{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T15:12:19Z","timestamp":1782832339048,"version":"3.54.5"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T00:00:00Z","timestamp":1745020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/50026\/2020"],"award-info":[{"award-number":["UIDB\/50026\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.tice.2025.102925","type":"journal-article","created":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T18:20:51Z","timestamp":1745086851000},"page":"102925","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Exploring hyperglycemia's impact on embryonic development: Insights from the chicken embryo model"],"prefix":"10.1016","volume":"95","author":[{"given":"Daniela","family":"Machado-Costa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gon\u00e7alo","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Correia-Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1763-9014","authenticated-orcid":false,"given":"Rute S.","family":"Moura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2025.102925_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2024.108583","article-title":"Perspectives on chick embryo models in developmental and reproductive toxicity screening","volume":"126","author":"Acharya","year":"2024","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.tice.2025.102925_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2024.102605","article-title":"Integrated care of diabetes during pregnancy: a Qatari nationwide cohort","volume":"72","author":"Bashir","year":"2024","journal-title":"eClinicalMedicine"},{"issue":"4","key":"10.1016\/j.tice.2025.102925_bib3","doi-asserted-by":"crossref","first-page":"405","DOI":"10.2337\/diab.40.4.405","article-title":"Role of oxidative stress in development of complications in diabetes","volume":"40","author":"Baynes","year":"1991","journal-title":"Diabetes"},{"issue":"7","key":"10.1016\/j.tice.2025.102925_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2021.101164","article-title":"Chicken embryo as a model in epigenetic research","volume":"100","author":"Bednarczyk","year":"2021","journal-title":"Poult. Sci."},{"issue":"2","key":"10.1016\/j.tice.2025.102925_bib5","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nrg998","article-title":"The chicken as a model for large-scale analysis of vertebrate gene function","volume":"4","author":"Brown","year":"2003","journal-title":"Nat. Rev. Genet."},{"issue":"2","key":"10.1016\/j.tice.2025.102925_bib6","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/tera.1420490206","article-title":"Ethyl alcohol reduces cardiac output, stroke volume, and end diastolic volume in the embryonic chick","volume":"49","author":"Bruyere","year":"1994","journal-title":"Teratology"},{"issue":"2","key":"10.1016\/j.tice.2025.102925_bib7","first-page":"245","article-title":"The use of animal models in the study of diabetes mellitus","volume":"23","author":"Chatzigeorgiou","year":"2009","journal-title":"Vivo"},{"issue":"3","key":"10.1016\/j.tice.2025.102925_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2008.06.028","article-title":"Diabetes mellitus and birth defects","volume":"199","author":"Correa","year":"2008","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"12","key":"10.1016\/j.tice.2025.102925_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2020.165955","article-title":"In ovo hyperglycemia causes congenital limb defects in chicken embryos via disruption of cell proliferation and apoptosis","volume":"1866","author":"Ding","year":"2020","journal-title":"Biochim. Et. Biophys. Acta (BBA) - Mol. Basis Dis."},{"issue":"5","key":"10.1016\/j.tice.2025.102925_bib10","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1210\/er.2001-0039","article-title":"Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes","volume":"23","author":"Evans","year":"2002","journal-title":"Endocr. Rev."},{"issue":"1","key":"10.1016\/j.tice.2025.102925_bib11","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/tera.1420350113","article-title":"Ethyl alcohol-induced cardiovascular malformations in the chick embryo","volume":"35","author":"Fang","year":"1987","journal-title":"Teratology"},{"key":"10.1016\/j.tice.2025.102925_bib12","unstructured":"Federation, I.D. (2021). Global picture (10 ed.)."},{"issue":"1","key":"10.1016\/j.tice.2025.102925_bib13","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s13578-021-00654-w","article-title":"Lung branching morphogenesis is accompanied by temporal metabolic changes towards a glycolytic preference","volume":"11","author":"Fernandes-Silva","year":"2021","journal-title":"Cell Biosci."},{"issue":"6","key":"10.1016\/j.tice.2025.102925_bib14","doi-asserted-by":"crossref","first-page":"451","DOI":"10.3109\/10715769609088044","article-title":"Altered Levels of Scavenging Enzymes in Embryos Subjected to a Diabetic Environment","volume":"24","author":"Forsberg","year":"1996","journal-title":"Free Radic. Res."