{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T03:50:56Z","timestamp":1780372256639,"version":"3.54.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.tice.2025.102760","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T19:50:11Z","timestamp":1738957811000},"page":"102760","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Structural changes in the ganglionic layer of the rat cerebellar cortex due to the use of monosodium glutamate and sodium nitrite in combination"],"prefix":"10.1016","volume":"93","author":[{"given":"Bohdan","family":"Kononov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serhii","family":"Bilash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihor","family":"Tretiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryna","family":"Kononova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olena","family":"Pronina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mykhailo","family":"Koptev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelina","family":"Pirog-Zakaznikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svitlana","family":"Donchenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7724-7333","authenticated-orcid":false,"given":"Yaryna","family":"Oliinichenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladyslav","family":"Oleksiienko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.tice.2025.102760_bib1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.15407\/ubj88.06.070","article-title":"Functioning of nitric oxide cycle in gastric mucosa of rats under excessive combined intake of sodium nitrate and fluoride","volume":"88","author":"Akimov","year":"2016","journal-title":"Ukr. Biochem J."},{"issue":"4","key":"10.1016\/j.tice.2025.102760_bib2","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.ncl.2014.07.001","article-title":"Toxic-metabolic, nutritional, and medicinal-induced disorders of cerebellum","volume":"32","author":"Alekseeva","year":"2014","journal-title":"Neurol. Clin."},{"issue":"1","key":"10.1016\/j.tice.2025.102760_bib3","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1423-0127-17-7","article-title":"Hypoglycemia induced changes in cholinergic receptor expression in the cerebellum of diabetic rats","volume":"17","author":"Antony","year":"2010","journal-title":"J. Biomed. Sci."},{"issue":"9","key":"10.1016\/j.tice.2025.102760_bib4","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1016\/j.bbadis.2015.06.007","article-title":"Ischemia-induced autophagy contributes to neurodegeneration in cerebellar Purkinje cells in the developing rat brain and in primary cortical neurons in vitro","volume":"1852","author":"Au","year":"2015","journal-title":"Biochim Biophys. Acta"},{"key":"10.1016\/j.tice.2025.102760_bib5","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.neulet.2018.05.013","article-title":"Insights into cerebellar development and connectivity","volume":"688","author":"Beckinghausen","year":"2019","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.tice.2025.102760_bib6","first-page":"24","article-title":"Formation of stress resistance and changes in cognitive functions under the influence of a complex of chemical food additives","volume":"3","author":"Bilash","year":"2024","journal-title":"Azerbaijan Med. J."},{"issue":"6","key":"10.1016\/j.tice.2025.102760_bib7","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.36740\/WLek202206124","article-title":"Morphometric features of the elements of the hemomicrocirculatory bed in the cortex of the adrenal glands influenced by the food additives complex","volume":"75","author":"Bilash","year":"2022","journal-title":"Wiadomosci Lek."},{"key":"10.1016\/j.tice.2025.102760_bib8","first-page":"145","article-title":"Alterations of the intensity of neun-immunoreactivity reactions in the cerebellar structural components of rats under influence of the food additives complex","volume":"322","author":"Bilash","year":"2022","journal-title":"Georgian Med N."},{"issue":"6","key":"10.1016\/j.tice.2025.102760_bib9","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.36740\/WLek202106123","article-title":"Particularities associated with the expression of glial acidic fibrillary protein on the structural components of cerebellum of the rats influenced by the food additives complex","volume":"74","author":"Bilash","year":"2021","journal-title":"Wiadomo\u015bci Lek."