{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:36:54Z","timestamp":1788910614350,"version":"build-2803163510"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.tice.2024.102371","type":"journal-article","created":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T06:59:21Z","timestamp":1711781961000},"page":"102371","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Paeonol can improve hypoxic-induced H9c2 cells injury and ion channel activity by up-regulating the expression of CKIP-1"],"prefix":"10.1016","volume":"88","author":[{"given":"Xinran","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesheng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yugen","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2024.102371_bib1","doi-asserted-by":"crossref","first-page":"8641026","DOI":"10.1155\/2020\/8641026","article-title":"Paeonol attenuates methotrexate-induced cardiac toxicity in rats by inhibiting oxidative stress and suppressing TLR4-induced NF-\u03baB inflammatory Pathway","volume":"2020","author":"Al-Taher","year":"2020","journal-title":"Mediat. Inflamm."},{"issue":"12","key":"10.1016\/j.tice.2024.102371_bib2","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1161\/CIR.0000000000000558","article-title":"Heart disease and stroke statistics-2018 Update: a report from the American Heart Association","volume":"137","author":"Benjamin","year":"2018","journal-title":"Circulation"},{"issue":"19","key":"10.1016\/j.tice.2024.102371_bib3","doi-asserted-by":"crossref","first-page":"14295","DOI":"10.1074\/jbc.275.19.14295","article-title":"Identification and characterization of CKIP-1, a novel pleckstrin homology domain-containing protein that interacts with protein kinase CK2","volume":"275","author":"Bosc","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"47","key":"10.1016\/j.tice.2024.102371_bib4","doi-asserted-by":"crossref","first-page":"36347","DOI":"10.1074\/jbc.M607595200","article-title":"The role of CKIP-1 in cell morphology depends on its interaction with actin-capping protein","volume":"281","author":"Canton","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.tice.2024.102371_bib5","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1080\/13880209.2022.2040543","article-title":"Paeonol attenuates heart failure induced by transverse aortic constriction via ERK1\/2 signalling","volume":"60","author":"Chen","year":"2022","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.tice.2024.102371_bib6","first-page":"987","article-title":"Study on the protective effect of paeonol activation of PI3K\/AKT on myocardial injury induced by septicaemia","volume":"06","author":"Chen JH","year":"2002","journal-title":"Chin. Pharm."},{"issue":"1","key":"10.1016\/j.tice.2024.102371_bib7","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/s41467-018-08171-0","article-title":"Domain insertion permissibility-guided engineering of allostery in ion channels","volume":"10","author":"Coyote-Maestas","year":"2019","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.tice.2024.102371_bib8","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/s41419-019-1849-x","article-title":"Paeonol induces cytoprotective autophagy via blocking the Akt\/mTOR pathway in ovarian cancer cells","volume":"10","author":"Gao","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.tice.2024.102371_bib9","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.freeradbiomed.2017.12.013","article-title":"CKIP-1 affects the polyubiquitination of Nrf2 and Keap1 via mediating Smurf1 to resist HG-induced renal fibrosis in GMCs and diabetic mice kidneys","volume":"115","author":"Gong","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.tice.2024.102371_bib10","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.bcp.2016.07.019","article-title":"CKIP-1 ameliorates high glucose-induced expression of fibronectin and intercellular cell adhesion molecule-1 by activating the Nrf2\/ARE pathway in glomerular mesangial cells","volume":"116","author":"Gong","year":"2016","journal-title":"Biochem Pharm."},{"issue":"10","key":"10.1016\/j.tice.2024.102371_bib11","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1177\/1535370218777972","article-title":"Dysfunctional nav1.5 channels due to SCN5A mutations","volume":"243","author":"Han","year":"2018","journal-title":"Exp. Biol. Med."},{"issue":"1","key":"10.1016\/j.tice.2024.102371_bib12","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2023.2236427","article-title":"CKIP-1 mediates P. gingivalis-suppressed osteogenic\/cementogenic differentiation of periodontal ligament cells partially via p38 signaling pathway","volume":"15","author":"Huang","year":"2023","journal-title":"J. Oral. Microbiol"},{"issue":"3","key":"10.1016\/j.tice.2024.102371_bib13","first-page":"601","article-title":"Dynamics and molecular mechanisms of ventricular fibrillation in structurally normal hearts","volume":"8","author":"Jalife","year":"2016","journal-title":"Card. Electro Clin."},{"key":"10.1016\/j.tice.2024.102371_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104552","article-title":"Prevention and treatment of chronic heart failure through traditional Chinese medicine: role of the gut microbiota","volume":"151","author":"Jia","year":"2020","journal-title":"Pharm. Res"},{"issue":"1","key":"10.1016\/j.tice.2024.102371_bib15","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s10753-015-0265-3","article-title":"Anti-inflammatory and anti-oxidative activities of Paeonol and its metabolites through blocking MAPK\/ERK\/p38 signaling pathway","volume":"39","author":"Jin","year":"2016","journal-title":"Inflammation"},{"issue":"5","key":"10.1016\/j.tice.2024.102371_bib16","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1093\/cvr\/cvx244","article-title":"Normal interventricular differences in tissue architecture underlie right ventricular susceptibility to conduction abnormalities in a mouse model of Brugada syndrome","volume":"114","author":"Kelly","year":"2018","journal-title":"Cardiovasc Res."