{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T06:22:25Z","timestamp":1777702945429,"version":"3.51.4"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","award":["971949"],"award-info":[{"award-number":["971949"]}],"id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","award":["IR.MUMS.MEDICAL.REC.1398.500"],"award-info":[{"award-number":["IR.MUMS.MEDICAL.REC.1398.500"]}],"id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.tice.2024.102657","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T12:34:44Z","timestamp":1733315684000},"page":"102657","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Aspartame subacute exposure does not affect immune system of BALB\/c mice following a tiered approach"],"prefix":"10.1016","volume":"93","author":[{"given":"Seyed Mostafa Moshirian","family":"Farahi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Forouzanfar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahram","family":"Memar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roghayeh","family":"Rashidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramin","family":"Mahdipour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bamdad","family":"Riahi-Zanjani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmood","family":"Sadeghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"15","key":"10.1016\/j.tice.2024.102657_bib1","article-title":"Studies on the effects of aspartame on memory and oxidative stress in brain of mice","volume":"16","author":"Abdel-Salam","year":"2012","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"15","key":"10.1016\/j.tice.2024.102657_bib2","doi-asserted-by":"crossref","first-page":"601","DOI":"10.5897\/AJB2015.15199","article-title":"Effect of monosodium glutamate and aspartame on behavioral and biochemical parameters of male albino mice","volume":"15","author":"Abu-Taweel","year":"2016","journal-title":"Afr. J. Biotechnol."},{"key":"10.1016\/j.tice.2024.102657_bib3","first-page":"101","article-title":"Delayed-type hypersensitivity models in mice. \"","author":"Allen","year":"2013","journal-title":"Mouse Models Innate Immun.: Methods Protoc."},{"issue":"6","key":"10.1016\/j.tice.2024.102657_bib4","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/iep.12458","article-title":"Long-term intake of aspartame-induced cardiovascular toxicity is reflected in altered histochemical parameters, evokes oxidative stress, and trigger P53-dependent apoptosis in a mouse model","volume":"103","author":"Anbara","year":"2022","journal-title":"Int. J. Exp. Pathol."},{"issue":"2","key":"10.1016\/j.tice.2024.102657_bib5","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/tox.23028","article-title":"Insight into the mechanism of aspartame-induced toxicity in male reproductive system following long-term consumption in mice model","volume":"36","author":"Anbara","year":"2021","journal-title":"Environ. Toxicol."},{"issue":"4","key":"10.1016\/j.tice.2024.102657_bib6","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.133093","article-title":"IL-4 induces M2 macrophages to produce sustained analgesia via opioids","volume":"5","author":"Celik","year":"2020","journal-title":"JCI Insight"},{"issue":"7","key":"10.1016\/j.tice.2024.102657_bib7","doi-asserted-by":"crossref","first-page":"653","DOI":"10.2174\/1573401314666181016124250","article-title":"\"Mechanistic Insights into Aspartame-induced Immune Dysregulation.\"","volume":"15","author":"Choudhary","year":"2019","journal-title":"Curr. Nutr. Food Sci."},{"issue":"8","key":"10.1016\/j.tice.2024.102657_bib8","doi-asserted-by":"crossref","first-page":"220","DOI":"10.5897\/AJPP2013.3838","article-title":"Imbalance of the oxidant-antioxidant status by aspartame in the organs of immune system of Wistar albino rats","volume":"8","author":"Choudhary","year":"2014","journal-title":"Afr. J. Pharm. Pharm."},{"issue":"3","key":"10.1016\/j.tice.2024.102657_bib9","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.endonu.2014.11.004","article-title":"Longer period of oral administration of aspartame on cytokine response in Wistar albino rats","volume":"62","author":"Choudhary","year":"2015","journal-title":"Endocrinol. \u00eda Y. Nutr. \u00f3N. (Engl. Ed. )"},{"issue":"9","key":"10.1016\/j.tice.2024.102657_bib10","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1093\/nutrit\/nux035","article-title":"Revisiting the safety of aspartame","volume":"75","author":"Choudhary","year":"2017","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.tice.2024.102657_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1743-7075-9-58","article-title":"Interactive effects of neonatal exposure to monosodium glutamate and aspartame on glucose homeostasis","volume":"9","author":"Collison","year":"2012","journal-title":"Nutr. Metab."