{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T19:43:04Z","timestamp":1780602184680,"version":"3.54.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.tice.2024.102643","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T16:33:49Z","timestamp":1732811629000},"page":"102643","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["The Shh-p38-NFATc1 signaling pathway is essential for osteoclastogenesis during tooth eruption"],"prefix":"10.1016","volume":"92","author":[{"given":"Jinan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiran","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueting","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2024.102643_bib1","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.intimp.2016.04.024","article-title":"Natural products for treatment of bone erosive diseases: The effects and mechanisms on inhibiting osteoclastogenesis and bone resorption","volume":"36","author":"An","year":"2016","journal-title":"Int Immunopharmacol."},{"key":"10.1016\/j.tice.2024.102643_bib2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/978-981-15-1580-4_9","article-title":"Siglecs that Associate with DAP12","volume":"1204","author":"Angata","year":"2020","journal-title":"Adv. Exp. Med Biol."},{"key":"10.1016\/j.tice.2024.102643_bib3","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-52935-7","article-title":"KMT2C, a histone methyltransferase, is mutated in a family segregating non-syndromic primary failure of tooth eruption","volume":"9","author":"Assiry","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2024.102643_bib4","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.3390\/ijms18102204","article-title":"Isoproterenol Increases RANKL Expression in a ATF4\/NFATc1-Dependent Manner in Mouse Osteoblastic Cells","volume":"18","author":"Baek","year":"2017","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.tice.2024.102643_bib5","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0722.2006.00399.x","article-title":"Runx2 and dental development","volume":"114","author":"Camilleri","year":"2006","journal-title":"Eur. J. Oral. Sci."},{"key":"10.1016\/j.tice.2024.102643_bib6","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1159\/000492554","article-title":"Psoralen and Bakuchiol Ameliorate M-CSF Plus RANKL-Induced Osteoclast Differentiation and Bone Resorption Via Inhibition of AKT and AP-1 Pathways in Vitro","volume":"48","author":"Chai","year":"2018","journal-title":"Cell Physiol. Biochem"},{"key":"10.1016\/j.tice.2024.102643_bib7","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/j.bbamcr.2007.03.010","article-title":"p38 MAP-kinases pathway regulation, function and role in human diseases","volume":"1773","author":"Cuenda","year":"2007","journal-title":"Biochim Biophys. Acta"},{"key":"10.1016\/j.tice.2024.102643_bib8","doi-asserted-by":"crossref","first-page":"9612","DOI":"10.1074\/jbc.M110.174920","article-title":"Hedgehog signaling induced by breast cancer cells promotes osteoclastogenesis and osteolysis","volume":"286","author":"Das","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tice.2024.102643_bib9","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.ajhg.2008.11.006","article-title":"PTHR1 loss-of-function mutations in familial, nonsyndromic primary failure of tooth eruption","volume":"83","author":"Decker","year":"2008","journal-title":"Am. J. Hum. Genet"},{"key":"10.1016\/j.tice.2024.102643_bib10","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1677\/joe.0.1540397","article-title":"Glucocorticoids inhibit bone resorption by isolated rat osteoclasts by enhancing apoptosis","volume":"154","author":"Dempster","year":"1997","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.tice.2024.102643_bib11","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/S1470-2045(05)70168-6","article-title":"The MAPK signalling pathways and colorectal cancer","volume":"6","author":"Fang","year":"2005","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.tice.2024.102643_bib12","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13005-018-0163-7","article-title":"Primary failure of eruption (PFE): a systematic review","volume":"14","author":"Hanisch","year":"2018","journal-title":"Head. Face Med."},{"key":"10.1016\/j.tice.2024.102643_bib13","doi-asserted-by":"crossref","first-page":"5840","DOI":"10.3390\/ijms20235840","article-title":"Recent Insights into Long Bone Development: Central Role of Hedgehog Signaling Pathway in Regulating Growth Plate","volume":"20","author":"Haraguchi","year":"2019","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.tice.2024.102643_bib14","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1158\/0008-5472.CAN-11-2681","article-title":"Hedgehog signaling inhibition blocks growth of resistant tumors through effects on tumor microenvironment","volume":"72","author":"Heller","year":"2012","journal-title":"Cancer Res"},{"key":"10.1016\/j.tice.2024.102643_bib15","doi-asserted-by":"crossref","first-page":"17860","DOI":"10.1074\/jbc.M112.347716","article-title":"Gli1 protein participates in Hedgehog-mediated specification of osteoblast lineage during endochondral ossification","volume":"287","author":"Hojo","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tice.2024.102643_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21051587","article-title":"Sonic hedgehog signaling and tooth development","volume":"21","author":"Hosoya","year":"2020","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.tice.2024.102643_bib17","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.biochi.2013.12.019","article-title":"Inhibition of hedgehog signaling by GANT58 induces apoptosis and shows synergistic antitumor activity with AKT inhibitor in acute T cell leukemia cells","volume":"101","author":"Hou","year":"2014","journal-title":"Biochimie"},{"key":"10.1016\/j.tice.2024.102643_bib18","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.bbrc.2006.10.011","article-title":"Induction of c-Fos and NFATc1 during RANKL-stimulated osteoclast differentiation is mediated by the p38 signaling pathway","volume":"351","author":"Huang","year":"2006","journal-title":"Biochem Biophys. Res Commun."