{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T15:41:13Z","timestamp":1781710873421,"version":"3.54.5"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010624","name":"Karabuk University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010624","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.tice.2025.102748","type":"journal-article","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T16:26:34Z","timestamp":1737217594000},"page":"102748","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Titanium dioxide-induced fibrotic liver model and the therapeutic effect of resveratrol by modulation of \u03b1-SMA and 8-oHdG expressions, oxidative stress, and inflammation"],"prefix":"10.1016","volume":"93","author":[{"given":"Feyza","family":"Ba\u015fak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tansu","family":"Ku\u015fat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf","family":"Ersan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahir","family":"Kahraman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2025.102748_bib1","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.2147\/IJN.S192382","article-title":"NLRP3 inflammasome, oxidative stress, and apoptosis induced in the intestine and liver of rats treated with titanium dioxide nanoparticles: in vivo and in vitro study","author":"Abbasi-Oshaghi","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.tice.2025.102748_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0260130","article-title":"The involvement of TGF-\u03b21\/FAK\/\u03b1-SMA pathway in the antifibrotic impact of rice bran oil on thioacetamide-induced liver fibrosis in rats","volume":"16","author":"Abdel-Rahman","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.tice.2025.102748_bib3","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.fct.2017.01.031","article-title":"Short-term oral exposure to low doses of nano-sized TiO2 and potential modulatory effects on intestinal cells","volume":"102","author":"Ammendolia","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tice.2025.102748_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2022.126988","article-title":"A review of research on the impact of E171\/TiO2 NPs on the digestive tract","volume":"72","author":"Baranowska-W\u00f3jcik","year":"2022","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.tice.2025.102748_bib5","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/641813","article-title":"Indium titanium oxide nanoparticles induced hepatic damage: hepatoprotective role of novel 2-Imino-4-methyl-1, 2-dihydropyrimido [5, 4C] Quinoline-5 (6H)-one","volume":"2014","author":"Bheeman","year":"2014","journal-title":"Adv. Toxicol."},{"key":"10.1016\/j.tice.2025.102748_bib6","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3390\/ijms22010207","article-title":"Possible adverse effects of food additive E171 (titanium dioxide) related to particle specific human toxicity, including the immune system","volume":"22","author":"Bischoff","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2025.102748_bib7","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.3390\/foods10081910","article-title":"Use of food additive titanium dioxide (E171) before the introduction of regulatory restrictions due to concern for genotoxicity","volume":"10","author":"Blaznik","year":"2021","journal-title":"Foods"},{"key":"10.1016\/j.tice.2025.102748_bib8","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1080\/17435390.2020.1778809","article-title":"Possible effects of titanium dioxide particles on human liver, intestinal tissue, spleen and kidney after oral exposure","volume":"14","author":"Brand","year":"2020","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.tice.2025.102748_bib9","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jcat.2019.09.030","article-title":"Titanium dioxide catalytic activity contributes to the process of free radical scavenging","volume":"381","author":"Canillas","year":"2020","journal-title":"J. Catal."},{"key":"10.1016\/j.tice.2025.102748_bib10","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.dld.2004.11.009","article-title":"Alpha-SMA expression in hepatic stellate cells and quantitative analysis of hepatic fibrosis in cirrhosis and in recurrent chronic hepatitis after liver transplantation","volume":"37","author":"Carpino","year":"2005","journal-title":"Dig. Liver Dis."},{"key":"10.1016\/j.tice.2025.102748_bib11","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.freeradbiomed.2020.02.025","article-title":"Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease","volume":"152","author":"Chen","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.tice.2025.102748_bib12","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12989-019-0332-2","article-title":"Hepatotoxicity and the role of the gut-liver axis in rats after oral administration of titanium dioxide nanoparticles","volume":"16","author":"Chen","year":"2019","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.tice.2025.102748_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12989-019-0332-2","article-title":"Hepatotoxicity and the role of the gut-liver axis in rats after oral administration of titanium dioxide