{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T02:44:20Z","timestamp":1787971460192,"version":"build-2784847793"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.tice.2025.102942","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T20:30:02Z","timestamp":1746736202000},"page":"102942","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Targeting the p38MAPK\/STAT3\/NF-\u03baB65 pathway modulates the hepatoprotective effect of pentoxifylline against sodium valproate-induced liver injury in rats; A study based on integrating network pharmacology and experiment validation"],"prefix":"10.1016","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6980-4726","authenticated-orcid":false,"given":"Gellan","family":"Alaa Mohamed Kamel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaimaa","family":"Hussein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.tice.2025.102942_bib1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00580-023-03454-5","article-title":"The effects of gallic acid on inflammation and oxidative stress in valproic acid-induced hepatotoxicity in rats","volume":"32","author":"Afshari","year":"2023","journal-title":"Comp. Clin. Pathol."},{"issue":"1","key":"10.1016\/j.tice.2025.102942_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11481-025-10193-7","article-title":"Pentoxifylline prevents neuroinflammation and modifies PTEN\/TrkB signaling in an LPS-induced depression model","volume":"20","author":"Ali","year":"2025","journal-title":"J. Neuroimmune Pharmacol."},{"key":"10.1016\/j.tice.2025.102942_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113225","article-title":"Pentoxifylline and berberine mitigate diclofenac-induced acute nephrotoxicity in male rats via modulation of inflammation and oxidative stress","volume":"152","author":"Alorabi","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"6","key":"10.1016\/j.tice.2025.102942_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/ph17060681","article-title":"Activation of AMPK\/MTOR-driven autophagy and suppression of the HMGB1\/TLR4 pathway with pentoxifylline attenuates doxorubicin-induced hepatic injury in rats","volume":"17","author":"Arab","year":"2024","journal-title":"Pharmaceuticals"},{"issue":"8","key":"10.1016\/j.tice.2025.102942_bib5","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1002\/cbf.3855","article-title":"The potential protective effect of liraglutide on valproic acid induced liver injury in rats: targeting HMGB1\/RAGE axis and RIPK3\/MLKL mediated necroptosis","volume":"41","author":"Atef","year":"2023","journal-title":"Cell Biochem. Funct."},{"issue":"5","key":"10.1016\/j.tice.2025.102942_bib6","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1007\/s10787-024-01560-6","article-title":"Pentoxifylline in patients with ulcerative colitis treated with mesalamine by modulation of IL-6\/STAT3, ZO-1, and S1P pathways: a randomized controlled double-blinded study","volume":"32","author":"Bahaa","year":"2024","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.tice.2025.102942_bib7","doi-asserted-by":"crossref","DOI":"10.1007\/s00210-025-04043-9","article-title":"Exploring the potential mechanism of atorvastatin in regulating ferroptosis as a treatment for heart failure based on network pharmacology","author":"Bai","year":"2025","journal-title":"Naunyn-Schmiede\u2019s Arch. Pharmacol."},{"key":"10.1016\/j.tice.2025.102942_bib8","series-title":"Theory and Practice of Histological Techniques","author":"Bancroft","year":"2008"},{"key":"10.1016\/j.tice.2025.102942_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2105-15-293","article-title":"Jvenn: an interactive venn diagram viewer","volume":"15","author":"Bardou","year":"2014","journal-title":"BMC Bioinform."},{"issue":"7","key":"10.1016\/j.tice.2025.102942_bib10","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.kjms.2016.05.005","article-title":"The effects of tadalafil and pentoxifylline on apoptosis and nitric oxide synthase in liver ischemia\/reperfusion injury","volume":"32","author":"Bektas","year":"2016","journal-title":"Kaohsiung J. Med. Sci."},{"key":"10.1016\/j.tice.2025.102942_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12929-017-0390-4","article-title":"Therapeutic efficacy of pentoxifylline on proteinuria and renal progression: an update","volume":"24","author":"Chen","year":"2017","journal-title":"J. Biomed. Sci."