{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T20:34:37Z","timestamp":1758054877331,"version":"3.44.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.tice.2025.102917","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T07:36:42Z","timestamp":1747121802000},"page":"102917","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The therapeutic effect of Astaxanthin on drill-induced closed femoral fracture model in male Wistar rats"],"prefix":"10.1016","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1288-8433","authenticated-orcid":false,"given":"Hasan","family":"Yousefi-Manesh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laleh","family":"Foroutani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armita","family":"Yousefi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khazar Adibmoradi","family":"Langroudi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahand Adib","family":"Moradi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasha Reza Shams","family":"Azar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Mohammad","family":"Tavangar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Hadizadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mojdeh","family":"Sarzaeim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiva","family":"Hadizadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasaman","family":"Kheirandish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azadeh","family":"Manayi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2025.102917_bib1","unstructured":"Abedi, G., Asghari, A., Dehghan, M., Sohrabi, H.I. & Safi, S. Effects of different amounts of vitamin D3 on ulnar bone healing in rabbit: biomechanic and histopathologic evaluation, 2011.."},{"key":"10.1016\/j.tice.2025.102917_bib2","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/jbmr.2038","article-title":"Delayed bone regeneration is linked to chronic inflammation in murine muscular dystrophy","volume":"29","author":"Abou-Khalil","year":"2014","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.tice.2025.102917_bib3","first-page":"434","article-title":"Astaxanthin protective barrier and its ability to improve the health in patients with COVID-19","volume":"13","author":"Ahmadi","year":"2021","journal-title":"Iran. J. Microbiol."},{"key":"10.1016\/j.tice.2025.102917_bib4","unstructured":"Akkaya, S., Nazali, M., Kilic, A. & Bir, F. Cefazolin-sodium has no adverse effect on fracture healing in an experimental rabbit model, 2012.."},{"key":"10.1016\/j.tice.2025.102917_bib5","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3390\/md12010128","article-title":"Astaxanthin: Sources, extraction, stability, biological activities and its commercial applications\u2014a review","volume":"12","author":"Ambati","year":"2014","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.tice.2025.102917_bib6","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/360438","article-title":"Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal","volume":"2014","author":"Ayala","year":"2014","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.tice.2025.102917_bib7","first-page":"160","article-title":"Effect of pentoxifylline on fracture healing: an experimental study","volume":"22","author":"Ayd\u0131n","year":"2011","journal-title":"Jt. Dis. Relat. Surg."},{"key":"10.1016\/j.tice.2025.102917_bib8","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/jor.24170","article-title":"Cellular biology of fracture healing","volume":"37","author":"Bahney","year":"2019","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.tice.2025.102917_bib9","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1097\/TA.0b013e3181de3dd9","article-title":"Effects of increased bone formation on fracture healing in mice","volume":"70","author":"Beil","year":"2011","journal-title":"J. Trauma Acute Care Surg."},{"key":"10.1016\/j.tice.2025.102917_bib10","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1097\/BOT.0b013e318274da8b","article-title":"Physiological challenges of bone repair","volume":"26","author":"Borrelli","year":"2012","journal-title":"J. Orthop. Trauma"},{"key":"10.1016\/j.tice.2025.102917_bib11","article-title":"Delayed fracture healing and increased callus adiposity in a C57BL\/6J murine model of obesity-associated type 2 diabetes mellitus","volume":"9","author":"Brown","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.tice.2025.102917_bib12","doi-asserted-by":"crossref","first-page":"5342","DOI":"10.3390\/molecules25225342","article-title":"Astaxanthin and its effects in inflammatory responses and inflammation-associated diseases: recent advances and future directions","volume":"25","author":"Chang","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.tice.2025.102917_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12891-021-04360-z","article-title":"Changes in macrophage