nanoparticles","volume":"16","author":"Chen","year":"2019","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.tice.2025.102748_bib14","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1111\/fcp.12746","article-title":"Hepatoprotective and therapeutic effects of resveratrol: a focus on anti-inflammatory and antioxidative activities","volume":"36","author":"Chupradit","year":"2022","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.tice.2025.102748_bib15","doi-asserted-by":"crossref","DOI":"10.1007\/s10753-024-02101-7","article-title":"Therapeutic effect of melatonin on CCl4-induced fibrotic liver model by modulating oxidative stress, inflammation, and TGF-\u03b21 signaling pathway in pinealectomized rats","author":"Cinar","year":"2024","journal-title":"Inflammation"},{"key":"10.1016\/j.tice.2025.102748_bib16","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s11010-020-03926-0","article-title":"Recent progress in the use of mitochondrial membrane permeability transition pore in mitochondrial dysfunction-related disease therapies","volume":"476","author":"Cui","year":"2021","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.tice.2025.102748_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2023.102182","article-title":"Antioxidant and anti-inflammatory potential of crocin on the doxorubicin mediated hepatotoxicity in Wistar rats","volume":"84","author":"Demir","year":"2023","journal-title":"Tissue Cell"},{"key":"10.1016\/j.tice.2025.102748_bib18","first-page":"249","article-title":"Histopathological effects of titanium dioxide nanoparticles and the possible protective role of N-Acetylcysteine on the testes of male albino rats","volume":"12","author":"Elnagar","year":"2018","journal-title":"Int. J. Fertil. Steril."},{"key":"10.1016\/j.tice.2025.102748_bib19","doi-asserted-by":"crossref","first-page":"590","DOI":"10.3390\/pr11020590","article-title":"A review on antimicrobial packaging for extending the shelf life of food","volume":"11","author":"Fadiji","year":"2023","journal-title":"Processes"},{"key":"10.1016\/j.tice.2025.102748_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.131915","article-title":"Getting fat and stressed: effects of dietary intake of titanium dioxide nanoparticles in the liver of turbot Scophthalmus maximus","volume":"458","author":"Fonseca","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.tice.2025.102748_bib21","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.immuni.2022.08.002","article-title":"Liver macrophages in health and disease","volume":"55","author":"Guilliams","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.tice.2025.102748_bib22","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1002\/fsn3.1012","article-title":"A comprehensive review on the determination of enzymatic assay and nonenzymatic antioxidant activities","volume":"7","author":"Haida","year":"2019","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.tice.2025.102748_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.130082","article-title":"Effects of thiacloprid exposure on microbiota\u2013gut\u2013liver axis: multiomics mechanistic analysis in Japanese quails","volume":"442","author":"Han","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.tice.2025.102748_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12989-018-0251-7","article-title":"Detection of titanium particles in human liver and spleen and possible health implications","volume":"15","author":"Heringa","year":"2018","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.tice.2025.102748_bib25","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/intimm\/dxaa078","article-title":"IL-6 in inflammation, autoimmunity and cancer","volume":"33","author":"Hirano","year":"2021","journal-title":"Int. Immunol."},{"key":"10.1016\/j.tice.2025.102748_bib26","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1021\/jf5034834","article-title":"Chronic exposure to nanoparticulate TiO2 causes renal fibrosis involving activation of the Wnt pathway in mouse kidney","volume":"63","author":"Hong","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.tice.2025.102748_bib27","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1166\/jbn.2020.2921","article-title":"Liver inflammation and fibrosis induced by long-term exposure to nano titanium dioxide (TiO2) nanoparticles in mice and its molecular mechanism","volume":"16","author":"Hong","year":"2020","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.tice.2025.102748_bib28","doi-asserted-by":"crossref","first-page":"6871","DOI":"10.1021\/jf501428w","article-title":"Th2 factors may be involved in TiO2 NP-induced hepatic inflammation","volume":"62","author":"Hong","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.tice.2025.102748_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s11671-017-2242-2","article-title":"The potential liver, brain, and embryo toxicity of titanium dioxide nanoparticles on mice","volume":"12","author":"Jia","year":"2017","journal-title":"Nanoscale Res. Lett."},{"key":"10.1016\/j.tice.2025.102748_bib30","first-page":"401","article-title":"Effects of oral administration of titanium dioxide particles on sperm parameters and in vitro fertilization potential in mice: a comparison between nano- and fine-sized particles","volume":"11","author":"Keramati Khiarak","year":"2020","journal-title":"Vet. Res. Forum.: Int. Q. J."