{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:05:26Z","timestamp":1790607926430,"version":"4.1.0"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.tice.2025.102725","type":"journal-article","created":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T16:03:38Z","timestamp":1736611418000},"page":"102725","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Gold nanoparticles \u201cAuNPs\u201d -mediated amelioration of experimentally toxic-induced cerebellar syndrome: Insights into cytomolecular and immuno-histochemical modifications, with a focus on CREB\/ Tau modulation"],"prefix":"10.1016","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5837-3921","authenticated-orcid":false,"given":"Mai A.","family":"Samak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yara M.","family":"Elfakharany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Huessiny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira Ebrahim","family":"Alsemeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"17","key":"10.1016\/j.tice.2025.102725_bib1","doi-asserted-by":"crossref","first-page":"9640","DOI":"10.3390\/ijms23179640","article-title":"Neuroprotective effect of gold nanoparticles and alpha-lipoic acid mixture against radiation-induced brain damage in rats","volume":"23","author":"Abdelkader","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2025.102725_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2023.173661","article-title":"Sertraline associated with gold nanoparticles reduce cellular toxicity and induce sex-specific responses in behavior and neuroinflammation biomarkers in a mouse model of anxiety","volume":"233","author":"Abelaira","year":"2023","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.tice.2025.102725_bib3","doi-asserted-by":"crossref","first-page":"1347987","DOI":"10.3389\/fnagi.2024.1347987","article-title":"The role of neuroinflammation in neurodegenerative diseases: current understanding and future therapeutic targets","volume":"16","author":"Adamu","year":"2024","journal-title":"Front. Aging Neurosci."},{"issue":"36","key":"10.1016\/j.tice.2025.102725_bib4","doi-asserted-by":"crossref","first-page":"8605","DOI":"10.1039\/D3TB01023F","article-title":"Anti-inflammatory role of gold nanoparticles in the prevention and treatment of Alzheimer's disease","volume":"11","author":"Aili","year":"2023","journal-title":"J. Mater. Chem. B"},{"issue":"2","key":"10.1016\/j.tice.2025.102725_bib5","doi-asserted-by":"crossref","first-page":"96","DOI":"10.14581\/jer.20016","article-title":"Irreversible cerebellar atrophy as a complication of short-term phenytoin exposure: clinical improvement following discontinuation of the culprit","volume":"10","author":"Algahtani","year":"2020","journal-title":"J. Epilepsy Res."},{"key":"10.1016\/j.tice.2025.102725_bib6","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3389\/fendo.2016.00115","article-title":"Effects of gadolinium-based contrast agents on thyroid hormone receptor action and thyroid hormone-induced cerebellar purkinje cell morphogenesis","volume":"7","author":"Ariyani","year":"2016","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.tice.2025.102725_bib7","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3389\/fncel.2020.00090","article-title":"Going the extra (synaptic) mile: excitotoxicity as the road toward neurodegenerative diseases","volume":"14","author":"Armada-Moreira","year":"2020","journal-title":"Front. Cell. Neurosci."},{"issue":"7","key":"10.1016\/j.tice.2025.102725_bib8","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.3390\/ijms21072480","article-title":"The basic properties of gold nanoparticles and their applications in tumor diagnosis and treatment","volume":"21","author":"Bai","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.tice.2025.102725_bib9","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.3390\/biomedicines9091157","article-title":"The childhood-onset neurodegeneration with cerebellar atrophy (Condca) disease caused by agtpbp1 gene mutations: The purkinje cell degeneration mouse as an animal model for the study of this human disease","volume":"9","author":"Baltan\u00e1s","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.tice.2025.102725_bib10","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/9780470110539.ch5","article-title":"Assays for superoxide dismutase","author":"Bannister","year":"1987","journal-title":"Methods Biochem. Anal."