},{"key":"10.1016\/j.tice.2024.102643_bib19","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/j.1601-0825.2009.01597.x","article-title":"Comparative study of gene expression during tooth eruption and orthodontic tooth movement in mice","volume":"15","author":"Huang","year":"2009","journal-title":"Oral. Dis."},{"key":"10.1016\/j.tice.2024.102643_bib20","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.ceca.2012.10.001","article-title":"Deletion of Orai1 alters expression of multiple genes during osteoclast and osteoblast maturation","volume":"52","author":"Hwang","year":"2012","journal-title":"Cell Calcium"},{"key":"10.1016\/j.tice.2024.102643_bib21","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1089\/scd.2011.0461","article-title":"Additive effects of sonic hedgehog and Nell-1 signaling in osteogenic versus adipogenic differentiation of human adipose-derived stromal cells","volume":"21","author":"James","year":"2012","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.tice.2024.102643_bib22","doi-asserted-by":"crossref","first-page":"39043","DOI":"10.1074\/jbc.M111.256768","article-title":"Inactivation of glycogen synthase kinase-3\u03b2 is required for osteoclast differentiation","volume":"286","author":"Jang","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tice.2024.102643_bib23","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S8756-3282(03)00092-9","article-title":"Hedgehog promotes primary osteoblast differentiation and increases PTHrP mRNA expression and iPTHrP secretion","volume":"32","author":"Jemtland","year":"2003","journal-title":"Bone"},{"key":"10.1016\/j.tice.2024.102643_bib24","doi-asserted-by":"crossref","first-page":"434","DOI":"10.4049\/jimmunol.163.1.434","article-title":"Osteoclast differentiation factor acts as a multifunctional regulator in murine osteoclast differentiation and function","volume":"163","author":"Jimi","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.tice.2024.102643_bib25","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.3390\/cells8121636","article-title":"The role of NF-\u03baB in physiological bone development and inflammatory bone diseases: Is NF-\u03baB inhibition \u201ckilling two birds with one stone\u201d?","volume":"8","author":"Jimi","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.tice.2024.102643_bib26","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1158\/0008-5472.CAN-10-2993","article-title":"TGF-beta promotion of Gli2-induced expression of parathyroid hormone-related protein, an important osteolytic factor in bone metastasis, is independent of canonical Hedgehog signaling","volume":"71","author":"Johnson","year":"2011","journal-title":"Cancer Res"},{"key":"10.1016\/j.tice.2024.102643_bib27","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.3390\/cells9092073","article-title":"Osteoblast-osteoclast communication and bone homeostasis","volume":"9","author":"Kim","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.tice.2024.102643_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21082745","article-title":"Hedgehog inhibitors suppress osteoclastogenesis in in vitro cultures, and deletion of smo in macrophage\/osteoclast lineage prevents age-related bone loss","volume":"21","author":"Kohara","year":"2020","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.tice.2024.102643_bib29","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S8756-3282(01)00657-3","article-title":"The phosphatidylinositol 3-kinase, p38, and extracellular signal-regulated kinase pathways are involved in osteoclast differentiation","volume":"30","author":"Lee","year":"2002","journal-title":"Bone"},{"key":"10.1016\/j.tice.2024.102643_bib30","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.pbiomolbio.2016.05.008","article-title":"Disturbed MEK\/ERK signaling increases osteoclast activity via the Hedgehog-Gli pathway in postmenopausal osteoporosis","volume":"122","author":"Li","year":"2016","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"10.1016\/j.tice.2024.102643_bib31","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1210\/endo.143.8.8954","article-title":"p38 MAPK-mediated signals are required for inducing osteoclast differentiation but not for osteoclast function","volume":"143","author":"Li","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.tice.2024.102643_bib32","first-page":"695","article-title":"Research progress on the regulation of NFATc1 in osteoclasts","volume":"23","author":"Li","year":"2017","journal-title":"Chin. J. Osteoporos."},{"key":"10.1016\/j.tice.2024.102643_bib33","doi-asserted-by":"crossref","first-page":"8380","DOI":"10.3892\/mmr.2017.7625","article-title":"High-dose PMA with RANKL and MCSF induces THP\u20111 cell differentiation into human functional osteoclasts in vitro","volume":"16","author":"Li","year":"2017","journal-title":"Mol. Med Rep."