":"2019","journal-title":"Life Sci."},{"issue":"2","key":"10.1016\/j.tice.2022.101992_bib74","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00441-019-02996-x","article-title":"The use of PRP injections in the management of knee osteoarthritis","volume":"376","author":"O\u2019Connell","year":"2019","journal-title":"Cell Tissue Res."},{"issue":"12","key":"10.1016\/j.tice.2022.101992_bib75","first-page":"2602","article-title":"Interleukin 17, a nitric oxide-producing cytokine with a peroxynitrite-independent inhibitory effect on proteoglycan synthesis","volume":"29","author":"Pacquelet","year":"2002","journal-title":"J. Rheumatol."},{"issue":"17","key":"10.1016\/j.tice.2022.101992_bib76","doi-asserted-by":"crossref","first-page":"9463","DOI":"10.3390\/ijms22179463","article-title":"Chondrocytes from osteoarthritis patients adopt distinct phenotypes in response to central th1\/th2\/th17 cytokines","volume":"22","author":"Pemmari","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2022.101992_bib77","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3389\/fimmu.2016.00415","article-title":"Human articular chondrocytes regulate immune response by affecting directly T cell proliferation and indirectly inhibiting monocyte differentiation to professional antigen-presenting cells","volume":"7","author":"Pereira","year":"2016","journal-title":"Front. Immunol."},{"issue":"9","key":"10.1016\/j.tice.2022.101992_bib78","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1007\/s40266-012-0006-3","article-title":"Nutraceuticals in the management of osteoarthritis: a critical review","volume":"29","author":"Ragle","year":"2012","journal-title":"Drugs Aging"},{"key":"10.1016\/j.tice.2022.101992_bib79","first-page":"1031","article-title":"Effects of platelet rich plasma and chondrocyte co-culture on MSC chondrogenesis, hypertrophy and pathological responses","volume":"16","author":"Ramezanifard","year":"2017","journal-title":"EXCLI J."},{"issue":"5","key":"10.1016\/j.tice.2022.101992_bib80","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1089\/ten.teb.2011.0141","article-title":"Nanomaterials and hydrogel scaffolds for articular cartilage regeneration","volume":"17","author":"Reddi","year":"2011","journal-title":"Tissue Eng. Part B: Rev."},{"key":"10.1016\/j.tice.2022.101992_bib81","first-page":"19","article-title":"Gene therapy for arthritis","volume":"17","author":"Robbins","year":"1999","journal-title":"Annu Rev. Immunol."},{"issue":"2","key":"10.1016\/j.tice.2022.101992_bib82","first-page":"79","article-title":"The role of gene therapy in cartilage repair","volume":"7","author":"Rodriguez-Merchan","year":"2019","journal-title":"Arch. Bone Jt Surg."},{"key":"10.1016\/j.tice.2022.101992_bib83","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/821279","article-title":"Chitosan and its potential use as a scaffold for tissue engineering in regenerative medicine","volume":"2015","author":"Rodr\u00edguez-V\u00e1zquez","year":"2015","journal-title":"BioMed. Res. Int."},{"key":"10.1016\/j.tice.2022.101992_bib84","first-page":"2011","article-title":"Current surgical treatment of knee osteoarthritis","author":"R\u00f6nn","year":"2011","journal-title":"Arthritis"},{"issue":"1","key":"10.1016\/j.tice.2022.101992_bib85","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13075-020-02410-w","article-title":"Proinflammatory T cell polarization is already present in patients with early knee osteoarthritis","volume":"23","author":"Rosshirt","year":"2021","journal-title":"Arthritis Res. Ther."},{"issue":"6","key":"10.1016\/j.tice.2022.101992_bib86","first-page":"612","article-title":"Multisociety consensus quality improvement revised consensus statement for endovascular therapy of acute ischemic stroke","volume":"13","author":"Sacks","year":"2018","journal-title":"Int J. Stroke"},{"key":"10.1016\/j.tice.2022.101992_bib87","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.biomaterials.2018.11.002","article-title":"Divergent immune responses to synthetic and biological scaffolds","volume":"192","author":"Sadtler","year":"2019","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.tice.2022.101992_bib88","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/s00774-009-0058-6","article-title":"Osteoblasts derived from osteophytes produce interleukin-6, interleukin-8, and matrix metalloproteinase-13 in osteoarthritis","volume":"27","author":"Sakao","year":"2009","journal-title":"J. Bone Miner. Metab."},{"issue":"3","key":"10.1016\/j.tice.2022.101992_bib89","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1302\/0301-620X.84B3.0840364","article-title":"Arthroscopic treatment for osteochondral defects of the talus: results at follow-up at 2 to 11 years","volume":"84","author":"Schuman","year":"2002","journal-title":"J. Bone Jt. Surg. Br. Vol."},{"key":"10.1016\/j.tice.2022.101992_bib90","series-title":"Architecture of Cartilage Tissue and Its Adaptation to Pathological Conditions, in Comparative Kinesiology of the Human Body","first-page":"91","author":"\u015eenol","year":"2020"},{"issue":"6","key":"10.1016\/j.tice.2022.101992_bib91","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.joca.2011.02.014","article-title":"T helper cells promote disease progression of osteoarthritis by inducing macrophage inflammatory protein-1\u03b3","volume":"19","author":"Shen","year":"2011","journal-title":"Osteoarthr. Cartil."