{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T02:11:43Z","timestamp":1778638303632,"version":"3.51.4"},"reference-count":408,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["406700\/2021-4"],"award-info":[{"award-number":["406700\/2021-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005672","name":"Funda\u00e7\u00e3o de Apoio ao Desenvolvimento do Ensino, Ci\u00eancia e Tecnologia do Estado de Mato Grosso do Sul","doi-asserted-by":"publisher","award":["155\/2024"],"award-info":[{"award-number":["155\/2024"]}],"id":[{"id":"10.13039\/501100005672","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.tice.2024.102717","type":"journal-article","created":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T16:11:01Z","timestamp":1736007061000},"page":"102717","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Disrupted homeostasis in sickle cells: Expanding the comprehension of metabolism adaptation and related therapeutic strategies"],"prefix":"10.1016","volume":"93","author":[{"given":"Victoria Sim\u00f5es","family":"Bernardo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flaviene Felix","family":"Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Clara Albertin","family":"Zuc\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nayara Alves","family":"Chaves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilana Luize Rocha","family":"Santana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danilo Gr\u00fcnig Humberto","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2024.102717_bib1","first-page":"5043","article-title":"Comparative effectiveness of adding Omega-3 or Vitamin D to standard therapy in preventing and treating episodes of painful crisis in pediatric sickle cell patients","volume":"26","author":"Abdelhalim","year":"2022","journal-title":"Eur. Rev. Med Pharm. Sci."},{"key":"10.1016\/j.tice.2024.102717_bib2","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1182\/blood.2019003776","article-title":"Gene therapy for sickle cell disease: moving from the bench to the bedside","volume":"138","author":"Abraham","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib3","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1179\/rer.2000.5.1.29","article-title":"Hydroxy-urea protects erythrocytes against oxidative damage","volume":"5","author":"Agil","year":"2000","journal-title":"Redox Rep."},{"key":"10.1016\/j.tice.2024.102717_bib4","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1002\/jcp.22195","article-title":"Sickle Cell Anemia and Vascular Dysfunction: The Nitric Oxide Connection","volume":"224","author":"Akinsheye","year":"2010","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.tice.2024.102717_bib5","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1203\/pdr.0b013e31802d7754","article-title":"Energy expenditure, inflammation, and oxidative stress in steady-state adolescents with sickle cell anemia","volume":"61","author":"Akohoue","year":"2007","journal-title":"Pedia Res"},{"key":"10.1016\/j.tice.2024.102717_bib6","doi-asserted-by":"crossref","first-page":"14473","DOI":"10.1002\/jcp.28228","article-title":"Hexose monophosphate shunt, the role of its metabolites and associated disorders: A review","volume":"234","author":"Akram","year":"2019","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.tice.2024.102717_bib7","doi-asserted-by":"crossref","DOI":"10.1038\/srep07173","article-title":"Heterogeneous red blood cell adhesion and deformability in sickle cell disease","volume":"4","author":"Alapan","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2024.102717_bib8","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1074\/jbc.274.4.2029","article-title":"Reactions of sperm whale myoglobin with hydrogen peroxide: Effects of distal pocket mutations on the formation and stability of the ferryl intermediate","volume":"274","author":"Alayash","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tice.2024.102717_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/10760296211047230","article-title":"Iron Chelation Reduces DNA Damage in Sickle Cell Anemia","volume":"27","author":"Al-khateeb","year":"2021","journal-title":"Clin. Appl. Thromb. Hemost."},{"key":"10.1016\/j.tice.2024.102717_bib10","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1177\/1076029614565880","article-title":"Modulation of Sickle Red Blood Cell Adhesion and its Associated Changes in Biomarkers by Sulfated Nonanticoagulant Heparin Derivative","volume":"22","author":"Alshaiban","year":"2015","journal-title":"Clin. Appl. Thromb. \/Hemost."},{"key":"10.1016\/j.tice.2024.102717_bib11","first-page":"239","article-title":"Adhesive properties of blood cells","volume":"23","author":"Altankov","year":"1990","journal-title":"Haematol. (Budap)"},{"key":"10.1016\/j.tice.2024.102717_bib12","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.bbagen.2007.11.009","article-title":"N-acetylcysteine amide (AD4) attenuates oxidative stress in beta-thalassemia blood cells","volume":"1780","author":"Amer","year":"2008","journal-title":"Biochim Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.tice.2024.102717_bib13","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1365-2141.2005.05834.x","article-title":"Red blood cells, platelets and polymorphonuclear neutrophils of patients with sickle cell disease exhibit oxidative stress that can be ameliorated by antioxidants","volume":"132","author":"Amer","year":"2005","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.tice.2024.102717_bib14","doi-asserted-by":"crossref","first-page":"31796","DOI":"10.1074\/jbc.M204567200","article-title":"Shear-response of the spectrin dimer-tetramer equilibrium in the red blood cell membrane","volume":"277","author":"An","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tice.2024.102717_bib15","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jprot.2012.06.032","article-title":"Effects of pre-storage leukoreduction on stored red blood cells signaling: A time-course evaluation from shape to proteome","volume":"76","author":"Antonelou","year":"2012","journal-title":"J. Proteom."},{"key":"10.1016\/j.tice.2024.102717_bib16","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1006\/bbrc.1996.1716","article-title":"Reactivity of mammalian 15-lipoxygenase with phospholipids in large unilamellar liposomes","volume":"228","author":"Arai","year":"1996","journal-title":"Biochem Biophys. Res Commun."},{"key":"10.1016\/j.tice.2024.102717_bib17","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1182\/bloodadvances.2020003376","article-title":"Characterization and statistical modeling of glycosylation changes in sickle cell disease","volume":"5","author":"Ashwood","year":"2021","journal-title":"Blood Adv."},{"key":"10.1016\/j.tice.2024.102717_bib18","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s10238-014-0293-6","article-title":"LC\u2013MS\/MS analysis of plasma polyunsaturated fatty acids in patients with homozygous sickle cell disease","volume":"15","author":"Aslan","year":"2015","journal-title":"Clin. Exp. Med"},{"key":"10.1016\/j.tice.2024.102717_bib19","doi-asserted-by":"crossref","first-page":"15215","DOI":"10.1073\/pnas.221292098","article-title":"Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease","volume":"98","author":"Aslan","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.tice.2024.102717_bib20","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1749-6632.2000.tb06201.x","article-title":"Reactive Species in Sickle Cell Disease","volume":"899","author":"Aslan","year":"2006","journal-title":"Ann. N. Y Acad. Sci."},{"key":"10.1016\/j.tice.2024.102717_bib21","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1056\/NEJMoa1611770","article-title":"Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease","volume":"376","author":"Ataga","year":"2017","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.tice.2024.102717_bib22","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1365-2141.2010.08520.x","article-title":"Improvements in haemolysis and indicators of erythrocyte survival do not correlate with acute vaso-occlusive crises in patients with sickle cell disease: A phase III randomized, placebo-controlled, double-blind study of the gardos channel blocker senicapo","volume":"153","author":"Ataga","year":"2011","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.tice.2024.102717_bib23","doi-asserted-by":"crossref","first-page":"3991","DOI":"10.1182\/blood-2007-08-110098","article-title":"Efficacy and safety of the Gardos channel blocker, senicapoc (ICA-17043), in patients with sickle cell anemia","volume":"111","author":"Ataga","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12878-017-0089-5","article-title":"Coagulation profile of Sudanese children with homozygous sickle cell disease and the effect of treatment with omega-3 fatty acid on the coagulation parameters","volume":"17","author":"Awoda","year":"2017","journal-title":"BMC Hematol."},{"key":"10.1016\/j.tice.2024.102717_bib25","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/pbc.24175","article-title":"A Global Perspective on Sickle Cell Disease","volume":"59","author":"Aygun","year":"2012","journal-title":"Pedia Blood Cancer"},{"key":"10.1016\/j.tice.2024.102717_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082338","article-title":"Energetic and molecular water permeation mechanisms of the human red blood cell urea transporter B","volume":"8","author":"Azouzi","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.tice.2024.102717_bib27","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1053\/shem.2001.20142","article-title":"Iron Overload Is a Determinant of Morbidity and Mortality in Adult Patientis With Sicke Cell Disease","volume":"38","author":"Ballas","year":"2001","journal-title":"Semin Hematol."},{"key":"10.1016\/j.tice.2024.102717_bib28","first-page":"1","article-title":"The evolving pharmacotherapeutic landscape for the treatment of sickle cell disease","volume":"11","author":"Ballas","year":"2020","journal-title":"Mediterr. J. Hematol. Infect. Dis."},{"key":"10.1016\/j.tice.2024.102717_bib29","doi-asserted-by":"crossref","DOI":"10.1100\/2012\/949535","article-title":"Beyond the Definitions of the Phenotypic Complications of Sickle Cell Disease: An Update on Management","volume":"2012","author":"Ballas","year":"2012","journal-title":"Sci. World J."},{"key":"10.1016\/j.tice.2024.102717_bib30","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/j.1365-2141.1999.01339.x","article-title":"Erythropoietic activity in patients with sickle cell anaemia before and after treatment with hydroxyurea","volume":"105","author":"Ballas","year":"1999","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.tice.2024.102717_bib31","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.trsl.2008.06.001","article-title":"Zinc supplementation decreases oxidative stress, incidence of infection, and generation of inflammatory cytokines in sickle cell disease patients","volume":"152","author":"Bao","year":"2008","journal-title":"Transl. Res."},{"key":"10.1016\/j.tice.2024.102717_bib32","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1182\/blood.V93.4.1422","article-title":"Anionic Polysaccharides Inhibit Adhesion of Sickle Erythrocytes to the Vascular Endothelium and Result in Improved Hemodynamic Behavior","volume":"93","author":"Barabino","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib33","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev-bioeng-070909-105339","article-title":"Sickle Cell Biomechanics","volume":"12","author":"Barabino","year":"2010","journal-title":"Annu Rev. Biomed. Eng."},{"key":"10.1016\/j.tice.2024.102717_bib34","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/trf.12291","article-title":"Nitroprusside inhibits calcium-induced impairment of red blood cell deformability","volume":"54","author":"Barodka","year":"2014","journal-title":"Transfus. (Paris)"},{"key":"10.1016\/j.tice.2024.102717_bib35","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1182\/blood-2009-12-257444","article-title":"Decreased sickle red blood cell adhesion to laminin by hydroxyurea is associated with inhibition of Lu\/BCAM protein phosphorylation","volume":"116","author":"Bartolucci","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib36","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nrd2060","article-title":"Therapeutic potential of resveratrol: The in vivo evidence","volume":"5","author":"Baur","year":"2006","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.tice.2024.102717_bib37","doi-asserted-by":"crossref","first-page":"41R","DOI":"10.1093\/glycob\/cwg054","article-title":"Fucose: Biosynthesis and biological function in mammals","volume":"13","author":"Becker","year":"2003","journal-title":"Glycobiology"},{"key":"10.1016\/j.tice.2024.102717_bib38","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1111\/trf.13134","article-title":"Effects of nitric oxide and its congeners on sickle red blood cell deformability","volume":"55","author":"Belanger","year":"2015","journal-title":"Transfus. (Paris)"},{"key":"10.1016\/j.tice.2024.102717_bib39","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1089\/ars.2009.2822","article-title":"Heme degradation and vascular injury","volume":"12","author":"Belcher","year":"2010","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.tice.2024.102717_bib40","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1152\/ajpheart.00986.2004","article-title":"Critical role of endothelial cell activation in hypoxia-induced vasoocclusion in transgenic sickle mice","volume":"288","author":"Belcher","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.tice.2024.102717_bib41","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1182\/blood.V97.5.1451","article-title":"Treatment with NS3623, a novel Cl-conductance blocker, ameliorates erythrocyte dehydration in transgenic SAD mice: A possible new therapeutic approach for sickle cell disease","volume":"97","author":"Bennekou","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib42","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1182\/blood.V95.5.1842.005a37_1842_1848","article-title":"Volume control in sickle cells is facilitated by the novel anion conductance inhibitor NS1652","volume":"95","author":"Bennekou","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib43","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.3390\/genes13122368","article-title":"Potential Cytoprotective and Regulatory Effects of Ergothioneine on Gene Expression of Proteins Involved in Erythroid Adaptation Mechanisms and Redox Pathways in","volume":"13","author":"Bernardo","year":"2022","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.tice.2024.102717_bib44","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.bbrc.2015.01.008","article-title":"Vitamin D cell signalling in health and disease","volume":"460","author":"Berridge","year":"2015","journal-title":"Biochem Biophys. Res Commun."},{"key":"10.1016\/j.tice.2024.102717_bib45","first-page":"759","article-title":"Red cell metabolism","volume":"54","author":"Beutler","year":"1971","journal-title":"Bases Mol. De. la Pathol."},{"key":"10.1016\/j.tice.2024.102717_bib46","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/ecam\/nem139","article-title":"Fetal hemoglobin inducers from the natural world: A novel approach for identification of drugs for the treatment of \u03b2-thalassemia and Sickle-cell anemia","volume":"6","author":"Bianchi","year":"2009","journal-title":"Evid. -Based Complement. Altern. Med."},{"key":"10.1016\/j.tice.2024.102717_bib47","doi-asserted-by":"crossref","first-page":"e334","DOI":"10.1016\/S2352-3026(21)00053-3","article-title":"Sevuparin for the treatment of acute pain crisis in patients with sickle cell disease: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial","volume":"8","author":"Biemond","year":"2021","journal-title":"Lancet Haematol."