{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:40:53Z","timestamp":1789594853011,"version":"build-2803163510"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.tice.2023.102117","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T20:40:36Z","timestamp":1684528836000},"page":"102117","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Combination of natural scaffolds and conditional medium to induce the differentiation of adipose-derived mesenchymal stem cells into keratocyte-like cells and its safety evaluation in the animal cornea"],"prefix":"10.1016","volume":"82","author":[{"given":"Mohsen","family":"Ghiasi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrdad","family":"Hashemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Salimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khosrow","family":"Jadidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmood","family":"Tavallaie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Aghamollaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2023.102117_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2021.108451","article-title":"Safety of grafting acellular human corneal lenticule seeded with Wharton's Jelly-Derived Mesenchymal Stem Cells in an experimental animal model","volume":"205","author":"Aghamollaei","year":"2021","journal-title":"Exp. Eye Res."},{"issue":"44","key":"10.1016\/j.tice.2023.102117_bib2","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201908996","article-title":"Designing scaffolds for corneal regeneration","volume":"30","author":"Ahearne","year":"2020","journal-title":"Adv. Funct. Mater."},{"issue":"2","key":"10.1016\/j.tice.2023.102117_bib3","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/(SICI)1096-9896(199901)187:2<223::AID-PATH219>3.0.CO;2-B","article-title":"Synthesis of basement membrane by gastrointestinal cancer cell lines","volume":"187","author":"Akashi","year":"1999","journal-title":"J. Pathol."},{"key":"10.1016\/j.tice.2023.102117_bib4","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ajo.2019.02.009","article-title":"Regenerative surgery of the corneal stroma for advanced keratoconus: 1-year outcomes","volume":"203","author":"Ali\u00f3","year":"2019","journal-title":"Am. J. Ophthalmol."},{"issue":"5","key":"10.1016\/j.tice.2023.102117_bib5","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1136\/bjo.85.5.567","article-title":"Amniotic membrane transplantation for partial limbal stem cell deficiency","volume":"85","author":"Anderson","year":"2001","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.tice.2023.102117_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1745-6215-13-75","article-title":"Small incision lenticule extraction (SMILE) versus laser in-situ keratomileusis (LASIK): study protocol for a randomized, non-inferiority trial","volume":"13","author":"Ang","year":"2012","journal-title":"Trials"},{"issue":"4","key":"10.1016\/j.tice.2023.102117_bib7","first-page":"459","article-title":"Amniotic membrane extract eye drop promotes limbal stem cell proliferation and corneal epithelium healing","volume":"20","author":"Asl","year":"2019","journal-title":"Cell J. (Yakhteh)"},{"issue":"1","key":"10.1016\/j.tice.2023.102117_bib8","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2217\/rme.09.74","article-title":"Stem cell paracrine actions and tissue regeneration","volume":"5","author":"Baraniak","year":"2010","journal-title":"Regen. Med."},{"issue":"4","key":"10.1016\/j.tice.2023.102117_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0096161","article-title":"Conditioned medium from hypoxic bone marrow-derived mesenchymal stem cells enhances wound healing in mice","volume":"9","author":"Chen","year":"2014","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.tice.2023.102117_bib10","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1096\/fj.03-1094fje","article-title":"Adhesion and signaling by B cell\u2010derived exosomes: the role of integrins","volume":"18","author":"Clayton","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.tice.2023.102117_bib11","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.exer.2015.01.020","article-title":"Acellular human corneal matrix sheets seeded with human adipose-derived mesenchymal stem cells integrate functionally in an experimental animal model","volume":"132","author":"del Barrio","year":"2015","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.tice.2023.102117_bib12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ajo.2017.10.026","article-title":"Corneal stroma enhancement with decellularized stromal laminas with or without stem cell recellularization for advanced keratoconus","volume":"186","author":"Del Barrio","year":"2018","journal-title":"Am. J. Ophthalmol."