},{"issue":"14","key":"10.1016\/j.tice.2022.101992_bib92","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.3390\/ma14143909","article-title":"Human olfactory mucosa stem cells delivery using a collagen hydrogel: as a potential candidate for bone tissue engineering","volume":"14","author":"Simorgh","year":"2021","journal-title":"Materials"},{"issue":"8","key":"10.1016\/j.tice.2022.101992_bib93","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1016\/j.actbio.2014.04.013","article-title":"Semi-interpenetrating networks of hyaluronic acid in degradable PEG hydrogels for cartilage tissue engineering","volume":"10","author":"Skaalure","year":"2014","journal-title":"Acta Biomater."},{"key":"10.1016\/j.tice.2022.101992_bib94","first-page":"121","article-title":"Mesenchymal stem cells in knee osteoarthritis treatment: a systematic review and meta-analysis","volume":"24","author":"Song","year":"2020","journal-title":"J. Orthop. Transl."},{"issue":"2","key":"10.1016\/j.tice.2022.101992_bib95","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1021\/acsbiomaterials.8b00910","article-title":"Macrophage polarization in response to collagen scaffold stiffness is dependent on cross-linking agent used to modulate the stiffness","volume":"5","author":"Sridharan","year":"2018","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"1","key":"10.1016\/j.tice.2022.101992_bib96","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1359\/JBMR.051004","article-title":"Immunocompetent properties of human osteoblasts: interactions with T lymphocytes","volume":"21","author":"Stanley","year":"2006","journal-title":"J. Bone Miner. Res."},{"issue":"Suppl 1","key":"10.1016\/j.tice.2022.101992_bib97","doi-asserted-by":"crossref","first-page":"S97","DOI":"10.1016\/j.injury.2008.01.034","article-title":"Concepts in gene therapy for cartilage repair","volume":"39 Suppl 1","author":"Steinert","year":"2008","journal-title":"Injury"},{"issue":"4","key":"10.1016\/j.tice.2022.101992_bib98","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s13770-021-00337-0","article-title":"Intra-articular atelocollagen injection for the treatment of articular cartilage defects in rabbit model","volume":"18","author":"Suh","year":"2021","journal-title":"Tissue Eng. Regen. Med."},{"issue":"9","key":"10.1016\/j.tice.2022.101992_bib99","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11926-016-0605-9","article-title":"Is synovial macrophage activation the inflammatory link between obesity and osteoarthritis?","volume":"18","author":"Sun","year":"2016","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.tice.2022.101992_bib100","article-title":"Multiple osteochondritis dissecans in multiple joints. Case Reports in","volume":"2021","author":"Takeda","year":"2021","journal-title":"Orthopedics"},{"issue":"2","key":"10.1016\/j.tice.2022.101992_bib101","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s40122-019-0131-3","article-title":"Viscosupplementation for management of knee osteoarthritis from an indian perspective: an expert consensus report","volume":"8","author":"Tapasvi","year":"2019","journal-title":"Pain. Ther."},{"key":"10.1016\/j.tice.2022.101992_bib102","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.carbpol.2018.10.039","article-title":"Polysaccharides for tissue engineering: current landscape and future prospects","volume":"205","author":"Tchobanian","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.tice.2022.101992_bib103","first-page":"12","article-title":"Synovial macrophages in osteoarthritis: the key to understanding pathogenesis?","author":"Thomson","year":"2021","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.tice.2022.101992_bib104","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.cmet.2017.08.012","article-title":"Cell-intrinsic glycogen metabolism supports early glycolytic reprogramming required for dendritic cell immune responses","volume":"26","author":"Thwe","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.tice.2022.101992_bib105","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3390\/jcm9041184","article-title":"AMIC\u2014autologous matrix-induced chondrogenesis technique in patellar cartilage defects treatment: a retrospective study with a mid-term follow-up","volume":"9","author":"Tradati","year":"2020","journal-title":"J. Clin. Med"},{"issue":"4","key":"10.1016\/j.tice.2022.101992_bib106","doi-asserted-by":"crossref","first-page":"991","DOI":"10.3390\/cells9040991","article-title":"Mesenchymal stem cell derived extracellular vesicles for tissue engineering and regenerative medicine applications","volume":"9","author":"Tsiapalis","year":"2020","journal-title":"Cells"},{"issue":"7","key":"10.1016\/j.tice.2022.101992_bib107","doi-asserted-by":"crossref","first-page":"898","DOI":"10.2522\/ptj.20110183","article-title":"Effects of transcutaneous electrical nerve stimulation on pain, pain sensitivity, and function in people with knee osteoarthritis: a randomized controlled trial","volume":"92","author":"Vance","year":"2012","journal-title":"Phys. Ther."},{"issue":"2","key":"10.1016\/j.tice.2022.101992_bib108","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S1083-7515(02)00064-5","article-title":"Systematic review of treatment strategies for osteochondral defects of the talar dome","volume":"8","author":"Verhagen","year":"2003","journal-title":"Foot ankle Clin."