},{"issue":"30","key":"10.1016\/j.tice.2025.102925_bib15","doi-asserted-by":"crossref","first-page":"18515","DOI":"10.1074\/jbc.272.30.18515","article-title":"Superoxide anion radical (O2-.), superoxide dismutases, and related matters","volume":"272","author":"Fridovich","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.tice.2025.102925_bib16","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1681\/ASN.2008080844","article-title":"Reduction of renal superoxide dismutase in progressive diabetic nephropathy","volume":"20","author":"Fujita","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.tice.2025.102925_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.791081","article-title":"The Chicken Embryo Model: A Novel and Relevant Model for Immune-Based Studies [Review]","volume":"12","author":"Garcia","year":"2021","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.tice.2025.102925_bib18","first-page":"231","article-title":"A series of normal stages in the development of the chick embryo","volume":"195","author":"Hamburger","year":"1992","journal-title":"1951. Dev. Dyn."},{"issue":"3","key":"10.1016\/j.tice.2025.102925_bib19","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.jep.2011.07.033","article-title":"Evaluation of antidiabetic potential of selected traditional Chinese medicines in STZ-induced diabetic mice","volume":"137","author":"He","year":"2011","journal-title":"J. Ethnopharmacol."},{"issue":"26","key":"10.1016\/j.tice.2025.102925_bib20","doi-asserted-by":"crossref","first-page":"15613","DOI":"10.1073\/pnas.2536196100","article-title":"Glucose transporter-1-deficient mice exhibit impaired development and deformities that are similar to diabetic embryopathy","volume":"100","author":"Heilig","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"S3","key":"10.1016\/j.tice.2025.102925_bib21","doi-asserted-by":"crossref","first-page":"S173","DOI":"10.1016\/S0020-7292(15)30007-2","article-title":"The International Federation of Gynecology and Obstetrics (FIGO) Initiative on gestational diabetes mellitus: A pragmatic guide for diagnosis, management, and care","volume":"131","author":"Hod","year":"2015","journal-title":"Int. J. Gynecol. \\ Obstet."},{"issue":"3","key":"10.1016\/j.tice.2025.102925_bib22","doi-asserted-by":"crossref","first-page":"768","DOI":"10.3390\/life13030768","article-title":"Embryonic Hyperglycemia Disrupts Myocardial Growth, Morphological Development, and Cellular Organization: An In Vivo Experimental Study","volume":"13","author":"Jaime-Cruz","year":"2023","journal-title":"Life"},{"issue":"6","key":"10.1016\/j.tice.2025.102925_bib23","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1016\/S0002-9440(10)64849-3","article-title":"Onset of Maternal Arterial Blood Flow and Placental Oxidative Stress: A Possible Factor in Human Early Pregnancy Failure","volume":"157","author":"Jauniaux","year":"2000","journal-title":"Am. J. Pathol."},{"issue":"5","key":"10.1016\/j.tice.2025.102925_bib24","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1210\/er.2009-0038","article-title":"Animal Models in Diabetes and Pregnancy","volume":"31","author":"Jawerbaum","year":"2010","journal-title":"Endocr. Rev."},{"issue":"8","key":"10.1016\/j.tice.2025.102925_bib25","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1055\/s-0033-1349080","article-title":"High glucose level induces cardiovascular dysplasia during early embryo development","volume":"121","author":"Jin","year":"2013","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"issue":"3","key":"10.1016\/j.tice.2025.102925_bib26","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.ecl.2019.05.009","article-title":"Type 2 Diabetes in Pregnancy","volume":"48","author":"Kapur","year":"2019","journal-title":"Endocrinol. Metab. Clin. North Am."},{"issue":"2","key":"10.1016\/j.tice.2025.102925_bib27","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1128\/MCB.00553-07","article-title":"Thalidomide induces limb anomalies by PTEN stabilization, Akt suppression, and stimulation of caspase-dependent cell death","volume":"28","author":"Knobloch","year":"2008","journal-title":"Mol. Cell Biol."},{"issue":"7","key":"10.1016\/j.tice.2025.102925_bib28","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1096\/fj.06-7603com","article-title":"Thalidomide induces limb deformities by perturbing the Bmp\/Dkk1\/Wnt signaling pathway","volume":"21","author":"Knobloch","year":"2007","journal-title":"Faseb J."},{"issue":"2","key":"10.1016\/j.tice.2025.102925_bib29","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1159\/000019702","article-title":"A chick embryo model for metastatic human prostate cancer","volume":"34","author":"Kobayashi","year":"1998","journal-title":"Eur. Urol."},{"issue":"2","key":"10.1016\/j.tice.2025.102925_bib30","first-page":"189","article-title":"Use of chick embryo in screening for teratogenicity","volume":"42","author":"Kotwani","year":"1998","journal-title":"Indian J. Physiol. Pharm."