{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:09:29Z","timestamp":1792613369790,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["RSP2024R414"],"award-info":[{"award-number":["RSP2024R414"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.tice.2024.102404","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T16:10:23Z","timestamp":1715098223000},"page":"102404","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Tanshinone IIA from Salvia miltiorrhiza alleviates follicular maturation arrest symptoms in zebrafish via binding to the human androgen receptors and modulating Tox3 and Dennd1a"],"prefix":"10.1016","volume":"88","author":[{"given":"G.C. Leela","family":"Priyanka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.C.","family":"Mahalakshmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhlid H.","family":"Almutairi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bader O.","family":"Almutairi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gokul","family":"Sudhakaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Premkumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesu","family":"Arockiaraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2024.102404_bib1","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.neuropharm.2009.01.005","article-title":"A study of brain insulin receptors, AChE activity and oxidative stress in rat model of ICV STZ induced dementia","volume":"56","author":"Agrawal","year":"2009","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.tice.2024.102404_bib2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ecoenv.2012.08.003","article-title":"Estrogenic and anti-estrogenic activity of 23 commercial textile dyes","volume":"85","author":"Bazin","year":"2012","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.tice.2024.102404_bib3","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1159\/000447804","article-title":"Cadmium Exposure Enhances Bisphenol A-Induced Genotoxicity through 8-Oxoguanine-DNA Glycosylase-1 OGG1 Inhibition in NIH3T3 Fibroblast Cells","volume":"39","author":"Chen","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.tice.2024.102404_bib4","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.3629","article-title":"Analysis of generalized fibrosis in mouse tissue sections with masson\u2019s trichrome staining","volume":"10","author":"van de Vlekkert","year":"2020","journal-title":"Bio Protoc."},{"key":"10.1016\/j.tice.2024.102404_bib5","doi-asserted-by":"crossref","first-page":"344","DOI":"10.3390\/toxics9120344","article-title":"Combined Toxicity of Xenobiotics Bisphenol A and Heavy Metals on Zebrafish Embryos (Danio rerio)","volume":"9","author":"Di Paola","year":"2021","journal-title":"Toxics"},{"key":"10.1016\/j.tice.2024.102404_bib6","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nrendo.2010.217","article-title":"Polycystic ovary syndrome: etiology, pathogenesis and diagnosis","volume":"7","author":"Goodarzi","year":"2011","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.tice.2024.102404_bib7","article-title":"Exposure to environmental pollutant bisphenol A causes oxidative damage and lipid accumulation in Zebrafish larvae: Protective role of WL15 peptide derived from cysteine and glycine-rich protein 2","author":"Guru","year":"2022","journal-title":"J. Biochem Mol. Toxicol."},{"key":"10.1016\/j.tice.2024.102404_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2020.103863","article-title":"Intracellular ROS scavenging and antioxidant regulation of WL15 from cysteine and glycine-rich protein 2 demonstrated in zebrafish in vivo model","volume":"114","author":"Guru","year":"2021","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.tice.2024.102404_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2020.103863","article-title":"Intracellular ROS scavenging and antioxidant regulation of WL15 from cysteine and glycine-rich protein 2 demonstrated in zebrafish in vivo model","volume":"114","author":"Guru","year":"2021","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.tice.2024.102404_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2022.136889","article-title":"Neuroprotective effect of Biochanin a against Bisphenol A-induced prenatal neurotoxicity in zebrafish by modulating oxidative stress and locomotory defects","volume":"790","author":"Haridevamuthu","year":"2022","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.tice.2024.102404_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2022.136889","article-title":"Neuroprotective effect of Biochanin a against Bisphenol A-induced prenatal neurotoxicity in zebrafish by modulating oxidative stress and locomotory defects","volume":"790","author":"Haridevamuthu","year":"2022","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.tice.2024.102404_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120507","article-title":"Hydroxyl containing benzo[b]thiophene analogs mitigates the acrylamide induced oxidative stress in the zebrafish larvae by stabilizing the glutathione redox cycle","volume":"298","author":"Haridevamuthu","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.tice.2024.102404_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111429","article-title":"Bisphenol A induces apoptosis through GPER-dependent activation of the ROS\/Ca2+-ASK1-JNK pathway in human granulosa cell line KGN","volume":"208","author":"Huang","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.tice.2024.102404_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119864","article-title":"Oxidative stress induced antioxidant and neurotoxicity demonstrated in vivo zebrafish embryo or larval model and their normalization due to morin showing therapeutic implications","volume":"283","author":"Issac","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.tice.2024.102404_bib15","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1073\/pnas.1417731112","article-title":"Low-dose exposure to bisphenol a and replacement bisphenol S induces precocious hypothalamic neurogenesis in embryonic zebrafish","volume":"112","author":"Kinch","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.tice.2024.102404_bib16","first-page":"1","article-title":"Triterpenoids extracted from antrodia cinnamomea mycelia attenuate acute alcohol-induced