{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T06:16:02Z","timestamp":1777702562379,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100009330","name":"Medical Science and Technology Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["A2015513"],"award-info":[{"award-number":["A2015513"]}],"id":[{"id":"10.13039\/501100009330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.tice.2023.102261","type":"journal-article","created":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T04:34:56Z","timestamp":1699072496000},"page":"102261","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Improvement of rat hepatocellular carcinoma model induced by diethylnitrosamine"],"prefix":"10.1016","volume":"86","author":[{"given":"Runzhui","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sitian","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengjie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianrui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingmu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2023.102261_bib1","article-title":"Safranal prevents liver cancer through inhibiting oxidative stress and alleviating inflammation","volume":"12","author":"Abdalla","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.tice.2023.102261_bib2","doi-asserted-by":"crossref","first-page":"716","DOI":"10.3892\/ol.2015.3313","article-title":"Calligonum comosum extract inhibits diethylnitrosamine-induced hepatocarcinogenesis in rats","volume":"10","author":"Abdo","year":"2015","journal-title":"Oncol. Lett."},{"issue":"22","key":"10.1016\/j.tice.2023.102261_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27228082","article-title":"Effects of sorafenib and quercetin alone or in combination in treating hepatocellular carcinoma: in vitro and in vivo approaches","volume":"27","author":"Abdu","year":"2022","journal-title":"Molecules"},{"issue":"9","key":"10.1016\/j.tice.2023.102261_bib4","article-title":"Therapeutic effects of crocin alone or in combination with sorafenib against hepatocellular carcinoma: in vivo & in vitro insights","volume":"11","author":"Abdu","year":"2022","journal-title":"Antioxid. (Basel, Switz. )"},{"issue":"16","key":"10.1016\/j.tice.2023.102261_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15164063","article-title":"Combining crocin and sorafenib improves their tumor-inhibiting effects in a rat model of diethylnitrosamine-induced cirrhotic-hepatocellular carcinoma","volume":"15","author":"Awad","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"3","key":"10.1016\/j.tice.2023.102261_bib6","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1007\/s12011-022-03221-7","article-title":"Antitumor activity of chitosan-coated iron oxide nanocomposite against hepatocellular carcinoma in animal models","volume":"201","author":"Badawy","year":"2023","journal-title":"Biol. Trace Elem. Res"},{"issue":"6","key":"10.1016\/j.tice.2023.102261_bib7","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/mc.23298","article-title":"Enrichment of progenitor cells by 2-acetylaminofluorene accelerates liver carcinogenesis induced by diethylnitrosamine in vivo","volume":"60","author":"Castro-Gil","year":"2021","journal-title":"Mol. Carcinog."},{"issue":"5","key":"10.1016\/j.tice.2023.102261_bib8","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s00432-017-2364-z","article-title":"Hepatic inflammation-fibrosis-cancer axis in the rat hepatocellular carcinoma induced by diethylnitrosamine","volume":"143","author":"Ding","year":"2017","journal-title":"J. Cancer Res Clin. Oncol."},{"key":"10.1016\/j.tice.2023.102261_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexmp.2021.104715","article-title":"Standardization of diethylnitrosamine-induced hepatocellular carcinoma rat model with time based molecular assessment","volume":"123","author":"Ghufran","year":"2021","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.tice.2023.102261_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115148","article-title":"Hibiscus-cisplatin combination treatment decreases liver toxicity in rats while increasing toxicity in lung cancer cells via oxidative stress- apoptosis pathway","volume":"165","author":"Hamza","year":"2023","journal-title":"Biomed. Pharm."},{"issue":"1","key":"10.1016\/j.tice.2023.102261_bib11","doi-asserted-by":"crossref","first-page":"3646","DOI":"10.1038\/s41598-021-82252-x","article-title":"Inhibition of androgen\/AR signaling inhibits diethylnitrosamine (DEN) induced tumour initiation and remodels liver immune cell networks","volume":"11","author":"Helms","year":"2021","journal-title":"Sci. Rep."},{"issue":"19","key":"10.1016\/j.tice.2023.102261_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221910774","article-title":"Anti-Hepatocellular Carcinoma Biomolecules: Molecular Targets Insights","volume":"22","author":"Juaid","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"21","key":"10.1016\/j.tice.2023.102261_bib13","article-title":"Hepatocyte deletion of IGF2 prevents DNA damage and tumor formation in hepatocellular carcinoma","volume":"9","author":"Kumar","year":"2022","journal-title":"Adv. Sci. (Weinh. )"},{"issue":"19","key":"10.1016\/j.tice.2023.102261_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13194981","article-title":"DEN-induced rat model reproduces key features of human hepatocellular carcinoma","volume":"13","author":"Kurma","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"9","key":"10.1016\/j.tice.2023.102261_bib15","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020106048","article-title":"Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner","volume":"40","author":"Lagnado","year":"2021","journal-title":"EMBO J."},{"key":"10.1016\/j.tice.2023.102261_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2020.103167","article-title":"Introducing immunotherapy for advanced hepatocellular carcinoma patients: Too early or too fast?","volume":"157","author":"Lai","year":"2021","journal-title":"Crit. Rev. Oncol. Hematol."