{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T22:58:56Z","timestamp":1793573936898,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.tice.2024.102639","type":"journal-article","created":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T02:28:34Z","timestamp":1732933714000},"page":"102639","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["SIRT6 mitigates oxidative stress and RSL3-induced ferroptosis in HTR-8\/SVneo cells"],"prefix":"10.1016","volume":"93","author":[{"given":"Lifang","family":"Qi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyan","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kan","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.tice.2024.102639_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19051496","article-title":"Oxidative stress in preeclampsia and placental diseases","volume":"19","author":"Aouache","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.tice.2024.102639_bib2","doi-asserted-by":"crossref","first-page":"3915","DOI":"10.1038\/s41598-021-82745-9","article-title":"The miRNA199a\/SIRT1\/P300\/Yy1\/sST2 signaling axis regulates adverse cardiac remodeling following MI","volume":"11","author":"Asensio-Lopez","year":"2021","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.tice.2024.102639_bib3","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.redox.2013.04.001","article-title":"Effects of 4-hydroxynonenal on vascular endothelial and smooth muscle cell redox signaling and function in health and disease","volume":"1","author":"Chapple","year":"2013","journal-title":"Redox Biol."},{"key":"10.1016\/j.tice.2024.102639_bib4","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.freeradbiomed.2022.01.012","article-title":"Mitochondrial oxidative stress mediated Fe-induced ferroptosis via the NRF2-ARE pathway","volume":"180","author":"Chen","year":"2022","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.tice.2024.102639_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2018.12.005","article-title":"Oxidative stress: Normal pregnancy versus preeclampsia","volume":"1866","author":"Chiarello","year":"2020","journal-title":"Biochim. Et. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.tice.2024.102639_bib6","article-title":"Mitochondrial iron overload-mediated inhibition of Nrf2-HO-1\/GPX4 assisted ALI-induced nephrotoxicity","volume":"11","author":"Deng","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.tice.2024.102639_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112859","article-title":"Knocking down macrophages Caspase-6 through HMGB1 coordinates macrophage trophoblast crosstalk to suppress ferroptosis and alleviate preeclampsia","volume":"140","author":"Deng","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.tice.2024.102639_bib8","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41572-023-00417-6","article-title":"Pre-eclampsia","volume":"9","author":"Dimitriadis","year":"2023","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.tice.2024.102639_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.927869","article-title":"Ferroptosis-related gene expression in the pathogenesis of preeclampsia","volume":"13","author":"Ding","year":"2022","journal-title":"Front. Genet."},{"key":"10.1016\/j.tice.2024.102639_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101107","article-title":"NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis","volume":"23","author":"Dodson","year":"2019","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.tice.2024.102639_bib11","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2024.2377785","article-title":"Sirt6 overexpression relieves ferroptosis and delays the progression of diabetic nephropathy via Nrf2\/GPX4 pathway","volume":"46","author":"Du","year":"2024","journal-title":"Ren. Fail"},{"issue":"10","key":"10.1016\/j.tice.2024.102639_bib12","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0174-24.2024","article-title":"Baicalein inhibits cerebral ischemia-reperfusion injury through SIRT6-mediated FOXA2 deacetylation to promote SLC7A11 expression","volume":"11","author":"Fang","year":"2024","journal-title":"eNeuro"},{"key":"10.1016\/j.tice.2024.102639_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175853","article-title":"Isoorientin reverses lung cancer drug resistance by promoting ferroptosis via the SIRT6\/Nrf2\/GPX4 signaling pathway","volume":"954","author":"Feng","year":"2023","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.tice.2024.102639_bib14","doi-asserted-by":"crossref","first-page":"232","DOI":"10.18388\/pb.2018_146","article-title":"[Preeclampsia - a disease of pregnant women]","volume":"64","author":"Filipek","year":"2018","journal-title":"Post. Biochem."