{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T01:54:04Z","timestamp":1762221244974,"version":"build-2065373602"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901484"],"award-info":[{"award-number":["81901484"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.tice.2025.102901","type":"journal-article","created":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T18:26:28Z","timestamp":1743963988000},"page":"102901","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Expression pattern of RNA demethylase ALKBH5 in fetal and adult human testis"],"prefix":"10.1016","volume":"95","author":[{"given":"Fang","family":"Fang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6434-7634","authenticated-orcid":false,"given":"Ke","family":"Ni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2025.102901_bib1","doi-asserted-by":"crossref","first-page":"4741","DOI":"10.1093\/nar\/gku085","article-title":"Structure of human RNA N\u2076-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation","volume":"42","author":"Aik","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.tice.2025.102901_bib2","doi-asserted-by":"crossref","DOI":"10.1093\/molehr\/gaab020","article-title":"RNA N6-methyladenosine modification, spermatogenesis, and human male infertility","volume":"27","author":"Cai","year":"2021","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.tice.2025.102901_bib3","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/molehr\/gaaa033","article-title":"New insights into the potential mechanisms of spermatogenic failure in patients with idiopathic azoospermia","volume":"26","author":"Cai","year":"2020","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.tice.2025.102901_bib4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s11658-022-00404-x","article-title":"ALKBH5 in mouse testicular Sertoli cells regulates Cdh2 mRNA translation to maintain blood-testis barrier integrity","volume":"27","author":"Cai","year":"2022","journal-title":"Cell Mol. Biol. Lett."},{"key":"10.1016\/j.tice.2025.102901_bib5","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/15548627.2020.1720431","article-title":"m(6)A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells","volume":"17","author":"Chen","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.tice.2025.102901_bib6","doi-asserted-by":"crossref","DOI":"10.1093\/molehr\/gaab025","article-title":"Epigenetic regulation of mRNA N6-methyladenosine modifications in mammalian gametogenesis","volume":"27","author":"Fang","year":"2021","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.tice.2025.102901_bib7","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1038\/ncomms2822","article-title":"FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA","volume":"4","author":"Fu","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tice.2025.102901_bib8","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.cell.2015.05.012","article-title":"DNA demethylation dynamics in the human prenatal germline","volume":"161","author":"Gkountela","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.tice.2025.102901_bib9","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.tig.2019.10.011","article-title":"The biogenesis and precise control of RNA m(6)A methylation","volume":"36","author":"Huang","year":"2020","journal-title":"Trends Genet"},{"key":"10.1016\/j.tice.2025.102901_bib10","doi-asserted-by":"crossref","DOI":"10.1111\/and.14620","article-title":"Chromosome 17 translocation affects sperm morphology: Two case studies and literature review","volume":"54","author":"Huang","year":"2022","journal-title":"Andrologia"},{"key":"10.1016\/j.tice.2025.102901_bib11","article-title":"Case Report: Balanced Reciprocal Translocation t (17; 22) (p11.2; q11.2) and 10q23.31 Microduplication in an Infertile Male Patient Suffering From Teratozoospermia","volume":"13","author":"Huang","year":"2022","journal-title":"Front Genet"},{"key":"10.1016\/j.tice.2025.102901_bib12","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s13075-023-03149-w","article-title":"M6A methylation modification in autoimmune diseases, a promising treatment strategy based on epigenetics","volume":"25","author":"Huang","year":"2023","journal-title":"Arthritis Res Ther."},{"key":"10.1016\/j.tice.2025.102901_bib13","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.theriogenology.2021.10.017","article-title":"The function of the m6A methyltransferase METTL3 in goat early embryo development under hypoxic and normoxic conditions","volume":"177","author":"Li","year":"2022","journal-title":"Theriogenology"},{"key":"10.1016\/j.tice.2025.102901_bib14","doi-asserted-by":"crossref","DOI":"10.1111\/aji.13892","article-title":"Construction of m6A-related gene prediction model and subtype analysis in non-obstructive azoospermia based on bioinformatics","volume":"92","author":"Li","year":"2024","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.tice.2025.102901_bib15","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s11658-023-00475-4","article-title":"N6-methyladenosine modification of PLOD2 causes spermatocyte damage in rats with varicocele","volume":"28","author":"Li","year":"2023","journal-title":"Cell Mol. Biol. Lett."},{"key":"10.1016\/j.tice.2025.102901_bib16","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s00018-024-05119-0","article-title":"RNA m(6)A modification regulates L1 retrotransposons in human spermatogonial stem cell differentiation in vitro and in vivo","volume":"81","author":"Li","year":"2024","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.tice.2025.102901_bib17","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12943-022-01620-x","article-title":"Mutual regulation between N6-methyladenosine (m6A) modification and circular RNAs in cancer: impacts on therapeutic resistance","volume":"21","author":"Lin","year":"2022","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.tice.2025.102901_bib18","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nchembio.1432","article-title":"A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation","volume":"10","author":"Liu","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.tice.2025.102901_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.791221","article-title":"Transcriptome-wide m6A analysis provides novel insights into testicular development and spermatogenesis in Xia-Nan Cattle","volume":"9","author":"Liu","year":"2021","journal-title":"Front Cell Dev. Biol."