},{"key":"10.1016\/j.tice.2025.102760_bib10","doi-asserted-by":"crossref","first-page":"135","DOI":"10.34921\/amj.2024.1.021","article-title":"The effect of a complex of food additives on cognitive functions and the speed of conditioned reflex formation","volume":"1","author":"Bilash","year":"2024","journal-title":"Azerbaijan Med. J."},{"issue":"2","key":"10.1016\/j.tice.2025.102760_bib11","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s12311-020-01202-x","article-title":"Thiamine Deficiency Increases Intrinsic Excitability of Mouse Cerebellar Purkinje Cells","volume":"20","author":"Bola\u00f1os-Burgos","year":"2021","journal-title":"Cerebellum"},{"issue":"3","key":"10.1016\/j.tice.2025.102760_bib12","doi-asserted-by":"crossref","first-page":"44","DOI":"10.31393\/morphology-journal-2024-30(3)-05","article-title":"Remodeling of the structural components of the capsule and glomerular zone of the adrenal glands cortex of white rats under the influence of a complex of food additives at the late terms of the experimental study","volume":"30","author":"Donchenko","year":"2024","journal-title":"Rep. Morphol."},{"issue":"10","key":"10.1016\/j.tice.2025.102760_bib13","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1111\/acer.14691","article-title":"Persistence of cerebellar ataxia during chronic ethanol exposure is associated with epigenetic up-regulation of Fmr1 gene expression in rat cerebellum","volume":"45","author":"Dulman","year":"2021","journal-title":"Alcohol Clin. Exp. Res"},{"issue":"5","key":"10.1016\/j.tice.2025.102760_bib14","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1007\/s12311-019-01059-9","article-title":"Cerebellar Syndrome Associated with Thyroid Disorders","volume":"18","author":"Ercoli","year":"2019","journal-title":"Cerebellum"},{"issue":"7","key":"10.1016\/j.tice.2025.102760_bib15","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1080\/14740338.2022.2058487","article-title":"Phenytoin and damage to the cerebellum - a systematic review of published cases","volume":"21","author":"Ferner","year":"2022","journal-title":"Expert Opin. Drug Saf."},{"key":"10.1016\/j.tice.2025.102760_bib16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0378-4274(99)00246-5","article-title":"Cerebellum as a target for toxic substances","volume":"112\u2013113","author":"Fonnum","year":"2000","journal-title":"Toxycology Lett."},{"issue":"6","key":"10.1016\/j.tice.2025.102760_bib17","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/s12311-018-0985-7","article-title":"Purkinje Neurons: Development, Morphology, and Function","volume":"17","author":"Hirano","year":"2018","journal-title":"Cerebellum"},{"issue":"4","key":"10.1016\/j.tice.2025.102760_bib18","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.cld.2024.06.004","article-title":"Beyond the Liver: Neurologic Manifestations of Alcohol Use","volume":"28","author":"Huang","year":"2024","journal-title":"Clin. Liver Dis."},{"issue":"8","key":"10.1016\/j.tice.2025.102760_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2021.e07863","article-title":"Host gene variability and SARS-CoV-2 infection: A review article","volume":"7","author":"Kaidashev","year":"2021","journal-title":"Heliyon"},{"issue":"1\u20132","key":"10.1016\/j.tice.2025.102760_bib20","doi-asserted-by":"crossref","first-page":"15","DOI":"10.31718\/mep.2022.26.1-2.04","article-title":"Comparative immunomorphological analysis of astrocytes and neurocytes of the cerebellar gray matter in rats influenced by the food additives complex","volume":"26","author":"Kononov","year":"2022","journal-title":"Med. Ecol. Probl."},{"key":"10.1016\/j.tice.2025.102760_bib21","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.neubiorev.2019.10.001","article-title":"Eye tracking correlates of acute alcohol consumption: A systematic and critical review","volume":"108","author":"Maurage","year":"2020","journal-title":"Neurosci. Biobehav Rev."},{"issue":"2","key":"10.1016\/j.tice.2025.102760_bib22","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3892\/etm.2021.11090","article-title":"Morphological and morphometric changes in the Purkinje cells of patients with essential tremor","volume":"23","author":"Mavroudis","year":"2022","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.tice.2025.102760_bib23","series-title":"Junqueira\u2019s Basic Histology: Text and Atlas","author":"Mescher","year":"2018"},{"key":"10.1016\/j.tice.2025.102760_bib24","series-title":"Immunohistochemistry: A Technical Guide to Current Practices","author":"Nguyen","year":"2022"},{"issue":"2","key":"10.1016\/j.tice.2025.102760_bib25","doi-asserted-by":"crossref","first-page":"368","DOI":"10.12775\/JEHS.2020.10.02.041","article-title":"Modern ideas about morphological changes in the cerebellar cortex under influence of factors of different origin","volume":"10","author":"Ohinska","year":"2020","journal-title":"J. Educ., Health Sport"},{"issue":"11","key":"10.1016\/j.tice.2025.102760_bib26","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1177\/0960327115572706","article-title":"High dosage of monosodium glutamate causes deficits of the motor coordination and the number of cerebellar Purkinje cells of rats","volume":"34","author":"Prastiwi","year":"2015","journal-title":"Hum. Exp. Toxicol."