},{"issue":"W1","key":"10.1016\/j.tice.2025.102942_bib12","doi-asserted-by":"crossref","first-page":"W357","DOI":"10.1093\/nar\/gkz382","article-title":"SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules","volume":"47","author":"Daina","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.tice.2025.102942_bib13","doi-asserted-by":"crossref","first-page":"D1257","DOI":"10.1093\/nar\/gkac833","article-title":"Comparative Toxicogenomics Database (CTD): update 2023","volume":"51","author":"Davis","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tice.2025.102942_bib14","doi-asserted-by":"crossref","DOI":"10.1096\/fasebj.22.1_supplement.166.8","article-title":"Pentoxifylline attenuates FMLP-induced oxidative burst in human neutrophils through PKA dependent and independent mechanisms: effect on Ras, Raf, and MAPK activation","volume":"22","author":"Deree","year":"2008","journal-title":"FASEB J."},{"issue":"12","key":"10.1016\/j.tice.2025.102942_bib15","doi-asserted-by":"crossref","first-page":"3296","DOI":"10.1002\/jcp.25773","article-title":"Acetoacetate induces hepatocytes apoptosis by the ROS-mediated MAPKs pathway in Ketotic cows","volume":"232","author":"Du","year":"2017","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.tice.2025.102942_bib16","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.redox.2015.09.005","article-title":"Reactive oxygen species and mitochondria: a nexus of cellular homeostasis","volume":"6","author":"Dunn","year":"2015","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.tice.2025.102942_bib17","first-page":"1","article-title":"Evaluation of the possible protective role of ginger on sodium valproate induced hepatotoxicity in adult male albino rat: a biochemical, histological, and immunohistochemical study","volume":"13","author":"El-kader","year":"2021","journal-title":"Egypt. Acad. J. Biol. Sci. D Histol. Histochem."},{"issue":"3","key":"10.1016\/j.tice.2025.102942_bib18","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jphs.2021.03.011","article-title":"Pentoxifylline treatment alleviates kidney ischemia\/reperfusion injury: novel involvement of Galectin-3 and ASK-1\/JNK & ERK1\/2\/NF-\u039aB\/HMGB-1 trajectories","volume":"146","author":"El-Sadek","year":"2021","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.tice.2025.102942_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2024.110084","article-title":"Modulation of keap-1\/Nrf2\/HO-1 and NF-\u0138b\/Caspase-3 signaling pathways by dihydromyricetin ameliorates sodium valproate-induced liver injury","volume":"758","author":"Emad","year":"2024","journal-title":"Arch. Biochem. Biophys."},{"issue":"8","key":"10.1016\/j.tice.2025.102942_bib20","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1080\/15376516.2021.1943089","article-title":"Vitamin U prevents valproic acid-induced liver injury through supporting enzymatic antioxidant system and increasing hepatocyte proliferation triggered by inflammation and apoptosis","volume":"31","author":"Celik Sevim Tunali","year":"2021","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.tice.2025.102942_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2022.103967","article-title":"Valproic acid induced liver injury: an insight into molecular toxicological mechanism","volume":"95","author":"Ezhilarasan","year":"2022","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.tice.2025.102942_bib22","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.2147\/DDDT.S136792","article-title":"Salidroside pretreatment attenuates apoptosis and autophagy during hepatic ischemia\u2013reperfusion injury by inhibiting the mitogen-activated protein kinase pathway in Mice","author":"Feng","year":"2017","journal-title":"Drug Des. Dev. Ther."},{"issue":"11","key":"10.1016\/j.tice.2025.102942_bib23","doi-asserted-by":"crossref","first-page":"3873","DOI":"10.1039\/D2CS00172A","article-title":"Recent progress in the development of fluorescent probes for imaging pathological oxidative stress","volume":"52","author":"Geng","year":"2023","journal-title":"Chem. Soc. Rev."},{"issue":"9","key":"10.1016\/j.tice.2025.102942_bib24","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1002\/tox.23557","article-title":"Syringic acid and silymarin concurrent administration inhibits sodium valproate-induced liver injury in rats","volume":"37","author":"Gheena","year":"2022","journal-title":"Environ. Toxicol."