{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:38:29Z","timestamp":1787647109555,"version":"build-2736575974"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.tice.2025.103008","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T20:12:40Z","timestamp":1749154360000},"page":"103008","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["OTUD5 enhances activation of multiple cell death pathways and hyperoxia-induced lung injury by stabilizing TRAF4 and activating the p38\/JNK pathway"],"prefix":"10.1016","volume":"96","author":[{"given":"Xia","family":"Gu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guihua","family":"Hang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.tice.2025.103008_bib1","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1186\/s13054-021-03815-y","article-title":"Dangers of hyperoxia","volume":"25","author":"Singer","year":"2021","journal-title":"Crit. Care"},{"issue":"2","key":"10.1016\/j.tice.2025.103008_bib2","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/j.2040-4603.2020.tb00122.x","article-title":"Effects of Perinatal Hyperoxia on Breathing","volume":"10","author":"Bavis","year":"2020","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.tice.2025.103008_bib3","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/978-1-4899-7678-9_13","article-title":"Hyperoxia and Functional MRI","volume":"903","author":"Bulte","year":"2016","journal-title":"Adv. Exp. Med Biol."},{"issue":"1","key":"10.1016\/j.tice.2025.103008_bib4","doi-asserted-by":"crossref","first-page":"L9","DOI":"10.1152\/ajplung.00443.2022","article-title":"Hyperoxia-induced lung injury in acute respiratory distress syndrome: what is its relative impact?","volume":"325","author":"Lilien","year":"2023","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"7","key":"10.1016\/j.tice.2025.103008_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112745","article-title":"Targeting CXCR1 alleviates hyperoxia-induced lung injury through promoting glutamine metabolism","volume":"42","author":"Qin","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.tice.2025.103008_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102405","article-title":"Regulation of hyperoxia-induced neonatal lung injury via post-translational cysteine redox modifications","volume":"55","author":"Zhang","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.tice.2025.103008_bib7","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.rmed.2016.08.010","article-title":"Jr., Molecular mechanisms underlying hyperoxia acute lung injury.","volume":"119","author":"Dias-Freitas","year":"2016","journal-title":"Respir. Med"},{"issue":"2","key":"10.1016\/j.tice.2025.103008_bib8","doi-asserted-by":"crossref","DOI":"10.1152\/ajplung.00442.2019","article-title":"Maternal antibiotics augment hyperoxia-induced lung injury in neonatal mice","volume":"318","author":"Lal","year":"2020","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"8","key":"10.1016\/j.tice.2025.103008_bib9","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1038\/s41423-020-00531-5","article-title":"OTUD5 promotes innate antiviral and antitumor immunity through deubiquitinating and stabilizing STING","volume":"18","author":"Guo","year":"2021","journal-title":"Cell Mol. Immunol."},{"issue":"1","key":"10.1016\/j.tice.2025.103008_bib10","doi-asserted-by":"crossref","first-page":"8393","DOI":"10.1038\/s41467-023-44228-5","article-title":"Autophagy of OTUD5 destabilizes GPX4 to confer ferroptosis-dependent kidney injury","volume":"14","author":"Chu","year":"2023","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.tice.2025.103008_bib11","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jcmgh.2023.11.014","article-title":"Hepatocyte Deubiquitinating Enzyme OTUD5 Deficiency is a Key Aggravator for Metabolic Dysfunction-Associated Steatohepatitis by Disturbing Mitochondrial Homeostasis","volume":"17","author":"Dai","year":"2024","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"issue":"4","key":"10.1016\/j.tice.2025.103008_bib12","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.ijrobp.2024.01.220","article-title":"USP11 Exacerbates Radiation-Induced Pneumonitis by Activating Endothelial Cell Inflammatory Response via OTUD5-STING Signaling","volume":"119","author":"Tang","year":"2024","journal-title":"Int J. Radiat. Oncol. Biol. Phys."