},{"issue":"5","key":"10.1016\/j.tice.2025.102760_bib27","doi-asserted-by":"crossref","first-page":"438","DOI":"10.3109\/15563650.2012.683437","article-title":"Methoxetamine associated reversible cerebellar toxicity: three cases with analytical confirmation","volume":"50","author":"Shields","year":"2012","journal-title":"Clin. Toxicol. (Philos. )"},{"issue":"3","key":"10.1016\/j.tice.2025.102760_bib28","doi-asserted-by":"crossref","first-page":"485","DOI":"10.4103\/1673-5374.245474","article-title":"Ethanol exposed maturing rat cerebellar granule cells show impaired energy metabolism and increased cell death after oxygen-glucose deprivation","volume":"14","author":"Spataru","year":"2019","journal-title":"Neural Regen. Res"},{"issue":"2","key":"10.1016\/j.tice.2025.102760_bib29","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1080\/14734220600788911","article-title":"GABA(B) receptor-mediated modulation of glutamate signaling in cerebellar Purkinje cells","volume":"5","author":"Tabata","year":"2006","journal-title":"Cerebellum"},{"issue":"4","key":"10.1016\/j.tice.2025.102760_bib30","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1023\/A:1016250121896","article-title":"Stress-protective effect of glutapyrone belonging to a new type of amino acid-containing 1,4-dihydropyridines on periodontal tissues and stomach in rats with different resistance to stress","volume":"133","author":"Tarasenko","year":"2002","journal-title":"Bull. Exp. Biol. Med"},{"key":"10.1016\/j.tice.2025.102760_bib31","series-title":"Metody tsyto-histolohichnoyi diahnostyky","author":"Varenyuk","year":"2019"},{"issue":"2","key":"10.1016\/j.tice.2025.102760_bib32","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s12011-016-0664-9","article-title":"Developmental Hypothyroxinemia and Hypothyroidism Reduce Parallel Fiber-Purkinje Cell Synapses in Rat Offspring by Downregulation of Neurexin1\/Cbln1\/GluD2 Tripartite Complex","volume":"173","author":"Wang","year":"2016","journal-title":"Biol. Trace Elem. Res"},{"issue":"4","key":"10.1016\/j.tice.2025.102760_bib33","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1136\/pn-2023-003817","article-title":"Alcohol and the central nervous system","volume":"23","author":"Wolfe","year":"2023","journal-title":"Pr. Neurol."},{"key":"10.1016\/j.tice.2025.102760_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106773","article-title":"Proinflammatory activation of microglia in the cerebellum hyperexcites Purkinje cells to trigger ataxia","volume":"191","author":"Xie","year":"2023","journal-title":"Pharm. Res"},{"issue":"1","key":"10.1016\/j.tice.2025.102760_bib35","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1186\/s12883-023-03337-w","article-title":"Acute hearing and visual loss caused by thiamine deficiency","volume":"23","author":"Xu","year":"2023","journal-title":"BMC Neurol."},{"issue":"71","key":"10.1016\/j.tice.2025.102760_bib36","doi-asserted-by":"crossref","first-page":"232","DOI":"10.26724\/2079-8334-2020-1-71-232-235","article-title":"A measure of the effect of complex food additives on rat\u2019s adaptive responses","volume":"1","author":"Yachmin","year":"2020","journal-title":"World Med. Biol."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625000400?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625000400?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T23:38:25Z","timestamp":1740785905000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816625000400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":36,"alternative-id":["S0040816625000400"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2025.102760","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structural changes in the ganglionic layer of the rat cerebellar cortex due to the use of monosodium glutamate and sodium nitrite in combination","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2025.102760","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102760"}}