{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T09:01:34Z","timestamp":1794474094669,"version":"4.9.1"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008748","name":"Guizhou Minzu University","doi-asserted-by":"publisher","award":["GZMUZK[2024]QD52"],"award-info":[{"award-number":["GZMUZK[2024]QD52"]}],"id":[{"id":"10.13039\/501100008748","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018555","name":"Science and Technology Program of Guizhou Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018555","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160820"],"award-info":[{"award-number":["82160820"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.tice.2025.102913","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T11:54:42Z","timestamp":1745841282000},"page":"102913","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Tetracera asiatica \ufb02avonoids attenuate alcohol-induced liver injury by suppressing oxidative stress and inflammation mediated by the Keap-1\/Nrf2\/HO-1, NF-\u03baB\/MAPK and PERK\/Nrf2 signaling pathways in alcoholic liver injury rats"],"prefix":"10.1016","volume":"96","author":[{"given":"Fang-fang","family":"Da","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao-ting","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-feng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-wan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-hua","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2025.102913_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2024.102574","article-title":"Alleviative effects of green-fabricated zinc oxide nanoparticles on acrylamide-induced oxidative and inflammatory reactions in the rat stomach via modulating gastric neuroactive substances and the MiR-27a-5p\/ROS\/NF-\u03baB axis","volume":"91","author":"Abd-Elhakim","year":"2024","journal-title":"Tissue Cell"},{"key":"10.1016\/j.tice.2025.102913_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115080","article-title":"Evaluation of lung protection of Sanghuangporus sanghuang through TLR4\/NF-\u03baB\/MAPK, keap1\/Nrf2\/HO-1, CaMKK\/AMPK\/Sirt1, and TGF-\u03b2\/SMAD3 signaling pathways mediating apoptosis and autophagy","volume":"165","author":"Chien","year":"2023","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.tice.2025.102913_bib3","doi-asserted-by":"crossref","first-page":"7198","DOI":"10.1128\/MCB.23.20.7198-7209.2003","article-title":"Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival","volume":"23","author":"Cullinan","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.tice.2025.102913_bib4","first-page":"22","article-title":"Investigation on germplasm resources of tetracera asiatica","volume":"24","author":"Da","year":"2018","journal-title":"Chin. J. Exp. Trad. Med. Form."},{"key":"10.1016\/j.tice.2025.102913_bib5","doi-asserted-by":"crossref","first-page":"599","DOI":"10.3390\/molecules25030599","article-title":"Baicalein alleviates liver oxidative stress and apoptosis induced by high-level glucose through the activation of the PERK\/Nrf2 signaling pathway","volume":"25","author":"Dong","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.tice.2025.102913_bib6","article-title":"Extracts of dracocephalum tanguticum maxim ameliorate acute alcoholic liver disease via regulating transcription factors in mice","volume":"13","author":"Guo","year":"2022","journal-title":"Front. Pharm."},{"key":"10.1016\/j.tice.2025.102913_bib7","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1002\/term.3053","article-title":"Keap1-Nrf2 signaling pathway in angiogenesis and vascular diseases","volume":"14","author":"Guo","year":"2020","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"10.1016\/j.tice.2025.102913_bib8","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1002\/hep.26135","article-title":"Targeting androgen receptor in bone marrow mesenchymal stem cells leads to better transplantation therapy efficacy in liver cirrhosis","volume":"57","author":"Huang","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.tice.2025.102913_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.117064","article-title":"Baicalin protects against ethanol-induced chronic gastritis in rats by inhibiting Akt\/NF-\u03baB pathway","volume":"239","author":"Ji","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.tice.2025.102913_bib10","first-page":"123","article-title":"Reliability of malondialdehyde as a biomarker of oxidative stress in psychological disorders","volume":"5","author":"Khoubnasabjafari","year":"2015","journal-title":"Bioimpacts"},{"key":"10.1016\/j.tice.2025.102913_bib11","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.3390\/ijms20112712","article-title":"Pathogenesis, early diagnosis, and therapeutic management of alcoholic liver disease","volume":"20","author":"Kong","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2025.102913_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpb.2022.110811","article-title":"Active