{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:06:34Z","timestamp":1792026394161,"version":"4.4.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Hubei Province Natural Science Foundation","doi-asserted-by":"publisher","award":["2024AFB739"],"award-info":[{"award-number":["2024AFB739"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.tice.2025.102919","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T22:57:28Z","timestamp":1744757848000},"page":"102919","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Inhibition of BRD4 alleviates pyroptosis induced by testicular ischemia\/reperfusion injury through the NLRP3 pathway"],"prefix":"10.1016","volume":"95","author":[{"given":"Jinrun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinzhuo","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2970-3554","authenticated-orcid":false,"given":"Haoyong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2025.102919_bib1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrc3256","article-title":"BET domain co-regulators in obesity, inflammation and cancer","volume":"12","author":"Belkina","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.tice.2025.102919_bib2","doi-asserted-by":"crossref","DOI":"10.1590\/acb383123","article-title":"Sevoflurane attenuates myocardial ischemia\/reperfusion injury by up-regulating microRNA-99a and down-regulating BRD4","volume":"38","author":"Bie","year":"2023","journal-title":"Acta Cir. Bras."},{"key":"10.1016\/j.tice.2025.102919_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105431","article-title":"Combined inhibition of histone deacetylases and BET family proteins as epigenetic therapy for nerve injury-induced neuropathic pain","volume":"165","author":"Borgonetti","year":"2021","journal-title":"Pharm. Res"},{"issue":"675","key":"10.1016\/j.tice.2025.102919_bib4","first-page":"e613","article-title":"Rho-kinase levels in testicular ischemia-reperfusion injury and effects of its inhibitor, Y-27632, on oxidative stress, spermatogenesis, and apoptosis","volume":"83","author":"\u00c7ayan","year":"2014","journal-title":"Urology"},{"key":"10.1016\/j.tice.2025.102919_bib5","doi-asserted-by":"crossref","first-page":"6537","DOI":"10.1128\/.20.17.6537-6549.2000","article-title":"A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M transition","volume":"20","author":"Dey","year":"2000","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.tice.2025.102919_bib6","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/20974","article-title":"Structure and ligand of a histone acetyltransferase bromodomain","volume":"399","author":"Dhalluin","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.tice.2025.102919_bib7","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nature18590","article-title":"Pore-forming activity and structural autoinhibition of the gasdermin family","volume":"535","author":"Ding","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.tice.2025.102919_bib8","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12931-023-02348-y","article-title":"BRD4 is involved in viral exacerbation of chronic obstructive pulmonary disease","volume":"24","author":"Duan","year":"2023","journal-title":"Respir. Res"},{"key":"10.1016\/j.tice.2025.102919_bib9","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/nature09504","article-title":"Selective inhibition of BET bromodomains","volume":"468","author":"Filippakopoulos","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.tice.2025.102919_bib10","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1146\/annurev.ph.57.030195.001523","article-title":"Physiologic mechanisms of postischemic tissue injury","volume":"57","author":"Granger","year":"1995","journal-title":"Annu Rev. Physiol."},{"key":"10.1016\/j.tice.2025.102919_bib11","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1038\/s41556-020-00599-1","article-title":"Author Correction: PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis","volume":"22","author":"Hou","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.tice.2025.102919_bib12","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1007\/s10875-010-9440-3","article-title":"Molecular mechanism of NLRP3 inflammasome activation","volume":"30","author":"Jin","year":"2010","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.tice.2025.102919_bib13","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nrurol.2014.135","article-title":"Mechanisms of testicular torsion and potential protective agents","volume":"11","author":"Karaguzel","year":"2014","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.tice.2025.102919_bib14","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1186\/s12967-023-04327-9","article-title":"Maresin1 alleviates liver ischemia\/reperfusion injury by reducing liver macrophage pyroptosis","volume":"21","author":"Li","year":"2023","journal-title":"J. Transl. Med"},{"key":"10.1016\/j.tice.2025.102919_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/bies.202100180","article-title":"BRD4 in physiology and pathology: ''BET'' on its partners","volume":"43","author":"Liang","year":"2021","journal-title":"Bioessays"},{"key":"10.1016\/j.tice.2025.102919_bib16","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/s41419-023-06149-5","article-title":"Methylation of BRD4 by PRMT1 regulates BRD4 phosphorylation and promotes ovarian cancer invasion","volume":"14","author":"Liu","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.tice.2025.102919_bib17","article-title":"Adipose mesenchymal stromal cell-derived exosomes prevent testicular torsion injury via activating PI3K\/AKT and MAPK\/ERK1\/2 pathways","volume":"2022","author":"Liu","year":"2022","journal-title":"Oxid. Med Cell Longev."