},{"issue":"3","key":"10.1016\/j.tice.2025.103008_bib13","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1038\/s41380-021-01398-2","article-title":"Epigenome-wide meta-analysis of PTSD symptom severity in three military cohorts implicates DNA methylation changes in genes involved in immune system and oxidative stress","volume":"27","author":"Katrinli","year":"2022","journal-title":"Mol. Psychiatry"},{"issue":"1","key":"10.1016\/j.tice.2025.103008_bib14","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1080\/16078454.2021.1974200","article-title":"Decreasing lncRNA PVT1 causes Treg\/Th17 imbalance via NOTCH signaling in immune thrombocytopenia","volume":"26","author":"Yu","year":"2021","journal-title":"Hematology"},{"issue":"1","key":"10.1016\/j.tice.2025.103008_bib15","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13062-024-00475-0","article-title":"OTUD5 promotes the growth of hepatocellular carcinoma by deubiquitinating and stabilizing SLC38A1","volume":"19","author":"Yang","year":"2024","journal-title":"Biol. Direct"},{"issue":"1","key":"10.1016\/j.tice.2025.103008_bib16","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.canlet.2014.12.005","article-title":"Deubiquitinase OTUD5 mediates the sequential activation of PDCD5 and p53 in response to genotoxic stress","volume":"357","author":"Park","year":"2015","journal-title":"Cancer Lett."},{"issue":"4","key":"10.1016\/j.tice.2025.103008_bib17","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abe2116","article-title":"Linkage-specific deubiquitylation by OTUD5 defines an embryonic pathway intolerant to genomic variation","volume":"7","author":"Beck","year":"2021","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.tice.2025.103008_bib18","doi-asserted-by":"crossref","first-page":"5441","DOI":"10.1038\/s41467-024-49854-1","article-title":"Podocyte OTUD5 alleviates diabetic kidney disease through deubiquitinating TAK1 and reducing podocyte inflammation and injury","volume":"15","author":"Zhao","year":"2024","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.tice.2025.103008_bib19","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/s41419-022-05128-6","article-title":"Deubiquitinase OTUD5 modulates mTORC1 signaling to promote bladder cancer progression","volume":"13","author":"Hou","year":"2022","journal-title":"Cell Death Dis."},{"issue":"28","key":"10.1016\/j.tice.2025.103008_bib20","article-title":"Deubiquitinase OTUD5 as a Novel Protector against 4-HNE-Triggered Ferroptosis in Myocardial Ischemia\/Reperfusion Injury","volume":"10","author":"Liu","year":"2023","journal-title":"Adv. Sci. (Weinh. )"},{"key":"10.1016\/j.tice.2025.103008_bib21","doi-asserted-by":"crossref","first-page":"1120034","DOI":"10.3389\/fimmu.2023.1120034","article-title":"Advances in mechanism and regulation of PANoptosis: Prospects in disease treatment","volume":"14","author":"Zhu","year":"2023","journal-title":"Front Immunol."},{"issue":"9","key":"10.1016\/j.tice.2025.103008_bib22","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.4049\/jimmunol.2200508","article-title":"PANoptosis: A Unique Innate Immune Inflammatory Cell Death Modality","volume":"209","author":"Pandian","year":"2022","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.tice.2025.103008_bib23","doi-asserted-by":"crossref","first-page":"899","DOI":"10.14336\/AD.2021.1023","article-title":"MiR-29a-3p Improves Acute Lung Injury by Reducing Alveolar Epithelial Cell PANoptosis","volume":"13","author":"Cui","year":"2022","journal-title":"Aging Dis."},{"issue":"Pt B","key":"10.1016\/j.tice.2025.103008_bib24","article-title":"Ursodeoxycholic acid alleviates sepsis-induced lung injury by blocking PANoptosis via STING pathway","volume":"125","author":"He","year":"2023","journal-title":"Int Immunopharmacol."},{"key":"10.1016\/j.tice.2025.103008_bib25","article-title":"MicroRNA-18a regulates the Pyroptosis","volume":"128","author":"Zhang","year":"2024","journal-title":"Apoptosis Necroptosis (PANoptosis) osteoblasts Induc. Tumor necrosis Factor\u03b1 via hypoxiainducible Factor1\u03b1. Int Immunopharmacol."},{"issue":"8","key":"10.1016\/j.tice.2025.103008_bib26","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1007\/s11064-024-04151-7","article-title":"Cytosolic Escape of Mitochondrial DNA Triggers cGAS-STING Pathway-Dependent Neuronal PANoptosis in Response to Intermittent Hypoxia","volume":"49","author":"Wang","year":"2024","journal-title":"Neurochem. Res"},{"issue":"7","key":"10.1016\/j.tice.2025.103008_bib27","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1172\/JCI96060","article-title":"TRAF4-mediated ubiquitination of NGF receptor TrkA regulates prostate cancer metastasis","volume":"128","author":"Singh","year":"2018","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.tice.2025.103008_bib28","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.2147\/DDDT.S319260","article-title":"Baicalin Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy via Nrf2 and MAPK Signaling Pathway","volume":"15","author":"Ma","year":"2021","journal-title":"Drug Des. Devel Ther."