},{"issue":"6","key":"10.1016\/j.tice.2024.102639_bib15","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1161\/HYPERTENSIONAHA.119.14598","article-title":"Animal models of preeclampsia: causes, consequences, and interventions","volume":"75","author":"Gatford","year":"2020","journal-title":"Hypertens. (Dallas, Tex: 1979)"},{"key":"10.1016\/j.tice.2024.102639_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101861","article-title":"Role of oxidative stress in the dysfunction of the placental endothelial nitric oxide synthase in preeclampsia","volume":"40","author":"Guerby","year":"2021","journal-title":"Redox Biol."},{"issue":"6","key":"10.1016\/j.tice.2024.102639_bib17","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.14336\/AD.2022.0413","article-title":"SIRT6 in aging, metabolism, inflammation and cardiovascular diseases","volume":"13","author":"Guo","year":"2022","journal-title":"Aging Dis."},{"issue":"23","key":"10.1016\/j.tice.2024.102639_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/nu14235025","article-title":"Puerariae lobatae radix alleviates pre-eclampsia by remodeling gut microbiota and protecting the gut and placental barriers","volume":"14","author":"Huang","year":"2022","journal-title":"Nutrients"},{"issue":"14","key":"10.1016\/j.tice.2024.102639_bib19","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/j.jacc.2020.08.014","article-title":"Preeclampsia-pathophysiology and clinical presentations: JACC state-of-the-art review","volume":"76","author":"Ives","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"issue":"5","key":"10.1016\/j.tice.2024.102639_bib20","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.jhep.2019.06.019","article-title":"The epigenetic regulator SIRT6 protects the liver from alcohol-induced tissue injury by reducing oxidative stress in mice","volume":"71","author":"Kim","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.tice.2024.102639_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.111214","article-title":"25-Hydroxycholesterol induces oxidative stress, leading to apoptosis and ferroptosis in extravillous trophoblasts","volume":"403","author":"Lee","year":"2024","journal-title":"Chem. Biol. Inter."},{"issue":"12","key":"10.1016\/j.tice.2024.102639_bib22","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1016\/j.molcel.2022.03.022","article-title":"Ferroptosis at the intersection of lipid metabolism and cellular signaling","volume":"82","author":"Liang","year":"2022","journal-title":"Mol. Cell"},{"issue":"4","key":"10.1016\/j.tice.2024.102639_bib23","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.ccell.2022.02.003","article-title":"CD8(+) T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4.","volume":"40","author":"Liao","year":"2022","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.tice.2024.102639_bib24","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.1038\/s41598-022-07065-y","article-title":"DJ-1 upregulates the Nrf2\/GPX4 signal pathway to inhibit trophoblast ferroptosis in the pathogenesis of preeclampsia","volume":"12","author":"Liao","year":"2022","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.tice.2024.102639_bib25","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/s41423-021-00636-5","article-title":"Placenta-derived IL-32\u03b2 activates neutrophils to promote preeclampsia development","volume":"18","author":"Liu","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.tice.2024.102639_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153773","article-title":"Atractylenolide inhibits apoptosis and oxidative stress of HTR-8\/SVneo cells by activating MAPK\/ERK signalling in preeclampsia","volume":"93","author":"Liu","year":"2021","journal-title":"Phytomedicine: Int. J. Phytother. Phytopharm."},{"issue":"2","key":"10.1016\/j.tice.2024.102639_bib27","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"issue":"6036","key":"10.1016\/j.tice.2024.102639_bib28","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1126\/science.1202723","article-title":"SIRT6 promotes DNA repair under stress by activating PARP1","volume":"332","author":"Mao","year":"2011","journal-title":"Sci. (N. Y., NY)"},{"key":"10.1016\/j.tice.2024.102639_bib29","article-title":"Melatonin inhibits ferroptosis and delays age-related cataract by regulating SIRT6\/p-Nrf2\/GPX4 and SIRT6\/NCOA4\/FTH1 pathways","volume":"157","author":"Mi","year":"2023","journal-title":"Biomed. Pharmacother. = Biomedecine Pharmacother."