},{"key":"10.1016\/j.tice.2025.102919_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101195","article-title":"Inhibition of Brd4 alleviates renal ischemia\/reperfusion injury-induced apoptosis and endoplasmic reticulum stress by blocking FoxO4-mediated oxidative stress","volume":"24","author":"Liu","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.tice.2025.102919_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113700","article-title":"Bone marrow mesenchymal stem cell-derived exosomes attenuate cerebral ischemia-reperfusion injury-induced neuroinflammation and pyroptosis by modulating microglia M1\/M2 phenotypes","volume":"341","author":"Liu","year":"2021","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.tice.2025.102919_bib20","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nrd.2018.149","article-title":"E. Targeting the NLRP3 inflammasome in inflammatory diseases","volume":"17","author":"Mangan","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.tice.2025.102919_bib21","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1038\/ni.1960","article-title":"Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria","volume":"11","author":"Miao","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.tice.2025.102919_bib22","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.euf.2020.07.006","article-title":"Orchidopexy for Testicular Torsion: A Systematic Review of Surgical Technique","volume":"7","author":"Moore","year":"2021","journal-title":"Eur. Urol. Focus"},{"key":"10.1016\/j.tice.2025.102919_bib23","doi-asserted-by":"crossref","first-page":"4869","DOI":"10.1158\/0008-5472.CAN-19-0442","article-title":"BRD4 Promotes Gastric Cancer Progression and Metastasis through Acetylation-Dependent Stabilization of Snail","volume":"79","author":"Qin","year":"2019","journal-title":"Cancer Res"},{"key":"10.1016\/j.tice.2025.102919_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21249620","article-title":"Inhibition of BRD4 Reduces Neutrophil Activation and Adhesion to the Vascular Endothelium Following Ischemia Reperfusion Injury","volume":"21","author":"Reid","year":"2020","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.tice.2025.102919_bib25","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.juro.2013.09.066","article-title":"Effect of antioxidants on outcome of testicular torsion in rats of different ages","volume":"191","author":"Ribeiro","year":"2014","journal-title":"J. Urol."},{"key":"10.1016\/j.tice.2025.102919_bib26","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1126\/science.aar7607","article-title":"ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation","volume":"362","author":"R\u00fchl","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.tice.2025.102919_bib27","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.tice.2025.102919_bib28","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1189\/jlb.0410205","article-title":"Bacteria-induced phagocyte secondary necrosis as a pathogenicity mechanism","volume":"88","author":"Silva","year":"2010","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.tice.2025.102919_bib29","doi-asserted-by":"crossref","first-page":"H1553","DOI":"10.1152\/ajpheart.00158.2018","article-title":"Inflammasome, pyroptosis, and cytokines in myocardial ischemia-reperfusion injury","volume":"315","author":"Toldo","year":"2018","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.tice.2025.102919_bib30","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1046\/j.1464-410X.2003.04307.x","article-title":"Testicular function after torsion of the spermatic cord","volume":"92","author":"Visser","year":"2003","journal-title":"BJU Int"},{"key":"10.1016\/j.tice.2025.102919_bib31","doi-asserted-by":"crossref","first-page":"8403","DOI":"10.1093\/nar\/gkx561","article-title":"BRD4 inhibitors block telomere elongation","volume":"45","author":"Wang","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.tice.2025.102919_bib32","article-title":"BRD4-IRF1 axis regulates chemoradiotherapy-induced PD-L1 expression and immune evasion in non-small cell lung cancer","volume":"12","author":"Wang","year":"2022","journal-title":"Clin. Transl. Med"},{"key":"10.1016\/j.tice.2025.102919_bib33","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1097\/FJC.0000000000001138","article-title":"BRD4 inhibition protects against myocardial ischemia\/reperfusion injury by suppressing inflammation and oxidative stress through the PI3K\/AKT Signaling Pathway","volume":"78","author":"Wei","year":"2021","journal-title":"J. Cardiovasc Pharm."},{"key":"10.1016\/j.tice.2025.102919_bib34","doi-asserted-by":"crossref","first-page":"13141","DOI":"10.1074\/jbc.R700001200","article-title":"The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation","volume":"282","author":"Wu","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tice.2025.102919_bib35","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s10875-010-9425-2","article-title":"Involvement of the AIM2, NLRC4, and NLRP3 inflammasomes in caspase-1 activation by Listeria monocytogenes","volume":"30","author":"Wu","year":"2010","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.tice.2025.102919_bib36","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/j.celrep.2016.07.001","article-title":"BRD4 Phosphorylation Regulates HPV E2-Mediated Viral Transcription, Origin Replication, and Cellular MMP-9 Expression","volume":"16","author":"Wu","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.tice.2025.102919_bib37","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/5992436","article-title":"Naringenin Alleviates Renal Ischemia Reperfusion Injury by Suppressing ER Stress-Induced Pyroptosis and Apoptosis through Activating Nrf2\/HO-1 Signaling Pathway","volume":"2022","author":"Zhang","year":"2022","journal-title":"Oxid. Med Cell Longev."},{"key":"10.1016\/j.tice.2025.102919_bib38","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12943-021-01471-y","article-title":"Exosomal circLPAR1 functions in colorectal cancer diagnosis and tumorigenesis through suppressing BRD4 via METTL3-eIF3h interaction","volume":"21","author":"Zheng","year":"2022","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.tice.2025.102919_bib39","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.bbrc.2019.07.097","article-title":"BRD4 suppression alleviates cerebral ischemia-induced brain injury by blocking glial activation via the inhibition of inflammatory response and pyroptosis","volume":"519","author":"Zhou","year":"2019","journal-title":"Biochem Biophys. Res Commun."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625001995?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625001995?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T15:28:44Z","timestamp":1750260524000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816625001995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":39,"alternative-id":["S0040816625001995"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2025.102919","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of BRD4 alleviates pyroptosis induced by testicular ischemia\/reperfusion injury through the NLRP3 pathway","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2025.102919","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102919"}}