and inflammatory cytokine expressions during fracture healing in an ovariectomized mice model","volume":"22","author":"Chen","year":"2021","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.tice.2025.102917_bib14","doi-asserted-by":"crossref","first-page":"10863","DOI":"10.3390\/ijms221910863","article-title":"Systemic administration of recombinant irisin accelerates fracture healing in mice","volume":"22","author":"Colucci","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2025.102917_bib15","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1097\/ALN.0b013e31828c23f8","article-title":"Bone fracture exacerbates murine ischemic cerebral injury","volume":"118","author":"Degos","year":"2013","journal-title":"Anesthesiology"},{"key":"10.1016\/j.tice.2025.102917_bib16","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1097\/ALN.0b013e31828c23f8","article-title":"Bone fracture exacerbates murine ischemic cerebral injury","volume":"118","author":"Degos","year":"2013","journal-title":"Anesthesiology"},{"key":"10.1016\/j.tice.2025.102917_bib17","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1210\/jc.2007-2325","article-title":"Circulating levels of inflammatory markers predict change in bone mineral density and resorption in older adults: a longitudinal study","volume":"93","author":"Ding","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tice.2025.102917_bib18","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.3390\/ijerph15122845","article-title":"Incidence, costs and predictors of non-union, delayed union and mal-union following long bone fracture","volume":"15","author":"Ekegren","year":"2018","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.tice.2025.102917_bib19","first-page":"319","article-title":"Astaxanthin protects human granulosa cells against oxidative stress through activation of NRF2\/ARE pathway and its downstream phase II enzymes","volume":"23","author":"Eslami","year":"2021","journal-title":"Cell J."},{"key":"10.1016\/j.tice.2025.102917_bib20","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1097\/BOT.0000000000000465","article-title":"Inflammation, bone healing, and anti-inflammatory drugs: an update","volume":"29","author":"Giannoudis","year":"2015","journal-title":"J. Orthop. Trauma"},{"key":"10.1016\/j.tice.2025.102917_bib21","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/j.injury.2018.04.016","article-title":"The biology of fracture healing in osteoporosis and in the presence of anti-osteoporotic drugs","volume":"49","author":"Hak","year":"2018","journal-title":"Injury"},{"key":"10.1016\/j.tice.2025.102917_bib22","doi-asserted-by":"crossref","first-page":"5951","DOI":"10.3892\/mmr.2015.4122","article-title":"Effect of CoCl2 on fracture repair in a rat model of bone fracture","volume":"12","author":"Huang","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.tice.2025.102917_bib23","doi-asserted-by":"crossref","first-page":"372","DOI":"10.12688\/f1000research.110244.1","article-title":"The effect of Aloe vera ethanolic extract in preventing ischemic-reperfusion injury during long bone fracture healing after tourniquet application: an animal study","volume":"11","author":"Huwae","year":"2022","journal-title":"F1000Research"},{"key":"10.1016\/j.tice.2025.102917_bib24","doi-asserted-by":"crossref","first-page":"912","DOI":"10.3390\/ijms19030912","article-title":"Suppression effect of astaxanthin on osteoclast formation in vitro and bone loss in vivo","volume":"19","author":"Hwang","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2025.102917_bib25","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3390\/nu10030281","article-title":"Effects of dietary supplementation of astaxanthin and sesamin on daily fatigue: a randomized, double-blind, placebo-controlled, two-way crossover study","volume":"10","author":"Imai","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.tice.2025.102917_bib26","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/ame2.12114","article-title":"A segmental defect adaptation of the mouse closed femur fracture model for the analysis of severely impaired bone healing","volume":"3","author":"Kaur","year":"2020","journal-title":"Anim. Models Exp. Med."},{"key":"10.1016\/j.tice.2025.102917_bib27","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jnutbio.2016.01.006","article-title":"Astaxanthin inhibits inflammation and fibrosis in the liver and adipose tissue of mouse models of diet-induced obesity and nonalcoholic steatohepatitis","volume":"43","author":"Kim","year":"2017","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.tice.2025.102917_bib28","first-page":"6","article-title":"Orthopedic implants and devices for bone fractures and defects: Past, present and perspective","volume":"1","author":"Kim","year":"2020","journal-title":"Eng. Regen."