},{"key":"10.1016\/j.tice.2024.102717_bib48","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1111\/febs.14606","article-title":"Oxidative stress, eryptosis and anemia: a pivotal mechanistic nexus in systemic diseases","volume":"286","author":"Bissinger","year":"2019","journal-title":"FEBS J."},{"key":"10.1016\/j.tice.2024.102717_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10245332.2018.1498441","article-title":"Oxidative stress, antioxidant capacity, biomolecule damage, and inflammation symptoms of sickle cell disease in children","volume":"24","author":"Biswal","year":"2019","journal-title":"Hematology"},{"key":"10.1016\/j.tice.2024.102717_bib50","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s40265-019-01254-2","article-title":"Crizanlizumab: First Approval","volume":"80","author":"Blair","year":"2020","journal-title":"Drugs"},{"key":"10.1016\/j.tice.2024.102717_bib51","doi-asserted-by":"crossref","first-page":"4516","DOI":"10.1021\/bi1003684","article-title":"Control of erythrocyte membrane-skeletal cohesion by the spectrin-membrane linkage","volume":"49","author":"Blanc","year":"2010","journal-title":"Biochemistry"},{"key":"10.1016\/j.tice.2024.102717_bib52","series-title":"Magnesium Therapy for Sickle Cell Anemia: A New Rationale","first-page":"545","author":"Bookchin","year":"1995"},{"key":"10.1016\/j.tice.2024.102717_bib53","doi-asserted-by":"crossref","DOI":"10.3390\/proteomes4040035","article-title":"The proteome of the red blood cell: An auspicious source of new insights into membrane-centered regulation of homeostasis","volume":"4","author":"Bosman","year":"2016","journal-title":"Proteomes"},{"key":"10.1016\/j.tice.2024.102717_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.103948","article-title":"Synthesis and evaluation of resveratrol derivatives as fetal hemoglobin inducers","volume":"100","author":"Bosquesi","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.tice.2024.102717_bib55","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0014-2999(03)01441-9","article-title":"Resveratrol provides late-phase cardioprotection by means of a nitric oxide- and adenosine-mediated mechanism","volume":"465","author":"Bradamante","year":"2003","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.tice.2024.102717_bib56","doi-asserted-by":"crossref","first-page":"4701","DOI":"10.1182\/blood.V88.12.4701.bloodjournal88124701","article-title":"A multiparameter analysis of sickle erythrocytes in patients undergoing hydroxyurea therapy","volume":"88","author":"Bridges","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib57","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1182\/blood-2015-05-647107","article-title":"A multicenter randomized controlled trial of intravenous magnesium for sickle cell pain crisis in children","volume":"126","author":"Brousseau","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib58","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1182\/blood-2014-10-609362","article-title":"Activation of the erythroid K-Cl cotransporter Kcc1 enhances sickle cell disease pathology in a humanized mouse model","volume":"126","author":"Brown","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib59","series-title":"Safety, tolerability, and pharmacokinetic\/pharmacodynamic results from phase 1 studies of GBT021601, a next-generation Hbs polymerization inhibitor for treatment of sickle cell disease","author":"Brown","year":"2022"},{"key":"10.1016\/j.tice.2024.102717_bib60","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1097\/00043426-200312000-00004","article-title":"Sickle Cell Disease: From Membrane Pathophysiology to Novel Therapies for Prevention of Erythrocyte Dehydration","volume":"25","author":"Brugnara","year":"2003","journal-title":"J. Pedia Hematol. Oncol."},{"key":"10.1016\/j.tice.2024.102717_bib61","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1172\/JCI118537","article-title":"Therapy with oral clotrimazole induces inhibition of the Gardos channel and reduction of erythrocyte dehydration in patients with sickle cell disease","volume":"97","author":"Brugnara","year":"1996","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.tice.2024.102717_bib62","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1182\/blood.V70.6.1810.1810","article-title":"Inhibition of K transport by divalent cations in sickle erythrocytes","volume":"70","author":"Brugnara","year":"1987","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib63","first-page":"1","article-title":"Iron chelation therapy","author":"Bruzzese","year":"2023","journal-title":"Eur. J. Haematol. Online ahe"},{"key":"10.1016\/j.tice.2024.102717_bib64","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1182\/blood-2014-07-589283","article-title":"Circulating cell membrane microparticles transfer heme to endothelial cells and trigger vasoocclusions in sickle cell disease","volume":"125","author":"Camus","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib65","doi-asserted-by":"crossref","first-page":"5050","DOI":"10.1182\/blood-2012-02-413138","article-title":"Erythrocyte microparticles can induce kidney vaso-occlusions in a murine model of sickle cell disease","volume":"120","author":"Camus","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib66","doi-asserted-by":"crossref","unstructured":"Carrell, R.W., Winterbourn, C.C., Rachmilewitz, E.A., 1975. Activated oxygen and haemolysis. Br. J. Haematol. 30, 259-264.","DOI":"10.1111\/j.1365-2141.1975.tb00540.x"},{"key":"10.1016\/j.tice.2024.102717_bib67","doi-asserted-by":"crossref","unstructured":"Caruso, C., Cheng, X., Michaud, M.E., Szafraniec, H.M., Thomas, B.E., Fay, M.E., Mannino, R.G., Zhang, X., Sakurai, Y., Li, W., Myers, D.R., Joiner, C.H., Wood, D.K., Bhasin, M., Graham, M.D., Lam, W.A., 2024. Less-deformable erythrocyte subpopulations biomechanically induce endothelial inflammation in sickle cell disease.","DOI":"10.1182\/blood.2024024608"},{"key":"10.1016\/j.tice.2024.102717_bib68","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/jat.993","article-title":"Acetylcholine and choline effects on erythrocyte nitrite and nitrate levels","volume":"24","author":"Carvalho","year":"2004","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.tice.2024.102717_bib69","first-page":"53","article-title":"Oxygen-linked modulation of erythrocyte metabolism: State of the art","volume":"8","author":"Castagnola","year":"2010","journal-title":"Blood Transfus."},{"key":"10.1016\/j.tice.2024.102717_bib70","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1080\/13510002.2017.1288973","article-title":"Increased oxidative stress alters nucleosides metabolite levels in sickle cell anemia","volume":"22","author":"Castilhos","year":"2017","journal-title":"Redox Rep."},{"key":"10.1016\/j.tice.2024.102717_bib71","doi-asserted-by":"crossref","first-page":"11512","DOI":"10.1074\/jbc.M113.506121","article-title":"Hydroxycarbamide decreases sickle reticulocyte adhesion to resting endothelium by inhibiting endothelial lutheran\/ basal cell adhesion molecule (Lu\/BCAM) through phosphodiesterase 4A activation","volume":"289","author":"Chaar","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tice.2024.102717_bib72","article-title":"Hematopoietic Protein-1 Regulates the Actin Membrane Skeleton and Membrane Stability in Murine Erythrocytes","volume":"8","author":"Chan","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.tice.2024.102717_bib73","first-page":"59","article-title":"Ankyrin is a target of spectrin\u2019s E2\/E3 ubiquitin-conjugating\/ligating activity","volume":"50","author":"Chang","year":"2004","journal-title":"Cell Mol. Biol. (Noisy-Le. -Gd. )"},{"key":"10.1016\/j.tice.2024.102717_bib74","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1182\/blood-2009-12-260513","article-title":"GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice","volume":"116","author":"Chang","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib75","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1055\/s-0038-1650055","article-title":"Aspirin-dipyridamole prophylaxis of sickle cell disease pain crises","volume":"43","author":"Chaplin","year":"1980","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.tice.2024.102717_bib76","first-page":"574","article-title":"Preliminary trial of minidose heparin prophylaxis for painful sickle cell crises","volume":"66","author":"Chaplin","year":"1989","journal-title":"East Afr. Med J."},{"key":"10.1016\/j.tice.2024.102717_bib77","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.freeradbiomed.2019.05.034","article-title":"Impaired antioxidant capacity causes a disruption of metabolic homeostasis in sickle erythrocytes","volume":"141","author":"Chaves","year":"2019","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.tice.2024.102717_bib78","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1179\/102453308X343356","article-title":"Oxidative process in erythrocytes of individuals with hemoglobin S","volume":"13","author":"Chaves","year":"2008","journal-title":"Hematology"},{"key":"10.1016\/j.tice.2024.102717_bib79","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.bbadis.2011.09.017","article-title":"Ergothioneine; antioxidant potential, physiological function and role in disease","volume":"1822","author":"Cheah","year":"2012","journal-title":"Biochim Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.tice.2024.102717_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101868","article-title":"Ergothioneine, recent developments","author":"Cheah","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.tice.2024.102717_bib81","first-page":"12788","article-title":"Red blood cell mechanical sensitivity improves in chronically transfused sickle-cell patients following prolonged, sub- hemolytic shear exposure","volume":"58","author":"Chen","year":"2018","journal-title":"Transfus. (Paris)"},{"key":"10.1016\/j.tice.2024.102717_bib82","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1749-6632.1982.tb31272.x","article-title":"Peroxidation, vitamin E, and sickle-cell anemia","volume":"393","author":"Chiu","year":"1982","journal-title":"Ann. N. Y Acad. Sci."},{"key":"10.1016\/j.tice.2024.102717_bib83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/ars.2009.2978","article-title":"Hydroxyurea-Induced Expression of Glutathione Peroxidase 1 in Red Blood Cells of Individuals with Sickle Cell Anemia","volume":"13","author":"Cho","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.tice.2024.102717_bib84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cca.2007.12.025","article-title":"Free radical metabolism in human erythrocytes","volume":"390","author":"\u00c7imen","year":"2008","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.tice.2024.102717_bib85","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1111\/bjh.14575","article-title":"How we manage iron overload in sickle cell patients","volume":"177","author":"Coates","year":"2017","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.tice.2024.102717_bib86","doi-asserted-by":"crossref","unstructured":"Cohen, G.M., Mannervik, B., 1987. 620t h M e e t i ng The enzymes of glutathione metabolism: an overview 15, 1986\u20131987.","DOI":"10.1042\/bst0150717"},{"key":"10.1016\/j.tice.2024.102717_bib87","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.freeradbiomed.2013.08.163","article-title":"Signaling properties of 4-hydroxyalkenals formed by lipid peroxidation in diabetes","volume":"65","author":"Cohen","year":"2013","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.tice.2024.102717_bib88","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1097\/MOH.0000000000000036","article-title":"Red cell adhesion in human diseases","volume":"21","author":"Colin","year":"2014","journal-title":"Curr. Opin. Hematol."},{"key":"10.1016\/j.tice.2024.102717_bib89","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.cell.2017.04.023","article-title":"The Logic of the 26S Proteasome","volume":"169","author":"Collins","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.tice.2024.102717_bib90","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1007\/s00277-021-04575-z","article-title":"Concise review: how do red blood cells born, live, and die?","volume":"100","author":"Corrons","year":"2021","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.tice.2024.102717_bib91","first-page":"192","article-title":"Nuclear factor erythroid-2 related factor 2 (Nrf2)-mediated protein quality control in cardiomyocytes","author":"Cui","year":"2017","journal-title":"Frint Biosci. 176"},{"key":"10.1016\/j.tice.2024.102717_bib92","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.tiv.2019.01.006","article-title":"Prolonged erythrocyte auto-incubation as an alternative model for oxidant generation system","volume":"56","author":"da Silva","year":"2019","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.tice.2024.102717_bib93","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/jpi.12204","article-title":"Potential utility of melatonin as an antioxidant therapy in the management of sickle cell anemia","volume":"58","author":"da Silva","year":"2015","journal-title":"J. Pineal Res"},{"key":"10.1016\/j.tice.2024.102717_bib94","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3945\/ajcn.112.036319","article-title":"Effect of omega-3 (n-3) fatty acid supplementation in patients with sickle cell anemia: Randomized, double-blind, placebo-controlled trial","volume":"97","author":"Daak","year":"2013","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.tice.2024.102717_bib95","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.plefa.2013.09.006","article-title":"Docosahexaenoic and eicosapentaenoic acid supplementation does not exacerbate oxidative stress or intravascular haemolysis in homozygous sickle cell patients","volume":"89","author":"Daak","year":"2013","journal-title":"Prostaglandins Leukot. Ess. Fat. Acids"},{"key":"10.1016\/j.tice.2024.102717_bib96","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctim.2020.102482","article-title":"Biochemical and therapeutic effects of Omega-3 fatty acids in sickle cell disease","volume":"52","author":"Daak","year":"2020","journal-title":"Complement Ther. Med"},{"key":"10.1016\/j.tice.2024.102717_bib97","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1089\/ars.2007.1716","article-title":"Molecular mechanisms and potential clinical significance of S-glutathionylation","volume":"10","author":"Dalle-Donne","year":"2008","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.tice.2024.102717_bib98","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1182\/blood.2022015797","article-title":"A randomized clinical trial of the efficacy and safety of rivipansel for sickle cell vaso-occlusive crisis","volume":"141","author":"Dampier","year":"2023","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib99","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1365-2141.1980.tb01186.x","article-title":"Superoxide Dismutase, Glutathione Peroxidase, Catalase and Lipid Peroxidation of Normal and Sickled Erythrocytes","volume":"44","author":"Das","year":"1980","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.tice.2024.102717_bib100","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1016\/j.freeradbiomed.2006.08.025","article-title":"Protective effect of arginine on oxidative stress in transgenic sickle mouse models","volume":"41","author":"Dasgupta","year":"2006","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.tice.2024.102717_bib101","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1365-2141.1972.tb08884.x","article-title":"Factors Affecting Pentose Phosphate Pathway Activity in Human Red Cells","volume":"23","author":"Davidson","year":"1972","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.tice.2024.102717_bib102","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1046\/j.1365-2141.2000.01861.x","article-title":"Oral