},{"issue":"3","key":"10.1016\/j.tice.2025.102942_bib25","doi-asserted-by":"crossref","first-page":"e344","DOI":"10.1097\/MJT.0000000000000706","article-title":"Levocarnitine for the treatment of valproic acid\u2013induced hyperammonemic encephalopathy in children: the experience of a large, tertiary care pediatric hospital and a poison center","volume":"26","author":"Glatstein","year":"2019","journal-title":"Am. J. Ther."},{"issue":"6","key":"10.1016\/j.tice.2025.102942_bib26","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1007\/s42114-024-00989-1","article-title":"Engineered mitochondrial ROS scavenger nanocomplex to enhance lung biodistribution and reduce inflammation for the treatment of ARDS","volume":"7","author":"Hu","year":"2024","journal-title":"Adv. Compos. Hybrid Mater."},{"issue":"1","key":"10.1016\/j.tice.2025.102942_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-80183-x","article-title":"The effects of hesperidin on valproic acid-induced reduction in hippocampal neurogenesis through the antioxidant and apoptotic pathways in adult rats","volume":"14","author":"Kaewngam","year":"2024","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.tice.2025.102942_bib28","doi-asserted-by":"crossref","first-page":"6063","DOI":"10.1007\/s11033-022-07395-0","article-title":"Rutin protects rat liver and kidney from sodium valproate-induce damage by attenuating oxidative stress, er stress, inflammation, apoptosis and autophagy","volume":"49","author":"Kandemir","year":"2022","journal-title":"Mol. Biol. Rep."},{"issue":"6","key":"10.1016\/j.tice.2025.102942_bib29","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.curtheres.2008.12.003","article-title":"Effects of silymarin and pentoxifylline on matrix metalloproteinase-1 and-2 expression and apoptosis in experimental hepatic fibrosis","volume":"69","author":"Kara","year":"2008","journal-title":"Curr. Ther. Res."},{"issue":"5","key":"10.1016\/j.tice.2025.102942_bib30","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2016.17","article-title":"Activated Rac1 regulates the degradation of I\u03baB\u03b1 and the nuclear translocation of STAT3\u2013NF\u03baB complexes in starved cancer cells","volume":"48","author":"Kim","year":"2016","journal-title":"Exp. Mol. Med."},{"issue":"D1","key":"10.1016\/j.tice.2025.102942_bib31","doi-asserted-by":"crossref","first-page":"D1265","DOI":"10.1093\/nar\/gkad976","article-title":"DrugBank 6.0: the drugbank knowledgebase for 2024","volume":"52","author":"Knox","year":"2024","journal-title":"Nucleic Acids Res."},{"issue":"16","key":"10.1016\/j.tice.2025.102942_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11164713","article-title":"Therapeutic potential of the combination of pentoxifylline and vitamin-E in inflammatory bowel disease: inhibition of intestinal fibrosis","volume":"11","author":"Lee","year":"2022","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.tice.2025.102942_bib33","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.molimm.2020.01.014","article-title":"Dapk1 improves inflammation, oxidative stress and autophagy in LPS-induced acute lung injury via P38MAPK\/NF-\u039aB signaling pathway","volume":"120","author":"Li","year":"2020","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.tice.2025.102942_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1349043","article-title":"Pre-treatment risk predictors of valproic acid-induced dyslipidemia in pediatric patients with epilepsy","volume":"15","author":"Liang","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.tice.2025.102942_bib35","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40360-023-00645-2","article-title":"Protective effects of pentoxifylline against chlorine-induced acute lung injury in rats","volume":"24","author":"Liu","year":"2023","journal-title":"BMC Pharmacol. Toxicol."},{"key":"10.1016\/j.tice.2025.102942_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.resp.2024.104388","article-title":"Effect of imatinib on lipopolysaccharide\u2011induced acute lung injury and endothelial dysfunction through the P38 MAPK and NF-\u039aB signaling pathways in vivo and in vitro","volume":"333","author":"Liu","year":"2025","journal-title":"Respir. Physiol. Neurobiol."