Nrf2 signaling flexibly regulates HO-1 and NQO-1 in hypoxic Gansu Zokor (Eospalax cansus)","volume":"264","author":"Li","year":"2023","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"key":"10.1016\/j.tice.2025.102913_bib13","doi-asserted-by":"crossref","first-page":"5170","DOI":"10.3390\/ijms22105170","article-title":"Alcohol-related liver disease: basic mechanisms and clinical perspectives","volume":"22","author":"Liu","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2025.102913_bib14","doi-asserted-by":"crossref","first-page":"217","DOI":"10.4103\/jpbs.JPBS_192_19","article-title":"Phytochemicals and biological activity of Tetracera scandens Linn. Merr. (Dilleniaceae): a short review","volume":"12","author":"Nokhala","year":"2020","journal-title":"J. Pharm. Bioallied Sci."},{"key":"10.1016\/j.tice.2025.102913_bib15","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S1471-4906(03)00181-9","article-title":"Heme oxygenase-1: unleashing the protective properties of heme","volume":"24","author":"Otterbein","year":"2003","journal-title":"Trends Immunol."},{"key":"10.1016\/j.tice.2025.102913_bib16","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3390\/biomedicines7030068","article-title":"Alcoholic liver disease: current mechanistic aspects with focus on their clinical relevance","volume":"7","author":"Teschke","year":"2019","journal-title":"Biomedicines"},{"key":"10.1016\/j.tice.2025.102913_bib17","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S2221-1691(15)30009-5","article-title":"Protective effect of tetracera scandens L. leaf extract against CCl4-induced acute liver injury in rats","volume":"5","author":"Thanh","year":"2015","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"10.1016\/j.tice.2025.102913_bib18","doi-asserted-by":"crossref","first-page":"11684","DOI":"10.3748\/wjg.v20.i33.11684","article-title":"Diagnosis of alcoholic liver disease","volume":"20","author":"Torruellas","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.tice.2025.102913_bib19","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1089\/ars.2007.1901","article-title":"Oxidative stress and antioxidants in the pathogenesis of pulmonary fibrosis: a potential role for Nrf2","volume":"10","author":"Walters","year":"2008","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.tice.2025.102913_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.106062","article-title":"Inulin alleviates inflammation of alcoholic liver disease via SCFAs-inducing suppression of M1 and facilitation of M2 macrophages in mice","volume":"78","author":"Wang","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.tice.2025.102913_bib21","doi-asserted-by":"crossref","first-page":"16268","DOI":"10.1007\/s11356-020-08044-4","article-title":"Acetaldehyde-induced oxidative modifications and morphological changes in isolated human erythrocytes: an in vitro study","volume":"27","author":"Waris","year":"2020","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.tice.2025.102913_bib22","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/8284107","article-title":"Protective effects of taraxasterol against ethanol-induced liver injury by regulating CYP2E1\/Nrf2\/HO-1 and NF-\u03baB signaling pathways in mice","volume":"2018","author":"Xu","year":"2018","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.tice.2025.102913_bib23","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.3390\/molecules23061447","article-title":"4'-methoxyresveratrol alleviated AGE-induced inflammation via RAGE-mediated NF-\u03baB and NLRP3 inflammasome pathway","volume":"23","author":"Yu","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.tice.2025.102913_bib24","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1631\/jzus.B2200612","article-title":"Scutellarin prevents acute alcohol-induced liver injury via inhibiting oxidative stress by regulating the Nrf2\/HO-1 pathway and inhibiting inflammation by regulating the AKT, p38 MAPK\/NF-\u03baB pathways","volume":"24","author":"Zhang","year":"2023","journal-title":"J. Zhejiang Univ. Sci. B"}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625001934?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625001934?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T04:49:40Z","timestamp":1757911780000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816625001934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":24,"alternative-id":["S0040816625001934"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2025.102913","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tetracera asiatica \ufb02avonoids attenuate alcohol-induced liver injury by suppressing oxidative stress and inflammation mediated by the Keap-1\/Nrf2\/HO-1, NF-\u03baB\/MAPK and PERK\/Nrf2 signaling pathways in alcoholic liver injury rats","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2025.102913","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102913"}}