},{"issue":"9","key":"10.1016\/j.tice.2025.102725_bib11","doi-asserted-by":"crossref","first-page":"4916","DOI":"10.1021\/acsbiomaterials.0c00743","article-title":"Effect of nanoparticle composition, size, shape, and stiffness on penetration across the blood\u2013brain barrier","volume":"6","author":"Brown","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.tice.2025.102725_bib12","article-title":"Acute exposure to environmentally relevant concentrations of phenytoin damages early development and induces oxidative stress in zebrafish embryos","volume":"253","author":"Cardoso-Vera","year":"2022","journal-title":"Comp. Biochem. Physiol. Part C: Toxicol. Pharmacol."},{"issue":"3","key":"10.1016\/j.tice.2025.102725_bib13","doi-asserted-by":"crossref","first-page":"277","DOI":"10.31083\/j.jin.2019.03.174","article-title":"Dl-3-n-butylphthalide inhibits phenytoin-induced neuronal apoptosis in rat hippocampus and cerebellum","volume":"18","author":"Chen","year":"2019","journal-title":"J. Integr. Neurosci."},{"issue":"1","key":"10.1016\/j.tice.2025.102725_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40824-019-0166-x","article-title":"Therapeutic efficacy of nanoparticles and routes of administration","volume":"23","author":"Chenthamara","year":"2019","journal-title":"Biomater. Res."},{"issue":"8","key":"10.1016\/j.tice.2025.102725_bib15","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/s41565-018-0146-7","article-title":"Combination of fucoidan-based magnetic nanoparticles and immunomodulators enhances tumour-localized immunotherapy","volume":"13","author":"Chiang","year":"2018","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.tice.2025.102725_bib16","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.neuroscience.2020.03.040","article-title":"Nanogold neuroprotection in human neural stem cells against amyloid-beta-induced mitochondrial dysfunction","volume":"435","author":"Chiang","year":"2020","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.tice.2025.102725_bib17","doi-asserted-by":"crossref","first-page":"100","DOI":"10.4103\/1673-5374.374137","article-title":"Biomaterials-based anti-inflammatory treatment strategies for Alzheimer\u2019s disease","volume":"19","author":"Chu","year":"2024","journal-title":"Neural Regen. Res."},{"issue":"1","key":"10.1016\/j.tice.2025.102725_bib18","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0165-0270(96)00011-8","article-title":"A modified catalase assay suitable for a plate reader and for the analysis of brain cell cultures","volume":"67","author":"Cohen","year":"1996","journal-title":"J. Neurosci. Methods"},{"issue":"17","key":"10.1016\/j.tice.2025.102725_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25179690","article-title":"Alzheimer\u2019s disease pathology and assistive nanotheranostic approaches for its therapeutic interventions","volume":"25","author":"Dey","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2025.102725_bib20","doi-asserted-by":"crossref","first-page":"3711","DOI":"10.1007\/s00436-015-4600-2","article-title":"Impact of gold nanoparticles on brain of mice infected with Schistosoma mansoni","volume":"114","author":"Dkhil","year":"2015","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.tice.2025.102725_bib21","doi-asserted-by":"crossref","first-page":"224","DOI":"10.14356\/kona.2020011","article-title":"Synthesis of precision gold nanoparticles using Turkevich method","volume":"37","author":"Dong","year":"2020","journal-title":"KONA Powder Part. J."},{"issue":"2","key":"10.1016\/j.tice.2025.102725_bib22","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.taap.2009.07.016","article-title":"Hydroxylated polychlorinated biphenyls increase reactive oxygen species formation and induce cell death in cultured cerebellar granule cells","volume":"240","author":"Dreiem","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1","key":"10.1016\/j.tice.2025.102725_bib23","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1186\/s12974-023-02992-7","article-title":"TNFR1 signaling converging on FGF14 controls neuronal hyperactivity and sickness behavior in experimental cerebral malaria","volume":"20","author":"Dvorak","year":"2023","journal-title":"J. Neuroinflamm."},{"issue":"4","key":"10.1016\/j.tice.2025.102725_bib24","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jmau.2015.05.001","article-title":"Histological and immunohistochemical study of the effect of gold nanoparticles on the brain of adult male albino rat","volume":"3","author":"El-Drieny","year":"2015","journal-title":"J. Microsc. Ultrastruct."},{"issue":"7","key":"10.1016\/j.tice.2025.102725_bib25","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1080\/14740338.2022.2058487","article-title":"Phenytoin and damage to the cerebellum\u2013a systematic review of published cases","volume":"21","author":"Ferner","year":"2022","journal-title":"Expert Opin. Drug Saf."