},{"issue":"7","key":"10.1016\/j.tice.2025.102942_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2024.107736","article-title":"A novel P55PIK signaling peptide inhibitor alleviates neuroinflammation via the STAT3\/NF-KB signaling pathway in experimental stroke","volume":"33","author":"Liu","year":"2024","journal-title":"J. Stroke Cerebrovasc. Dis."},{"issue":"6","key":"10.1016\/j.tice.2025.102942_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10061153","article-title":"Valproic acid-induced liver injury: a case-control study from a prospective pharmacovigilance program in a tertiary hospital","volume":"10","author":"Meseguer","year":"2021","journal-title":"J. Clin. Med."},{"issue":"3","key":"10.1016\/j.tice.2025.102942_bib39","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s10787-022-00993-1","article-title":"A raising dawn of pentoxifylline in management of inflammatory disorders in covid-19","volume":"30","author":"Mostafa-Hedeab","year":"2022","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.tice.2025.102942_bib40","first-page":"193","article-title":"Reduction in ischemic brain injury following the administration of pentoxifylline after transient global ischemia\/ reperfusion in a rat model","volume":"29","author":"Nadia Sharifi","year":"2015","journal-title":"Med. J. Islam. Repub. Iran"},{"key":"10.1016\/j.tice.2025.102942_bib41","unstructured":"National Center for Biotechnology Information, 2024. PubChem Compound Summary for CID 4740, Pentoxifylline. \u3008https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Pentoxifylline\u3009."},{"issue":"W1","key":"10.1016\/j.tice.2025.102942_bib42","doi-asserted-by":"crossref","first-page":"W26","DOI":"10.1093\/nar\/gku477","article-title":"SuperPred: update on drug classification and target prediction","volume":"42","author":"Nickel","year":"2014","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"10.1016\/j.tice.2025.102942_bib43","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s10565-006-0019-y","article-title":"Comparison of the effects of melatonin and pentoxifylline on carbon tetrachloride-induced liver toxicity in mice","volume":"22","author":"Noyan","year":"2006","journal-title":"Cell Biol. Toxicol."},{"issue":"D1","key":"10.1016\/j.tice.2025.102942_bib44","doi-asserted-by":"crossref","first-page":"D1353","DOI":"10.1093\/nar\/gkac1046","article-title":"The next-generation open targets platform: reimagined, redesigned, rebuilt","volume":"51","author":"Ochoa","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tice.2025.102942_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2024.114920","article-title":"Behavioral and neurotransmitter changes on antiepileptic drugs treatment in the zebrafish pentylenetetrazol-induced seizure model","volume":"464","author":"Okanari","year":"2024","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.tice.2025.102942_bib46","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s11033-019-05134-6","article-title":"Melatonin ameliorates sodium valproate-induced hepatotoxicity in rats","volume":"47","author":"Oztopuz","year":"2020","journal-title":"Mol. Biol. Rep."},{"issue":"1","key":"10.1016\/j.tice.2025.102942_bib47","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s42114-024-01135-7","article-title":"Preparation, characterization, bioactivity, and safety evaluation of pei-modified plga nanoparticles loaded with polysaccharide from cordyceps militaris","volume":"8","author":"Pei","year":"2024","journal-title":"Adv. Compos. Hybrid Mater."},{"key":"10.1016\/j.tice.2025.102942_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112955","article-title":"Anticoagulant active ingredients identification of total saponin extraction of different panax medicinal plants based on grey relational analysis combined with UPLC-MS and molecular docking","volume":"260","author":"Ren","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.tice.2025.102942_bib49","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S1499-3872(15)60348-4","article-title":"Pentoxifylline enhances the protective effects of hypertonic saline solution on liver ischemia reperfusion injury through inhibition of oxidative stress","volume":"14","author":"Rocha-Santos","year":"2015","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"issue":"11","key":"10.1016\/j.tice.2025.102942_bib50","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.tice.2025.102942_bib51","unstructured":"Shifow, Anwar A., Naidu, M.U.R., Vijay Kumar, K., Prayag, A., Ratnakar, K.S. 2000. Effect of Pentoxifylline on Cyclosporine-Induced Nephrotoxicity in Rats."