{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T10:59:17Z","timestamp":1769511557621,"version":"3.49.0"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004775","name":"Natural Science Foundation of Gansu Province","doi-asserted-by":"publisher","award":["21JR1RA081"],"award-info":[{"award-number":["21JR1RA081"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.tice.2023.102057","type":"journal-article","created":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T16:10:25Z","timestamp":1678205425000},"page":"102057","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Apelin-36 alleviates LPS-induced trophoblast cell injury by inhibiting GRP78\/ASK1\/JNK signaling"],"prefix":"10.1016","volume":"82","author":[{"given":"Rongrong","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yali","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Man","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gui","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2023.102057_bib1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.cca.2018.05.012","article-title":"Review: apelin in disease","volume":"483","author":"Antushevich","year":"2018","journal-title":"Clin. Chim. Acta"},{"issue":"5","key":"10.1016\/j.tice.2023.102057_bib2","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/aji.12417","article-title":"Placental regulation of inflammation and hypoxia after TNF-alpha infusion in mice","volume":"74","author":"Bobek","year":"2015","journal-title":"Am. J. Reprod. Immunol."},{"issue":"1","key":"10.1016\/j.tice.2023.102057_bib3","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1046\/j.1365-2249.1996.d01-647.x","article-title":"Tumour necrosis factor-alpha (TNF-alpha) gene polymorphism and expression in pre-eclampsia","volume":"104","author":"Chen","year":"1996","journal-title":"Clin. Exp. Immunol."},{"issue":"3","key":"10.1016\/j.tice.2023.102057_bib4","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1053\/j.semperi.2009.02.010","article-title":"The global impact of pre-eclampsia and eclampsia","volume":"33","author":"Duley","year":"2009","journal-title":"Semin Perinatol."},{"issue":"6","key":"10.1016\/j.tice.2023.102057_bib5","doi-asserted-by":"crossref","first-page":"897","DOI":"10.3109\/14767058.2015.1022865","article-title":"TNF-R1 as a first trimester marker for prediction of pre-eclampsia","volume":"29","author":"E Holanda Moura","year":"2016","journal-title":"J. Matern. Fetal. Neonatal Med."},{"issue":"4","key":"10.1016\/j.tice.2023.102057_bib6","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s10741-015-9475-x","article-title":"Effects of apelin on the cardiovascular system","volume":"20","author":"Folino","year":"2015","journal-title":"Heart Fail Rev."},{"issue":"5","key":"10.1016\/j.tice.2023.102057_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22052627","article-title":"Inflammatory biomarkers in the short-term prognosis of venous thromboembolism: a narrative review","volume":"22","author":"Galeano-Valle","year":"2021","journal-title":"Int J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.tice.2023.102057_bib8","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1042\/CS20150702","article-title":"The role of inflammation in the pathology of preeclampsia","volume":"130","author":"Harmon","year":"2016","journal-title":"Clin. Sci. (Lond.)"},{"issue":"1","key":"10.1016\/j.tice.2023.102057_bib9","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2020.11644","article-title":"Apelin36 protects against lipopolysaccharideinduced acute lung injury by inhibiting the ASK1\/MAPK signaling pathway","volume":"23","author":"He","year":"2021","journal-title":"Mol. Med. Rep."},{"issue":"5","key":"10.1016\/j.tice.2023.102057_bib10","first-page":"412","article-title":"Tumor necrosis factor-alpha, interleukin-6, and interleukin-10 levels are altered in preeclampsia: a systematic review and meta-analysis","volume":"70","author":"Lau","year":"2013","journal-title":"Am. J. Reprod. Immunol."},{"issue":"1","key":"10.1016\/j.tice.2023.102057_bib11","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.bbrc.2014.04.079","article-title":"Functional role of NF-kappaB in expression of human endothelial nitric oxide synthase","volume":"448","author":"Lee","year":"2014","journal-title":"Biochem Biophys. Res Commun."},{"issue":"5","key":"10.1016\/j.tice.2023.102057_bib12","article-title":"Prevention of preeclampsia","volume":"25","author":"Ma'ayeh","year":"2020","journal-title":"Semin Fetal Neonatal Med"},{"key":"10.1016\/j.tice.2023.102057_bib13","doi-asserted-by":"crossref","first-page":"556","DOI":"10.3389\/fneur.2017.00556","article-title":"Low dose of apelin-36 attenuates ER stress-associated apoptosis in rats with ischemic stroke","volume":"8","author":"Qiu","year":"2017","journal-title":"Front. Neurol."