magnesium pidolate effects of long-term administration in patients with sickle cell disease","volume":"108","author":"De Franceschi","year":"2000","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.tice.2024.102717_bib103","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1182\/blood.V88.7.2738.bloodjournal8872738","article-title":"Modulation of erythrocyte potassium chloride cotransport, potassium content, and density by dietary magnesium intake in transgenic SAD mouse","volume":"88","author":"De Franceschi","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib104","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1172\/JCI117149","article-title":"Treatment with oral clotrimazole blocks Ca2+\u2009-activated K+\u2009transport and reverses erythrocyte dehydration in transgenic SAD mice. A model for therapy of sickle cell disease","volume":"93","author":"De Franceschi","year":"1994","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.tice.2024.102717_bib105","first-page":"454a","article-title":"Treatment with oral magnesium pidolate in children with sickle cell disease","volume":"100","author":"De Montalembert","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib106","first-page":"63","article-title":"An overview about erythrocyte membrane","volume":"44","author":"De Oliveira","year":"2010","journal-title":"Clin. Hemorheol. Micro"},{"key":"10.1016\/j.tice.2024.102717_bib107","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/nu11092211","article-title":"Selenium Status and Hemolysis in Sickle Cell Disease Patients","volume":"11","author":"Delesderrier","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.tice.2024.102717_bib108","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1182\/blood-2022-160011","article-title":"Proteomic and Lipidomic Investigation of an Ex-Vivo Human Model of Sickle Cell Disease Erythropoiesis and Patient Erythrocytes Reveals the Abnormal Localization and Dysfunction of the Proteasome, Disrupted Antioxidant Defenses and Altered Lipid Profiles","volume":"140","author":"Delobel","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib109","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s11010-019-03633-5","article-title":"Effects of oral administration of common antioxidant supplements on the energy metabolism of red blood cells. Attenuation of oxidative stress-induced changes in Rett syndrome erythrocytes by CoQ10","volume":"463","author":"Di Pierro","year":"2020","journal-title":"Mol. Cell Biochem"},{"key":"10.1016\/j.tice.2024.102717_bib110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphys.2018.00332","article-title":"On the effects of reactive oxygen species and nitric oxide on red blood cell deformability","volume":"9","author":"Diederich","year":"2018","journal-title":"Front Physiol."},{"key":"10.1016\/j.tice.2024.102717_bib111","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.blre.2018.06.001","article-title":"Modelling human haemoglobin switching","volume":"33","author":"Diepstraten","year":"2019","journal-title":"Blood Rev."},{"key":"10.1016\/j.tice.2024.102717_bib112","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0152895","article-title":"Phase 1 Study of a Sulforaphane-Containing Broccoli Sprout Homogenate for Sickle Cell Disease","volume":"11","author":"Doss","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.tice.2024.102717_bib113","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1182\/blood-2017-02-765891","article-title":"Treating sickle cell disease by targeting HbS polymerization","volume":"129","author":"Eaton","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib114","first-page":"4778","article-title":"Effect of Vitamin C on Reactive Oxygen Species Formation in Erythrocytes of Sickle Cell Anemia Patients","volume":"130","author":"Egini","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib115","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1159\/000089472","article-title":"Diastolic Dysfunction and Pulmonary Hypertension in Sickle Cell Anemia: Is There a Role for L-Carnitine Treatment\u00a0?","volume":"115","author":"El-Beshlawy","year":"2006","journal-title":"Acta Haematol."},{"key":"10.1016\/j.tice.2024.102717_bib116","doi-asserted-by":"crossref","DOI":"10.1111\/jfbc.14322","article-title":"Underutilized legumes, Cajanus cajan and Glycine max may bring about antisickling effect in sickle cell disease by modulation of redox homeostasis in sickled erythrocytes and alteration of its functional chemistry","volume":"46","author":"Elemo","year":"2022","journal-title":"J. Food Biochem"},{"key":"10.1016\/j.tice.2024.102717_bib117","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/bjh.12114","article-title":"L-arginine as an adjuvant drug in the treatment of sickle cell anaemia","volume":"160","author":"Elias","year":"2013","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.tice.2024.102717_bib118","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/0885-4505(90)90066-A","article-title":"Erythrocyte membrane enzymes in sickle cell anemia","volume":"44","author":"Eluwa","year":"1990","journal-title":"Biochem Med Metab. Biol."},{"key":"10.1016\/j.tice.2024.102717_bib119","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1182\/blood-2004-02-0713","article-title":"The contribution of endothelial cell P-selectin to the microvascular flow of mouse sickle erythrocytes in vivo","volume":"104","author":"Embury","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib120","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.cbi.2017.11.007","article-title":"Erythrocytes as a biological model for screening of xenobiotics toxicity","volume":"279","author":"Farag","year":"2018","journal-title":"Chem. Biol. Inter."},{"key":"10.1016\/j.tice.2024.102717_bib121","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1177\/1535370215584931","article-title":"Inosine and hypoxanthine as novel biomarkers for cardiac ischemia: From bench to point-of-care","volume":"240","author":"Farthing","year":"2015","journal-title":"Exp. Biol. Med"},{"key":"10.1016\/j.tice.2024.102717_bib122","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1007\/s00109-008-0368-5","article-title":"A central role for free heme in the pathogenesis of severe malaria: The missing link?","volume":"86","author":"Ferreira","year":"2008","journal-title":"J. Mol. Med"},{"key":"10.1016\/j.tice.2024.102717_bib123","doi-asserted-by":"crossref","first-page":"5998","DOI":"10.1182\/blood-2010-11-317024","article-title":"Regulation of membrane-cytoskeletal interactions by tyrosine phosphorylation of erythrocyte band 3","volume":"117","author":"Ferru","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib124","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1182\/bloodadvances.2017007708","article-title":"The case for HLA-identical sibling hematopoietic stem cell transplantation in children with symptomatic sickle cell anemia","volume":"1","author":"Fitzhugh","year":"2017","journal-title":"Blood Adv."},{"key":"10.1016\/j.tice.2024.102717_bib125","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/cdd.2013.70","article-title":"Functional significance of glutamate-cysteine ligase modifier for erythrocyte survival in vitro and in vivo","volume":"20","author":"F\u00f6ller","year":"2013","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.tice.2024.102717_bib126","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/iub.106","article-title":"Erythrocyte programmed cell death","volume":"60","author":"F\u00f6ller","year":"2008","journal-title":"IUBMB Life"},{"key":"10.1016\/j.tice.2024.102717_bib127","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0014-5793(97)01572-X","article-title":"Resveratrol, a remarkable inhibitor of ribonucleotide reductase","volume":"421","author":"Fontecave","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.tice.2024.102717_bib128","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1002\/cpdd.1058","article-title":"Safety, Pharmacokinetics, and Pharmacodynamics of Etavopivat (FT-4202), an Allosteric Activator of Pyruvate Kinase-R, in Healthy Adults: A Randomized, Placebo-Controlled, Double-Blind, First-in-Human Phase 1 Trial","volume":"11","author":"Forsyth","year":"2022","journal-title":"Clin. Pharm. Drug Dev."},{"key":"10.1016\/j.tice.2024.102717_bib129","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1056\/NEJMoa2031054","article-title":"CRISPR-Cas9 Gene Editing for Sickle Cell Disease and \u03b2-Thalassemia","volume":"384","author":"Frangoul","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tice.2024.102717_bib130","series-title":"Essentials of Glycobiology","first-page":"615","article-title":"Glycans in Acquired Human Diseases","author":"Freeze","year":"2022"},{"key":"10.1016\/j.tice.2024.102717_bib131","doi-asserted-by":"crossref","unstructured":"Frenette, P.S., Atweh, G.F., 2007. Science in medicine Sickle cell disease: old discoveries, new concepts, and future promise 117. https:\/\/doi.org\/10.1172\/JCI30920.850.","DOI":"10.1172\/JCI30920"},{"key":"10.1016\/j.tice.2024.102717_bib132","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1172\/JCI115669","article-title":"A common type of the spectrin \u03b1I 46-50a-kD peptide abnormality in hereditary elliptocytosis and pyropoikilocytosis is associated with a mutation distant from the proteolytic cleavage site: Evidence for the functional importance of the triple helical model","volume":"89","author":"Gallagher","year":"1992","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.tice.2024.102717_bib133","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1515\/bc.2010.100","article-title":"Resveratrol treatment induces redox stress in red blood cells: A possible role of caspase 3 in metabolism and anion transport","volume":"391","author":"Galtieri","year":"2010","journal-title":"Biol. Chem."},{"key":"10.1016\/j.tice.2024.102717_bib134","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s13045-019-0766-x","article-title":"K+\u2009-Cl- cotransporter 1 (KCC1): A housekeeping membrane protein that plays key supplemental roles in hematopoietic and cancer cells","volume":"12","author":"Garneau","year":"2019","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.tice.2024.102717_bib135","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4103\/1117-1936.175256","article-title":"Effect of changes in plasma vitamin E level of vascular responses and lipid peroxidation in sickle cell anaemia subjects","volume":"12","author":"Gbenebitse","year":"2005","journal-title":"Niger. Post. Med J."},{"key":"10.1016\/j.tice.2024.102717_bib136","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1182\/blood-2012-07-441188","article-title":"Erythrocyte NADPH oxidase activity modulated by Rac GTPases, PKC, and plasma cytokines contributes to oxidative stress in sickle cell disease","volume":"121","author":"George","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib137","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.bcmd.2010.02.006","article-title":"Altered phosphorylation of cytoskeleton proteins in sickle red blood cells: The role of protein kinase C, Rac GTPases, and reactive oxygen species","volume":"45","author":"George","year":"2010","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.tice.2024.102717_bib138","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.81090","article-title":"Nonhematopoietic Nrf2 dominantly impedes adult progression of sickle cell anemia in mice","volume":"1","author":"Ghosh","year":"2016","journal-title":"JCI Insight"},{"key":"10.1016\/j.tice.2024.102717_bib139","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1006\/bcmd.2002.0515","article-title":"Membrane transport in sickle cell disease","volume":"28","author":"Gibson","year":"2002","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.tice.2024.102717_bib140","doi-asserted-by":"crossref","first-page":"4373","DOI":"10.1182\/blood.V91.11.4373","article-title":"The efficacy of reducing agents or antioxidants in blocking the formation of dense cells and irreversibly sickled cells in vitro","volume":"91","author":"Gibson","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib141","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1006\/exmp.2001.2377","article-title":"Spectrin oligomerization is cooperatively coupled to membrane assembly: A linkage targeted by many hereditary hemolytic anemias?","volume":"70","author":"Giorgi","year":"2001","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.tice.2024.102717_bib142","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.amjhyper.2004.06.009","article-title":"Treatment by N-acetylcysteine and melatonin increases cardiac baroreflex and improves antioxidant reserve","volume":"17","author":"Girouard","year":"2004","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.tice.2024.102717_bib143","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1021\/acs.chemrestox.8b00408","article-title":"Membrane Skeletal Protein S-Glutathionylation in Human Red Blood Cells as Index of Oxidative Stress","volume":"32","author":"Giustarini","year":"2019","journal-title":"Chem. Res Toxicol."},{"key":"10.1016\/j.tice.2024.102717_bib144","first-page":"1548","article-title":"Sickle cell disease: an international survey of results of HLA-identical sibling hematopoietic stem cell","volume":"129","author":"Gluckman","year":"2017","journal-title":"transplantation"},{"key":"10.1016\/j.tice.2024.102717_bib145","first-page":"1548","article-title":"Sickle cell disease: an international survey of results of HLA-identical sibling hematopoietic stem cell","volume":"129","author":"Gluckman","year":"2017","journal-title":"transplantation"},{"key":"10.1016\/j.tice.2024.102717_bib146","first-page":"74","article-title":"Hydroxyurea and erythropoietin therapy in sickle cell anemia","volume":"19","author":"Goldberg","year":"1992","journal-title":"Semin Oncol."},{"key":"10.1016\/j.tice.2024.102717_bib147","doi-asserted-by":"crossref","first-page":"e1634","DOI":"10.1542\/peds.2013-2065","article-title":"Intravenous magnesium sulfate for vaso-occlusive episodes in sickle cell disease","volume":"132","author":"Goldman","year":"2013","journal-title":"Pediatrics"},{"key":"10.1016\/j.tice.2024.102717_bib148","doi-asserted-by":"crossref","first-page":"S2880","DOI":"10.1093\/jn\/134.10.2880S","article-title":"Arginine and endothelial and vascular health","volume":"134","author":"Gornik","year":"2004","journal-title":"J. Nutr."},{"key":"10.1016\/j.tice.2024.102717_bib149","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1056\/NEJMsa1311707","article-title":"HLA Match Likelihoods for Hematopoietic Stem-Cell Grafts in the U.S. Registry","volume":"371","author":"Gragert","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tice.2024.102717_bib150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0056759","article-title":"RBC-NOS-Dependent S-Nitrosylation of Cytoskeletal Proteins Improves RBC Deformability","volume":"8","author":"Grau","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.tice.2024.102717_bib151","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0006-3495(84)84211-3","article-title":"Ca2+\u2009-activated K+\u2009channels in human red cells. Comparison of single-channel currents with ion fluxes","volume":"45","author":"Grygorczyk","year":"1984","journal-title":"Biophys. J."},{"key":"10.1016\/j.tice.2024.102717_bib152","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1007\/s00424-020-02406-0","article-title":"Erythroid glucose transport in health and disease","volume":"472","author":"Guizouarn","year":"2020","journal-title":"Pflug. Arch."},{"key":"10.1016\/j.tice.2024.102717_bib153","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s12291-017-0691-0","article-title":"Correlation of Red Blood Cell Acetylcholinesterase Enzyme Activity with Various RBC Indices","volume":"33","author":"Gupta","year":"2018","journal-title":"Indian J. Clin. Biochem."