},{"key":"10.1016\/j.tice.2025.102725_bib26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0378-4274(99)00246-5","article-title":"Cerebellum as a target for toxic substances","volume":"112","author":"Fonnum","year":"2000","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tice.2025.102725_bib27","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.actbio.2018.12.046","article-title":"Size-dependent anti-inflammatory activity of a peptide-gold nanoparticle hybrid in vitro and in a mouse model of acute lung injury","volume":"85","author":"Gao","year":"2019","journal-title":"Acta Biomater."},{"issue":"34","key":"10.1016\/j.tice.2025.102725_bib28","doi-asserted-by":"crossref","first-page":"30347","DOI":"10.1021\/acsomega.2c03616","article-title":"Inhibition of Tau protein aggregation by a chaperone-like \u03b2-boswellic acid conjugated to gold nanoparticles","volume":"7","author":"Gharb","year":"2022","journal-title":"ACS Omega"},{"key":"10.1016\/j.tice.2025.102725_bib29","series-title":"In Nanobiomaterials in Antimicrobial Therapy","first-page":"229","article-title":"Enhancement of pathogen detection and therapy with laser-activated, functionalized gold nanoparticles","author":"Glickman","year":"2016"},{"key":"10.1016\/j.tice.2025.102725_bib30","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jconrel.2019.12.034","article-title":"Receptor specific, stimuli responsive and subcellular targeted approaches for effective therapy of Alzheimer: role of surface engineered nanocarriers","volume":"319","author":"Gopalan","year":"2020","journal-title":"J. Control. Release"},{"issue":"2","key":"10.1016\/j.tice.2025.102725_bib31","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.jpba.2006.07.030","article-title":"Rapid quantification of malondialdehyde in plasma by high performance liquid chromatography\u2013visible detection","volume":"43","author":"Grotto","year":"2007","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.tice.2025.102725_bib32","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s12640-020-00270-5","article-title":"Sepsis and cerebral dysfunction: BBB damage, neuroinflammation, oxidative stress, apoptosis and autophagy as key mediators and the potential therapeutic approaches","volume":"39","author":"Gu","year":"2021","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.tice.2025.102725_bib33","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.3389\/fphar.2019.01008","article-title":"Neuroinflammation as a common feature of neurodegenerative disorders","volume":"10","author":"Guzman-Martinez","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.tice.2025.102725_bib34","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.taap.2008.12.014","article-title":"Gene expression as a sensitive endpoint to evaluate cell differentiation and maturation of the developing central nervous system in primary cultures of rat cerebellar granule cells (CGCs) exposed to pesticides","volume":"235","author":"Hogberg","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tice.2025.102725_bib35","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.neuroscience.2021.01.024","article-title":"Promotion of dendritic differentiation of cerebellar Purkinje cells by Ca2+\u2009\/calmodulin-dependent protein kinase II\u03b1, II\u03b2 and IV and possible involvement of CREB phosphorylation","volume":"458","author":"Horie","year":"2021","journal-title":"Neuroscience"},{"key":"10.1016\/j.tice.2025.102725_bib36","doi-asserted-by":"crossref","first-page":"990","DOI":"10.3389\/fbioe.2020.00990","article-title":"Multifunctional gold nanoparticles: a novel nanomaterial for various medical applications and biological activities","volume":"8","author":"Hu","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"4","key":"10.1016\/j.tice.2025.102725_bib37","doi-asserted-by":"crossref","first-page":"2302015","DOI":"10.1002\/adfm.202302015","article-title":"Alzheimer's disease: status of low-dimensional nanotherapeutic materials","volume":"34","author":"Huang","year":"2024","journal-title":"Adv. Funct. Mater."},{"issue":"7","key":"10.1016\/j.tice.2025.102725_bib38","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.3390\/cells12071012","article-title":"Microglia mediated neuroinflammation in Parkinson\u2019s disease","volume":"12","author":"Isik","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.tice.2025.102725_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.921947","article-title":"Extracellular vesicles from hyperammonemic rats induce neuroinflammation in cerebellum of normal rats: role of increased TNF\u03b1 content","volume":"13","author":"Izquierdo-Altarejos","year":"2022","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.tice.2025.102725_bib40","doi-asserted-by":"crossref","first-page":"20230148","DOI":"10.1515\/ntrev-2023-0148","article-title":"Induction of apoptosis and autophagy via regulation of AKT and JNK mitogen-activated protein kinase pathways in breast cancer cell lines exposed to gold nanoparticles loaded with TNF-\u03b1 and combined with doxorubicin","volume":"12","author":"Jawad","year":"2023","journal-title":"Nanotechnol. Rev."