},{"key":"10.1016\/j.tice.2025.103008_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110563","article-title":"Liensinine pretreatment reduces inflammation, oxidative stress, apoptosis, and autophagy to alleviate sepsis acute kidney injury","volume":"122","author":"Zhang","year":"2023","journal-title":"Int Immunopharmacol."},{"key":"10.1016\/j.tice.2025.103008_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.814510","article-title":"BMI1 Silencing Induces Mitochondrial Dysfunction in Lung Epithelial Cells Exposed to Hyperoxia","volume":"13","author":"Hernandez-Cuervo","year":"2022","journal-title":"Front Physiol."},{"issue":"1","key":"10.1016\/j.tice.2025.103008_bib31","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/s41598-017-00516-x","article-title":"Role of Cytochrome P450 (CYP)1A in Hyperoxic Lung Injury: Analysis of the Transcriptome and Proteome","volume":"7","author":"Lingappan","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2025.103008_bib32","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.molimm.2023.09.016","article-title":"ROS-mediated MAPK activation aggravates hyperoxia-induced acute lung injury by promoting apoptosis of type II alveolar epithelial cells via the STAT3\/miR-21-5p axis","volume":"163","author":"Qin","year":"2023","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.tice.2025.103008_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.120064","article-title":"The protective effect of quercetin on macrophage pyroptosis via TLR2\/Myd88\/NF-\u03baB and ROS\/AMPK pathway","volume":"291","author":"Luo","year":"2022","journal-title":"Life Sci."},{"issue":"2","key":"10.1016\/j.tice.2025.103008_bib34","first-page":"170","article-title":"Polyherbal extract improves glycometabolic control in alloxan-induced diabetic rats via down-regulating the MAPK\/JNK pathway, modulating Nrf-2\/Keap-1 expression, and stimulating insulin signaling","volume":"27","author":"Aslam","year":"2024","journal-title":"Iran. J. Basic Med Sci."},{"issue":"6","key":"10.1016\/j.tice.2025.103008_bib35","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/s41418-024-01293-7","article-title":"OTUD5 promotes the inflammatory immune response by enhancing MyD88 oligomerization and Myddosome formation","volume":"31","author":"Liu","year":"2024","journal-title":"Cell Death Differ."},{"issue":"11","key":"10.1016\/j.tice.2025.103008_bib36","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1007\/s00018-023-04995-2","article-title":"Deubiquitinase OTUD5 promotes hepatitis B virus replication by removing K48-linked ubiquitination of HBV core\/precore and upregulates HNF4\u0251 expressions by inhibiting the ERK1\/2\/mitogen-activated protein kinase pathway","volume":"80","author":"Lou","year":"2023","journal-title":"Cell Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.tice.2025.103008_bib37","doi-asserted-by":"crossref","first-page":"4184","DOI":"10.1038\/s41467-020-17926-7","article-title":"OTUD5 cooperates with TRIM25 in transcriptional regulation and tumor progression via deubiquitination activity","volume":"11","author":"Li","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tice.2025.103008_bib38","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/978-0-387-70630-6_5","article-title":"TRAF4, the unique family member","volume":"597","author":"Kedinger","year":"2007","journal-title":"Adv. Exp. Med Biol."},{"key":"10.1016\/j.tice.2025.103008_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.842072","article-title":"The Research Progress in Physiological and Pathological Functions of TRAF4","volume":"12","author":"Ruan","year":"2022","journal-title":"Front Oncol."},{"issue":"12","key":"10.1016\/j.tice.2025.103008_bib40","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1007\/s11427-014-4727-x","article-title":"TRAF4 mediates activation of TGF-\u03b2 signaling and is a biomarker for oncogenesis in breast cancer","volume":"57","author":"Zhou","year":"2014","journal-title":"Sci. China Life Sci."},{"issue":"1","key":"10.1016\/j.tice.2025.103008_bib41","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s40291-020-00509-z","article-title":"The Ubiquitin Proteasome System and Skin Fibrosis","volume":"25","author":"Shen","year":"2021","journal-title":"Mol. Diagn. Ther."