},{"key":"10.1016\/j.tice.2024.102717_bib154","doi-asserted-by":"crossref","first-page":"3357","DOI":"10.1002\/1873-3468.13123","article-title":"Ergothioneine \u2013 a diet-derived antioxidant with therapeutic potential","volume":"592","author":"Halliwell","year":"2018","journal-title":"FEBS Lett."},{"key":"10.1016\/j.tice.2024.102717_bib155","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1177\/1535370220976397","article-title":"Nitric oxide and sickle cell disease \u2014 Is there a painful connection?","volume":"246","author":"Hallmark","year":"2021","journal-title":"Exp. Biol. Med (Maywood)"},{"key":"10.1016\/j.tice.2024.102717_bib156","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/bjh.13028","article-title":"Red blood cells of sickle cell disease patients exhibit abnormally high abundance of N-methyl D-aspartate receptors mediating excessive calcium uptake","volume":"167","author":"H\u00e4nggi","year":"2014","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.tice.2024.102717_bib157","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.1365-2141.2007.06884.x","article-title":"Phase I study of magnesium pidolate in combination with hydroxycarbamide for children with sickle cell anaemia","volume":"140","author":"Hankins","year":"2008","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.tice.2024.102717_bib158","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/ijlh.13885","article-title":"The hemoglobinopathies, molecular disease mechanisms and diagnostics","volume":"44","author":"Harteveld","year":"2022","journal-title":"Int J. Lab Hematol."},{"key":"10.1016\/j.tice.2024.102717_bib159","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1159\/000485089","article-title":"Antioxidants Maintain Cellular Redox Homeostasis by Elimination of Reactive Oxygen Species","volume":"44","author":"He","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.tice.2024.102717_bib160","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1172\/JCI110724","article-title":"Spontaneous oxygen radical generation by sickle erythrocytes","volume":"70","author":"Hebbel","year":"1982","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.tice.2024.102717_bib161","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1080\/10739680490278402","article-title":"The endothelial biology of sickle cell disease: Inflammation and a chronic vasculopathy","volume":"11","author":"Hebbel","year":"2004","journal-title":"Microcirculation"},{"key":"10.1016\/j.tice.2024.102717_bib162","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1111\/bjh.14476","article-title":"Exacerbation of oxidative stress during sickle vaso-occlusive crisis is associated with decreased anti-band 3 autoantibodies rate and increased red blood cell-derived microparticle level: a prospective study","volume":"176","author":"Hierso","year":"2017","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.tice.2024.102717_bib163","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.abb.2015.07.023","article-title":"SOD1 deficiency decreases proteasomal function, leading to the accumulation of ubiquitinated proteins in erythrocytes","volume":"583","author":"Homma","year":"2015","journal-title":"Arch. Biochem Biophys."},{"key":"10.1016\/j.tice.2024.102717_bib164","doi-asserted-by":"crossref","DOI":"10.1093\/cdn\/nzz044.OR11-05-19","article-title":"Selenium Deficiency in a Mouse Model of Sickle Cell Disease Resulted in Increased Oxygen Consumption and Aberrant Mitochondrial Retention (OR11-05-19)","volume":"3","author":"Hong","year":"2019","journal-title":"Curr. Dev. Nutr."},{"key":"10.1016\/j.tice.2024.102717_bib165","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctim.2020.102342","article-title":"Vitamin D supplementation and pain-related emergency department visits in children with sickle cell disease","volume":"49","author":"Hood","year":"2020","journal-title":"Complement Ther. Med"},{"key":"10.1016\/j.tice.2024.102717_bib166","doi-asserted-by":"crossref","first-page":"8303","DOI":"10.1016\/S0021-9258(18)47564-3","article-title":"Purification of two high molecular weight proteases from rabbit reticulocyte lysate","volume":"262","author":"Hough","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tice.2024.102717_bib167","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.freeradbiomed.2015.05.026","article-title":"Dermato-protective properties of ergothioneine through induction of Nrf2\/ARE-mediated antioxidant genes in UVA-irradiated Human keratinocytes","volume":"86","author":"Hseu","year":"2015","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.tice.2024.102717_bib168","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1182\/blood-2006-08-039438","article-title":"Hemolysis in sickle cell mice causes pulmonary hypertension due to global impairment in nitric oxide bioavailability","volume":"109","author":"Hsu","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib169","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.hoc.2005.08.004","article-title":"New Therapies for Sickle Cell Disease","volume":"19","author":"Iheanyi","year":"2005","journal-title":"Hematol. Oncol. Clin. North Am."},{"key":"10.1016\/j.tice.2024.102717_bib170","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.880834","article-title":"Nrf2 Activation With CDDO-Methyl Promotes Beneficial and Deleterious Clinical Effects in Transgenic Mice With Sickle Cell Anemia","volume":"13","author":"Ihunnah","year":"2022","journal-title":"Front Pharm."},{"key":"10.1016\/j.tice.2024.102717_bib171","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/269659","article-title":"Phytomedicines and Nutraceuticals: Alternative Therapeutics for Sickle Cell Anemia","volume":"2013","author":"Imaga","year":"2013","journal-title":"Sci. World J."},{"key":"10.1016\/j.tice.2024.102717_bib172","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1111\/j.1476-5381.1996.tb16056.x","article-title":"Protection of low density lipoprotein oxidation at chemical and cellular level by the antioxidant drug dipyridamole","volume":"119","author":"Iuliano","year":"1996","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.tice.2024.102717_bib173","first-page":"93","article-title":"The Abnormal Presence of Mitochondria in Circulating Red Blood Cells Cause an Increased Oxygen Consumption Rate, ROS Generation and Hemolysis in Patients with Sickle Cell Disease","volume":"130","author":"Jagadeeswaran","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib174","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2018-99-111833","article-title":"The Impact of Selenium Deficiency on a Sickle Cell Disease Mouse Model","volume":"132","author":"Jagadeeswaran","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib175","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.exphem.2017.02.003","article-title":"Pharmacological inhibition of LSD1 and mTOR reduces mitochondrial retention and associated ROS levels in the red blood cells of sickle cell disease","volume":"50","author":"Jagadeeswaran","year":"2017","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.tice.2024.102717_bib176","doi-asserted-by":"crossref","first-page":"110","DOI":"10.4103\/1117-1936.175263","article-title":"Changes in erythrocytes following supplementation with alpha-tocopherol in children suffering from sickle cell anaemia","volume":"12","author":"Jaja","year":"2005","journal-title":"Niger. Post. Med J."},{"key":"10.1016\/j.tice.2024.102717_bib177","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.cell.2004.05.002","article-title":"Two enzymes in one: Two yeast peroxiredoxins display oxidative stress-dependent switching from a peroxidase to a molecular chaperone function","volume":"117","author":"Jang","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.tice.2024.102717_bib178","article-title":"Bone marrow transplantation in patient with sickle cell anemia","author":"Johnson","year":"1983","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.tice.2024.102717_bib179","doi-asserted-by":"crossref","first-page":"3976","DOI":"10.1182\/blood.V97.12.3976","article-title":"Dipyridamole inhibits sickling-induced cation fluxes in sickle red blood cells","volume":"97","author":"Joiner","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib180","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00277-011-1340-y","article-title":"Oxidative stress and antioxidant capacity in sickle cell anaemia patients receiving different treatments and medications for different periods of time","volume":"91","author":"Junior","year":"2012","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.tice.2024.102717_bib181","doi-asserted-by":"crossref","first-page":"11630","DOI":"10.1021\/bi010176t","article-title":"Erythrocyte spectrin is an E2 ubiquitin conjugating enzyme","volume":"40","author":"Kakhniashvili","year":"2001","journal-title":"Biochemistry"},{"key":"10.1016\/j.tice.2024.102717_bib182","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1177\/153537020523001102","article-title":"The Proteomics of Sickle Cell Disease: Profiling of Erythrocyte Membrane Proteins by 2D-DIGE and Tandem Mass Spectrometry","volume":"230","author":"Kakhniashvili","year":"2005","journal-title":"Exp. Biol. Med (Maywood)"},{"key":"10.1016\/j.tice.2024.102717_bib183","doi-asserted-by":"crossref","first-page":"3637","DOI":"10.1182\/blood-2006-03-005942","article-title":"Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton","volume":"108","author":"Kalfa","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib184","doi-asserted-by":"crossref","first-page":"870","DOI":"10.3324\/haematol.2015.124586","article-title":"Dietary \u03c9-3 fatty acids protect against vasculopathy in a transgenic mouse model of sickle cell disease","volume":"100","author":"Kalish","year":"2015","journal-title":"Haematologica"},{"key":"10.1016\/j.tice.2024.102717_bib185","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1023\/A:1006880132030","article-title":"Effects of nucleoside transport inhibitors and adenine\/ribose supply on ATP concentration and adenosine production in cardiac myocytes","volume":"180","author":"Kalsi","year":"1998","journal-title":"Mol. Cell Biochem"},{"key":"10.1016\/j.tice.2024.102717_bib186","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.redox.2013.01.014","article-title":"Teaching the basics of redox biology to medical and graduate students: Oxidants, antioxidants and disease mechanisms","volume":"1","author":"Kalyanaraman","year":"2013","journal-title":"Redox Biol."},{"key":"10.1016\/j.tice.2024.102717_bib187","article-title":"Pharmacokinetics, pharmacodynamics, safety and efficacy of crizanlizumab in patients with sickle cell disease","author":"Kanter","year":"2022","journal-title":"Blood Adv."},{"key":"10.1016\/j.tice.2024.102717_bib188","doi-asserted-by":"crossref","first-page":"3668","DOI":"10.1182\/bloodadvances.2021004394C","article-title":"American Society of Hematology 2021 guidelines for sickle cell disease: Stem cell transplantation","volume":"5","author":"Kanter","year":"2021","journal-title":"Blood Adv."},{"key":"10.1016\/j.tice.2024.102717_bib189","doi-asserted-by":"crossref","first-page":"849","DOI":"10.2147\/JPR.S278285","article-title":"P-selectin blockade in the treatment of painful vaso-occlusive crises in sickle cell disease: A spotlight on crizanlizumab","volume":"14","author":"Karki","year":"2021","journal-title":"J. Pain. Res"},{"key":"10.1016\/j.tice.2024.102717_bib190","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s11239-013-1028-3","article-title":"Clinical significance of circulating blood and endothelial cell microparticles in sickle-cell disease","volume":"38","author":"Kasar","year":"2014","journal-title":"J. Thromb. Thrombolysis"},{"key":"10.1016\/j.tice.2024.102717_bib191","doi-asserted-by":"crossref","first-page":"27939","DOI":"10.1074\/jbc.M115.651257","article-title":"Sickle cell hemoglobin in the ferryl state promotes \u03b2Cys-93 oxidation and mitochondrial dysfunction in Epithelial Lung Cells (E10)","volume":"290","author":"Kassa","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tice.2024.102717_bib192","first-page":"1","article-title":"Sickle cell disease","volume":"4","author":"Kato","year":"2018","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.tice.2024.102717_bib193","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1172\/JCI89741","article-title":"Intravascular hemolysis and the pathophysiology of sickle cell disease","volume":"127","author":"Kato","year":"2017","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.tice.2024.102717_bib194","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.tracli.2008.03.012","article-title":"Sickle red cell adhesion: Many issues and some answers","volume":"15","author":"Kaul","year":"2008","journal-title":"Transfus. Clin. Et. Biol."},{"key":"10.1016\/j.tice.2024.102717_bib195","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/10739680802279394","article-title":"Sickle Red Cell - Endothelium Interactions","volume":"16","author":"Kaul","year":"2009","journal-title":"Microcirculation"},{"key":"10.1016\/j.tice.2024.102717_bib196","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1152\/ajpheart.00162.2008","article-title":"Arginine therapy of transgenic-knockout sickle mice improves microvascular function by reducing non-nitric oxide vasodilators, hemolysis, and oxidative stress","volume":"295","author":"Kaul","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.tice.2024.102717_bib197","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.pathophys.2015.05.001","article-title":"L-Arginine supplementation enhances antioxidant activity and erythrocyte integrity in sickle cell anaemia subjects","volume":"22","author":"Kehinde","year":"2015","journal-title":"Pathophysiology"},{"key":"10.1016\/j.tice.2024.102717_bib198","doi-asserted-by":"crossref","first-page":"12169","DOI":"10.1073\/pnas.1509158112","article-title":"Amelioration of inflammation and tissue damage in sickle cell model mice by Nrf2 activation","volume":"112","author":"Keleku-lukwete","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.tice.2024.102717_bib199","article-title":"Lipid modulatory effects of omega-3 fatty acids in children with sickle cell disease","volume":"34","author":"Khan","year":"2022","journal-title":"J. King Saud. Univ. Sci."},{"key":"10.1016\/j.tice.2024.102717_bib200","article-title":"Impact of omega-3 fatty acids supplementation in children with sickle cell disease in Saudi Arabia","volume":"34","author":"Khan","year":"2022","journal-title":"J. King Saud. Univ. Sci."},{"key":"10.1016\/j.tice.2024.102717_bib201","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.jped.2022.01.001","article-title":"Omega 3 fatty acids - Potential modulators for oxidative stress and inflammation in the management of sickle cell disease","volume":"98","author":"Khan","year":"2022","journal-title":"J. Pedia (Rio J."},{"key":"10.1016\/j.tice.2024.102717_bib202","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/00062752-200003000-00007","article-title":"Oxidation and erythrocyte senescence","volume":"7","author":"Kiefer","year":"2000","journal-title":"Curr. Opin. Hematol."},{"key":"10.1016\/j.tice.2024.102717_bib203","first-page":"223","article-title":"Nitric Oxide Pathology and Therapeutics in Sickle Cell Disease","volume":"68","author":"Kim-Shapiro","year":"2018","journal-title":"Clin. Hemorheol. Micro"},{"key":"10.1016\/j.tice.2024.102717_bib204","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.exphem.2004.08.009","article-title":"Expression of organic cation transporter OCTN1 in hematopoietic cells during erythroid differentiation","volume":"32","author":"Kobayashi","year":"2004","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.tice.2024.102717_bib205","first-page":"1","article-title":"Erythrocyte type 1 equilibrative nucleoside transporter expression in sickle cell disease and sickle cell trait","author":"Koehl","year":"2022","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.tice.2024.102717_bib206","first-page":"1","article-title":"Antisickling and Antioxidant Properties of Omega-3 Fatty Acids EPA\/DHA","volume":"9","author":"Kotue","year":"2019","journal-title":"Nutr. Food Sci. Int J."