},{"issue":"3","key":"10.1016\/j.tice.2023.102117_bib13","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.jcrs.2010.12.037","article-title":"Anatomy and physiology of the cornea","volume":"37","author":"DelMonte","year":"2011","journal-title":"J. Cataract Refract. Surg."},{"issue":"8","key":"10.1016\/j.tice.2023.102117_bib14","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1167\/iovs.19-27008","article-title":"Differentiation capacity of human mesenchymal stem cells into keratocyte lineage","volume":"60","author":"Dos Santos","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"4","key":"10.1016\/j.tice.2023.102117_bib15","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1002\/pmic.201000530","article-title":"Conditioned media from cell lines: a complementary model to clinical specimens for the discovery of disease\u2010specific biomarkers","volume":"11","author":"Dowling","year":"2011","journal-title":"Proteomics"},{"issue":"1","key":"10.1016\/j.tice.2023.102117_bib16","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1083\/jcb.112.1.169","article-title":"Receptor functions for the integrin VLA-3: fibronectin, collagen, and laminin binding are differentially influenced by Arg-Gly-Asp peptide and by divalent cations","volume":"112","author":"Elices","year":"1991","journal-title":"J. Cell Biol."},{"issue":"4","key":"10.1016\/j.tice.2023.102117_bib17","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S1350-9462(98)00033-0","article-title":"Keratocyte and fibroblast phenotypes in the repairing cornea","volume":"18","author":"Fini","year":"1999","journal-title":"Prog. Retin. Eye Res."},{"issue":"1","key":"10.1016\/j.tice.2023.102117_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.327","article-title":"Mesenchymal stem cells and immunomodulation: current status and future prospects","volume":"7","author":"Gao","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.tice.2023.102117_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2021.101600","article-title":"Application of mesenchymal stem cells in corneal regeneration","volume":"73","author":"Ghiasi","year":"2021","journal-title":"Tissue Cell"},{"issue":"1","key":"10.1016\/j.tice.2023.102117_bib20","first-page":"910","article-title":"Culture, optimization and validation of human corneal stromal keratocytes from discarded corneal tissue","volume":"10","author":"Ghiasi","year":"2023","journal-title":"J. Appl. Biotechnol. Rep."},{"issue":"4","key":"10.1016\/j.tice.2023.102117_bib21","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/term.2806","article-title":"Conditioned media derived from mesenchymal stem cell cultures: The next generation for regenerative medicine","volume":"13","author":"Gunawardena","year":"2019","journal-title":"J. Tissue Eng. Regen. Med."},{"issue":"7","key":"10.1016\/j.tice.2023.102117_bib22","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1167\/iovs.07-0900","article-title":"Epidermal growth factor synergism with TGF-\u03b21 via PI-3 kinase activity in corneal keratocyte differentiation","volume":"49","author":"He","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.tice.2023.102117_bib23","first-page":"276","article-title":"Keratocyte apoptosis after corneal surgery","volume":"39","author":"Helena","year":"1998","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.tice.2023.102117_bib24","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/ar.1092120108","article-title":"Distribution and characterization of anionic sites in the basal lamina of developing human amniotic epithelium","volume":"212","author":"King","year":"1985","journal-title":"Anat. Rec."},{"issue":"5","key":"10.1016\/j.tice.2023.102117_bib25","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.ophtha.2007.04.067","article-title":"Laser scanning in vivo confocal analysis of keratocyte density in keratoconus","volume":"115","author":"Ku","year":"2008","journal-title":"Ophthalmology"},{"issue":"2","key":"10.1016\/j.tice.2023.102117_bib26","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/S0006-3495(03)74940-6","article-title":"Force measurements of the \u03b15\u03b21 integrin\u2013fibronectin interaction","volume":"84","author":"Li","year":"2003","journal-title":"Biophys. J."