},{"key":"10.1016\/j.tice.2024.102643_bib34","doi-asserted-by":"crossref","first-page":"31155","DOI":"10.1074\/jbc.M001229200","article-title":"Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-kappa B ligand (RANKL)","volume":"275","author":"Matsumoto","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tice.2024.102643_bib35","doi-asserted-by":"crossref","first-page":"638","DOI":"10.18632\/oncotarget.310","article-title":"The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer","volume":"2","author":"Mazumdar","year":"2011","journal-title":"Oncotarget"},{"key":"10.1016\/j.tice.2024.102643_bib36","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1038\/s12276-020-0484-z","article-title":"The M-CSF receptor in osteoclasts and beyond","volume":"52","author":"Mun","year":"2020","journal-title":"Exp. Mol. Med"},{"key":"10.1016\/j.tice.2024.102643_bib37","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1177\/0022034519882692","article-title":"Mesenchymal progenitor regulation of tooth eruption: a view from PTHrP","volume":"99","author":"Nagata","year":"2020","journal-title":"J. Dent. Res"},{"key":"10.1016\/j.tice.2024.102643_bib38","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.devcel.2008.03.007","article-title":"Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity","volume":"14","author":"Ohba","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.tice.2024.102643_bib39","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0002-9416(81)90217-7","article-title":"Primary failure of eruption: a possible cause of posterior open-bite","volume":"80","author":"Proffit","year":"1981","journal-title":"Am. J. Orthod."},{"key":"10.1016\/j.tice.2024.102643_bib40","doi-asserted-by":"crossref","first-page":"4140","DOI":"10.3390\/polym13234140","article-title":"Cellulose Acetate Nanofibers: Incorporating Hydroxyapatite (HA), HA\/Berberine or HA\/Moghat Composites, as Scaffolds to Enhance In Vitro Osteoporotic Bone Regeneration","volume":"13","author":"Shaban","year":"2021","journal-title":"Polym. (Basel)"},{"key":"10.1016\/j.tice.2024.102643_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0151731","article-title":"The role of sonic hedgehog signaling in osteoclastogenesis and jaw bone destruction","volume":"11","author":"Shimo","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.tice.2024.102643_bib42","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1210\/edrv.20.3.0367","article-title":"Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families","volume":"20","author":"Suda","year":"1999","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.tice.2024.102643_bib43","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1196\/annals.1402.071","article-title":"The role of NFAT in osteoclast formation","volume":"1116","author":"Takayanagi","year":"2007","journal-title":"Ann. N. Y Acad. Sci."},{"key":"10.1016\/j.tice.2024.102643_bib44","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S1534-5807(02)00369-6","article-title":"Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts","volume":"3","author":"Takayanagi","year":"2002","journal-title":"Dev. Cell"},{"key":"10.1016\/j.tice.2024.102643_bib45","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1242\/jcs.03309","article-title":"Hedgehog signaling","volume":"120","author":"Varjosalo","year":"2007","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.tice.2024.102643_bib46","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1177\/0022034512474469","article-title":"Tooth eruption without roots","volume":"92","author":"Wang","year":"2013","journal-title":"J. Dent. Res"},{"key":"10.1016\/j.tice.2024.102643_bib47","article-title":"RUNX2 mutation impairs 1\u03b1,25-dihydroxyvitamin D3 mediated osteoclastogenesis in dental follicle cells","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2024.102643_bib48","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1101\/gad.1087303","article-title":"JNK initiates a cytokine cascade that causes Pax2 expression and closure of the optic fissure","volume":"17","author":"Weston","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.tice.2024.102643_bib49","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1601-6343.2009.01439.x","article-title":"Cellular and molecular basis of tooth eruption","volume":"12","author":"Wise","year":"2009","journal-title":"Orthod. Craniofac Res"},{"key":"10.1016\/j.tice.2024.102643_bib50","first-page":"409","article-title":"Differential effects of mechanical strain on osteoclastogenesis and osteoclast-related gene expression in RAW264.7 cells","volume":"6","author":"Xu","year":"2012","journal-title":"Mol. Med Rep."},{"key":"10.1016\/j.tice.2024.102643_bib51","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nature12396","article-title":"Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling","volume":"499","author":"Yang","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.tice.2024.102643_bib52","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/sj.cr.7290257","article-title":"Activation and signaling of the p38 MAP kinase pathway","volume":"15","author":"Zarubin","year":"2005","journal-title":"Cell Res"},{"key":"10.1016\/j.tice.2024.102643_bib53","doi-asserted-by":"crossref","first-page":"5122","DOI":"10.1111\/jcmm.15153","article-title":"Guaiacol suppresses osteoclastogenesis by blocking interactions of RANK with TRAF6 and C-Src and inhibiting NF-\u03baB, MAPK and AKT pathways","volume":"24","author":"Zhi","year":"2020","journal-title":"J. Cell Mol. Med"},{"key":"10.1016\/j.tice.2024.102643_bib54","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.1111\/jcmm.14333","article-title":"Isorhamnetin attenuates osteoarthritis by inhibiting osteoclastogenesis and protecting chondrocytes through modulating reactive oxygen species homeostasis","volume":"23","author":"Zhou","year":"2019","journal-title":"J. Cell Mol. Med"}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816624003446?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816624003446?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T23:02:53Z","timestamp":1733958173000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816624003446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":54,"alternative-id":["S0040816624003446"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2024.102643","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Shh-p38-NFATc1 signaling pathway is essential for osteoclastogenesis during tooth eruption","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2024.102643","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102643"}}