},{"key":"10.1016\/j.tice.2025.102725_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117987","article-title":"Plasma exosomes protect against cerebral ischemia\/reperfusion injury via exosomal HSP70 mediated suppression of ROS","volume":"256","author":"Jiang","year":"2020","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.tice.2025.102725_bib42","doi-asserted-by":"crossref","first-page":"8278","DOI":"10.1038\/s41598-019-44569-6","article-title":"Surface modification of gold nanoparticles with neuron-targeted exosome for enhanced blood\u2013brain barrier penetration","volume":"9","author":"Khongkow","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2025.102725_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2019.576999","article-title":"Cytokines and biological markers in autoimmune GFAP astrocytopathy: the potential role for pathogenesis and therapeutic implications","volume":"334","author":"Kimura","year":"2019","journal-title":"J. Neuroimmunol."},{"issue":"3","key":"10.1016\/j.tice.2025.102725_bib44","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/ddr.21506","article-title":"Synthesis, in vivo and in silico evaluation of novel 2, 3-dihydroquinazolin-4 (1H)-one derivatives as potential anticonvulsant agents","volume":"80","author":"Kothayer","year":"2019","journal-title":"Drug Dev. Res."},{"issue":"6","key":"10.1016\/j.tice.2025.102725_bib45","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1007\/s12640-022-00609-0","article-title":"miR-200a-3p regulates PRKACB and participates in aluminium-induced tau phosphorylation in PC12 cells","volume":"40","author":"Li","year":"2022","journal-title":"Neurotox. Res."},{"issue":"21","key":"10.1016\/j.tice.2025.102725_bib46","doi-asserted-by":"crossref","first-page":"12734","DOI":"10.3390\/ijms232112734","article-title":"Neuroprotective action of coumarin derivatives through activation of TRKB-CREB-BDNF pathway and reduction of caspase activity in neuronal cells expressing pro-aggregated Tau protein","volume":"23","author":"Lin","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2025.102725_bib47","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.neuro.2015.10.011","article-title":"GDNF-induced cerebellar toxicity: a brief review","volume":"52","author":"Luz","year":"2016","journal-title":"Neurotoxicology"},{"issue":"1","key":"10.1016\/j.tice.2025.102725_bib48","doi-asserted-by":"crossref","first-page":"5622","DOI":"10.1038\/s41598-024-55412-y","article-title":"A multimodal submillimeter MRI atlas of the human cerebellum","volume":"14","author":"Lyu","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2025.102725_bib49","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.2147\/IJN.S176013","article-title":"Amelioration of diabetic nephropathy using pomegranate peel extract-stabilized gold nanoparticles: assessment of NF-\u03baB and Nrf2 signaling system","author":"Manna","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.tice.2025.102725_bib50","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/B978-0-444-51892-7.00012-7","article-title":"Toxic agents causing cerebellar ataxias","volume":"103","author":"Manto","year":"2012","journal-title":"Handb. Clin. Neurol."},{"issue":"16","key":"10.1016\/j.tice.2025.102725_bib51","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.2174\/0929867325666180117111404","article-title":"Surface-bioengineered gold nanoparticles for biomedical applications","volume":"25","author":"Miao","year":"2018","journal-title":"Curr. Med. Chem."},{"issue":"16","key":"10.1016\/j.tice.2025.102725_bib52","doi-asserted-by":"crossref","first-page":"8678","DOI":"10.3390\/ijerph18168678","article-title":"Mechanisms of ethanol-induced cerebellar ataxia: underpinnings of neuronal death in the cerebellum","volume":"18","author":"Mitoma","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.tice.2025.102725_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2023.125119","article-title":"Towards new fluorometric methodologies based on the in-situ generation of gold nanoclusters","volume":"266","author":"Navarro","year":"2024","journal-title":"Talanta"},{"issue":"8","key":"10.1016\/j.tice.2025.102725_bib54","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1001\/archneur.1994.00540200043014","article-title":"Cerebellar atrophy in patients with long-term phenytoin exposure and epilepsy","volume":"51","author":"Ney","year":"1994","journal-title":"Arch. Neurol."