{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:04:18Z","timestamp":1788498258592,"version":"build-2803163510"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.tice.2025.102912","type":"journal-article","created":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T17:32:15Z","timestamp":1744479135000},"page":"102912","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Investigation of the healing effects of D-limonene on ovarian ischemia and reperfusion injury"],"prefix":"10.1016","volume":"95","author":[{"given":"Roohollah","family":"Dehghani tafti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghasem","family":"Farjani kish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Raisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farshid","family":"Davoodi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Tadayon far","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadhossein","family":"Abbasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mobina","family":"Torabi feijani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhossein","family":"Ghiasvand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahand","family":"Moradi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2025.102912_bib1","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1080\/01443615.2021.1916813","article-title":"3\u2032, 4\u2032-Dihydroxyflavonol (DiOHF) prevents DNA damage, lipid peroxidation and inflammation in ovarian ischaemia-reperfusion injury of rats","volume":"42","author":"Agartan","year":"2022","journal-title":"J. Obstet. Gynaecol."},{"key":"10.1016\/j.tice.2025.102912_bib2","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/tox.22523","article-title":"Antifibrotic effects of D-limonene (5 (1-methyl-4-[1-methylethenyl]) cyclohexane) in CCl4 induced liver toxicity in Wistar rats","volume":"33","author":"Ahmad","year":"2018","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.tice.2025.102912_bib3","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00404-015-3646-9","article-title":"Is ursodeoxycholic acid crucial for ischemia\/reperfusion-induced ovarian injury in rat ovary?","volume":"292","author":"Akdemir","year":"2015","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.tice.2025.102912_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116840","article-title":"Underlying mechanisms behind the protective effect of angiotensin (1\u20137) in experimental rat model of ovarian ischemia reperfusion injury","volume":"235","author":"Ali","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.tice.2025.102912_bib5","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.pbb.2014.01.006","article-title":"Potential antioxidant and anxiolytic effects of (+)-limonene epoxide in mice after marble-burying test","volume":"118","author":"de Almeida","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.tice.2025.102912_bib6","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s10753-016-0496-y","article-title":"Physio-pharmacological investigations about the anti-inflammatory and antinociceptive efficacy of (+)-limonene epoxide","volume":"40","author":"de Almeida","year":"2017","journal-title":"Inflammation"},{"key":"10.1016\/j.tice.2025.102912_bib7","doi-asserted-by":"crossref","DOI":"10.1111\/jfbc.13566","article-title":"D-limonene: a multifunctional compound with potent therapeutic effects","volume":"45","author":"Anandakumar","year":"2021","journal-title":"J. Food Biochem"},{"key":"10.1016\/j.tice.2025.102912_bib8","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1016\/j.jpedsurg.2012.03.082","article-title":"Protective effect of intraperitoneal ozone application in experimental ovarian ischemia\/reperfusion injury","volume":"47","author":"Aslan","year":"2012","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.tice.2025.102912_bib9","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.fct.2015.04.015","article-title":"The antioxidant and antigenotoxic properties of citrus phenolics limonene and naringin","volume":"81","author":"Bacanl\u0131","year":"2015","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tice.2025.102912_bib10","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s00404-015-3878-8","article-title":"The protective effect of G-CSF on experimental ischemia\/reperfusion injury in rat ovary","volume":"293","author":"Bostanc\u0131","year":"2016","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.tice.2025.102912_bib11","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s00210-010-0504-y","article-title":"Atorvastatin reduces tissue damage in rat ovaries subjected to torsion and detorsion: biochemical and histopathologic evaluation","volume":"381","author":"Cadirci","year":"2010","journal-title":"Naunyn-Schmiede 'S. Arch. Pharmacol."},{"key":"10.1016\/j.tice.2025.102912_bib12","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1007\/s11064-016-1889-x","article-title":"The effect of 3\u2032, 4\u2032-dihydroxyflavonol on lipid peroxidation in rats with cerebral ischemia reperfusion injury","volume":"41","author":"Caliskan","year":"2016","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.tice.2025.102912_bib13","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1007\/s00404-020-05934-3","article-title":"The effect of folate on ischemia\/reperfusion injury in a rat adnexal torsion model","volume":"303","author":"\u00c7andar","year":"2021","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.tice.2025.102912_bib14","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ejogrb.2004.05.007","article-title":"The protective effect of caffeic acid phenethyl ester on ischemia-reperfusion injury in rat ovary","volume":"117","author":"Celik","year":"2004","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.tice.2025.102912_bib15","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1177\/0960327111434948","article-title":"D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis","volume":"31","author":"Chaudhary","year":"2012","journal-title":"Hum. Expl. Toxicol."