liver injury in C57BL\/6 mice via suppression inflammatory response","volume":"11","author":"Liu","year":"2020","journal-title":"Front Microbiol"},{"key":"10.1016\/j.tice.2024.102404_bib17","first-page":"1","article-title":"Improving the sexual activity and reproduction of female zebrafish with high testosterone levels","volume":"11","author":"Liu","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2024.102404_bib18","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3390\/antiox9050405","article-title":"Oxidative stress and BPA toxicity: an antioxidant approach for male and female reproductive dysfunction","volume":"9","author":"Meli","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.tice.2024.102404_bib19","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/4298195","article-title":"Characterization of follicular atresia responsive to BPA in zebrafish by morphometric analysis of follicular stage progression","volume":"2018","author":"Migliaccio","year":"2018","journal-title":"Int J. Endocrinol."},{"key":"10.1016\/j.tice.2024.102404_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jksus.2022.101861","article-title":"Neuroprotective and antioxidant capability of RW20 peptide from histone acetyltransferases caused by oxidative stress-induced neurotoxicity in in vivo zebrafish larval model","volume":"34","author":"Prabha","year":"2022","journal-title":"J. King Saud. Univ. Sci."},{"key":"10.1016\/j.tice.2024.102404_bib21","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1002\/jcc.26712","article-title":"Exploration of potential inhibitors for tuberculosis via structure-based drug design, molecular docking, and molecular dynamics simulation studies","volume":"42","author":"Rajasekhar","year":"2021","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.tice.2024.102404_bib22","doi-asserted-by":"crossref","first-page":"R109","DOI":"10.1530\/JOE-17-0023","article-title":"Exposure to endocrine disruptors during adulthood: consequences for female fertility","volume":"233","author":"Rattan","year":"2017","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.tice.2024.102404_bib23","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/1989042","article-title":"Validation of an HPLC method for determination of bisphenol-A migration from baby feeding bottles","volume":"2019","author":"Rodriguez","year":"2019","journal-title":"J. Anal. Methods Chem."},{"key":"10.1016\/j.tice.2024.102404_bib24","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.fertnstert.2016.08.031","article-title":"Polycystic ovary syndrome and environmental toxins","volume":"106","author":"Rutkowska","year":"2016","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.tice.2024.102404_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.120276","article-title":"Evidence-based hormonal, mutational, and endocrine-disrupting chemical-induced zebrafish as an alternative model to study PCOS condition similar to mammalian PCOS model","volume":"291","author":"Sudhakaran","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.tice.2024.102404_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122280","article-title":"Osteoporosis in polycystic ovary syndrome (PCOS) and involved mechanisms","volume":"335","author":"Sudhakaran","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.tice.2024.102404_bib27","doi-asserted-by":"crossref","unstructured":"Sudhakaran, G., Rajesh, R., Murugan, R., Velayutham, M., Guru, A., Boopathi, S., Muthupandian, S., Gopinath, P., Arockiaraj, J., 2022b. Nimbin analog <scp>N2<\/scp> alleviates high testosterone induced oxidative stress in <scp>CHO<\/scp> cells and alters the expression of Tox3 and Dennd1a signal transduction pathway involved in the <scp>PCOS<\/scp> zebrafish. Phytotherapy Research. https:\/\/doi.org\/10.1002\/ptr.7685.","DOI":"10.1002\/ptr.7685"},{"key":"10.1016\/j.tice.2024.102404_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2023.102259","article-title":"Skeletal and neurological risks demonstrated in zebrafish due to second-hand cigarette smoke and the neutralization of luteolin","author":"Sudhakaran","year":"2023","journal-title":"Tissue Cell"},{"key":"10.1016\/j.tice.2024.102404_bib29","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1741-7015-8-41","article-title":"Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan","volume":"8","author":"Teede","year":"2010","journal-title":"BMC Med."},{"key":"10.1016\/j.tice.2024.102404_bib30","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jbiotec.2021.10.010","article-title":"GR15 peptide of S-adenosylmethionine synthase (SAMe) from Arthrospira platensis demonstrated antioxidant mechanism against H2O2 induced oxidative stress in in-vitro MDCK cells and in-vivo zebrafish larvae model","volume":"342","author":"Velayutham","year":"2021","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.tice.2024.102404_bib31","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1210\/me.2014-1042","article-title":"Early embryonic androgen exposure induces transgenerational epigenetic and metabolic changes","volume":"28","author":"Xu","year":"2014","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.tice.2024.102404_bib32","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/CAD.0b013e32834e5592","article-title":"Tanshinone IIA induces apoptosis and inhibits the proliferation, migration, and invasion of the osteosarcoma MG-63 cell line in vitro","volume":"23","author":"Zhang","year":"2012","journal-title":"Anticancer Drugs"}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816624001058?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816624001058?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T12:25:56Z","timestamp":1718454356000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816624001058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":32,"alternative-id":["S0040816624001058"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2024.102404","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tanshinone IIA from Salvia miltiorrhiza alleviates follicular maturation arrest symptoms in zebrafish via binding to the human androgen receptors and modulating Tox3 and Dennd1a","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2024.102404","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102404"}}