},{"issue":"1","key":"10.1016\/j.tice.2023.102117_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-019-1377-8","article-title":"YBX-1 mediated sorting of miR-133 into hypoxia\/reoxygenation-induced EPC-derived exosomes to increase fibroblast angiogenesis and MEndoT","volume":"10","author":"Lin","year":"2019","journal-title":"Stem Cell Res. Ther."},{"issue":"3","key":"10.1016\/j.tice.2023.102117_bib28","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1177\/0885066617690725","article-title":"Noninvasive ventilation in patients with hematologic malignancy: a retrospective study","volume":"34","author":"Liu","year":"2019","journal-title":"J. Intensive Care Med."},{"key":"10.1016\/j.tice.2023.102117_bib29","doi-asserted-by":"crossref","unstructured":"Liu X., Li X., Wu G., Qi P., Zhang Y., Liu Z., 2022 et al. Umbilical cord mesenchymal stem cells-derived exosomes deliver miR-21 to promote corneal epithelial wound healing through PTEN\/PI3K\/Akt pathway.","DOI":"10.21203\/rs.3.rs-571150\/v2"},{"key":"10.1016\/j.tice.2023.102117_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2021.108907","article-title":"Analysis of different conditioned media secreted by limbal progenitor cells in the modulation of corneal healing","volume":"215","author":"Loureiro","year":"2022","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.tice.2023.102117_bib31","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s00441-012-1424-6","article-title":"Amniotic membrane: from structure and functions to clinical applications","volume":"349","author":"Mamede","year":"2012","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.tice.2023.102117_bib32","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.reth.2023.04.001","article-title":"Carbachol, along with calcium, indicates new strategy in neural differentiation of human adipose tissue-derived mesenchymal stem cells in vitro","volume":"23","author":"Masoumi","year":"2023","journal-title":"Regen. Ther."},{"key":"10.1016\/j.tice.2023.102117_bib33","series-title":"Corneal replacement tissue. Principles of Tissue Engineering","first-page":"1413","author":"McCabe","year":"2014"},{"issue":"1\u20132","key":"10.1016\/j.tice.2023.102117_bib34","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.tice.2023.102117_bib35","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.biomaterials.2018.08.027","article-title":"Lineage-specific exosomes could override extracellular matrix mediated human mesenchymal stem cell differentiation","volume":"182","author":"Narayanan","year":"2018","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.tice.2023.102117_bib36","doi-asserted-by":"crossref","first-page":"5475","DOI":"10.1016\/j.actbio.2012.11.002","article-title":"The effects of interactive mechanical and biochemical niche signaling on osteogenic differentiation of adipose-derived stem cells using combinatorial hydrogels","volume":"9","author":"Nii","year":"2013","journal-title":"Acta Biomater."},{"key":"10.1016\/j.tice.2023.102117_bib37","doi-asserted-by":"crossref","DOI":"10.2174\/1574888X18666230216085615","article-title":"A novel nanocomposite scaffold based on polyurethane [PU] containing cobalt nanoparticles [CoNPs] for Bone tissue engineering applications","author":"Norouz","year":"2023","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"10.1016\/j.tice.2023.102117_bib38","first-page":"232","article-title":"Extracellular matrix in the regulation of stem cell differentiation","volume":"84","author":"Novoseletskaya","year":"2019","journal-title":"Biochemistry"},{"issue":"2","key":"10.1016\/j.tice.2023.102117_bib39","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2174\/157488810791268663","article-title":"Cornea and ocular surface treatment","volume":"5","author":"P De Miguel","year":"2010","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"10.1016\/j.tice.2023.102117_bib40","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.exer.2012.05.009","article-title":"Human mesenchymal stem cells differentiate into keratocyte-like cells in keratocyte-conditioned medium","volume":"101","author":"Park","year":"2012","journal-title":"Exp. Eye Res."