},{"key":"10.1016\/j.tice.2025.102917_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112179","article-title":"Anti-inflammatory action of astaxanthin and its use in the treatment of various diseases","volume":"145","author":"Kohandel","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.tice.2025.102917_bib30","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s43440-019-00022-z","article-title":"Astaxanthin attenuates oxidative stress and inflammatory responses in complete Freund-adjuvant-induced arthritis in rats","volume":"72","author":"Kumar","year":"2020","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.tice.2025.102917_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2020.616389","article-title":"A comparison of isolation stress and unpredictable chronic mild stress for the establishment of mouse models of depressive disorder","volume":"14","author":"Lee","year":"2021","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.tice.2025.102917_bib32","doi-asserted-by":"crossref","first-page":"6064","DOI":"10.3390\/md13106064","article-title":"Astaxanthin inhibits proliferation and induces apoptosis of human hepatocellular carcinoma cells via Inhibition of NF-\u03baB P65 and Wnt\/\u03b2-catenin in vitro","volume":"13","author":"Li","year":"2015","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.tice.2025.102917_bib33","first-page":"1","article-title":"Effect of leptin combined with CoCl2 on healing in Sprague Dawley Rat fracture model","volume":"6","author":"Liu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2025.102917_bib34","doi-asserted-by":"crossref","first-page":"386","DOI":"10.3389\/fendo.2020.00386","article-title":"Modulation of the inflammatory response and bone healing","volume":"11","author":"Maruyama","year":"2020","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.tice.2025.102917_bib35","first-page":"1","article-title":"Astaxanthin: an algae-based natural compound with a potential role in human health-promoting effect: an updated comprehensive review","volume":"9","author":"Medhi","year":"2021","journal-title":"J. Appl. Biol. Biotechnol."},{"key":"10.1016\/j.tice.2025.102917_bib36","first-page":"14","article-title":"Anti-inflammatory effects of astaxanthin in the human gingival keratinocyte line NDUSD-1","author":"Miyachi","year":"2015","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.tice.2025.102917_bib37","first-page":"681","article-title":"Total hip arthroplasty after failed fixation of a proximal femur fracture: analysis of 59 cases of intra-and extra-capsular fractures","volume":"104","author":"Morice","year":"2018","journal-title":"Orthop. Traumatol.: Surg. Res."},{"key":"10.1016\/j.tice.2025.102917_bib38","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1089\/ten.teb.2011.0182","article-title":"Harnessing and modulating inflammation in strategies for bone regeneration","volume":"17","author":"Mountziaris","year":"2011","journal-title":"Tissue Eng. Part B: Rev."},{"key":"10.1016\/j.tice.2025.102917_bib39","article-title":"Histopathological and histomorphometrical effects of atorvastatin on experimental femoral cortical bone defect healing in rats","volume":"70","author":"Mousavi","year":"2012","journal-title":"Tehran Univ. Med. J."},{"key":"10.1016\/j.tice.2025.102917_bib40","article-title":"Total hip arthroplasty after failed osteosynthesis of proximal femoral fractures: revision and mortality of 80 patients","volume":"25","author":"M\u00fcller","year":"2017","journal-title":"J. Orthop. Surg."},{"key":"10.1016\/j.tice.2025.102917_bib41","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.injury.2020.11.029","article-title":"Fracture nonunion in long bones: A literature review of risk factors and surgical management","volume":"52","author":"Nicholson","year":"2021","journal-title":"Injury"},{"key":"10.1016\/j.tice.2025.102917_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-019-2161-5","article-title":"CircRNA hsa_circ_0074834 promotes the osteogenesis-angiogenesis coupling process in bone mesenchymal stem cells (BMSCs) by acting as a ceRNA for miR-942-5p","volume":"10","author":"Ouyang","year":"2019","journal-title":"Cell death Dis."},{"key":"10.1016\/j.tice.2025.102917_bib43","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1302\/2046-3758.26.2000142","article-title":"The effect of smoking on bone healing: a systematic review","volume":"2","author":"Patel","year":"2013","journal-title":"Bone Jt. Res."