},{"key":"10.1016\/j.tice.2025.102912_bib16","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S1074-3804(99)80091-7","article-title":"Laparoscopic detorsion allows sparing of the twisted ischemic adnexa","volume":"6","author":"Cohen","year":"1999","journal-title":"J. Am. Gynecol. Laparosc."},{"key":"10.1016\/j.tice.2025.102912_bib17","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.tjog.2020.10.004","article-title":"Metformin reduces ovarian ischemia reperfusion injury in rats by improving oxidative\/nitrosative stress","volume":"60","author":"Demir","year":"2021","journal-title":"Taiwan. J. Obstet. Gynecol."},{"key":"10.1016\/j.tice.2025.102912_bib18","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.clinbiochem.2003.10.014","article-title":"A novel automated method to measure total antioxidant response against potent free radical reactions","volume":"37","author":"Erel","year":"2004","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.tice.2025.102912_bib19","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.clinbiochem.2005.08.008","article-title":"A new automated colorimetric method for measuring total oxidant status","volume":"38","author":"Erel","year":"2005","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.tice.2025.102912_bib20","first-page":"8973","article-title":"Protective effects of sildenafil and resveratrol on ovarian ischemiareperfusion injury in rats","volume":"20","author":"Ert\u00fcrk","year":"2017","journal-title":"Biomed. Res."},{"key":"10.1016\/j.tice.2025.102912_bib21","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1023\/A:1009616228304","article-title":"Role of reactive oxygen species (ROS) in apoptosis induction","volume":"5","author":"HU","year":"2000","journal-title":"Apoptosis"},{"key":"10.1016\/j.tice.2025.102912_bib22","first-page":"287","article-title":"First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): their fundamental role in the entire antioxidant defence grid","volume":"54","author":"Ighodaro","year":"2018","journal-title":"Alex. J. Med."},{"key":"10.1016\/j.tice.2025.102912_bib23","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3109\/00498257409049347","article-title":"Studies on the metabolism of d-limonene (p-mentha-1, 8-diene): I. the absorption, distribution and excretion of d-limonene in rats","volume":"4","author":"Igimi","year":"1974","journal-title":"Xenobiotica"},{"key":"10.1016\/j.tice.2025.102912_bib24","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1538\/expanim.20-0080","article-title":"The effect of a natural molecule in ovary ischemia reperfusion damage: does lycopene protect ovary?","volume":"70","author":"Kirmizi","year":"2021","journal-title":"Exp. Anim."},{"key":"10.1016\/j.tice.2025.102912_bib25","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.3748\/wjg.v10.i14.2140","article-title":"Inhibition of growth and metastasis of human gastric cancer implanted in nude mice by d-limonene","volume":"10","author":"Lu","year":"2004","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.tice.2025.102912_bib26","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3390\/molecules28010122","article-title":"Ameliorative effect of citrus lemon Peel extract and resveratrol on premature ovarian failure rat model: role of iNOS\/Caspase-3 pathway","volume":"28","author":"Mobasher","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.tice.2025.102912_bib27","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/bcpt.12010","article-title":"Protective effects of D-limonene on lipid peroxidation and antioxidant enzymes in streptozotocin-induced diabetic rats","volume":"112","author":"Murali","year":"2013","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.tice.2025.102912_bib28","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.bionut.2012.08.008","article-title":"Antidiabetic effect of d-limonene, a monoterpene in streptozotocin-induced diabetic rats","volume":"2","author":"Murali","year":"2012","journal-title":"Biomed. Prev. Nutr."},{"key":"10.1016\/j.tice.2025.102912_bib29","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1159\/000353425","article-title":"Evaluation of the protective effects of CoQ10 on ovarian I\/R injury: an experimental study","volume":"76","author":"Ozler","year":"2013","journal-title":"Gynecol. Obstet. Investig."},{"key":"10.1016\/j.tice.2025.102912_bib30","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1177\/1933719113485300","article-title":"The biochemical and histologic effects of adnexal torsion and early surgical intervention to unwind detorsion on ovarian reserve: an experimental study","volume":"20","author":"\u00d6zler","year":"2013","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.tice.2025.102912_bib31","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1080\/08941930802709470","article-title":"Nitric oxide mechanism of protection in ischemia and reperfusion injury","volume":"22","author":"Phillips","year":"2009","journal-title":"J. Investig. Surg."