},{"issue":"5","key":"10.1016\/j.tice.2023.102117_bib41","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1136\/bjophthalmol-2011-300539","article-title":"Global estimates of visual impairment: 2010","volume":"96","author":"Pascolini","year":"2012","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.tice.2023.102117_bib42","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/965849","article-title":"Prospect of stem cell conditioned medium in regenerative medicine","volume":"2014","author":"Pawitan","year":"2014","journal-title":"BioMed. Res. Int."},{"issue":"2","key":"10.1016\/j.tice.2023.102117_bib43","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/cxo.12230","article-title":"Corneal biomechanics: a review","volume":"98","author":"Pi\u00f1ero","year":"2015","journal-title":"Clin. Exp. Optom."},{"issue":"2","key":"10.1016\/j.tice.2023.102117_bib44","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1242\/jcs.106.2.685","article-title":"Keratocyte networks visualised in the living cornea using vital dyes","volume":"106","author":"Poole","year":"1993","journal-title":"J. Cell Sci."},{"issue":"3","key":"10.1016\/j.tice.2023.102117_bib45","first-page":"266","article-title":"Isolation, expansion, and in vitro differentiation of human umbilical cord blood mesenchymal stromal cells into neural progenitor cells","volume":"12","author":"Rafieemehr","year":"2015","journal-title":"Sci. J. Iran Blood Transfus. Organ"},{"issue":"12","key":"10.1016\/j.tice.2023.102117_bib46","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1038\/s41375-020-01041-z","article-title":"Extracellular microvesicles\/exosomes: discovery, disbelief, acceptance, and the future?","volume":"34","author":"Ratajczak","year":"2020","journal-title":"Leukemia"},{"key":"10.1016\/j.tice.2023.102117_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2019.100780","article-title":"Stromal keratophakia: corneal inlay implantation","volume":"75","author":"Riau","year":"2020","journal-title":"Prog. Retin. Eye Res."},{"issue":"3","key":"10.1016\/j.tice.2023.102117_bib48","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.trsl.2013.11.004","article-title":"Halim WHWA, Zahidin AZM, Saim A, et al. Reconstruction of limbal stem cell deficient corneal surface with induced human bone marrow mesenchymal stem cells on amniotic membrane","volume":"163","author":"Rohaina","year":"2014","journal-title":"Transl. Res."},{"issue":"14","key":"10.1016\/j.tice.2023.102117_bib49","doi-asserted-by":"crossref","first-page":"7967","DOI":"10.3390\/ijms23147967","article-title":"Human SMILE-derived stromal lenticule scaffold for regenerative therapy: Review and perspectives","volume":"23","author":"Santra","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"7097","key":"10.1016\/j.tice.2023.102117_bib50","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1038\/nature04957","article-title":"The stem-cell niche as an entity of action","volume":"441","author":"Scadden","year":"2006","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.tice.2023.102117_bib51","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1089\/ten.tec.2011.0072","article-title":"Decellularized human cornea for reconstructing the corneal epithelium and anterior stroma","volume":"18","author":"Shafiq","year":"2012","journal-title":"Tissue Eng. Part C: Methods"},{"issue":"1","key":"10.1016\/j.tice.2023.102117_bib52","doi-asserted-by":"crossref","first-page":"9907","DOI":"10.1038\/s41598-020-66735-x","article-title":"RNA sequencing of corneas from two keratoconus patient groups identifies potential biomarkers and decreased NRF2-antioxidant responses","volume":"10","author":"Shinde","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2023.102117_bib53","doi-asserted-by":"crossref","DOI":"10.1517\/14712598.2015.1053867","article-title":"Adipose-derived stem cells for wound repair and regeneration","author":"Shingyochi","year":"2015","journal-title":"Expert Opin. Biol. Ther."},{"issue":"1","key":"10.1016\/j.tice.2023.102117_bib54","doi-asserted-by":"crossref","DOI":"10.1002\/term.2316","article-title":"Corneal keratocyte transition to mesenchymal stem cell phenotype and reversal using serum\u2010free medium supplemented with fibroblast growth factor\u20102, transforming growth factor\u2010\u03b23 and retinoic acid","volume":"12","author":"Sidney","year":"2018","journal-title":"J. Tissue Eng. Regen. Med."