},{"issue":"4","key":"10.1016\/j.tice.2025.102725_bib55","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1002\/mds.21318","article-title":"Permanent lithium-induced cerebellar toxicity: three cases and review of literature","volume":"22","author":"Niethammer","year":"2007","journal-title":"Mov. Disord."},{"issue":"1","key":"10.1016\/j.tice.2025.102725_bib56","doi-asserted-by":"crossref","first-page":"29874","DOI":"10.1038\/srep29874","article-title":"Battery of behavioral tests in mice to study postoperative delirium","volume":"6","author":"Peng","year":"2016","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.tice.2025.102725_bib57","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/alcalc\/35.1.35","article-title":"Cerebellar Purkinje neurons with altered terminal dendritic segments are present in all lobules of the cerebellar vermis of ageing, ethanol-treated F344 rats","volume":"35","author":"Pentney","year":"2000","journal-title":"Alcohol. Alcohol."},{"issue":"5","key":"10.1016\/j.tice.2025.102725_bib58","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.3390\/cells9051160","article-title":"Role of endoplasmic reticulum stress sensor IRE1\u03b1 in cellular physiology, calcium, ROS signaling, and metaflammation","volume":"9","author":"Riaz","year":"2020","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.tice.2025.102725_bib59","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1080\/15569543.2021.1966637","article-title":"Atrazine neural and reproductive toxicity","volume":"41","author":"Sadeghnia","year":"2022","journal-title":"Toxin Rev."},{"key":"10.1016\/j.tice.2025.102725_bib60","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1007\/s12035-019-01780-w","article-title":"Gold nanoparticles treatment reverses brain damage in Alzheimer\u2019s disease model","volume":"57","author":"dos Santos Tramontin","year":"2020","journal-title":"Mol. Neurobiol."},{"issue":"3","key":"10.1016\/j.tice.2025.102725_bib61","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1021\/cr300143v","article-title":"Functionalizing nanoparticles with biological molecules: developing chemistries that facilitate nanotechnology","volume":"113","author":"Sapsford","year":"2013","journal-title":"Chem. Rev."},{"key":"10.1016\/j.tice.2025.102725_bib62","first-page":"241","article-title":"Protective effect of alpha lipoic acid against phenytoin induced behavioral abnormalities in rats","volume":"5","author":"Saraswathy","year":"2015","journal-title":"J. Mol. Biomark. Diagn."},{"issue":"7","key":"10.1016\/j.tice.2025.102725_bib63","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1002\/asia.202001202","article-title":"Plasmonic gold nanoparticles (AuNPs): properties, synthesis and their advanced energy, environmental and biomedical applications","volume":"16","author":"Sarfraz","year":"2021","journal-title":"Chem. Asian J."},{"key":"10.1016\/j.tice.2025.102725_bib64","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.neulet.2018.07.005","article-title":"The cerebellum and cognition","volume":"688","author":"Schmahmann","year":"2019","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.tice.2025.102725_bib65","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.seizure.2018.01.019","article-title":"Phenytoin-related ataxia in patients with epilepsy: clinical and radiological characteristics","volume":"56","author":"Shanmugarajah","year":"2018","journal-title":"Seizure"},{"key":"10.1016\/j.tice.2025.102725_bib66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12883-021-02403-5","article-title":"Combination of structural MRI, functional MRI and brain PET-CT provide more diagnostic and prognostic value in patients of cerebellar ataxia associated with anti-Tr\/DNER: a case report","volume":"21","author":"Shen","year":"2021","journal-title":"BMC Neurol."},{"issue":"5","key":"10.1016\/j.tice.2025.102725_bib67","doi-asserted-by":"crossref","first-page":"438","DOI":"10.3109\/15563650.2012.683437","article-title":"Methoxetamine associated reversible cerebellar toxicity: three cases with analytical confirmation","volume":"50","author":"Shields","year":"2012","journal-title":"Clin. Toxicol."},{"issue":"2","key":"10.1016\/j.tice.2025.102725_bib68","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/jnr.21504","article-title":"L-DOPA-induced activation of striatal p38MAPK and CREB in neonatal dopaminergic denervated rat: relevance to self-injurious behavior","volume":"86","author":"Sivam","year":"2008","journal-title":"J. Neurosci. Res."},{"issue":"6","key":"10.1016\/j.tice.2025.102725_bib69","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1046\/j.1365-2613.2001.00206.x","article-title":"Ultrastructure of Purkinje cell perikarya and their dendritic processes in the rat cerebellar cortex in experimental encephalopathy induced by chronic application of valproate","volume":"82","author":"Sobaniec-Lotowska","year":"2001","journal-title":"Int. J. Exp. Pathol."