},{"issue":"2","key":"10.1016\/j.tice.2024.102657_bib12","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3109\/08923973.2014.890216","article-title":"In vitro immunomodulatory effects of 5-amino-3-methyl-4-isoxazolecarboxylic acid hydrazide on the cellular immune response","volume":"36","author":"Drynda","year":"2014","journal-title":"Immunopharmacol. Immunotoxicol."},{"issue":"2","key":"10.1016\/j.tice.2024.102657_bib13","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.intimp.2007.10.018","article-title":"\"Evaluation of immunosuppression induced by metronidazole in Balb\/c mice and human peripheral blood lymphocytes.\"","volume":"8","author":"Fararjeh","year":"2008","journal-title":"Int. Immunopharmacol."},{"issue":"11","key":"10.1016\/j.tice.2024.102657_bib14","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1038\/jid.2015.234","article-title":"Aspartame attenuates 2, 4-dinitrofluorobenzene-induced atopic dermatitis\u2013like clinical symptoms in NC\/Nga mice","volume":"135","author":"Kim","year":"2015","journal-title":"J. Invest. Dermatol."},{"issue":"3","key":"10.1016\/j.tice.2024.102657_bib15","doi-asserted-by":"crossref","first-page":"298","DOI":"10.18006\/2015.3(3).298.306","article-title":"Nutritional and biochemical effects of aspartame intake in rats under an experimental diet","volume":"3","author":"Martinez-Morales","year":"2015","journal-title":"J. Exp. Biol. Agric. Sci."},{"issue":"3","key":"10.1016\/j.tice.2024.102657_bib16","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.tox.2003.08.012","article-title":"Evaluation of immunotoxicity induced by diazinon in C57bl\/6 mice","volume":"196","author":"Neishabouri","year":"2004","journal-title":"Toxicology"},{"key":"10.1016\/j.tice.2024.102657_bib17","unstructured":"news, W.H.O.. 2023. \"Aspartame hazard and risk assessment results released.\""},{"issue":"9","key":"10.1016\/j.tice.2024.102657_bib18","doi-asserted-by":"crossref","first-page":"4509","DOI":"10.1002\/cam4.1700","article-title":"Interferon gamma in cancer immunotherapy","volume":"7","author":"Ni","year":"2018","journal-title":"Cancer Med"},{"key":"10.1016\/j.tice.2024.102657_bib19","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s12038-014-9487-z","article-title":"Prooxidative effects of aspartame on antioxidant defense status in erythrocytes of rats","volume":"39","author":"Proki\u0107","year":"2014","journal-title":"J. Biosci."},{"issue":"6","key":"10.1016\/j.tice.2024.102657_bib20","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/j.fct.2010.03.036","article-title":"Immunotoxicity of paraquat after subacute exposure to mice","volume":"48","author":"Riahi","year":"2010","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.tice.2024.102657_bib21","doi-asserted-by":"crossref","first-page":"10","DOI":"10.5114\/fn.2013.34191","article-title":"Effects of aspartame metabolites on astrocytes and neurons","volume":"51","author":"Rycerz","year":"2013","journal-title":"Folia Neuropathol."},{"issue":"6","key":"10.1016\/j.tice.2024.102657_bib22","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.3945\/ajcn.111.030833","article-title":"Consumption of artificial sweetener\u2013and sugar-containing soda and risk of lymphoma and leukemia in men and women","volume":"96","author":"Schernhammer","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"issue":"3","key":"10.1016\/j.tice.2024.102657_bib23","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1289\/ehp.8711","article-title":"First experimental demonstration of the multipotential carcinogenic effects of aspartame administered in the feed to Sprague-Dawley rats","volume":"114","author":"Soffritti","year":"2006","journal-title":"Environ. Health Perspect."},{"issue":"9","key":"10.1016\/j.tice.2024.102657_bib24","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1289\/ehp.10271","article-title":"Life-span exposure to low doses of aspartame beginning during prenatal life increases cancer effects in rats","volume":"115","author":"Soffritti","year":"2007","journal-title":"Environ. Health Perspect."},{"issue":"2","key":"10.1016\/j.tice.2024.102657_bib25","doi-asserted-by":"crossref","first-page":"23","DOI":"10.15406\/mojt.2017.03.00046","article-title":"Aspartame: effects and awareness","volume":"3","author":"Zafar","year":"2017","journal-title":"MOJ Toxicol."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816624003586?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816624003586?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:37:18Z","timestamp":1777455438000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816624003586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":25,"alternative-id":["S0040816624003586"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2024.102657","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aspartame subacute exposure does not affect immune system of BALB\/c mice following a tiered approach","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2024.102657","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102657"}}