{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T03:55:35Z","timestamp":1787630135784,"version":"build-2736575974"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.tice.2025.102839","type":"journal-article","created":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T17:37:09Z","timestamp":1741455429000},"page":"102839","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Cyclic mechanical stress promotes osteogenic differentiation of periodontal ligament stem cells via KAT2A-mediated succinylation of WDR5"],"prefix":"10.1016","volume":"95","author":[{"given":"Xiaofeng","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanshan","family":"Zhuge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.tice.2025.102839_bib1","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s11914-023-00774-x","article-title":"Osteoimmunology in periodontitis and orthodontic tooth movement","volume":"21","author":"Alghamdi","year":"2023","journal-title":"Curr. Osteoporos. Rep."},{"issue":"3","key":"10.1016\/j.tice.2025.102839_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/biom13030412","article-title":"Insights into the Structure and Function of TRIP-1, a Newly Identified Member in Calcified Tissues","volume":"13","author":"Arivalagan","year":"2023","journal-title":"Biomolecules"},{"issue":"15","key":"10.1016\/j.tice.2025.102839_bib3","doi-asserted-by":"crossref","first-page":"10537","DOI":"10.1021\/acs.jmedchem.1c00037","article-title":"Targeting WD Repeat-Containing Protein 5 (WDR5): A Medicinal Chemistry Perspective","volume":"64","author":"Chen","year":"2021","journal-title":"J. Med Chem."},{"issue":"6","key":"10.1016\/j.tice.2025.102839_bib4","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/s11914-016-0328-x","article-title":"Bone Response of Loaded Periodontal Ligament","volume":"14","author":"Dutra","year":"2016","journal-title":"Curr. Osteoporos. Rep."},{"issue":"1","key":"10.1016\/j.tice.2025.102839_bib5","doi-asserted-by":"crossref","first-page":"148","DOI":"10.2319\/1945-7103-92.1.148","article-title":"Aligners, environmental contamination, and the role of orthodontics","volume":"92","author":"Freitas","year":"2022","journal-title":"Angle Orthod."},{"issue":"1","key":"10.1016\/j.tice.2025.102839_bib6","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/jerd.12702","article-title":"Quality in orthodontics: the role of customized appliances","volume":"33","author":"Grauer","year":"2021","journal-title":"J. Esthet. Restor. Dent."},{"issue":"2","key":"10.1016\/j.tice.2025.102839_bib7","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13551","article-title":"NAP1L2 drives mesenchymal stem cell senescence and suppresses osteogenic differentiation","volume":"21","author":"Hu","year":"2022","journal-title":"Aging Cell"},{"issue":"5","key":"10.1016\/j.tice.2025.102839_bib8","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/cac2.12284","article-title":"HSF1 facilitates the multistep process of lymphatic metastasis in bladder cancer via a novel PRMT5-WDR5-dependent transcriptional program","volume":"42","author":"Huang","year":"2022","journal-title":"Cancer Commun. (Lond. )"},{"issue":"4","key":"10.1016\/j.tice.2025.102839_bib9","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.7150\/ijbs.69454","article-title":"The lncRNA BDNF-AS\/WDR5\/FBXW7 axis mediates ferroptosis in gastric cancer peritoneal metastasis by regulating VDAC3 ubiquitination","volume":"18","author":"Huang","year":"2022","journal-title":"Int J. Biol. Sci."},{"key":"10.1016\/j.tice.2025.102839_bib10","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/6531216","article-title":"Mechanobiology of periodontal ligament stem cells in orthodontic tooth movement","volume":"2018","author":"Huang","year":"2018","journal-title":"Stem Cells Int"},{"issue":"4","key":"10.1016\/j.tice.2025.102839_bib11","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.kjms.2018.01.007","article-title":"Orthodontic tooth movement: the biology and clinical implications","volume":"34","author":"Li","year":"2018","journal-title":"Kaohsiung J. Med Sci."},{"key":"10.1016\/j.tice.2025.102839_bib12","first-page":"109","article-title":"Molecular Basis of KAT2A Selecting Acyl-CoA Cofactors for Histone Modifications","volume":"6","author":"Li","year":"2023","journal-title":"Res. (Wash. D. C. )"},{"issue":"24","key":"10.1016\/j.tice.2025.102839_bib13","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.1038\/s41388-022-02340-8","article-title":"Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic","volume":"41","author":"Li","year":"2022","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.tice.2025.102839_bib14","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41368-021-00125-5","article-title":"Biomechanical and biological responses of periodontium in orthodontic tooth movement: up-date in a new decade","volume":"13","author":"Li","year":"2021","journal-title":"Int J. Oral. Sci."},{"issue":"5","key":"10.1016\/j.tice.2025.102839_bib15","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1111\/jre.12911","article-title":"Pyrophosphate inhibits periodontal ligament stem cell differentiation and mineralization through MAPK signaling pathways","volume":"56","author":"Liang","year":"2021","journal-title":"J. Periodontal Res"},{"issue":"4","key":"10.1016\/j.tice.2025.102839_bib16","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.bbrc.2020.02.034","article-title":"LncRNA HOTTIP enhances human osteogenic BMSCs differentiation via interaction with WDR5 and activation of Wnt\/beta-catenin signalling pathway","volume":"524","author":"Liu","year":"2020","journal-title":"Biochem Biophys. Res Commun."