},{"key":"10.1016\/j.tice.2025.102925_bib31","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.biochi.2015.12.013","article-title":"Harvesting clues from genome wide transcriptome analysis for exploring thalidomide mediated anomalies in eye development of chick embryo: Nitric oxide rectifies the thalidomide mediated anomalies by swinging back the system to normal transcriptome pattern","volume":"121","author":"Kumar","year":"2016","journal-title":"Biochimie"},{"issue":"3","key":"10.1016\/j.tice.2025.102925_bib32","doi-asserted-by":"crossref","first-page":"752","DOI":"10.2337\/diabetes.53.3.752","article-title":"Hyperglycemia-induced defects in angiogenesis in the chicken chorioallantoic membrane model","volume":"53","author":"Larger","year":"2004","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.tice.2025.102925_bib33","first-page":"13","article-title":"Hyperglycemia Alters the Structure and Hemodynamics of the Developing Embryonic Heart","volume":"5","author":"Lawson","year":"2018","journal-title":"J. Cardiovasc. Dev. Dis."},{"issue":"1","key":"10.1016\/j.tice.2025.102925_bib34","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s40104-016-0099-3","article-title":"Effect of in ovo folic acid injection on hepatic IGF2 expression and embryo growth of broilers","volume":"7","author":"Liu","year":"2016","journal-title":"J. Anim. Sci. Biotechnol."},{"issue":"4","key":"10.1016\/j.tice.2025.102925_bib35","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"6","key":"10.1016\/j.tice.2025.102925_bib36","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/cen.12446","article-title":"Insulin-like growth factor-II: its role in metabolic and endocrine disease","volume":"80","author":"Livingstone","year":"2014","journal-title":"Clin. Endocrinol."},{"issue":"5","key":"10.1016\/j.tice.2025.102925_bib37","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1210\/jc.2011-3296","article-title":"Maternal and Fetal IGF-I and IGF-II Levels, Fetal Growth, and Gestational Diabetes","volume":"97","author":"Luo","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.tice.2025.102925_bib38","article-title":"Effects of in ovo injection of glucose and vitamin C on hatching performance in broiler fertile eggs","volume":"16","author":"Tarhan","year":"2023","journal-title":"J. Radiat. Res. Appl. Sci."},{"issue":"19","key":"10.1016\/j.tice.2025.102925_bib39","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1056\/NEJMoa0707943","article-title":"Hyperglycemia and adverse pregnancy outcomes","volume":"358","author":"Metzger","year":"2008","journal-title":"N. Engl. J. Med"},{"issue":"3","key":"10.1016\/j.tice.2025.102925_bib40","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.cbpc.2005.04.008","article-title":"Hyperglycemia-induced changes in hepatic membrane fatty acid composition correlate with increased caspase-3 activities and reduced chick embryo viability","volume":"141","author":"Miller","year":"2005","journal-title":"Comp. Biochem. Physiol. Part B: Biochem. Mol. Biol."},{"issue":"2","key":"10.1016\/j.tice.2025.102925_bib41","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1055\/s-2007-1016221","article-title":"Diabetes and preimplantation events of embryogenesis","volume":"17","author":"Moley","year":"1999","journal-title":"Semin Reprod. Endocrinol."},{"issue":"5","key":"10.1016\/j.tice.2025.102925_bib42","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1007\/s10995-016-2209-4","article-title":"Pre-pregnancy Obesity as a Modifier of Gestational Diabetes and Birth Defects Associations: A Systematic Review","volume":"21","author":"Parnell","year":"2017","journal-title":"Matern Child Health J."},{"issue":"1","key":"10.1016\/j.tice.2025.102925_bib43","doi-asserted-by":"crossref","first-page":"8867","DOI":"10.1038\/s41598-023-35652-0","article-title":"Allantoic fluid metabolome reveals specific metabolic signatures in chicken lines different for their muscle glycogen content","volume":"13","author":"Petit","year":"2023","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.tice.2025.102925_bib44","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00125-014-3403-9","article-title":"The long-term effects of stillbirth on women with and without gestational diabetes: a population-based cohort study","volume":"58","author":"Pintaudi","year":"2015","journal-title":"Diabetologia"},{"issue":"4","key":"10.1016\/j.tice.2025.102925_bib45","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/bies.200800168","article-title":"The chick embryo: hatching a model for contemporary biomedical research","volume":"31","author":"Rashidi","year":"2009","journal-title":"BioEssays"},{"issue":"2","key":"10.1016\/j.tice.2025.102925_bib46","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ogc.2018.01.002","article-title":"Pregestational Diabetes in Pregnancy","volume":"45","author":"Ronan","year":"2018","journal-title":"Obstet. Gynecol. Clin. North Am."},{"issue":"1","key":"10.1016\/j.tice.2025.102925_bib47","doi-asserted-by":"crossref","first-page":"234","DOI":"10.2337\/db12-0161","article-title":"Hyperglycemia slows embryonic growth and suppresses cell cycle via cyclin D1 and p21","volume":"62","author":"Scott-Drechsel","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.tice.2025.102925_bib48","first-page":"97","article-title":"An Analysis of the Effects of D-Glucose and L-Glucose on Chicken Embryos during HH18 and HH24","volume":"5","author":"Shrimali","year":"2023","journal-title":"High. Sch. J."