},{"issue":"4","key":"10.1016\/j.tice.2023.102117_bib55","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/01.ICL.0000140221.41806.6E","article-title":"Orthokeratology (corneal refractive therapy): what is it and how does it work?","volume":"30","author":"Swarbrick","year":"2004","journal-title":"Eye Contact Lens"},{"issue":"11","key":"10.1016\/j.tice.2023.102117_bib56","doi-asserted-by":"crossref","DOI":"10.1111\/aor.12891","article-title":"Hardystonite\u2010coated poly (l\u2010lactide) nanofibrous scaffold and efficient osteogenic differentiation of adipose\u2010derived mesenchymal stem cells","volume":"42","author":"Tavangar","year":"2018","journal-title":"Artif. Organs"},{"issue":"4","key":"10.1016\/j.tice.2023.102117_bib57","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1001\/archopht.116.4.431","article-title":"Amniotic membrane transplantation with or without limbal allografts for corneal surface reconstruction in patients with limbal stem cell deficiency","volume":"116","author":"Tseng","year":"1998","journal-title":"Arch. Ophthalmol."},{"issue":"3","key":"10.1016\/j.tice.2023.102117_bib58","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1124\/pr.112.005983","article-title":"Classification, functions, and clinical relevance of extracellular vesicles","volume":"64","author":"Van der Pol","year":"2012","journal-title":"Pharmacol. Rev."},{"issue":"6","key":"10.1016\/j.tice.2023.102117_bib59","doi-asserted-by":"crossref","first-page":"4423","DOI":"10.1002\/jcp.26291","article-title":"The use of cell conditioned medium for musculoskeletal tissue regeneration","volume":"233","author":"Veronesi","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"4","key":"10.1016\/j.tice.2023.102117_bib60","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.stem.2012.02.018","article-title":"The stem cell niche in regenerative medicine","volume":"10","author":"Wagers","year":"2012","journal-title":"Cell Stem Cell"},{"issue":"10","key":"10.1016\/j.tice.2023.102117_bib61","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1016\/j.biocel.2006.03.010","article-title":"The keratocyte: corneal stromal cell with variable repair phenotypes","volume":"38","author":"West-Mays","year":"2006","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"3","key":"10.1016\/j.tice.2023.102117_bib62","first-page":"214","article-title":"Corneal blindness: a global perspective","volume":"79","author":"Whitcher","year":"2001","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.tice.2023.102117_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108062","article-title":"Keratocyte biology","volume":"196","author":"Yam","year":"2020","journal-title":"Exp. Eye Res."},{"issue":"2","key":"10.1016\/j.tice.2023.102117_bib64","doi-asserted-by":"crossref","first-page":"365","DOI":"10.18388\/abp.2016_1488","article-title":"Osteogenic differentiation of human mesenchymal stem cells from adipose tissue and Wharton\u2019s jelly of the umbilical cord","volume":"64","author":"Zajdel","year":"2017","journal-title":"Acta Biochim. Pol."},{"issue":"2","key":"10.1016\/j.tice.2023.102117_bib65","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1074\/jbc.M116.766832","article-title":"Protein phosphotyrosine phosphatase 1B (PTP1B) in calpain-dependent feedback regulation of vascular endothelial growth factor receptor (VEGFR2) in endothelial cells: implications in VEGF-dependent angiogenesis and diabetic wound healing","volume":"292","author":"Zhang","year":"2017","journal-title":"J. Biol. Chem."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816623001052?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816623001052?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:33:59Z","timestamp":1758573239000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816623001052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":65,"alternative-id":["S0040816623001052"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2023.102117","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combination of natural scaffolds and conditional medium to induce the differentiation of adipose-derived mesenchymal stem cells into keratocyte-like cells and its safety evaluation in the animal cornea","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2023.102117","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102117"}}