},{"key":"10.1016\/j.tice.2025.102839_bib17","article-title":"Succinylation regulators promote clear cell renal cell carcinoma by immune regulation and RNA N6-methyladenosine methylation","volume":"9","author":"Lu","year":"2021","journal-title":"Front Cell Dev. Biol."},{"key":"10.1016\/j.tice.2025.102839_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2023.110724","article-title":"Brain-derived neurotrophic factor promotes orthodontic tooth movement by alleviating periodontal ligament stem cell senescence","volume":"108","author":"Meng","year":"2023","journal-title":"Cell Signal"},{"issue":"6","key":"10.1016\/j.tice.2025.102839_bib19","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1016\/j.gendis.2022.10.028","article-title":"Lysine succinylation, the metabolic bridge between cancer and immunity","volume":"10","author":"Shen","year":"2023","journal-title":"Genes Dis."},{"issue":"3","key":"10.1016\/j.tice.2025.102839_bib20","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1139\/bcb-2022-0080","article-title":"GCN5 regulates ZBTB16 through acetylation, mediates osteogenic differentiation, and affects orthodontic tooth movement","volume":"101","author":"Shi","year":"2023","journal-title":"Biochem Cell Biol."},{"issue":"1","key":"10.1016\/j.tice.2025.102839_bib21","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s13643-019-1000-1","article-title":"Seeking adverse effects in systematic reviews of orthodontic interventions: protocol for a cross-sectional study","volume":"8","author":"Steegmans","year":"2019","journal-title":"Syst. Rev."},{"key":"10.1016\/j.tice.2025.102839_bib22","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/4775445","article-title":"Force-Induced Nitric Oxide Promotes Osteogenic Activity during Orthodontic Tooth Movement in Mice","volume":"2022","author":"Sun","year":"2022","journal-title":"Stem Cells Int"},{"issue":"1","key":"10.1016\/j.tice.2025.102839_bib23","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1186\/s13287-022-03055-z","article-title":"Role of TRPC6 in periodontal tissue reconstruction mediated by appropriate stress","volume":"13","author":"Wang","year":"2022","journal-title":"Stem Cell Res Ther."},{"issue":"1","key":"10.1016\/j.tice.2025.102839_bib24","doi-asserted-by":"crossref","DOI":"10.1080\/10641963.2023.2271196","article-title":"MG53 alleviates hypoxia\/reoxygenation-induced cardiomyocyte injury by succinylation and ubiquitination modification","volume":"45","author":"Wang","year":"2023","journal-title":"Clin. Exp. Hypertens."},{"issue":"2","key":"10.1016\/j.tice.2025.102839_bib25","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.jds.2021.10.003","article-title":"N-acetylcysteine promotes cyclic mechanical stress-induced osteogenic differentiation of periodontal ligament stem cells by down-regulating Nrf2 expression","volume":"17","author":"Xi","year":"2022","journal-title":"J. Dent. Sci."},{"issue":"2","key":"10.1016\/j.tice.2025.102839_bib26","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1089\/cell.2021.0113","article-title":"General Control Nonrepressed Protein 5 Modulates Odontogenic Differentiation Through NF-kappaB Pathway in Tumor Necrosis Factor-alpha-Mediated Impaired Human Dental Pulp Stem Cells","volume":"24","author":"Xiao","year":"2022","journal-title":"Cell Reprogram"},{"issue":"17-18","key":"10.1016\/j.tice.2025.102839_bib27","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1002\/pmic.201300435","article-title":"Posttranslational modifications of human histone H3: an update","volume":"14","author":"Xu","year":"2014","journal-title":"Proteomics"},{"issue":"10","key":"10.1016\/j.tice.2025.102839_bib28","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1007\/s11064-019-02780-x","article-title":"Succinylation links metabolism to protein functions","volume":"44","author":"Yang","year":"2019","journal-title":"Neurochem. Res"},{"issue":"1","key":"10.1016\/j.tice.2025.102839_bib29","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s11626-019-00410-y","article-title":"LncRNA TUG1 promoted osteogenic differentiation through promoting bFGF ubiquitination","volume":"56","author":"Yu","year":"2020","journal-title":"Vitr. Cell Dev. Biol. Anim."},{"key":"10.1016\/j.tice.2025.102839_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2022.110285","article-title":"Mechanical force-sensitive lncRNA SNHG8 inhibits osteogenic differentiation by regulating EZH2 in hPDLSCs","volume":"93","author":"Zhang","year":"2022","journal-title":"Cell Signal"},{"issue":"9","key":"10.1016\/j.tice.2025.102839_bib31","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1369","article-title":"Arginine methylation of PPP1CA by CARM1 regulates glucose metabolism and affects osteogenic differentiation and osteoclastic differentiation","volume":"13","author":"Zhang","year":"2023","journal-title":"Clin. Transl. Med"},{"key":"10.1016\/j.tice.2025.102839_bib32","article-title":"INO80 is Required for Osteogenic Differentiation of Human Mesenchymal Stem Cells","volume":"6","author":"Zhou","year":"2016","journal-title":"Sci. Rep."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625001193?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625001193?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T01:51:17Z","timestamp":1762221077000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816625001193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":32,"alternative-id":["S0040816625001193"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2025.102839","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cyclic mechanical stress promotes osteogenic differentiation of periodontal ligament stem cells via KAT2A-mediated succinylation of WDR5","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2025.102839","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102839"}}