},{"key":"10.1016\/j.tice.2024.102717_bib207","doi-asserted-by":"crossref","first-page":"195","DOI":"10.5507\/bp.2011.052","article-title":"Fatty acids as biocompounds: Their role in human metabolism, health and disease - a review. Part 2: Fatty acid physiological roles and applications in human health and disease","volume":"155","author":"Kremmyda","year":"2011","journal-title":"Biomed. Pap."},{"key":"10.1016\/j.tice.2024.102717_bib208","doi-asserted-by":"crossref","first-page":"134","DOI":"10.2478\/v10039-012-0067-x","article-title":"Can melatonin delay oxidative damage of human erythrocytes during prolonged incubation","volume":"58","author":"Krokosz","year":"2013","journal-title":"Adv. Med Sci."},{"key":"10.1016\/j.tice.2024.102717_bib209","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/0005-2736(92)90099-8","article-title":"The effects of cholesterol oxidation products in sickle and normal red blood cell membranes","volume":"1103","author":"Kucuk","year":"1992","journal-title":"Biochim. Et. Biophys. Acta Acta"},{"key":"10.1016\/j.tice.2024.102717_bib210","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.chemphyslip.2016.03.001","article-title":"Cholesterol oxidation products and their biological importance","volume":"199","author":"Kulig","year":"2016","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.tice.2024.102717_bib211","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.hoc.2013.12.002","article-title":"Hemoglobin S polymerization and red cell membrane changes","volume":"28","author":"Kuypers","year":"2014","journal-title":"Hematol. Oncol. Clin. North Am."},{"key":"10.1016\/j.tice.2024.102717_bib212","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1182\/bloodadvances.2021004938","article-title":"Deferiprone vs deferoxamine for transfusional iron overload in SCD and other anemias: a randomized, open-label noninferiority study","volume":"6","author":"Kwiatkowski","year":"2022","journal-title":"Blood Adv."},{"key":"10.1016\/j.tice.2024.102717_bib213","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ajh.2830150102","article-title":"Impaired pentose phosphate shunt function in sickle cell disease: A potential mechanism for increased heinz body formation and membrane lipid peroxidation","volume":"15","author":"Lachant","year":"1983","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.tice.2024.102717_bib214","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/00000441-198607000-00001","article-title":"Antioxidants in Sickle Cell Disease: The In Vitro Effects of Ascorbic Acid","volume":"292","author":"Lachant","year":"1986","journal-title":"Am. J. Med Sci."},{"key":"10.1016\/j.tice.2024.102717_bib215","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1096\/fj.13-228817","article-title":"Sustained nitric oxide (NO)-releasing compound reverses dysregulated NO signal transduction in priapism","volume":"28","author":"Lagoda","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.tice.2024.102717_bib216","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1179\/135100008X259150","article-title":"Lipoic acid and acetyl-carnitine reverse iron-induced oxidative stress in human fibroblasts","volume":"13","author":"Lal","year":"2008","journal-title":"Redox Rep."},{"key":"10.1016\/j.tice.2024.102717_bib217","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.1182\/blood.V110.11.3799.3799","article-title":"Anti-Oxidant Treatment with \u03b1 -Lipoic Acid and Acetyl L-Carnitine in Hemoglobinopathies","volume":"110","author":"Lal","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib218","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/bjh.14137","article-title":"Low molecular weight heparin inhibits sickle erythrocyte adhesion to VCAM-1 through VLA-4 blockade in a standardized microfluidic flow adhesion assay","volume":"178","author":"Lancelot","year":"2017","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.tice.2024.102717_bib219","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/sj.cdd.4401144","article-title":"Cation channels trigger apoptotic death of erythrocytes","volume":"10","author":"Lang","year":"2003","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.tice.2024.102717_bib220","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.semcdb.2015.01.009","article-title":"Mechanisms and pathophysiological significance of eryptosis, the suicidal erythrocyte death","volume":"39","author":"Lang","year":"2015","journal-title":"Semin Cell Dev. Biol."},{"key":"10.1016\/j.tice.2024.102717_bib221","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1159\/000086406","article-title":"Mechanisms of Suicidal Erythrocyte Death","author":"Lang","year":"2005","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.tice.2024.102717_bib222","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1159\/000016357","article-title":"K-Cl Cotransport: Properties and Molecular Mechanism","volume":"10","author":"Lauf","year":"2000","journal-title":"Cell Physiol. Biochem"},{"key":"10.1016\/j.tice.2024.102717_bib223","doi-asserted-by":"crossref","first-page":"e383","DOI":"10.3324\/haematol.2015.130435","article-title":"Hydroxyurea treatment does not increase blood viscosity and improves red blood cell rheology in sickle cell anemia","volume":"100","author":"Lemonne","year":"2015","journal-title":"Haematologica"},{"key":"10.1016\/j.tice.2024.102717_bib224","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/bjh.16437","article-title":"Curative options for sickle cell disease: haploidentical stem cell transplantation or gene therapy?","volume":"189","author":"Leonard","year":"2020","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.tice.2024.102717_bib225","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1742-7843.2006.pto_222.x","article-title":"a-Tocopherol and a-Lipoic Acid Enhance the Erythrocyte Antioxidant Defence in Cyclosporine A-Treated Rats","volume":"98","author":"Lexis","year":"2006","journal-title":"Basic Clin. Pharm. Toxicol."},{"key":"10.1016\/j.tice.2024.102717_bib226","first-page":"2407","article-title":"Repurposing pyridoxamine for therapeutic intervention of intravascular cell-cell interactions in mouse models of sickle cell disease","volume":"105","author":"Li","year":"2020","journal-title":"Haematologica"},{"key":"10.1016\/j.tice.2024.102717_bib227","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1600-0609.2009.01210.x","article-title":"Hematologic, biochemical, and cardiopulmonary effects of L- arginine supplementation or phosphodiesterase 5 inhibition in patients with sickle cell disease who are on hydroxyurea therapy","volume":"82","author":"Little","year":"2009","journal-title":"Eur. J. Haematol."},{"issue":"1979","key":"10.1016\/j.tice.2024.102717_bib228","first-page":"252","article-title":"Uncoupling of the Spectrin-Based Skeleton from the Lipid Bilayer in Sickled Red Cells","author":"Liu","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.tice.2024.102717_bib229","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1385\/CBB:45:2:185","article-title":"Cholesterol, not polyunsaturated fatty acids, is target molecule in oxidation induced by reactive oxygen species in membrane of human erythrocytes","volume":"45","author":"Liu","year":"2006","journal-title":"Cell Biochem Biophys."},{"key":"10.1016\/j.tice.2024.102717_bib230","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1089\/ars.2008.2081","article-title":"Peroxiredoxin 2 and peroxide metabolism in the erythrocyte","volume":"10","author":"Low","year":"2008","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.tice.2024.102717_bib231","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/ajh.24255","article-title":"Effects of hydroxyurea treatment for patients with hemoglobin SC disease","volume":"91","author":"Luchtman-Jones","year":"2016","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.tice.2024.102717_bib232","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1182\/blood-2014-12-512772","article-title":"Anatomy of the red cell membrane skeleton: unanswered questions","volume":"127","author":"Lux-IV","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib233","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101097","article-title":"Disrupting the vicious cycle created by NOX activation in sickle erythrocytes exposed to hypoxia\/reoxygenation prevents adhesion and vasoocclusion","volume":"25","author":"MacKinney","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.tice.2024.102717_bib234","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/jha2.11","article-title":"A pilot clinical phase II trial MemSID: Acute and durable changes of red blood cells of sickle cell disease patients on memantine treatment","volume":"1","author":"Mahkro","year":"2020","journal-title":"EJHaem"},{"key":"10.1016\/j.tice.2024.102717_bib235","doi-asserted-by":"crossref","first-page":"C1123","DOI":"10.1152\/ajpcell.00031.2013","article-title":"N-methyl-D-aspartate receptors in human erythroid precursor cells and in circulating red blood cells contribute to the intracellular calcium regulation","volume":"305","author":"Makhro","year":"2013","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.tice.2024.102717_bib236","first-page":"897","article-title":"Blood antioxidant parameters in sickle cell anemia patients in steady state","volume":"100","author":"Manfredini","year":"2008","journal-title":"J. Natl. Med Assoc."},{"key":"10.1016\/j.tice.2024.102717_bib237","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1182\/blood.V86.5.2014.bloodjournal8652014","article-title":"Role of hemichrome binding to erythrocyte membrane in the generation of band-3 alterations in \u03b2-thalassemia intermedia erythrocytes","volume":"86","author":"Mannu","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib238","doi-asserted-by":"crossref","first-page":"3892","DOI":"10.1182\/blood-2013-05-498311","article-title":"Vaso-Occlusion in sickle cell disease: Pathophysiology and novel targeted therapies","volume":"122","author":"Manwani","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib239","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/S0891-5849(99)00155-0","article-title":"Comparison of the effect of alpha-lipoic acid and alpha-tocopherol supplementation on measures of oxidative stress","volume":"27","author":"Marangon","year":"1999","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.tice.2024.102717_bib240","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.clnu.2009.01.017","article-title":"Alpha-lipoic acid modifies oxidative stress parameters in sickle cell trait subjects and sickle cell patients","volume":"28","author":"Martins","year":"2009","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.tice.2024.102717_bib241","doi-asserted-by":"crossref","first-page":"3790","DOI":"10.1182\/blood-2002-02-0626","article-title":"Heparin inhibits the flow adhesion of sickle red blood cells to P-selectin","volume":"100","author":"Matsui","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib242","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.freeradbiomed.2012.10.543","article-title":"Membrane association of peroxiredoxin-2 in red cells is mediated by the N-terminal cytoplasmic domain of band 3","volume":"55","author":"Matte","year":"2013","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.tice.2024.102717_bib243","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1021\/jm070663s","article-title":"Novel inhibitors of the gardos channel for the treatment of sickle cell disease","volume":"51","author":"McNaughton-Smith","year":"2008","journal-title":"J. Med Chem."},{"key":"10.1016\/j.tice.2024.102717_bib244","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/jci.insight.96910","article-title":"Intravascular hemolysis activates complement via cell-free heme and heme-loaded microvesicles","volume":"3","author":"Merle","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.tice.2024.102717_bib245","first-page":"153","article-title":"Effects of acetylcholine and SpermineNONOate on erythrocyte hemorheologic and oxygen carrying properties","volume":"25","author":"Mesquita","year":"2001","journal-title":"Clin. Hemorheol. Micro"},{"key":"10.1016\/j.tice.2024.102717_bib246","first-page":"94","article-title":"Circulating platelet-derived microparticles in systemic lupus erythematosus","volume":"95","author":"Mezzano","year":"2017","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.tice.2024.102717_bib247","series-title":"Platelets","first-page":"1079","article-title":"Antiplatelet drugs in the management of thrombotic\/ischemic events in children","author":"Michelson","year":"2019"},{"key":"10.1016\/j.tice.2024.102717_bib248","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3390\/pharmacy10050123","article-title":"Recent Advances in Sickle-Cell Disease Therapies: A Review of Voxelotor, Crizanlizumab, and L-glutamine","volume":"10","author":"Migotsky","year":"2022","journal-title":"Pharmacy"},{"key":"10.1016\/j.tice.2024.102717_bib249","doi-asserted-by":"crossref","first-page":"3548","DOI":"10.1182\/blood.2020007281","article-title":"The equilibrative nucleoside transporter ENT1 is critical for nucleotide homeostasis and optimal erythropoiesis","volume":"137","author":"Mikdar","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib250","doi-asserted-by":"crossref","first-page":"4510","DOI":"10.1021\/ja029262m","article-title":"Direct evidence of singlet molecular oxygen [O2 (1\u0394g)] production in the reaction of linoleic acid hydroperoxide with peroxynitrite","volume":"125","author":"Miyamoto","year":"2003","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.tice.2024.102717_bib251","doi-asserted-by":"crossref","first-page":"3939","DOI":"10.1182\/blood-2008-07-161166","article-title":"Red cell membrane: past, present, and future","volume":"112","author":"Mohandas","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib252","first-page":"867","article-title":"Resveratrol provides cardioprotection after ischemia\/reperfusion injury via modulation of antioxidant enzyme activities","volume":"12","author":"Mokni","year":"2013","journal-title":"Iran. J. Pharm. Res."