},{"issue":"22","key":"10.1016\/j.tice.2025.102725_bib70","doi-asserted-by":"crossref","first-page":"3772","DOI":"10.1021\/acschemneuro.0c00366","article-title":"Piperine-coated gold nanoparticles alleviate paraquat-induced neurotoxicity in Drosophila melanogaster","volume":"11","author":"Srivastav","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.tice.2025.102725_bib71","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.fct.2019.05.025","article-title":"Neurobehavioral toxicity of triclosan in mice","volume":"130","author":"Tabari","year":"2019","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.tice.2025.102725_bib72","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1186\/s12951-024-02526-0","article-title":"Tau-and \u03b1-synuclein-targeted gold nanoparticles: applications, opportunities, and future outlooks in the diagnosis and therapy of neurodegenerative diseases","volume":"22","author":"Tapia-Arellano","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.tice.2025.102725_bib73","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.alcohol.2022.02.005","article-title":"Purkinje cell-specific deletion of CREB worsens alcohol-induced cerebellar neuronal losses and motor deficits","volume":"101","author":"Todd","year":"2022","journal-title":"Alcohol"},{"key":"10.1016\/j.tice.2025.102725_bib74","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1039\/df9511100055","article-title":"A study of the nucleation and growth processes in the synthesis of colloidal gold","volume":"11","author":"Turkevich","year":"1951","journal-title":"Discuss. Faraday Soc."},{"key":"10.1016\/j.tice.2025.102725_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101417","article-title":"Exploring ER stress response in cellular aging and neuroinflammation in Alzheimer's disease","volume":"70","author":"Uddin","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.tice.2025.102725_bib76","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neuro.2022.12.011","article-title":"Protective mechanism of gold nanoparticles on human neural stem cells injured by \u03b2-amyloid protein through miR-21\u20135p\/SOCS6 pathway","volume":"95","author":"Wang","year":"2023","journal-title":"NeuroToxicology"},{"issue":"35","key":"10.1016\/j.tice.2025.102725_bib77","doi-asserted-by":"crossref","first-page":"5336","DOI":"10.1039\/C9TB01070J","article-title":"In situ biosynthesized gold nanoclusters inhibiting cancer development via the PI3K\u2013AKT signaling pathway","volume":"7","author":"Wang","year":"2019","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.tice.2025.102725_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106773","article-title":"Proinflammatory activation of microglia in the cerebellum hyperexcites Purkinje cells to trigger ataxia","volume":"191","author":"Xie","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.tice.2025.102725_bib79","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.omtn.2021.11.019","article-title":"Implications of miR-148a-3p\/p35\/PTEN signaling in tau hyperphosphorylation and autoregulatory feedforward of Akt\/CREB in Alzheimer\u2019s disease","volume":"27","author":"Zeng","year":"2022","journal-title":"Mol. Ther. Nucleic Acids"},{"issue":"3","key":"10.1016\/j.tice.2025.102725_bib80","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3109\/17435390.2010.512401","article-title":"Uptake of gold nanoparticles in murine macrophage cells without cytotoxicity or production of pro-inflammatory mediators","volume":"5","author":"Zhang","year":"2011","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.tice.2025.102725_bib81","first-page":"9","article-title":"Purkinje cell neurotransmission patterns cerebellar basket cells into zonal modules defined by distinct pinceau sizes","author":"Zhou","year":"2020","journal-title":"Elife"}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625000059?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625000059?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T23:36:52Z","timestamp":1740785812000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816625000059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":81,"alternative-id":["S0040816625000059"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2025.102725","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gold nanoparticles \u201cAuNPs\u201d -mediated amelioration of experimentally toxic-induced cerebellar syndrome: Insights into cytomolecular and immuno-histochemical modifications, with a focus on CREB\/ Tau modulation","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2025.102725","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102725"}}