},{"issue":"6","key":"10.1016\/j.tice.2025.102925_bib49","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.freeradbiomed.2005.12.018","article-title":"Developmental origins of diabetes: the role of oxidative stress","volume":"40","author":"Simmons","year":"2006","journal-title":"Free Radic. Biol. Med"},{"issue":"6","key":"10.1016\/j.tice.2025.102925_bib50","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.2337\/diab.46.6.1054","article-title":"Vitamin E decreases the occurrence of malformations in the offspring of diabetic rats","volume":"46","author":"Sim\u00e1n","year":"1997","journal-title":"Diabetes"},{"key":"10.1016\/j.tice.2025.102925_bib51","series-title":"Animal models in biomedical research: poultry","author":"Smith","year":"1992"},{"issue":"1","key":"10.1016\/j.tice.2025.102925_bib52","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s12035-015-9581-8","article-title":"Abnormal O-GlcNAcylation of Pax3 Occurring from Hyperglycemia-Induced Neural Tube Defects Is Ameliorated by Carnosine But Not Folic Acid in Chicken Embryos","volume":"54","author":"Tan","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.tice.2025.102925_bib53","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.fct.2013.07.059","article-title":"Glucose metabolism disorder is a risk factor in ethanol exposure induced malformation in embryonic brain","volume":"60","author":"Tan","year":"2013","journal-title":"Food Chem. Toxicol."},{"issue":"4","key":"10.1016\/j.tice.2025.102925_bib54","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2174\/1568009054064624","article-title":"The chick embryo chorioallantoic membrane as a model system for the study of tumor angiogenesis, invasion and development of anti-angiogenic agents","volume":"5","author":"Tufan","year":"2005","journal-title":"Curr. Cancer Drug Targets"},{"issue":"11","key":"10.1016\/j.tice.2025.102925_bib55","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.addr.2007.04.019","article-title":"The chick embryo and its chorioallantoic membrane (CAM) for the in vivo evaluation of drug delivery systems","volume":"59","author":"Vargas","year":"2007","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.tice.2025.102925_bib56","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2021.666726","article-title":"From the Farm to the Lab: How Chicken Embryos Contribute to the Field of Teratology","volume":"12","author":"Wachholz","year":"2021","journal-title":"Front Genet"},{"issue":"1","key":"10.1016\/j.tice.2025.102925_bib57","article-title":"High glucose environment inhibits cranial neural crest survival by activating excessive autophagy in the chick embryo","volume":"5","author":"Wang","year":"2015","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.tice.2025.102925_bib58","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/pr.2014.139","article-title":"Diabetes-associated changes in the fetal insulin\/insulin-like growth factor system are organ specific in rats","volume":"77","author":"White","year":"2015","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.tice.2025.102925_bib59","series-title":"WHO Global Report on Diabetes","author":"WHO","year":"2016"},{"key":"10.1016\/j.tice.2025.102925_bib60","unstructured":"World Health, O. (2013). Diagnostic criteria and classification of hyperglycaemia first detected in pregnancy. \u3008https:\/\/iris.who.int\/handle\/10665\/85975http:\/\/iris.paho.org\/xmlui\/handle\/123456789\/27870\u3009."},{"issue":"2","key":"10.1016\/j.tice.2025.102925_bib61","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1210\/en.2007-1273","article-title":"One-cell zygote transfer from diabetic to nondiabetic mouse results in congenital malformations and growth retardation in offspring","volume":"149","author":"Wyman","year":"2008","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.tice.2025.102925_bib62","first-page":"177","article-title":"A new gestational diabetes mellitus model: hyperglycemia-induced eye malformation via inhibition of Pax6 in the chick embryo","volume":"9","author":"Zhang","year":"2016","journal-title":"Dis. Models Mech."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625002058?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625002058?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:37:39Z","timestamp":1777455459000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816625002058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":62,"alternative-id":["S0040816625002058"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2025.102925","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring hyperglycemia's impact on embryonic development: Insights from the chicken embryo model","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2025.102925","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102925"}}