},{"key":"10.1016\/j.tice.2025.102917_bib44","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3892\/ijmm.2020.4783","article-title":"Antioxidant and anti-inflammatory mechanisms of action of astaxanthin in cardiovascular diseases","volume":"47","author":"Pereira","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.tice.2025.102917_bib45","doi-asserted-by":"crossref","first-page":"24","DOI":"10.55095\/achot2017\/003","article-title":"Delayed fracture healing in diabetics with distal radius fractures","volume":"84","author":"Pscherer","year":"2017","journal-title":"Acta Chir. Orthop. Trauma. Cech"},{"key":"10.1016\/j.tice.2025.102917_bib46","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.1016\/j.ajpath.2014.08.017","article-title":"Fracture healing via periosteal callus formation requires macrophages for both initiation and progression of early endochondral ossification","volume":"184","author":"Raggatt","year":"2014","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.tice.2025.102917_bib47","first-page":"17","article-title":"Histologic and histomorphometric evaluation of osteogenesis induced by implantation of octacalcium phosphate-gelatin composite in tibia bone defects in rat","volume":"27","author":"Sargolzaei Aval","year":"2017","journal-title":"J. Mazandaran Univ. Med. Sci."},{"key":"10.1016\/j.tice.2025.102917_bib48","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S1016-8478(23)13772-1","article-title":"Astaxanthin inhibits nitric oxide production and inflammatory gene expression by suppressing IkB kinase-dependent NF-kB activation","volume":"16","author":"Seon-Jin","year":"2003","journal-title":"Mol. Cells"},{"key":"10.1016\/j.tice.2025.102917_bib49","unstructured":"Shao, H. & America, B.N.A. Safe & Natural Broad-Spectrum Anti-Inflammatory: Natural Astaxanthin. (2016)."},{"key":"10.1016\/j.tice.2025.102917_bib50","doi-asserted-by":"crossref","first-page":"890","DOI":"10.3390\/md10040890","article-title":"Astaxanthin treatment reduced oxidative induced pro-inflammatory cytokines secretion in U937: SHP-1 as a novel biological target","volume":"10","author":"Speranza","year":"2012","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.tice.2025.102917_bib51","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.1007\/s11999-012-2739-z","article-title":"Segmental tibial fractures: an infrequent but demanding injury","volume":"471","author":"Teraa","year":"2013","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.tice.2025.102917_bib52","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1016\/j.injury.2007.02.006","article-title":"Molecular aspects of fracture healing: which are the important molecules?","volume":"38","author":"Tsiridis","year":"2007","journal-title":"Injury"},{"key":"10.1016\/j.tice.2025.102917_bib53","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.3892\/mmr.2020.11284","article-title":"A potential role for astaxanthin in the treatment of bone diseases","volume":"22","author":"Valenti","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.tice.2025.102917_bib54","doi-asserted-by":"crossref","first-page":"5750","DOI":"10.3390\/md13095750","article-title":"Astaxanthin as a potential neuroprotective agent for neurological diseases","volume":"13","author":"Wu","year":"2015","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.tice.2025.102917_bib55","first-page":"275","article-title":"Effect of acupuncture therapy on fracture healing in rats with femur fractures","volume":"40","author":"Yilmaz","year":"2020","journal-title":"J. Tradit. Chin. Med."},{"key":"10.1016\/j.tice.2025.102917_bib56","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.3390\/ph14111106","article-title":"Therapeutic effects of hydroalcoholic extracts from the ancient apple mela rosa dei monti sibillini in transient global ischemia in rats","volume":"14","author":"Yousefi-Manesh","year":"2021","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.tice.2025.102917_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexmp.2021.104737","article-title":"Protective effect of dapsone against bleomycin-induced lung fibrosis in rat","volume":"124","author":"Yousefi-Manesh","year":"2022","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.tice.2025.102917_bib58","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.seizure.2017.09.015","article-title":"Behavioral effects of antiepileptic drugs in rats: Are the effects on mood and behavior detectable in open-field test?","volume":"52","author":"Zimcikova","year":"2017","journal-title":"Seizure"}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625001971?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625001971?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T04:51:56Z","timestamp":1757911916000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816625001971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":58,"alternative-id":["S0040816625001971"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2025.102917","relation":{},"ISSN":["0040-8166"],"issn-type":[{"type":"print","value":"0040-8166"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The therapeutic effect of Astaxanthin on drill-induced closed femoral fracture model in male Wistar rats","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2025.102917","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102917"}}