},{"issue":"1","key":"10.1016\/j.tice.2025.102942_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cpbi.5","article-title":"The GeneCards suite: from gene data mining to disease genome sequence analyses","volume":"54","author":"Stelzer","year":"2016","journal-title":"Curr. Protoc. Bioinforma."},{"issue":"1","key":"10.1016\/j.tice.2025.102942_bib53","article-title":"Reactive oxygen species-induced lipid peroxidation in apoptosis, autophagy, and ferroptosis","volume":"2019","author":"Su","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"D1","key":"10.1016\/j.tice.2025.102942_bib54","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein\u2013protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tice.2025.102942_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.177306","article-title":"The PPAR-\u03b1 Agonist Oleoyethanolamide (OEA) ameliorates valproic acid-induced steatohepatitis in rats via suppressing Wnt3a\/\u03b2-Catenin and activating PGC-1\u03b1: involvement of network pharmacology and molecular docking","volume":"991","author":"El Tabaa","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.tice.2025.102942_bib56","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.biosystems.2014.11.005","article-title":"CytoNCA: a cytoscape plugin for centrality analysis and evaluation of protein interaction networks","volume":"127","author":"Tang","year":"2015","journal-title":"Biosystems"},{"issue":"4","key":"10.1016\/j.tice.2025.102942_bib57","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S1665-2681(19)31751-X","article-title":"Hepatoprotective effect of pentoxifylline against D-galactosamine-induced hepatotoxicity in rats","volume":"8","author":"Taye","year":"2009","journal-title":"Ann. Hepatol."},{"key":"10.1016\/j.tice.2025.102942_bib58","first-page":"1","article-title":"Protective effects of curcumin against valproic acid induced brain kidney and liver damage in rats","author":"Terim Kapakin","year":"2024","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.tice.2025.102942_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174283","article-title":"PEX5 prevents cardiomyocyte hypertrophy via suppressing the redox-sensitive signaling pathways MAPKs and STAT3","volume":"906","author":"Wang","year":"2021","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.tice.2025.102942_bib60","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3390\/brainsci10030187","article-title":"Valproic acid-induced hyperammonemic encephalopathy in a patient with bipolar disorder: a case report","volume":"10","author":"Wu","year":"2020","journal-title":"Brain Sci."},{"issue":"3","key":"10.1016\/j.tice.2025.102942_bib61","doi-asserted-by":"crossref","DOI":"10.1002\/cpz1.90","article-title":"Gene set knowledge discovery with enrichr","volume":"1","author":"Xie","year":"2021","journal-title":"Curr. Protoc."},{"key":"10.1016\/j.tice.2025.102942_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113690","article-title":"The bidirectional role of the JAK2\/STAT3 signaling pathway and related mechanisms in cerebral ischemia-reperfusion injury","volume":"341","author":"Zhong","year":"2021","journal-title":"Exp. Neurol."},{"issue":"2","key":"10.1016\/j.tice.2025.102942_bib63","first-page":"126","article-title":"Valproic acid as a potentiator of metabolic syndrome in institutionalized residents on concomitant antipsychotics: fat chance, or slim to none?","volume":"40","author":"Zuo","year":"2015","journal-title":"Pharm. Ther."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625002228?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625002228?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T04:50:27Z","timestamp":1757911827000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816625002228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":63,"alternative-id":["S0040816625002228"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2025.102942","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting the p38MAPK\/STAT3\/NF-\u03baB65 pathway modulates the hepatoprotective effect of pentoxifylline against sodium valproate-induced liver injury in rats; A study based on integrating network pharmacology and experiment validation","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2025.102942","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102942"}}