},{"issue":"4","key":"10.1016\/j.tice.2022.101992_bib109","article-title":"Balneotherapy (or spa therapy) for rheumatoid arthritis","volume":"2015","author":"Verhagen","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"issue":"4","key":"10.1016\/j.tice.2022.101992_bib110","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.jbspin.2006.03.001","article-title":"Osteoarthritis of the knee and hip and activity: a systematic international review and synthesis (OASIS)","volume":"73","author":"Vignon","year":"2006","journal-title":"Jt. Bone Spine"},{"key":"10.1016\/j.tice.2022.101992_bib111","series-title":"Biomedical Composites","first-page":"261","article-title":"3D Printing of Biocomposites For Osteochondral Tissue Engineering","author":"Vyas","year":"2017"},{"issue":"1","key":"10.1016\/j.tice.2022.101992_bib112","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40898-020-00008-y","article-title":"Biological perspectives and current biofabrication strategies in osteochondral tissue engineering","volume":"5","author":"Vyas","year":"2020","journal-title":"Biomanuf. Rev."},{"key":"10.1016\/j.tice.2022.101992_bib113","first-page":"711","article-title":"Neutrophil elastase induces chondrocyte apoptosis and facilitates the occurrence of osteoarthritis via caspase signaling pathway","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"12","key":"10.1016\/j.tice.2022.101992_bib114","first-page":"4830","article-title":"Articular cartilage and osteochondral tissue engineering techniques: Recent advances and challenges","volume":"6","author":"Wei","year":"2021","journal-title":"Bioact. Mater."},{"issue":"2","key":"10.1016\/j.tice.2022.101992_bib115","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/BOR.0000000000000478","article-title":"Exercise in the management of knee and hip osteoarthritis","volume":"30","author":"Wellsandt","year":"2018","journal-title":"Curr. Opin. Rheuma"},{"key":"10.1016\/j.tice.2022.101992_bib116","doi-asserted-by":"crossref","unstructured":"Wheeler, T.A., et al., T cells mediate progression of load-induced osteoarthritis. BioRxiv, 2020.","DOI":"10.1101\/2020.05.20.106435"},{"issue":"5","key":"10.1016\/j.tice.2022.101992_bib117","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.joca.2019.12.007","article-title":"The role of macrophages in osteoarthritis and cartilage repair","volume":"28","author":"Wu","year":"2020","journal-title":"Osteoarthr. Cartil."},{"issue":"21","key":"10.1016\/j.tice.2022.101992_bib118","doi-asserted-by":"crossref","first-page":"9843","DOI":"10.7150\/thno.46450","article-title":"Exquisite design of injectable Hydrogels in Cartilage Repair","volume":"10","author":"Wu","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.tice.2022.101992_bib119","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.biomaterials.2015.08.045","article-title":"Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels","volume":"73","author":"Yue","year":"2015","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.tice.2022.101992_bib120","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.3390\/jcm9041167","article-title":"The role of physical activity as conservative treatment for hip and knee osteoarthritis in older people: a systematic review and meta-analysis","volume":"9","author":"Zampogna","year":"2020","journal-title":"J. Clin. Med."},{"issue":"1","key":"10.1016\/j.tice.2022.101992_bib121","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3390\/microorganisms9010124","article-title":"Application of natural neutrophil products for stimulation of monocyte-derived macrophages obtained before and after osteochondral or bone injury","volume":"9","author":"Zdziennicka","year":"2021","journal-title":"Microorganisms"},{"issue":"1","key":"10.1016\/j.tice.2022.101992_bib122","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41536-021-00122-6","article-title":"Heterogeneity of mesenchymal stem cells in cartilage regeneration: from characterization to application","volume":"6","author":"Zha","year":"2021","journal-title":"NPJ Regen. Med."},{"issue":"5","key":"10.1016\/j.tice.2022.101992_bib123","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.joca.2020.01.007","article-title":"Macrophages regulate the progression of osteoarthritis","volume":"28","author":"Zhang","year":"2020","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.tice.2022.101992_bib124","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101249","article-title":"The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis","volume":"66","author":"Zheng","year":"2021","journal-title":"Ageing Res. Rev."},{"issue":"1","key":"10.1016\/j.tice.2022.101992_bib125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41420-021-00418-y","article-title":"Exosomes derived from miR-126-3p-overexpressing synovial fibroblasts suppress chondrocyte inflammation and cartilage degradation in a rat model of osteoarthritis","volume":"7","author":"Zhou","year":"2021","journal-title":"Cell Death Discov."},{"issue":"1","key":"10.1016\/j.tice.2022.101992_bib126","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13075-021-02457-3","article-title":"Phenotypic alteration of macrophages during osteoarthritis: a systematic review","volume":"23","author":"Zhu","year":"2021","journal-title":"Arthritis Res. Ther."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816622002646?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816622002646?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:24:59Z","timestamp":1758572699000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816622002646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":126,"alternative-id":["S0040816622002646"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2022.101992","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Challenges in osteoarthritis treatment","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2022.101992","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101992"}}