},{"key":"10.1016\/j.tice.2024.102717_bib253","doi-asserted-by":"crossref","first-page":"eaay2176","DOI":"10.1126\/scitranslmed.aay2176","article-title":"Inhibition of aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide","volume":"12","author":"Montiel","year":"2020","journal-title":"Sci. Transl. Med"},{"key":"10.1016\/j.tice.2024.102717_bib254","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1182\/blood.2019003672","article-title":"Impact of arginine therapy on mitochondrial function in children with sickle cell disease during vaso-occlusive pain","volume":"136","author":"Morris","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib255","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1001\/jama.294.1.81","article-title":"Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease","volume":"294","author":"Morris","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.tice.2024.102717_bib256","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.3324\/haematol.2013.086637","article-title":"A randomized, placebo-controlled trial of arginine therapy for the treatment of children with sickle cell disease hospitalized with vaso-occlusive pain episodes","volume":"98","author":"Morris","year":"2013","journal-title":"Haematologica"},{"key":"10.1016\/j.tice.2024.102717_bib257","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1182\/blood.V108.11.1208.1208","article-title":"Oral Arginine Increases Erythrocyte Glutathione Levels in Sickle Cell Disease: Implications for Pulmonary Hypertension","volume":"108","author":"Morris","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib258","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/01480545.2018.1465948","article-title":"Modulatory role of rutin on 2,5-hexanedione-induced chromosomal and DNA damage in rats: validation of computational predictions","volume":"43","author":"Muhammad","year":"2018","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.tice.2024.102717_bib259","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2019.e01905","article-title":"Sickling-preventive effects of rutin is associated with modulation of deoxygenated haemoglobin, 2,3-bisphosphoglycerate mutase, redox status and alteration of functional chemistry in sickle erythrocytes","volume":"5","author":"Muhammad","year":"2019","journal-title":"Heliyon"},{"key":"10.1016\/j.tice.2024.102717_bib260","first-page":"471","article-title":"Advances in the understanding of mechanisms and therapeutic use of bortezomib","volume":"12","author":"Mujtaba","year":"2011","journal-title":"Discov. Med"},{"key":"10.1016\/j.tice.2024.102717_bib261","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1093\/ajcn\/54.4.736","article-title":"Supplementation of patients with homozygous sickle cell disease with zinc, a-tocopherol, vitamin C, soybean oil, and fish oil","volume":"54","author":"Muskiet","year":"1999","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.tice.2024.102717_bib262","first-page":"1","article-title":"Extracellular Vesicles in Sickle Cell Disease: Plasma Concentration, Blood Cell Types Origin Distribution and Biological Properties","volume":"8","author":"Nader","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.tice.2024.102717_bib263","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.niox.2018.10.003","article-title":"Hydroxyurea therapy modulates sickle cell anemia red blood cell physiology: Impact on RBC deformability, oxidative stress, nitrite levels and nitric oxide synthase signalling pathway","volume":"81","author":"Nader","year":"2018","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.tice.2024.102717_bib264","first-page":"130","article-title":"Selenium and glutathione peroxidase levels in sickle cell anemia","volume":"83","author":"Natta","year":"1990","journal-title":"Acta Haematol."},{"key":"10.1016\/j.tice.2024.102717_bib265","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1258\/ebm.2011.010394","article-title":"Functional 20s proteasomes in mature human red blood cells","volume":"236","author":"Neelam","year":"2011","journal-title":"Exp. Biol. Med"},{"key":"10.1016\/j.tice.2024.102717_bib266","doi-asserted-by":"crossref","first-page":"207","DOI":"10.5581\/1516-8484.20110055","article-title":"Analysis of oxidative status and biochemical parameters in adult patients with sickle cell anemia treated with hydroxyurea, Cear\u00e1, Brazil","volume":"33","author":"Neto","year":"2011","journal-title":"Rev. Bras. Hematol. Hemoter."},{"key":"10.1016\/j.tice.2024.102717_bib267","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1182\/blood.V75.5.1192.1192","article-title":"Synergistic effects of oxidation and deformation on erythrocyte monovalent cation leak","volume":"75","author":"Ney","year":"1990","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib268","doi-asserted-by":"crossref","first-page":"116","DOI":"10.4172\/2167-065X.1000116","article-title":"L-Glutamine Therapy Reduces Hospitalization for Sickle Cell Anemia and Sickle \u03b2\u00b0-Thalassemia Patients at Six Months \u2013 A Phase II Randomized Trial","volume":"3","author":"Niihara","year":"2014","journal-title":"Clin. Pharm. Biopharm."},{"key":"10.1016\/j.tice.2024.102717_bib269","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1056\/NEJMoa1715971","article-title":"A Phase 3 Trial of L-Glutamine in Sickle Cell Disease","volume":"379","author":"Niihara","year":"2018","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.tice.2024.102717_bib270","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0022-2143(97)90062-7","article-title":"Increased red cell glutamine availability in sickle cell anemia: Demonstration of increased active transport, affinity, and increased glutamate level in intact red cells","volume":"130","author":"Niihara","year":"1997","journal-title":"J. Lab Clin. Med"},{"key":"10.1016\/j.tice.2024.102717_bib271","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/(SICI)1096-8652(199806)58:2<117::AID-AJH5>3.0.CO;2-V","article-title":"Oral L-Glutamine Therapy for Sickle Cell Anemia: I. Subjective Clinical Improvement and Favorable Change in Red Cell NAD Redox Potential","volume":"58","author":"Niihara","year":"1998","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.tice.2024.102717_bib272","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0009-8981(02)00328-5","article-title":"Coenzyme Q 10 in plasma and erythrocytes: comparison of antioxidant levels in healthy probands after oral supplementation and in patients suffering from sickle cell anemia","volume":"326","author":"Niklowitz","year":"2002","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.tice.2024.102717_bib273","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1093\/clinchem\/46.1.82","article-title":"Increased glutathionyl hemoglobin in diabetes mellitus and hyperlipidemia demonstrated by liquid chromatography\/electrospray ionization- mass spectrometry","volume":"46","author":"Niwa","year":"2000","journal-title":"Clin. Chem."},{"key":"10.1016\/j.tice.2024.102717_bib274","doi-asserted-by":"crossref","first-page":"100","DOI":"10.4103\/1119-0388.185427","article-title":"Impact of Vitamins C and E supplement on anti-oxidant enzymes (catalase, superoxide dismutase, and glutathione peroxidase) and lipid peroxidation product (malondialdehyde levels) in sickle subjects","volume":"19","author":"Nku-Ekpang","year":"2016","journal-title":"Trop. J. Med. Res."},{"key":"10.1016\/j.tice.2024.102717_bib275","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1600-079X.2006.00344.x","article-title":"Melatonin reduces oxidative stress in erythrocytes and plasma of senescence-accelerated mice","volume":"41","author":"Nogu\u00e9s","year":"2006","journal-title":"J. Pineal Res"},{"key":"10.1016\/j.tice.2024.102717_bib276","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/bjh.16671","article-title":"Inhibition of Band 3 tyrosine phosphorylation: a new mechanism for treatment of sickle cell disease","volume":"190","author":"Noomuna","year":"2020","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.tice.2024.102717_bib277","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1016\/j.bbadis.2011.04.011","article-title":"Increased efflux of oxidized glutathione (GSSG) causes glutathione depletion and potentially diminishes antioxidant defense in sickle erythrocytes","volume":"1812","author":"Nur","year":"2011","journal-title":"Biochim Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.tice.2024.102717_bib278","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1056\/NEJM199105163242007","article-title":"The Role of Reperfusion-Induced Injury in the Pathogenesis of the Crush Syndrome","volume":"324","author":"Odeh","year":"1991","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.tice.2024.102717_bib279","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.2147\/OTT.S49187","article-title":"An evidence-based review of ixazomib citrate and its potential in the treatment of newly diagnosed multiple myeloma","author":"Offidani","year":"2014","journal-title":"Onco Targets Ther. 7"},{"key":"10.1016\/j.tice.2024.102717_bib280","first-page":"532","article-title":"Sulfated non-anticoagulant heparin derivative modifies intracellular hemoglobin, inhibits cell sickling in vitro, and prolongs survival of sickle cell mice under hypoxia","volume":"107","author":"Ohnishi","year":"2022","journal-title":"Haematologica 2022"},{"key":"10.1016\/j.tice.2024.102717_bib281","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S0899-9007(00)00257-4","article-title":"Sickle Cell Anemia: A Potential Nutritional Approach for a Molecular Disease","volume":"16","author":"Ohnishi","year":"2000","journal-title":"Nutrition"},{"key":"10.1016\/j.tice.2024.102717_bib282","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1093\/jn\/131.3.1085S","article-title":"In Vitro Effects of Aged Garlic Extract and Other Nutritional Supplements on Sickle Erythrocytes","volume":"131","author":"Ohnishi","year":"2001","journal-title":"J. Nutr."},{"key":"10.1016\/j.tice.2024.102717_bib283","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1007\/s00277-019-03792-x","article-title":"Red blood cells microparticles are associated with hemolysis markers and may contribute to clinical events among sickle cell disease patients","volume":"98","author":"Olatunya","year":"2019","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.tice.2024.102717_bib284","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/bjh.12019","article-title":"High dose vitamin D therapy for chronic pain in children and adolescents with sickle cell disease: results of a randomized double blind pilot study","volume":"159","author":"Osunkwo","year":"2012","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.tice.2024.102717_bib285","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1182\/blood.V128.22.1299.1299","article-title":"A Pilot Study of High-Dose N-Acetylcysteine Infusion in Patients with Sickle Cell Disease","volume":"128","author":"Ozpolat","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib286","doi-asserted-by":"crossref","first-page":"4911","DOI":"10.1182\/blood-2018-99-117087","article-title":"Effect of Intravenous and Oral N-Acetylcysteine Treatment in a Patient with Sickle Cell Disease at Disease Baseline","volume":"132","author":"Ozpolat","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib287","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/ajh.10321","article-title":"Effects of N-acetylcysteine on dense cell formation in sickle cell disease","volume":"73","author":"Pace","year":"2003","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.tice.2024.102717_bib288","doi-asserted-by":"crossref","first-page":"30492","DOI":"10.1074\/jbc.M110.206516","article-title":"K-Cl cotransporter gene expression during human and murine erythroid differentiation","volume":"286","author":"Pan","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tice.2024.102717_bib289","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4161\/oxim.3.1.10476","article-title":"Markers of oxidative stress in erythrocytes and plasma during aging in humans","volume":"3","author":"Pandey","year":"2010","journal-title":"Oxid. Med Cell Longev."},{"key":"10.1016\/j.tice.2024.102717_bib290","doi-asserted-by":"crossref","first-page":"131","DOI":"10.5507\/bp.2011.027","article-title":"Biomarkers of oxidative stress in red blood cells","volume":"155","author":"Pandey","year":"2011","journal-title":"Biomed. Pap. Med Fac. Univ. Palacky. Olomouc Czech Repub."},{"key":"10.1016\/j.tice.2024.102717_bib291","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.autrev.2008.03.017","article-title":"Naturally occurring anti-band 3 antibodies and red blood cell removal under physiological and pathological conditions","volume":"7","author":"Pantaleo","year":"2008","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.tice.2024.102717_bib292","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nrd1159","article-title":"Bortezomib","volume":"2","author":"Paramore","year":"2003","journal-title":"Mark. Anal. Nat. Rev. Drug Discov."},{"key":"10.1016\/j.tice.2024.102717_bib293","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.chroma.2015.11.015","article-title":"Quantification of oxysterols in human plasma and red blood cells by liquid chromatography high-resolution tandem mass spectrometry","volume":"1439","author":"Pataj","year":"2016","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.tice.2024.102717_bib294","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1038\/cdd.2009.163","article-title":"The unusual amino acid L-ergothioneine is a physiologic cytoprotectant","volume":"17","author":"Paul","year":"2010","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.tice.2024.102717_bib295","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3109\/14767058.2012.715471","article-title":"Oxidative injury in neonatal erythrocytes","volume":"25","author":"Perrone","year":"2012","journal-title":"J. Matern. -Fetal Neonatal Med."},{"key":"10.1016\/j.tice.2024.102717_bib296","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.jprot.2012.08.010","article-title":"A label-free proteome analysis strategy for identifying quantitative changes in erythrocyte membranes induced by red cell disorders","volume":"76","author":"Pesciotta","year":"2012","journal-title":"J. Proteom."},{"key":"10.1016\/j.tice.2024.102717_bib297","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1046\/j.1365-2362.2001.00922.x","article-title":"Glutathione in blood of patients with Friedreich\u2019s ataxia","volume":"31","author":"Piemonte","year":"2001","journal-title":"Eur. J. Clin. Invest"},{"key":"10.1016\/j.tice.2024.102717_bib298","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1161\/ATVBAHA.110.211615","article-title":"P-selectin mediated platelet-neutrophil aggregate formation activates neutrophils in mouse and human sickle cell disease","volume":"30","author":"Polanowska-grabowska","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.tice.2024.102717_bib299","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1093\/ajcn\/75.2.181","article-title":"Zinc deficiency in patients with sickle cell disease","volume":"75","author":"Prasad","year":"2002","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.tice.2024.102717_bib300","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1159\/000447895","article-title":"A Comprehensive Review on Eryptosis","volume":"39","author":"Pretorius","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.tice.2024.102717_bib301","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/S0008-6363(96)00065-X","article-title":"Biophysical aspects of blood flow in the microvasculature","volume":"32","author":"Pries","year":"1996","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.tice.2024.102717_bib302","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3109\/03630269.2014.898651","article-title":"Proteasome inhibition induces both antioxidant and Hb F responses in sickle cell disease via the Nrf2 pathway","volume":"38","author":"Pullarkat","year":"2014","journal-title":"Hemoglobin"},{"key":"10.1016\/j.tice.2024.102717_bib303","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1160\/Th06-12-0718","article-title":"Reduction of painful vaso-occlusive crisis of sickle cell anaemia by tinzaparin in a double-blind randomized trial","volume":"98","author":"Qari","year":"2007","journal-title":"hrombosis Haemost."