},{"key":"10.1016\/j.tice.2025.102912_bib32","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.fct.2018.07.052","article-title":"Review of toxicological assessment of d-limonene, a food and cosmetics additive","volume":"120","author":"Ravichandran","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tice.2025.102912_bib33","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1007\/s10787-023-01417-4","article-title":"D-limonene inhibits peritoneal adhesion formation in rats via anti-inflammatory, anti-angiogenic, and antioxidative effects","volume":"32","author":"Razazi","year":"2024","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.tice.2025.102912_bib34","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0300-483X(01)00537-6","article-title":"Additive toxicity of limonene and 50% oxygen and the role of glutathione in detoxification in human lung cells","volume":"170","author":"Rolseth","year":"2002","journal-title":"Toxicology"},{"key":"10.1016\/j.tice.2025.102912_bib35","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1111\/j.1447-0756.2008.00846.x","article-title":"Protective effect of aprotinin on ischemia\u2013reperfusion injury in rat ovary","volume":"34","author":"Sahin","year":"2008","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"10.1016\/j.tice.2025.102912_bib36","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.ijsu.2013.06.007","article-title":"The protective effect of curcumin on ischemia-reperfusion injury in rat ovary","volume":"11","author":"Sak","year":"2013","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.tice.2025.102912_bib37","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.phymed.2018.09.027","article-title":"Gastroprotective effect of limonene in rats: influence on oxidative stress, inflammation and gene expression","volume":"53","author":"de Souza","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.tice.2025.102912_bib38","first-page":"259","article-title":"D-Limonene: safety and clinical applications","volume":"12","author":"Sun","year":"2007","journal-title":"Alter. Med. Rev."},{"key":"10.1016\/j.tice.2025.102912_bib39","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ejogrb.2014.03.049","article-title":"Effect of 2-aminoethoxydiphenyl borate on ischemia-reperfusion injury in a rat ovary model","volume":"178","author":"Taskin","year":"2014","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Bio"},{"key":"10.1016\/j.tice.2025.102912_bib40","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-11818-5","article-title":"Antimutagenic and antioxidant activity of the essential oils of Citrus sinensis and Citrus latifolia","volume":"7","author":"Toscano-Garibay","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2025.102912_bib41","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/jsfa.4164","article-title":"Juice components and antioxidant capacity of four Tunisian Citrus varieties","volume":"91","author":"Tounsi","year":"2011","journal-title":"J. Sci. Food Agr."},{"key":"10.1016\/j.tice.2025.102912_bib42","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/3415046","article-title":"The protective effects of alpha-lipoic acid and coenzyme Q10 combination on ovarian ischemia-reperfusion injury: an experimental study","volume":"2016","author":"Tuncer","year":"2016","journal-title":"Adv. Med."},{"key":"10.1016\/j.tice.2025.102912_bib43","first-page":"53","article-title":"Antioxidant and antiapoptotic effects of erdosteine in a rat model of ovarian ischemia-reperfusion injury","volume":"20","author":"Ugurel","year":"2017","journal-title":"Iran. J. Basic Med. Sci."},{"key":"10.1016\/j.tice.2025.102912_bib44","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1159\/000489241","article-title":"Current mechanistic concepts in ischemia and reperfusion injury","volume":"46","author":"Wu","year":"2018","journal-title":"Cell Physiol. Biochem."},{"key":"10.1016\/j.tice.2025.102912_bib45","first-page":"280","article-title":"Limonene terpenoid obstructs human bladder cancer cell (T24 cell line) growth by inducing cellular apoptosis, caspase activation, G2\/M phase cell cycle arrest and stops cancer metastasis","volume":"25","author":"Ye","year":"2020","journal-title":"J. Buon. \/Off. J. Balk. Union. Oncol."},{"key":"10.1016\/j.tice.2025.102912_bib46","doi-asserted-by":"crossref","first-page":"415","DOI":"10.5650\/jos.59.415","article-title":"Limonene suppresses lipopolysaccharide-induced production of nitric oxide, prostaglandin E2, and pro-inflammatory cytokines in RAW 264.7 macrophages","volume":"59","author":"Yoon","year":"2010","journal-title":"J. Oleo Sci."},{"key":"10.1016\/j.tice.2025.102912_bib47","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.2147\/OTT.S155716","article-title":"D-limonene exhibits antitumor activity by inducing autophagy and apoptosis in lung cancer","author":"Yu","year":"2018","journal-title":"OncoTarget Ther."},{"key":"10.1016\/j.tice.2025.102912_bib48","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.3892\/mmr.2017.6241","article-title":"D-limonene exhibits anti-inflammatory and antioxidant properties in an ulcerative colitis rat model via regulation of iNOS, COX-2, PGE2 and ERK signaling pathways","volume":"15","author":"Yu","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.tice.2025.102912_bib49","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.ejogrb.2014.03.029","article-title":"Folicular reserve changes in torsion\u2013detorsion of the ovary: an experimental study","volume":"177","author":"Yucel","year":"2014","journal-title":"Eur. J. Obstet. GynecoL. Reprod. Bio"},{"key":"10.1016\/j.tice.2025.102912_bib50","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.jpedsurg.2014.12.013","article-title":"Dose dependent protective effects of vardenafil on ischemia\u2013reperfusion injury with biochemical and histopathologic evaluation in rat ovary","volume":"50","author":"Yurtcu","year":"2015","journal-title":"J. Pediatr. Surg."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625001922?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625001922?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T01:49:13Z","timestamp":1762220953000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816625001922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":50,"alternative-id":["S0040816625001922"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2025.102912","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigation of the healing effects of D-limonene on ovarian ischemia and reperfusion injury","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2025.102912","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102912"}}