},{"issue":"2","key":"10.1016\/j.tice.2023.102261_bib17","doi-asserted-by":"crossref","first-page":"11599","DOI":"10.1080\/21655979.2021.1993716","article-title":"Mulberry fruit polysaccharides alleviate diethylnitrosamine\/phenobarbital-induced hepatocarcinogenesis in vivo: the roles of cell apoptosis and inflammation","volume":"12","author":"Li","year":"2021","journal-title":"Bioengineered"},{"issue":"1","key":"10.1016\/j.tice.2023.102261_bib18","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s13046-018-0823-2","article-title":"Protein phosphatase 2A activation mechanism contributes to JS-K induced caspase-dependent apoptosis in human hepatocellular carcinoma cells","volume":"37","author":"Liu","year":"2018","journal-title":"J. Exp. Clin. Cancer Res"},{"issue":"12","key":"10.1016\/j.tice.2023.102261_bib19","doi-asserted-by":"crossref","DOI":"10.1158\/1535-7163.MCT-18-1380","article-title":"CNDAC-induced DNA double-strand breaks cause aberrant mitosis prior to cell death","volume":"18","author":"Liu","year":"2019","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.tice.2023.102261_bib20","doi-asserted-by":"crossref","first-page":"7722231","DOI":"10.1155\/2021\/7722231","article-title":"Clinicopathologic characteristics and outcomes of simultaneous multiple primary lung cancer","volume":"2021","author":"Liu","year":"2021","journal-title":"J. Oncol."},{"key":"10.1016\/j.tice.2023.102261_bib21","article-title":"ASF1B serves as a potential therapeutic target by influencing cell cycle and proliferation in hepatocellular carcinoma","volume":"11","author":"Ouyang","year":"2021","journal-title":"Front Oncol."},{"issue":"11","key":"10.1016\/j.tice.2023.102261_bib22","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1042\/BCJ20220023","article-title":"Alphabetti kinase Spaghetti: the complex roles of IKKalpha and beta in the canonical NF-kappaB pathway","volume":"479","author":"Perkins","year":"2022","journal-title":"Biochem J."},{"issue":"1","key":"10.1016\/j.tice.2023.102261_bib23","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/s12885-021-08282-w","article-title":"KDM6B promotes ESCC cell proliferation and metastasis by facilitating C\/EBPbeta transcription","volume":"21","author":"Qin","year":"2021","journal-title":"BMC Cancer"},{"issue":"6","key":"10.1016\/j.tice.2023.102261_bib24","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1177\/0023677218771720","article-title":"Diurnally active rodents for laboratory research","volume":"52","author":"Refinetti","year":"2018","journal-title":"Lab Anim."},{"issue":"1","key":"10.1016\/j.tice.2023.102261_bib25","doi-asserted-by":"crossref","first-page":"2094583","DOI":"10.1080\/2162402X.2022.2094583","article-title":"CDK4\/6 blockade provides an alternative approach for treatment of mismatch-repair deficient tumors","volume":"11","author":"Salewski","year":"2022","journal-title":"Oncoimmunology"},{"issue":"1","key":"10.1016\/j.tice.2023.102261_bib26","first-page":"7","article-title":"Cancer Statistics, 2021","volume":"71","author":"Siegel","year":"2021","journal-title":"CA Cancer J. Clin."},{"issue":"3","key":"10.1016\/j.tice.2023.102261_bib27","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"issue":"5","key":"10.1016\/j.tice.2023.102261_bib28","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nri.2017.142","article-title":"inflammation, immunity and cancer: coming of age","volume":"18","author":"Taniguchi","year":"2018","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.tice.2023.102261_bib29","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1148\/radiol.211028","article-title":"Transarterial embolization modulates the immune response within target and nontarget hepatocellular carcinomas in a rat model","volume":"303","author":"Tischfield","year":"2022","journal-title":"Radiology"},{"issue":"1","key":"10.1016\/j.tice.2023.102261_bib30","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.1038\/s41598-022-09208-7","article-title":"The inner side of yeast PCNA contributes to genome stability by mediating interactions with Rad18 and the replicative DNA polymerase delta","volume":"12","author":"Toth","year":"2022","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.tice.2023.102261_bib31","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.3390\/cimb44070198","article-title":"Correlation between cancer stem cells, inflammation and malignant transformation in a DEN-induced model of hepatic carcinogenesis","volume":"44","author":"Wu","year":"2022","journal-title":"Curr. Issues Mol. Biol."},{"issue":"1","key":"10.1016\/j.tice.2023.102261_bib32","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1186\/s13046-021-02062-x","article-title":"Phosphorylation of NF-kappaBp65 drives inflammation-mediated hepatocellular carcinogenesis and is a novel therapeutic target","volume":"40","author":"Xu","year":"2021","journal-title":"J. Exp. Clin. Cancer Res"},{"key":"10.1016\/j.tice.2023.102261_bib33","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3389\/fonc.2018.00166","article-title":"Inhibition of NF-kappaB signaling reduces the stemness characteristics of lung cancer stem cells","volume":"8","author":"Zakaria","year":"2018","journal-title":"Front Oncol."},{"key":"10.1016\/j.tice.2023.102261_bib34","doi-asserted-by":"crossref","first-page":"5888432","DOI":"10.1155\/2021\/5888432","article-title":"ROS signaling-mediated novel biological targets: Brf1 and RNA pol iii genes","volume":"2021","author":"Zheng","year":"2021","journal-title":"Oxid. Med Cell Longev."},{"issue":"7","key":"10.1016\/j.tice.2023.102261_bib35","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1089\/dna.2018.4224","article-title":"Rs2303428 of MSH2 is associated with hepatocellular carcinoma prognosis in a Chinese population","volume":"37","author":"Zhu","year":"2018","journal-title":"DNA Cell Biol."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816623002495?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816623002495?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:36:12Z","timestamp":1777455372000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816623002495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":35,"alternative-id":["S0040816623002495"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2023.102261","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Improvement of rat hepatocellular carcinoma model induced by diethylnitrosamine","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2023.102261","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102261"}}