},{"key":"10.1016\/j.tice.2024.102717_bib304","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1182\/blood-2018-03-834440","article-title":"L-Glutamine for sickle cell anemia: More questions than answers","volume":"132","author":"Quinn","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib305","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1002\/ajh.24562","article-title":"Biochemical surrogate markers of hemolysis do not correlate with directly measured erythrocyte survival in sickle cell anemia","volume":"91","author":"Quinn","year":"2016","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.tice.2024.102717_bib306","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1182\/blood-2021-145374","article-title":"Pharmacodynamic Effects of AG-946, a Highly Potent Next-Generation Activator of Pyruvate Kinase, in Ex Vivo Treatment of Red Blood Cells from Sickle Cell Disease Patients","volume":"138","author":"Rab","year":"2021","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.tice.2024.102717_bib307","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1182\/blood-2021-144956","article-title":"Nicotinamide Improves Anemia and Decreases Reactive Oxygen Species in Sickle Cell Disease Mice","volume":"138","author":"Ramasamy","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib308","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3181\/00379727-196-43166A","article-title":"Calcium-stressed erythrocyte membrane structure and function for assessing glipizide effects on transglutaminase activation","volume":"196","author":"Redding","year":"1991","journal-title":"Proc. Soc. Exp. Biol. Med"},{"key":"10.1016\/j.tice.2024.102717_bib309","first-page":"65","article-title":"Glutathione in disease","volume":"4","author":"Reid","year":"2001","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1016\/j.tice.2024.102717_bib310","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1038\/nm1202-799","article-title":"Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease","volume":"8","author":"Reiter","year":"2002","journal-title":"Nat. Med"},{"key":"10.1016\/j.tice.2024.102717_bib311","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1007\/s00277-005-1023-7","article-title":"Blood mononuclear cells and platelets have abnormal fatty acid composition in homozygous sickle cell disease","volume":"84","author":"Ren","year":"2005","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.tice.2024.102717_bib312","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1007\/s00277-020-03987-7","article-title":"Oxidative stress assessment in sickle cell anemia patients treated with hydroxyurea","volume":"99","author":"Ren\u00f3","year":"2020","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.tice.2024.102717_bib313","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/antiox10101599","article-title":"Biochemical evaluation of the effects of hydroxyurea in vitro on red blood cells","volume":"10","author":"Ren\u00f3","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.tice.2024.102717_bib314","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0158182","article-title":"Effect of age on blood rheology in sickle cell anaemia and sickle cell haemoglobin C disease: A cross-sectional study","volume":"11","author":"Renoux","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.tice.2024.102717_bib315","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/9405617","article-title":"Eryptosis: An Erythrocyte\u2019s Suicidal Type of Cell Death","author":"Repsold","year":"2018","journal-title":"Biomed. Res Int"},{"key":"10.1016\/j.tice.2024.102717_bib316","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/2109269","article-title":"The influence of oxidative stress and natural antioxidants on morphometric parameters of red blood cells, the hemoglobin oxygen binding capacity, and the activity of antioxidant enzymes","volume":"2019","author":"Revin","year":"2019","journal-title":"Biomed. Res Int"},{"key":"10.1016\/j.tice.2024.102717_bib317","doi-asserted-by":"crossref","first-page":"1","DOI":"10.14348\/molcells.2016.2368","article-title":"Overview on Peroxiredoxin","volume":"39","author":"Rhee","year":"2016","journal-title":"Mol. Cells"},{"key":"10.1016\/j.tice.2024.102717_bib318","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.phrs.2008.05.002","article-title":"Polyunsaturated fatty acids as antioxidants","volume":"57","author":"Richard","year":"2008","journal-title":"Pharm. Res"},{"key":"10.1016\/j.tice.2024.102717_bib319","first-page":"1","article-title":"The pathophysiology of extracellular hemoglobin associated with enhanced oxidative reactions","volume":"6","author":"Rifkind","year":"2015","journal-title":"Front Physiol."},{"key":"10.1016\/j.tice.2024.102717_bib320","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1046\/j.1365-2141.2001.02746.x","article-title":"Resveratrol, a natural dietary phytoalexin, possesses similar properties to hydroxyurea towards erythroid differentiation","volume":"113","author":"Rodrigue","year":"2001","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.tice.2024.102717_bib321","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1089\/wound.2018.0789","article-title":"Iron Chelation with Transdermal Deferoxamine Accelerates Healing of Murine Sickle Cell Ulcers","volume":"7","author":"Rodrigues","year":"2018","journal-title":"Adv. Wound Care (N. Rochelle)"},{"key":"10.1016\/j.tice.2024.102717_bib322","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1182\/blood-2012-02-414037","article-title":"Sickle hemoglobin disturbs normal coupling among erythrocyte O2 content, glycolysis, and antioxidant capacity","volume":"121","author":"Rogers","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib323","first-page":"319","article-title":"Microparticles in sickle cell disease","volume":"68","author":"Romana","year":"2018","journal-title":"Clin. Hemorheol. Micro"},{"key":"10.1016\/j.tice.2024.102717_bib324","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1182\/blood.V99.4.1103","article-title":"Arginine supplementation of sickle transgenic mice reduces red cell density and Gardos channel activity","volume":"99","author":"Romero","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib325","first-page":"187","article-title":"Effect of L-propionyl carnitine on in-vitro membrane alteration of sickle-cell anaemia erythrocytes","volume":"16","author":"Ronca","year":"1994","journal-title":"Int J. Tissue React."},{"key":"10.1016\/j.tice.2024.102717_bib326","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.bcmd.2006.09.003","article-title":"Membrane skeletal protein S-glutathionylation and hemolysis in human red blood cells","volume":"37","author":"Rossi","year":"2006","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.tice.2024.102717_bib327","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/ajh.25742","article-title":"Complement activation in sickle cell disease: Dependence on cell density, hemolysis and modulation by hydroxyurea therapy","volume":"95","author":"Roumenina","year":"2020","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.tice.2024.102717_bib328","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1182\/blood.V45.1.45.45","article-title":"Inhibition of sickling in erythrocytes by amino acids","volume":"45","author":"Rumen","year":"1975","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib329","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1172\/JCI30630","article-title":"Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice","volume":"117","author":"Rust","year":"2007","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.tice.2024.102717_bib330","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1177\/1535370219900637","article-title":"L-glutamine for sickle cell disease: Knight or pawn?","volume":"245","author":"Sadaf","year":"2020","journal-title":"Exp. Biol. Med (Maywood)"},{"key":"10.1016\/j.tice.2024.102717_bib331","article-title":"L-Arginine supplementation enhanced expression of glucose transporter (GLUT 1) in sickle cell anaemia subjects in the steady state","volume":"6","author":"Saka","year":"2022","journal-title":"Curr. Res Physiol."},{"key":"10.1016\/j.tice.2024.102717_bib332","first-page":"517","article-title":"Physiological role of erythrocyte nitric oxide","volume":"64","author":"Saldanha","year":"2016","journal-title":"Clin. Hemorheol. Micro"},{"key":"10.1016\/j.tice.2024.102717_bib333","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.3390\/molecules22091499","article-title":"Human erythrocyte acetylcholinesterase in health and disease","volume":"22","author":"Saldanha","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.tice.2024.102717_bib334","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000040964","article-title":"Levels of endothelial, neutrophil and platelet-specific factors in sickle cell anemia patients during hydroxyurea therapy","volume":"102","author":"Saleh","year":"1999","journal-title":"Acta Haematol."},{"key":"10.1016\/j.tice.2024.102717_bib335","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/biomedicines6030091","article-title":"Resveratrol: A double-edged sword in health benefits","volume":"6","author":"Salehi","year":"2018","journal-title":"Biomedicines"},{"key":"10.1016\/j.tice.2024.102717_bib336","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2020.01488","article-title":"Hydroxyurea Scavenges Free Radicals and Induces the Expression of Antioxidant Genes in Human Cell Cultures Treated With Hemin","volume":"11","author":"Santana","year":"2020","journal-title":"Front Immunol."},{"key":"10.1016\/j.tice.2024.102717_bib337","first-page":"41","article-title":"Effects of choline on hemorheological properties and NO metabolism of human erythrocytes","volume":"29","author":"Santos","year":"2003","journal-title":"Clin. Hemorheol. Micro"},{"key":"10.1016\/j.tice.2024.102717_bib338","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1182\/blood-2023-177781","article-title":"Preliminary Pharmacodynamic Results from a Multicenter Phase 2\/3 Study of Next-Generation HbS Polymerization Inhibitor GBT021601 for the Treatment of Patients with Sickle Cell Disease","volume":"142","author":"Saraf","year":"2023","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib339","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1096\/fasebj.2.3.3350236","article-title":"Altered amount and activity of superoxide dismutase in sickle cell anemia","volume":"2","author":"Schacter","year":"1988","journal-title":"FASEB Journa"},{"key":"10.1016\/j.tice.2024.102717_bib340","doi-asserted-by":"crossref","first-page":"3927","DOI":"10.1182\/blood-2008-04-078188","article-title":"Hemoglobin research and the origins of molecular medicine","volume":"112","author":"Schechter","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib341","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0190-9622(18)30758-8","article-title":"Propionyl-L-carnitine in chronic leg ulcers of homozygous sickle cell disease: A pilot study","volume":"37","author":"Serjeant","year":"1997","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.tice.2024.102717_bib342","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21062084","article-title":"Potential adverse effects of resveratrol: A literature review","volume":"21","author":"Shaito","year":"2020","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.tice.2024.102717_bib343","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1182\/blood.V86.5.2008.bloodjournal8652008","article-title":"Deferiprone (L1) Chelates Pathologic Iron Deposits From Membranes of Intact Thalassemic and Sickle Red Blood Cells Both In Vitro and In Vivo","volume":"86","author":"Shalev","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib344","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.freeradbiomed.2011.03.031","article-title":"Ubiquitin-proteasome pathway and cellular responses to oxidative stress","volume":"51","author":"Shang","year":"2011","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.tice.2024.102717_bib345","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1056\/NEJMoa2215643","article-title":"CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat Sickle Cell Disease","volume":"389","author":"Sharma","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tice.2024.102717_bib346","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/(SICI)1096-8652(199909)62:1<19::AID-AJH4>3.0.CO;2-C","article-title":"N-acetylcysteine and clotrimazole inhibit sickle erythrocyte dehydration induced by 1-Chloro-2,4-Dinitrobenzene","volume":"62","author":"Shartava","year":"1999","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.tice.2024.102717_bib347","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.bcmd.2010.08.013","article-title":"Serum melatonin level and oxidative stress in sickle cell anemia","volume":"45","author":"Shimauti","year":"2010","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.tice.2024.102717_bib348","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1172\/JCI113898","article-title":"Differing erythrocyte membrane skeletal protein defects in alpha and beta thalassemia","volume":"83","author":"Shinar","year":"1989","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.tice.2024.102717_bib349","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.freeradbiomed.2013.08.181","article-title":"Oxidative stress in sickle cell disease: An overview of erythrocyte redox metabolism and current antioxidant therapeutic strategies","volume":"65","author":"Silva","year":"2013","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.tice.2024.102717_bib350","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.bcmd.2011.03.004","article-title":"Relationship between oxidative stress, glutathione S-transferase polymorphisms and hydroxyurea treatment in sickle cell anemia","volume":"47","author":"Silva","year":"2011","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.tice.2024.102717_bib351","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/1471-2350-14-108","article-title":"Genetic and biochemical markers of hydroxyurea therapeutic response in sickle cell anemia","volume":"14","author":"Silva","year":"2013","journal-title":"BMC Med Genet"},{"key":"10.1016\/j.tice.2024.102717_bib352","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1182\/blood.V128.22.123.123","article-title":"N-Acetylcysteine in Patients with Sickle Cell Disease: A Randomized Controlled Trial","volume":"128","author":"Sins","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib353","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1111\/bjh.14809","article-title":"Effect of N -acetylcysteine on pain in daily life in patients with sickle cell disease: a randomised clinical trial","volume":"182","author":"Sins","year":"2018","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.tice.2024.102717_bib354","doi-asserted-by":"crossref","first-page":"169","DOI":"10.2165\/00139709-200423030-00004","article-title":"Oxidant stress and haemolysis of the human erythrocyte","volume":"23","author":"Sivilotti","year":"2004","journal-title":"Toxicol. Rev."},{"key":"10.1016\/j.tice.2024.102717_bib355","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1182\/blood.V97.7.1937","article-title":"Modulation of endothelial cell activation in sickle cell disease: A pilot study","volume":"97","author":"Solovey","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib356","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1016\/j.fct.2010.09.030","article-title":"Ergothioneine protects against neuronal injury induced by cisplatin both in vitro and in vivo","volume":"48","author":"Song","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tice.2024.102717_bib357","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1002\/ajh.23232","article-title":"Genetic modifiers of sickle cell disease","volume":"87","author":"Steinberg","year":"2012","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.tice.2024.102717_bib358","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1182\/blood-2002-05-1433","article-title":"ICA-17043, a novel Gardos channel blocker, prevents sickled red blood cell dehydration in vitro and in vivo in SAD mice","volume":"101","author":"Stocker","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib359","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1182\/blood.V110.11.2252.2252","article-title":"Arginine Therapy Does Not Benefit Children with Sickle Cell Anemia \u2014 Results of the CSCC Clinical Trial Consortium Multi-Institutional Study","volume":"110","author":"Styles","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib360","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-13667-8","article-title":"Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease","volume":"7","author":"Sun","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2024.102717_bib361","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1182\/blood.V108.11.685.685","article-title":"A 48-Week Open-Label Study of Senicapoc (ICA-17043), a Gardos Channel Blocker, in Patients with Sickle Cell Disease","volume":"108","author":"Swerdlow","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib362","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1093\/jn\/136.3.803S","article-title":"Aged Garlic Extract Is a Potential Therapy for Sickle-Cell Anemia","volume":"136","author":"Takasu","year":"2006","journal-title":"J. Nutr."