},{"key":"10.1016\/j.tice.2024.102371_bib17","doi-asserted-by":"crossref","first-page":"23693","DOI":"10.1038\/srep23693","article-title":"Paeonol and danshensu combination attenuates apoptosis in myocardial infarcted rats by inhibiting oxidative stress: roles of Nrf2\/HO-1 and PI3K\/Akt pathway","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2024.102371_bib18","doi-asserted-by":"crossref","first-page":"3704647","DOI":"10.1155\/2016\/3704647","article-title":"Neuroprotective effect of Paeonol mediates anti-inflammation via suppressing Toll-Like receptor 2 and Toll-Like receptor 4 signaling pathways in cerebral ischemia-reperfusion injured rats","volume":"2016","author":"Liao","year":"2016","journal-title":"Evid. Based Complement Altern. Med."},{"issue":"25","key":"10.1016\/j.tice.2024.102371_bib19","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1161\/CIRCULATIONAHA.112.102780","article-title":"CKIP-1 inhibits cardiac hypertrophy by regulating class II histone deacetylase phosphorylation through recruiting PP2A","volume":"126","author":"Ling","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.tice.2024.102371_bib20","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fphys.2018.00040","article-title":"Myocardial CKIP-1 overexpression protects from simulated microgravity-induced cardiac remodeling","volume":"9","author":"Ling","year":"2018","journal-title":"Front Physiol."},{"issue":"3","key":"10.1016\/j.tice.2024.102371_bib21","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1097\/FJC.0000000000000341","article-title":"Valsartan attenuates KIR2.1 by downregulating the Th1 immune response in rats following myocardial infarction","volume":"67","author":"Li","year":"2016","journal-title":"J. Cardiovasc Pharm."},{"key":"10.1016\/j.tice.2024.102371_bib22","doi-asserted-by":"crossref","first-page":"1098617","DOI":"10.1155\/2018\/1098617","article-title":"Beneficial effects exerted by Paeonol in the management of atherosclerosis","volume":"2018","author":"Lu","year":"2018","journal-title":"Oxid. Med. Cell Longev."},{"issue":"11","key":"10.1016\/j.tice.2024.102371_bib23","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1161\/CIRCRESAHA.117.311872","article-title":"Cardiac Kir2.1 and Na(V)1.5 channels traffic together to the sarcolemma to control excitability","volume":"122","author":"Ponce-Balbuena","year":"2018","journal-title":"Circ. Res."},{"issue":"16","key":"10.1016\/j.tice.2024.102371_bib24","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.013049","article-title":"Association between cardiovascular risk and perceived fatigability in Mid-to-Late Life","volume":"8","author":"Qiao","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.tice.2024.102371_bib25","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.biochi.2019.06.008","article-title":"Overexpression of CKIP-1 alleviates hypoxia-induced cardiomyocyte injury by up-regulating Nrf2 antioxidant signaling via Keap1 inhibition","volume":"163","author":"Ren","year":"2019","journal-title":"Biochimie"},{"key":"10.1016\/j.tice.2024.102371_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2019.153994","article-title":"Fibroblast growth factor 21 in non-alcoholic fatty liver disease","volume":"101","author":"Tucker","year":"2019","journal-title":"Metabolism"},{"issue":"10","key":"10.1016\/j.tice.2024.102371_bib27","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.3390\/ijms11103696","article-title":"Effect of salvianolic acid B and paeonol on blood lipid metabolism and hemorrheology in myocardial ischemia rabbits induced by pituitruin","volume":"11","author":"Yang","year":"2010","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2024.102371_bib28","doi-asserted-by":"crossref","first-page":"3231424","DOI":"10.1155\/2019\/3231424","article-title":"The role of traditional Chinese medicine in the regulation of oxidative stress in treating coronary heart disease","volume":"2019","author":"Yang","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.tice.2024.102371_bib29","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.intimp.2019.04.033","article-title":"Paeonol: pharmacological effects and mechanisms of action","volume":"72","author":"Zhang","year":"2019","journal-title":"Int Immunopharmacol."},{"issue":"4","key":"10.1016\/j.tice.2024.102371_bib30","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/sj.emboj.7600532","article-title":"Role for the pleckstrin homology domain-containing protein CKIP-1 in AP-1 regulation and apoptosis","volume":"24","author":"Zhang","year":"2005","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.tice.2024.102371_bib31","doi-asserted-by":"crossref","first-page":"622","DOI":"10.3892\/or.2016.5233","article-title":"Silencing of CKIP-1 promotes tumor proliferation and cell adhesion-mediated drug resistance via regulating AKT activity in non-Hodgkin's lymphoma","volume":"37","author":"Zhu","year":"2017","journal-title":"Oncol. Rep."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816624000727?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816624000727?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T12:23:25Z","timestamp":1718454205000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816624000727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":31,"alternative-id":["S0040816624000727"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2024.102371","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Paeonol can improve hypoxic-induced H9c2 cells injury and ion channel activity by up-regulating the expression of CKIP-1","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2024.102371","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102371"}}