},{"issue":"18","key":"10.1016\/j.tice.2025.103008_bib42","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.169736","article-title":"TRAF4 is crucial for ST2+ memory Th2 cell expansion in IL-33-driven airway inflammation","volume":"8","author":"Xiao","year":"2023","journal-title":"JCI Insight"},{"issue":"12","key":"10.1016\/j.tice.2025.103008_bib43","article-title":"TRAF4-Mediated LAMTOR1 Ubiquitination Promotes mTORC1 Activation and Inhibits the Inflammation-Induced Colorectal Cancer Progression","volume":"11","author":"Zhao","year":"2024","journal-title":"Adv. Sci. (Weinh. )"},{"key":"10.1016\/j.tice.2025.103008_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.855139","article-title":"TRAF4 Inhibits the Apoptosis and Promotes the Proliferation of Breast Cancer Cells by Inhibiting the Ubiquitination of Spindle Assembly-Associated Protein Eg5","volume":"12","author":"Hao","year":"2022","journal-title":"Front Oncol."},{"issue":"1","key":"10.1016\/j.tice.2025.103008_bib45","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s42003-023-04982-0","article-title":"An IL-17-EGFR-TRAF4 axis contributes to the alleviation of lung inflammation in severe influenza","volume":"6","author":"Dutta","year":"2023","journal-title":"Commun. Biol."},{"key":"10.1016\/j.tice.2025.103008_bib46","article-title":"TRAF4 is crucial for the propagation of ST2+ memory Th2 cells in IL-33-mediated type 2 airway inflammation","author":"Xiao","year":"2023","journal-title":"bioRxiv"},{"issue":"43","key":"10.1016\/j.tice.2025.103008_bib47","doi-asserted-by":"crossref","first-page":"35793","DOI":"10.1074\/jbc.C500260200","article-title":"MEKK4 is an effector of the embryonic TRAF4 for JNK activation","volume":"280","author":"Abell","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.tice.2025.103008_bib48","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s11658-023-00505-1","article-title":"Exosomal miR-155-5p drives widespread macrophage M1 polarization in hypervirulent Klebsiella pneumoniae-induced acute lung injury via the MSK1\/p38-MAPK axis","volume":"28","author":"Xu","year":"2023","journal-title":"Cell Mol. Biol. Lett."},{"issue":"1","key":"10.1016\/j.tice.2025.103008_bib49","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/s41392-022-00953-9","article-title":"TRIM47 is a novel endothelial activation factor that aggravates lipopolysaccharide-induced acute lung injury in mice via K63-linked ubiquitination of TRAF2","volume":"7","author":"Qian","year":"2022","journal-title":"Signal Transduct. Target Ther."},{"issue":"1","key":"10.1016\/j.tice.2025.103008_bib50","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12865-022-00500-9","article-title":"Lack of STAT6 enhances murine acute lung injury through NLRP3\/p38 MAPK signaling pathway in macrophages","volume":"23","author":"Hu","year":"2022","journal-title":"BMC Immunol."},{"issue":"8","key":"10.1016\/j.tice.2025.103008_bib51","first-page":"1876","article-title":"Peroxiredoxin 1 inhibits lipopolysaccharide-induced oxidative stress in lung tissue by regulating P38\/JNK signaling pathway","volume":"21","author":"Lv","year":"2017","journal-title":"Eur. Rev. Med Pharm. Sci."},{"key":"10.1016\/j.tice.2025.103008_bib52","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.etap.2018.03.020","article-title":"High molecular weight hyaluronan attenuates fine particulate matter-induced acute lung injury through inhibition of ROS-ASK1-p38\/JNK-mediated epithelial apoptosis","volume":"59","author":"Xu","year":"2018","journal-title":"Environ. Toxicol. Pharm."},{"key":"10.1016\/j.tice.2025.103008_bib53","doi-asserted-by":"crossref","DOI":"10.1538\/expanim.25-0007","article-title":"Soyasaponin I alleviates inflammation and oxidative stress in chronic obstructive pulmonary disease through inhibiting the MAPK signaling pathway","author":"Zhang","year":"2025","journal-title":"Exp. Anim."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625002885?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625002885?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T04:56:31Z","timestamp":1757912191000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816625002885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":53,"alternative-id":["S0040816625002885"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2025.103008","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"OTUD5 enhances activation of multiple cell death pathways and hyperoxia-induced lung injury by stabilizing TRAF4 and activating the p38\/JNK pathway","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2025.103008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103008"}}