{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T12:55:44Z","timestamp":1793019344091,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.tice.2024.102468","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T11:26:12Z","timestamp":1720524372000},"page":"102468","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Gegen Qinlian decoction inhibited M1 macrophage polarization and ulcerative colitis progression through regulating histone lactylation"],"prefix":"10.1016","volume":"89","author":[{"given":"Zhen-Peng","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Yuan","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Er-Wei","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Yan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2024.102468_bib1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.2147\/IJN.S286392","article-title":"Oral nanoparticles of SNX10-shRNA plasmids ameliorate mouse colitis","volume":"16","author":"Bao","year":"2021","journal-title":"Int. J. Nanomed."},{"issue":"11","key":"10.1016\/j.tice.2024.102468_bib2","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.3390\/nu10111684","article-title":"Isolation and characterization of potentially probiotic bacterial strains from mice: proof of concept for personalized probiotics","volume":"10","author":"Celiberto","year":"2018","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.tice.2024.102468_bib3","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1165\/rcmb.2020-0360OC","article-title":"Lung myofibroblasts promote macrophage profibrotic activity through lactate-induced histone lactylation","volume":"64","author":"Cui","year":"2021","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"5","key":"10.1016\/j.tice.2024.102468_bib4","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1080\/00325481.2017.1319730","article-title":"Reviewing treatments and outcomes in the evolving landscape of ulcerative colitis","volume":"129","author":"Dubinsky","year":"2017","journal-title":"Post. Med."},{"issue":"4","key":"10.1016\/j.tice.2024.102468_bib5","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.gtc.2020.07.005","article-title":"Epidemiology and pathogenesis of ulcerative colitis","volume":"49","author":"Du","year":"2020","journal-title":"Gastroenterol. Clin. North Am."},{"issue":"5","key":"10.1016\/j.tice.2024.102468_bib6","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adc9465","article-title":"Lactate promotes endothelial-to-mesenchymal transition via Snail1 lactylation after myocardial infarction","volume":"9","author":"Fan","year":"2023","journal-title":"Sci. Adv."},{"issue":"4","key":"10.1016\/j.tice.2024.102468_bib7","doi-asserted-by":"crossref","first-page":"E330","DOI":"10.1152\/ajpendo.00159.2022","article-title":"Lactylation: novel epigenetic regulatory and therapeutic opportunities","volume":"324","author":"Fan","year":"2023","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.tice.2024.102468_bib8","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1128\/CMR.15.1.79-94.2002","article-title":"Clinical aspects and pathophysiology of inflammatory bowel disease","volume":"15","author":"Hendrickson","year":"2002","journal-title":"Clin. Microbiol. Rev."},{"issue":"13","key":"10.1016\/j.tice.2024.102468_bib9","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.3748\/wjg.v25.i13.1603","article-title":"Performance of tacrolimus in hospitalized patients with steroid-refractory acute severe ulcerative colitis","volume":"25","author":"Hoffmann","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.tice.2024.102468_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2021.766126","article-title":"The communication between intestinal microbiota and ulcerative colitis: an exploration of pathogenesis, animal models, and potential therapeutic strategies","volume":"8","author":"Hu","year":"2021","journal-title":"Front. Med."},{"issue":"48","key":"10.1016\/j.tice.2024.102468_bib11","doi-asserted-by":"crossref","first-page":"30628","DOI":"10.1073\/pnas.2009778117","article-title":"TLR signaling adapter BCAP regulates inflammatory to reparatory macrophage transition by promoting histone lactylation","volume":"117","author":"Irizarry-Caro","year":"2020","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.tice.2024.102468_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-49129-6","article-title":"Flightless I exacerbation of inflammatory responses contributes to increased colonic damage in a mouse model of dextran sulphate sodium-induced ulcerative colitis","volume":"9","author":"Kopecki","year":"2019","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.tice.2024.102468_bib13","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.tibs.2019.12.004","article-title":"Histone lactylation: a new role for glucose metabolism","volume":"45","author":"Liberti","year":"2020","journal-title":"Trends Biochem Sci."},{"key":"10.1016\/j.tice.2024.102468_bib14","article-title":"Lactylation, an emerging hallmark of metabolic reprogramming: current progress and open challenges","volume":"10","author":"Liu","year":"2022","journal-title":"Front Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.tice.2024.102468_bib15","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/s41392-022-01151-3","article-title":"Lactate metabolism in human health and disease","volume":"7","author":"Li","year":"2022","journal-title":"Signal Transduct. Target Ther."},{"issue":"1","key":"10.1016\/j.tice.2024.102468_bib16","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13020-023-00794-w","article-title":"Gegen-Qinlian decoction alleviates anxiety-like behaviors in methamphetamine-withdrawn mice by regulating Akkermansia and metabolism in the colon","volume":"18","author":"Lu","year":"2023","journal-title":"Chin. Med."},{"key":"10.1016\/j.tice.2024.102468_bib17","article-title":"Constituents, pharmacokinetics, and pharmacology of gegen-qinlian decoction","volume":"12","author":"Lu","year":"2021","journal-title":"Front. Pharm."},{"issue":"7","key":"10.1016\/j.tice.2024.102468_bib18","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/s42255-020-0243-4","article-title":"Lactate: the ugly duckling of energy metabolism","volume":"2","author":"Rabinowitz","year":"2020","journal-title":"Nat. Metab."