},{"issue":"5","key":"10.1016\/j.tice.2024.102639_bib30","article-title":"Oxidative stress, lipid peroxidation and ferroptosis are major pathophysiological signatures in the placental tissue of women with late-onset preeclampsia","volume":"13","author":"Ortega","year":"2024","journal-title":"Antioxid. (Basel)"},{"issue":"6","key":"10.1016\/j.tice.2024.102639_bib31","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.2215\/CJN.12081115","article-title":"Preeclampsia: updates in pathogenesis, definitions, and guidelines","volume":"11","author":"Phipps","year":"2016","journal-title":"Clin. J. Am. Soc. Nephrol.: CJASN"},{"issue":"5","key":"10.1016\/j.tice.2024.102639_bib32","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s41581-019-0119-6","article-title":"Pre-eclampsia: pathogenesis, novel diagnostics and therapies","volume":"15","author":"Phipps","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"issue":"1","key":"10.1016\/j.tice.2024.102639_bib33","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1080\/21655979.2021.2004980","article-title":"Lapatinib induces mitochondrial dysfunction to enhance oxidative stress and ferroptosis in doxorubicin-induced cardiomyocytes via inhibition of PI3K\/AKT signaling pathway","volume":"13","author":"Sun","year":"2022","journal-title":"Bioengineered"},{"issue":"8","key":"10.1016\/j.tice.2024.102639_bib34","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1007\/s00394-024-03495-8","article-title":"Melatonin alleviates LPS-induced depression-like behavior in mice by inhibiting ferroptosis by regulating RNA methylation-mediated SIRT6\/Nrf2\/HO-1 pathway","volume":"63","author":"Su","year":"2024","journal-title":"Eur. J. Nutr."},{"issue":"2","key":"10.1016\/j.tice.2024.102639_bib35","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"issue":"17","key":"10.1016\/j.tice.2024.102639_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20174246","article-title":"Preeclampsia: maternal systemic vascular disorder caused by generalized endothelial dysfunction due to placental antiangiogenic factors","volume":"20","author":"Tomimatsu","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2024.102639_bib37","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","article-title":"Lipid peroxidation and ferroptosis: The role of GSH and GPx4","volume":"152","author":"Ursini","year":"2020","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.tice.2024.102639_bib38","article-title":"Caffeic acid phenethyl ester suppresses oxidative stress and regulates M1\/M2 microglia polarization via Sirt6\/Nrf2 pathway to mitigate cognitive impairment in aged mice following anesthesia and surgery","volume":"12","author":"Wang","year":"2023","journal-title":"Antioxid. (Basel, Switz. )"},{"key":"10.1016\/j.tice.2024.102639_bib39","article-title":"Inflammation in preeclampsia: genetic biomarkers, mechanisms, and therapeutic strategies","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tice.2024.102639_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110713","article-title":"Matrine disrupts Nrf2\/GPX4 antioxidant system and promotes hepatocyte ferroptosis","volume":"384","author":"Wang","year":"2023","journal-title":"Chem. -Biol. Interact."},{"key":"10.1016\/j.tice.2024.102639_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102555","article-title":"Ferritin light chain deficiency-induced ferroptosis is involved in preeclampsia pathophysiology by disturbing uterine spiral artery remodelling","volume":"58","author":"Yang","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.tice.2024.102639_bib42","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.placenta.2024.10.013","article-title":"Puerarin alleviates symptoms of preeclampsia through the repression of trophoblast ferroptosis via the CREB\/HO-1 pathway","volume":"158","author":"Yue","year":"2024","journal-title":"Placenta"},{"key":"10.1016\/j.tice.2024.102639_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101402","article-title":"miR-30-5p-mediated ferroptosis of trophoblasts is implicated in the pathogenesis of preeclampsia","volume":"29","author":"Zhang","year":"2020","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.tice.2024.102639_bib44","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.apsb.2020.06.016","article-title":"SIRT6 as a key event linking P53 and NRF2 counteracts APAP-induced hepatotoxicity through inhibiting oxidative stress and promoting hepatocyte proliferation","volume":"11","author":"Zhou","year":"2021","journal-title":"Acta Pharm. Sin. B"}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816624003409?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816624003409?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T18:34:17Z","timestamp":1740767657000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816624003409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":44,"alternative-id":["S0040816624003409"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2024.102639","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SIRT6 mitigates oxidative stress and RSL3-induced ferroptosis in HTR-8\/SVneo cells","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2024.102639","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102639"}}