},{"key":"10.1016\/j.tice.2024.102717_bib363","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3109\/10715769609149918","article-title":"Antioxidant status and susceptibility of sickle erythrocytes to oxidative and osmotic stress","volume":"25","author":"Tatum","year":"1996","journal-title":"Free Radic. Res"},{"key":"10.1016\/j.tice.2024.102717_bib364","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1172\/JCI110275","article-title":"Deficiency of skeletal membrane protein band 4.1 in homozygous hereditary elliptocytosis. Implications for erythrocyte membrane stability","volume":"68","author":"Tchernia","year":"1981","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.tice.2024.102717_bib365","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.3324\/haematol.2020.257998","article-title":"Pyridoxamine: another vitamin for sickle cell disease?","volume":"105","author":"Telen","year":"2020","journal-title":"Haematologica"},{"key":"10.1016\/j.tice.2024.102717_bib366","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1111\/bjh.14303","article-title":"Sevuparin binds to multiple adhesive ligands and reduces sickle red blood cell-induced vaso-occlusion","volume":"175","author":"Telen","year":"2016","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.tice.2024.102717_bib367","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1182\/blood-2014-06-583351","article-title":"Randomized phase 2 study of GMI-1070 in SCD: Reduction in time to resolution of vaso-occlusive events and decreased opioid use","volume":"125","author":"Telen","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib368","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s12291-012-0277-9","article-title":"Hematological Parameters and RBC TBARS Level of Q 10 Supplemented Tribal Sickle Cell Patients: A Hospital Based Study","volume":"28","author":"Thakur","year":"2013","journal-title":"Ind. J. Clin. Biochem"},{"key":"10.1016\/j.tice.2024.102717_bib369","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1182\/bloodadvances.2020001642","article-title":"Mn porphyrins as a novel treatment targeting sickle cell NOXs to reverse and prevent acute vaso-occlusion in vivo","volume":"4","author":"Thamilarasan","year":"2020","journal-title":"Blood Adv."},{"key":"10.1016\/j.tice.2024.102717_bib370","doi-asserted-by":"crossref","first-page":"4822","DOI":"10.1182\/blood-2019-122840","article-title":"Hydroxyurea Reverses Dysfunctional Ubiquitin-Proteasomal System in Sickle CELL Disease and Suppresses Posttranslational Alterations in Hemoglobin and CELL Membranes","volume":"34","author":"Thein","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib371","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.bcmd.2011.02.007","article-title":"Ion channels in human red blood cell membrane: Actors or relics?","volume":"46","author":"Thomas","year":"2011","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.tice.2024.102717_bib372","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1055\/s-0037-1615948","article-title":"Reduction of pain episodes and prothrombotic activity in sickle cell disease by dietary n-3 fatty acids","volume":"85","author":"Tomer","year":"2001","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.tice.2024.102717_bib373","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.3390\/genes13122337","article-title":"Influence of Melatonin Treatment on Cellular Mechanisms of Redox Adaptation in K562 Erythroleukemic Cells","volume":"13","author":"Torres","year":"2022","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.tice.2024.102717_bib374","doi-asserted-by":"crossref","first-page":"421","DOI":"10.5581\/1516-8484.20120106","article-title":"The influence of hydroxyurea on oxidative stress in sickle cell anemia","volume":"34","author":"Torres","year":"2012","journal-title":"Rev. Bras. Hematol. Hemoter."},{"key":"10.1016\/j.tice.2024.102717_bib375","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1182\/blood.2020009063","article-title":"Circulating mitochondrial DNA is a proinflammatory DAMP in sickle cell disease","volume":"137","author":"Tumburu","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib376","first-page":"27","article-title":"Red cell proteasome modulation by storage, redox metabolism and transfusion","volume":"20","author":"Tzounakas","year":"2022","journal-title":"Blood Transfus."},{"key":"10.1016\/j.tice.2024.102717_bib377","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcmd.2021.102564","article-title":"Pilot assessment of omega-3 fatty acids and potassium thiocyanate in sickle cell anemia patients with conditional peak systolic cerebral artery blood velocity","volume":"89","author":"Ugwu","year":"2021","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.tice.2024.102717_bib378","doi-asserted-by":"crossref","first-page":"799","DOI":"10.3390\/antiox10050799","article-title":"Dietary \u03c9-3 Fatty Acid Supplementation Improves Murine Sickle Cell Bone Disease and Reprograms Adipogenesis","volume":"10","author":"Valenti","year":"2021","journal-title":"Antioxid. (Basel)"},{"key":"10.1016\/j.tice.2024.102717_bib379","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3324\/haematol.2015.137489","article-title":"Spinal glial activation and oxidative stress are alleviated by treatment with curcumin or coenzyme Q in sickle mice","volume":"101","author":"Valverde","year":"2016","journal-title":"Haematologica"},{"key":"10.1016\/j.tice.2024.102717_bib380","doi-asserted-by":"crossref","first-page":"4034","DOI":"10.1182\/blood-2005-04-1622","article-title":"The energy-less red blood cell is lost: Erythrocyte enzyme abnormalities of glycolysis","volume":"106","author":"Van Wijk","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib381","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.freeradbiomed.2013.11.022","article-title":"Inborn defects in the antioxidant systems of human red blood cells","volume":"67","author":"Van Zwieten","year":"2014","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.tice.2024.102717_bib382","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-76075-5","article-title":"Hydroxyurea treatment is associated with reduced degree of oxidative perturbation in children and adolescents with sickle cell anemia","volume":"10","author":"Vinhaes","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2024.102717_bib383","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.redox.2015.07.018","article-title":"Oxidative stress in \u03b2-thalassaemia and sickle cell disease","volume":"6","author":"Voskou","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.tice.2024.102717_bib384","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1124\/dmd.104.000885","article-title":"High absorption but very low bioavailability of oral resveratrol in humans","volume":"32","author":"Walle","year":"2004","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.tice.2024.102717_bib385","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1056\/NEJM199608083350601","article-title":"Bone marrow transplantaion for sickle cell disease","volume":"335","author":"Walters","year":"1996","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.tice.2024.102717_bib386","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.bcmd.2014.11.004","article-title":"Dietary supplementation with docosahexanoic acid (DHA) increases red blood cell membrane flexibility in mice with sickle cell disease","volume":"54","author":"Wandersee","year":"2015","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.tice.2024.102717_bib387","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/j.1365-2141.2005.05767.x","article-title":"Erythrocyte adhesion is modified by alterations in cellular tonicity and volume","volume":"131","author":"Wandersee","year":"2005","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.tice.2024.102717_bib388","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1111\/j.1365-2141.2010.08523.x","article-title":"The effects of hydroxycarbamide and magnesium on haemoglobin SC disease: Results of the multi-centre CHAMPS trial","volume":"152","author":"Wang","year":"2011","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.tice.2024.102717_bib389","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/bjh.15437","article-title":"Potential involvement of ubiquitin-proteasome system dysfunction associated with oxidative stress in the pathogenesis of sickle cell disease","volume":"182","author":"Warang","year":"2018","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.tice.2024.102717_bib390","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/jth.14360","article-title":"Red blood cells: the forgotten player in hemostasis and thrombosis","volume":"17","author":"Weisel","year":"2019","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.tice.2024.102717_bib391","first-page":"677","article-title":"The Dynamic State of Body Constituents","volume":"14","author":"White","year":"1942","journal-title":"Yale J. Biol. Med."},{"key":"10.1016\/j.tice.2024.102717_bib392","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1111\/bjh.15188","article-title":"Sevuparin blocks sickle blood cell adhesion and sickle-leucocyte rolling on immobilized L-selectin in a dose dependent manner","volume":"184","author":"White","year":"2019","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.tice.2024.102717_bib393","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1182\/blood.V88.5.1873.1873","article-title":"Increased erythrocyte phosphatidylserine exposure in sickle cell disease: Flow-cytometric measurement and clinical associations","volume":"88","author":"Wood","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib394","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1016\/j.freeradbiomed.2008.01.008","article-title":"Sickle cell disease vasculopathy: A state of nitric oxide resistance","volume":"44","author":"Wood","year":"2008","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.tice.2024.102717_bib395","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0968-0004(02)00003-8","article-title":"Structure, mechanism and regulation of peroxiredoxins","volume":"28","author":"Wood","year":"2003","journal-title":"Trends Biochem Sci."},{"key":"10.1016\/j.tice.2024.102717_bib396","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1042\/bj1330521","article-title":"Multiple forms of acetylcholinesterase from human erythrocytes","volume":"133","author":"Wright","year":"1973","journal-title":"Biochem. J."},{"key":"10.1016\/j.tice.2024.102717_bib397","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1182\/blood-2020-137716","article-title":"Phase 1 Multiple Ascending Dose Study of Safety, Tolerability, and Pharmacokinetics\/Pharmacodynamics of Mitapivat (AG-348) in Subjects with Sickle Cell Disease","volume":"136","author":"Xu","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib398","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1182\/blood-2021-145398","article-title":"Mitapivat (AG-348) Demonstrates Safety, Tolerability, and Improvements in Anemia, Hemolysis, Oxygen Affinity, and Hemoglobin S Polymerization Kinetics in Adults with Sickle Cell Disease: A Phase 1 Dose Escalation Study","volume":"138","author":"Xu","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib399","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.lwt.2007.06.010","article-title":"In vitro antioxidant properties of rutin","volume":"41","author":"Yang","year":"2008","journal-title":"Lwt"},{"key":"10.1016\/j.tice.2024.102717_bib400","first-page":"133","article-title":"Cell Membrane: The Red Blood Cell as a Model","author":"Yawata","year":"2006","journal-title":": Cell Membr.: Red. Blood Cell a Model"},{"key":"10.1016\/j.tice.2024.102717_bib401","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3390\/metabo8020030","article-title":"Adenosine 5\u2019-triphosphate metabolism in red blood cells as a potential biomarker for post-exercise hypotension and a drug target for cardiovascular protection","volume":"8","author":"Yeung","year":"2018","journal-title":"Metabolites"},{"key":"10.1016\/j.tice.2024.102717_bib402","first-page":"27","article-title":"Red blood cell storage lesion: Causes and potential clinical consequences","volume":"17","author":"Yoshida","year":"2019","journal-title":"Blood Transfus."},{"key":"10.1016\/j.tice.2024.102717_bib403","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1182\/blood.V76.5.1008.1008","article-title":"Impaired erythrocyte methemoglobin reduction in sickle cell disease: Dependence of methemoglobin reduction on reduced nicotinamide adenine dinucleotide content","volume":"76","author":"Zerez","year":"1990","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib404","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1172\/JCI74604","article-title":"Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression","volume":"124","author":"Zhang","year":"2014","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.tice.2024.102717_bib405","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nm.2280","article-title":"Detrimental effects of adenosine signaling in sickle cell disease","volume":"17","author":"Zhang","year":"2011","journal-title":"Nat. Med"},{"key":"10.1016\/j.tice.2024.102717_bib406","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.biopha.2017.12.094","article-title":"DJ-1 preserving mitochondrial complex I activity plays a critical role in resveratrol\u2013mediated cardioprotection against hypoxia\/reoxygenation\u2013induced oxidative stress","volume":"98","author":"Zhang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.tice.2024.102717_bib407","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1182\/blood-2015-09-618538","article-title":"Neutrophils, platelets, and inflammatory pathways at the nexus of sickle cell disease pathophysiology","volume":"127","author":"Zhang","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.tice.2024.102717_bib408","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1009286","article-title":"GATA factor-regulated solute carrier ensemble reveals a nucleoside transporter-dependent differentiation mechanism","volume":"16","author":"Zwifelhofer","year":"2020","journal-title":"PLoS Genet"}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004081662400418X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004081662400418X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:40:34Z","timestamp":1778636434000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004081662400418X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":408,"alternative-id":["S004081662400418X"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2024.102717","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Disrupted homeostasis in sickle cells: Expanding the comprehension of metabolism adaptation and related therapeutic strategies","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2024.102717","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102717"}}