},{"key":"10.1016\/j.tice.2023.102057_bib14","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.bpobgyn.2019.06.005","article-title":"Immunomodulation and preeclampsia","volume":"60","author":"Rambaldi","year":"2019","journal-title":"Best. Pr. Res Clin. Obstet. Gynaecol."},{"issue":"7","key":"10.1016\/j.tice.2023.102057_bib15","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1161\/CIRCRESAHA.118.313276","article-title":"Preeclampsia: pathophysiology, challenges, and perspectives","volume":"124","author":"Rana","year":"2019","journal-title":"Circ. Res."},{"key":"10.1016\/j.tice.2023.102057_bib16","first-page":"11","article-title":"Role of the NLRP3 inflammasome in preeclampsia","author":"Shirasuna","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"2","key":"10.1016\/j.tice.2023.102057_bib17","doi-asserted-by":"crossref","DOI":"10.1007\/s43032-019-00039-y","article-title":"Intermittent hypoxia impairs trophoblast cell viability by triggering the endoplasmic reticulum stress pathway","volume":"27","author":"Song","year":"2020","journal-title":"Reprod. Sci."},{"issue":"10","key":"10.1016\/j.tice.2023.102057_bib18","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.imbio.2011.04.009","article-title":"Epithelial cells modulate genes associated with NF kappa B activation in co-cultured human macrophages","volume":"216","author":"Striz","year":"2011","journal-title":"Immunobiology"},{"issue":"2","key":"10.1016\/j.tice.2023.102057_bib19","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1006\/bbrc.1998.9489","article-title":"Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor","volume":"251","author":"Tatemoto","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tice.2023.102057_bib20","doi-asserted-by":"crossref","first-page":"8238727","DOI":"10.1155\/2019\/8238727","article-title":"Cross-talk between oxidative stress and inflammation in preeclampsia","volume":"2019","author":"Tenorio","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"issue":"2","key":"10.1016\/j.tice.2023.102057_bib21","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1210\/jc.2018-00512","article-title":"Microvascular endothelial dysfunction in human obesity: role of TNF-alpha","volume":"104","author":"Virdis","year":"2019","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"6","key":"10.1016\/j.tice.2023.102057_bib22","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1530\/REP-10-0360","article-title":"A balancing act: mechanisms by which the fetus avoids rejection by the maternal immune system","volume":"141","author":"Warning","year":"2011","journal-title":"Reproduction"},{"issue":"1","key":"10.1016\/j.tice.2023.102057_bib23","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1186\/s13071-018-2835-3","article-title":"Toxoplasma gondii dense granule protein 15 induces apoptosis in choriocarcinoma JEG-3 cells through endoplasmic reticulum stress","volume":"11","author":"Wei","year":"2018","journal-title":"Parasit. Vectors"},{"issue":"10","key":"10.1016\/j.tice.2023.102057_bib24","doi-asserted-by":"crossref","first-page":"E852","DOI":"10.1152\/ajpendo.00272.2015","article-title":"Downregulation of apelin in the human placental chorionic villi from preeclamptic pregnancies","volume":"309","author":"Yamaleyeva","year":"2015","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tice.2023.102057_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2019.146493","article-title":"Apelin-36 mediates neuroprotective effects by regulating oxidative stress, autophagy and apoptosis in MPTP-induced Parkinson's disease model mice","volume":"1726","author":"Zhu","year":"2020","journal-title":"Brain Res."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816623000459?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816623000459?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:29:00Z","timestamp":1758572940000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816623000459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":25,"alternative-id":["S0040816623000459"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2023.102057","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Apelin-36 alleviates LPS-induced trophoblast cell injury by inhibiting GRP78\/ASK1\/JNK signaling","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2023.102057","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102057"}}