},{"key":"10.1016\/j.tice.2025.102748_bib31","article-title":"Hepatotoxicity of titanium dioxide nanoparticles","author":"Khan","year":"2024","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.tice.2025.102748_bib32","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.jare.2024.01.019","article-title":"Chronic arsenic exposure-provoked biotoxicity involved in liver-microbiota-gut axis disruption in chickens based on multi-omics technologies","volume":"67","author":"Li","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.tice.2025.102748_bib33","doi-asserted-by":"crossref","first-page":"15985","DOI":"10.1021\/acs.jafc.4c02349","article-title":"Resveratrol alleviates liver fibrosis induced by long-term inorganic mercury exposure through activating the Sirt 1\/PGC-1\u03b1 signaling pathway","volume":"72","author":"Li","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.tice.2025.102748_bib34","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s11671-009-9451-2","article-title":"Interaction between nano-anatase TiO 2 and liver DNA from mice in vivo","volume":"5","author":"Li","year":"2010","journal-title":"Nanoscale Res. Lett."},{"key":"10.1016\/j.tice.2025.102748_bib35","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/jat.4534","article-title":"The toxicological effects of nano titanium dioxide on target organs and mechanisms of toxicity","volume":"44","author":"Li","year":"2024","journal-title":"J.\u00a0Appl.\u00a0Toxicol."},{"key":"10.1016\/j.tice.2025.102748_bib36","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1007\/s00204-023-03536-x","article-title":"Titanium dioxide nanoparticles: revealing the mechanisms underlying hepatotoxicity and effects in the gut microbiota","volume":"97","author":"Ma","year":"2023","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tice.2025.102748_bib37","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1042\/EBC20180038","article-title":"Understanding biochemistry: structure and function of nucleic acids","volume":"63","author":"Minchin","year":"2019","journal-title":"Essays Biochem."},{"key":"10.1016\/j.tice.2025.102748_bib38","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s12011-019-01955-5","article-title":"Grape seed proanthocyanidin extract mitigates titanium dioxide nanoparticle (TiO2-NPs)\u2013induced hepatotoxicity through TLR-4\/NF-\u03baB signaling pathway","volume":"196","author":"Mohammed","year":"2020","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.tice.2025.102748_bib39","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.3390\/nano10061110","article-title":"Titanium dioxide nanoparticles in food and personal care products\u2014What do we know about their safety?","volume":"10","author":"Musial","year":"2020","journal-title":"Nanomaterials"},{"key":"10.1016\/j.tice.2025.102748_bib40","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/tox.23412","article-title":"Inhalation exposure to silver nanoparticles induces hepatic inflammation and oxidative stress, associated with altered renin-angiotensin system signaling, in Wistar rats","volume":"37","author":"Nayek","year":"2022","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.tice.2025.102748_bib41","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1600-0676.1991.tb00499.x","article-title":"Appearance of \u03b1-smooth-muscle-actin-positive cells in hepatic fibrosis","volume":"11","author":"Nouchi","year":"1991","journal-title":"Liver"},{"key":"10.1016\/j.tice.2025.102748_bib42","doi-asserted-by":"crossref","first-page":"9939","DOI":"10.2147\/IJN.S275937","article-title":"Presence of titanium and toxic effects observed in rat lungs, kidneys, and central nervous system in vivo and in cultured astrocytes in vitro on exposure by titanium dioxide nanorods","author":"Papp","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.tice.2025.102748_bib43","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/8416763","article-title":"Oxidative stress: harms and benefits for human health","volume":"2017","author":"Pizzino","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.tice.2025.102748_bib44","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1038\/s41598-022-06414-1","article-title":"The anti-inflammatory effects of Akkermansia muciniphila and its derivates in HFD\/CCL4-induced murine model of liver injury","volume":"12","author":"Raftar","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2025.102748_bib45","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1002\/fsn3.3308","article-title":"Phytobioactive compounds as therapeutic agents for human diseases: a review","volume":"11","author":"Riaz","year":"2023","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.tice.2025.102748_bib46","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1016\/j.ajpath.2019.07.019","article-title":"Smooth muscle \u03b1-actin deficiency leads to decreased liver fibrosis via impaired cytoskeletal signaling in hepatic stellate cells","volume":"189","author":"Rockey","year":"2019","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.tice.2025.102748_bib47","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1080\/17435390.2016.1222457","article-title":"Oral intake of added titanium dioxide and its nanofraction from food products, food supplements and toothpaste by the Dutch population","volume":"10","author":"Rompelberg","year":"2016","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.tice.2025.102748_bib48","doi-asserted-by":"crossref","first-page":"18648","DOI":"10.1038\/s41598-022-23302-w","article-title":"Estimation of genotoxicity, apoptosis and oxidative stress induction by TiO2 nanoparticles and acrylamide subacute oral coadministration in mice","volume":"12","author":"Safwat","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2025.102748_bib49","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.rinp.2016.11.006","article-title":"Hubbard U calculations on optical properties of 3d transition metal oxide TiO2","volume":"6","author":"Samat","year":"2016","journal-title":"Results Phys."