},{"key":"10.1016\/j.tice.2025.102901_bib20","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.tcb.2017.10.001","article-title":"Reading m(6)A in the Transcriptome: m(6)A-Binding Proteins","volume":"28","author":"Patil","year":"2018","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.tice.2025.102901_bib21","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/cr.2014.3","article-title":"Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase","volume":"24","author":"Ping","year":"2014","journal-title":"Cell Res"},{"key":"10.1016\/j.tice.2025.102901_bib22","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13164","article-title":"m(6) A reader protein YTHDF2 regulates spermatogenesis by timely clearance of phase-specific transcripts","volume":"55","author":"Qi","year":"2022","journal-title":"Cell Prolif."},{"key":"10.1016\/j.tice.2025.102901_bib23","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.molcel.2019.04.025","article-title":"Where, when, and how: context-dependent functions of RNA methylation writers, readers, and erasers","volume":"74","author":"Shi","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.tice.2025.102901_bib24","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/s41588-023-01452-5","article-title":"Crosstalk between RNA m(6)A and DNA methylation regulates transposable element chromatin activation and cell fate in human pluripotent stem cells","volume":"55","author":"Sun","year":"2023","journal-title":"Nat. Genet"},{"key":"10.1016\/j.tice.2025.102901_bib25","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.141","article-title":"Characterization of m6A in mouse ovary and testis","volume":"10","author":"Sun","year":"2020","journal-title":"Clin. Transl. Med"},{"key":"10.1016\/j.tice.2025.102901_bib26","doi-asserted-by":"crossref","first-page":"E325","DOI":"10.1073\/pnas.1717794115","article-title":"ALKBH5-dependent m6A demethylation controls splicing and stability of long 3\u2032-UTR mRNAs in male germ cells","volume":"115","author":"Tang","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.tice.2025.102901_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1063929","article-title":"Joint analysis of m(6)A and mRNA expression profiles in the testes of idiopathic nonobstructive azoospermia patients","volume":"13","author":"Tang","year":"2022","journal-title":"Front Endocrinol. (Lausanne)"},{"key":"10.1016\/j.tice.2025.102901_bib28","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.stem.2018.08.007","article-title":"Single-Cell RNA Sequencing Analysis Reveals Sequential Cell Fate Transition during Human Spermatogenesis","volume":"23","author":"Wang","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.tice.2025.102901_bib29","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/s41556-022-00915-x","article-title":"N(6)-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition","volume":"24","author":"Wu","year":"2022","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.tice.2025.102901_bib30","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.theriogenology.2023.11.020","article-title":"l-valine supplementation disturbs vital molecular pathways and induces apoptosis in mouse testes","volume":"215","author":"Wu","year":"2024","journal-title":"Theriogenology"},{"key":"10.1016\/j.tice.2025.102901_bib31","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/s41556-019-0315-4","article-title":"The RNA N(6)-methyladenosine modification landscape of human fetal tissues","volume":"21","author":"Xiao","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.tice.2025.102901_bib32","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.repbio.2020.09.002","article-title":"Function and transcriptomic dynamics of Sertoli cells during prospermatogonia development in mouse testis","volume":"20","author":"Yan","year":"2020","journal-title":"Reprod. Biol."},{"key":"10.1016\/j.tice.2025.102901_bib33","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.omto.2021.05.003","article-title":"Regulatory role and mechanism of m(6)A RNA modification in human metabolic diseases","volume":"22","author":"Zhang","year":"2021","journal-title":"Mol. Ther. Oncolytics"},{"key":"10.1016\/j.tice.2025.102901_bib34","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.molcel.2012.10.015","article-title":"ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility","volume":"49","author":"Zheng","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.tice.2025.102901_bib35","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.tem.2022.12.006","article-title":"N6-methyladenosine in macrophage function: a novel target for metabolic diseases","volume":"34","author":"Zhu","year":"2023","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.tice.2025.102901_bib36","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1460","article-title":"Crosstalk between m6A modification and alternative splicing during cancer progression","volume":"13","author":"Zhu","year":"2023","journal-title":"Clin. Transl. Med"}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625001818?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625001818?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T01:51:23Z","timestamp":1762221083000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816625001818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":36,"alternative-id":["S0040816625001818"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2025.102901","relation":{},"ISSN":["0040-8166"],"issn-type":[{"type":"print","value":"0040-8166"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expression pattern of RNA demethylase ALKBH5 in fetal and adult human testis","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2025.102901","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102901"}}