},{"issue":"4","key":"10.1016\/j.tice.2024.102468_bib19","doi-asserted-by":"crossref","first-page":"576","DOI":"10.3390\/pharmaceutics13040576","article-title":"Spray-dried formulation of epicertin, a recombinant cholera toxin b subunit variant that induces mucosal healing","volume":"13","author":"Reeves","year":"2021","journal-title":"Pharmaceutics"},{"issue":"8","key":"10.1016\/j.tice.2024.102468_bib20","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/j.cmet.2023.06.013","article-title":"Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis","volume":"35","author":"Rho","year":"2023","journal-title":"Cell Metab."},{"key":"10.1016\/j.tice.2024.102468_bib21","article-title":"pH\/enzyme dual sensitive Gegenqinlian pellets coated with Bletilla striata polysaccharide membranes for the treatment of ulcerative colitis","volume":"229","author":"Sun","year":"2023","journal-title":"Colloids Surf. B\u00a0Biointerfaces"},{"issue":"2","key":"10.1016\/j.tice.2024.102468_bib22","doi-asserted-by":"crossref","first-page":"583","DOI":"10.3892\/ijmm.2020.4605","article-title":"Decitabine attenuates dextran sodium sulfate\u2011induced ulcerative colitis through regulation of immune regulatory cells and intestinal barrier","volume":"46","author":"Su","year":"2020","journal-title":"Int. J. Mol. Med."},{"issue":"3","key":"10.1016\/j.tice.2024.102468_bib23","doi-asserted-by":"crossref","first-page":"548","DOI":"10.3390\/cells11030548","article-title":"Lactate activates germline and cleavage embryo genes in mouse embryonic stem cells","volume":"11","author":"Tian","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.tice.2024.102468_bib24","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.atherosclerosis.2023.05.009","article-title":"Exercise-induced endothelial Mecp2 lactylation suppresses atherosclerosis via the Ereg\/MAPK signalling pathway","volume":"375","author":"Wang","year":"2023","journal-title":"Atherosclerosis"},{"issue":"1","key":"10.1016\/j.tice.2024.102468_bib25","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s13059-023-02931-y","article-title":"YY1 lactylation in microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2","volume":"24","author":"Wang","year":"2023","journal-title":"Genome Biol."},{"issue":"42","key":"10.1016\/j.tice.2024.102468_bib26","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abb5202","article-title":"An NF-\u03baB-driven lncRNA orchestrates colitis and circadian clock","volume":"6","author":"Wang","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.tice.2024.102468_bib27","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13478","article-title":"Lactate-induced protein lactylation: A bridge between epigenetics and metabolic reprogramming in cancer","author":"Wang","year":"2023","journal-title":"Cell Prolif."},{"key":"10.1016\/j.tice.2024.102468_bib28","article-title":"Unveiling the key genes, environmental toxins, and drug exposures in modulating the severity of ulcerative colitis: a comprehensive analysis","volume":"14","author":"Wang","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tice.2024.102468_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.949252","article-title":"The role and mechanism of histone lactylation in health and diseases","volume":"13","author":"Xie","year":"2022","journal-title":"Front. Genet."},{"issue":"4","key":"10.1016\/j.tice.2024.102468_bib30","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1007\/s10753-022-01637-w","article-title":"Lactylation: a passing fad or the future of posttranslational modification","volume":"45","author":"Xin","year":"2022","journal-title":"Inflammation"},{"key":"10.1016\/j.tice.2024.102468_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.1063423","article-title":"Research progress of abnormal lactate metabolism and lactate modification in immunotherapy of hepatocellular carcinoma","volume":"12","author":"Xu","year":"2023","journal-title":"Front. Oncol."},{"key":"10.1016\/j.tice.2024.102468_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154940","article-title":"Royal jelly acid suppresses hepatocellular carcinoma tumorigenicity by inhibiting H3 histone lactylation at H3K9la and H3K14la sites","volume":"118","author":"Xu","year":"2023","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.tice.2024.102468_bib33","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13059-021-02308-z","article-title":"Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma","volume":"22","author":"Yu","year":"2021","journal-title":"Genome Biol."},{"issue":"6","key":"10.1016\/j.tice.2024.102468_bib34","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/s41401-019-0343-4","article-title":"Aggravated ulcerative colitis caused by intestinal Metrnl deficiency is associated with reduced autophagy in epithelial cells","volume":"41","author":"Zhang","year":"2020","journal-title":"Acta Pharm. Sin."},{"issue":"5","key":"10.1016\/j.tice.2024.102468_bib35","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1016\/j.gendis.2022.10.006","article-title":"The function and mechanism of lactate and lactylation in tumor metabolism and microenvironment","volume":"10","author":"Zhang","year":"2023","journal-title":"Genes Dis."},{"issue":"7779","key":"10.1016\/j.tice.2024.102468_bib36","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41586-019-1678-1","article-title":"Metabolic regulation of gene expression by histone lactylation","volume":"574","author":"Zhang","year":"2019","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.tice.2024.102468_bib37","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41419-021-04203-8","article-title":"Astrocytic YAP prevents the demyelination through promoting expression of cholesterol synthesis genes in experimental autoimmune encephalomyelitis","volume":"12","author":"Zhang","year":"2021","journal-title":"Cell Death Dis."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816624001691?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816624001691?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T08:39:09Z","timestamp":1728376749000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816624001691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":37,"alternative-id":["S0040816624001691"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2024.102468","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gegen Qinlian decoction inhibited M1 macrophage polarization and ulcerative colitis progression through regulating histone lactylation","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2024.102468","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102468"}}