},{"key":"10.1016\/j.tice.2025.102748_bib50","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.3390\/ijms21062084","article-title":"Potential adverse effects of resveratrol: a literature review","volume":"21","author":"Shaito","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2025.102748_bib51","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s12011-016-0677-4","article-title":"Toxic effects of titanium dioxide nanoparticles and titanium dioxide bulk salt in the liver and blood of male Sprague-Dawley rats assessed by different assays","volume":"173","author":"Shakeel","year":"2016","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.tice.2025.102748_bib52","doi-asserted-by":"crossref","first-page":"227","DOI":"10.2478\/v10019-011-0037-0","article-title":"Titanium dioxide in our everyday life; is it safe?","volume":"45","author":"Skocaj","year":"2011","journal-title":"Radiol. Oncol."},{"key":"10.1016\/j.tice.2025.102748_bib53","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/5563759","article-title":"A common feature of pesticides: oxidative stress\u2014the role of oxidative stress in pesticide-induced toxicity","volume":"2022","author":"Sule","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.tice.2025.102748_bib54","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1080\/17435390.2019.1640910","article-title":"Repeated administration of the food additive E171 to mice results in accumulation in intestine and liver and promotes an inflammatory status","volume":"13","author":"Talamini","year":"2019","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.tice.2025.102748_bib55","article-title":"Reactive oxygen species induce fatty liver and ischemia-reperfusion injury by promoting inflammation and cell death","volume":"13","author":"Tang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tice.2025.102748_bib56","doi-asserted-by":"crossref","unstructured":"X. Valentini, P. Rugira, A. Frau, V. Tagliatti, R. Conotte, S. Laurent, Hepatic and Renal Toxicity Induced by TiO(2) Nanoparticles in Rats: A Morphological and Metabonomic Study, 2019 (2019) 5767012.","DOI":"10.1155\/2019\/5767012"},{"key":"10.1016\/j.tice.2025.102748_bib57","article-title":"Resveratrol as a privileged molecule with antioxidant activity","volume":"3","author":"Teodora","year":"2023","journal-title":"Food Chem. Adv."},{"key":"10.1016\/j.tice.2025.102748_bib58","article-title":"Oral toxic exposure of titanium dioxide nanoparticles on serum biochemical changes in adult male Wistar rats","volume":"2","author":"Vasantharaja","year":"2015","journal-title":"Nanomed. J."},{"key":"10.1016\/j.tice.2025.102748_bib59","article-title":"Resveratrol: a comprehensive review of its multifaceted health benefits, mechanisms of action, and potential therapeutic applications in chronic disease","author":"Vikal","year":"2024","journal-title":"Pharmacol. Res. -Nat. Prod."},{"key":"10.1016\/j.tice.2025.102748_bib60","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/jat.3499","article-title":"Review of the effects of manufactured nanoparticles on mammalian target organs","volume":"38","author":"Wu","year":"2018","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.tice.2025.102748_bib61","doi-asserted-by":"crossref","first-page":"8787","DOI":"10.2147\/IJN.S212907","article-title":"The toxicity of metallic nanoparticles on liver: the subcellular damages, mechanisms, and outcomes","author":"Yao","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.tice.2025.102748_bib62","doi-asserted-by":"crossref","first-page":"986","DOI":"10.3390\/foods10050986","article-title":"Foodborne TiO2 nanoparticles induced more severe hepatotoxicity in fructose-induced metabolic syndrome mice via exacerbating oxidative stress-mediated intestinal barrier damage","volume":"10","author":"Zhao","year":"2021","journal-title":"Foods"}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004081662500028X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004081662500028X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T23:37:59Z","timestamp":1740785879000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004081662500028X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":62,"alternative-id":["S004081662500028X"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2025.102748","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Titanium dioxide-induced fibrotic liver model and the therapeutic effect of resveratrol by modulation of \u03b1-SMA and 8-oHdG expressions, oxidative stress, and inflammation","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2025.102748","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102748"}}