{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:46:14Z","timestamp":1787312774357,"version":"build-2736575974"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.tice.2025.103043","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T18:34:55Z","timestamp":1752604495000},"page":"103043","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Mesenchymal stem cell therapy for diabetes: An umbrella review"],"prefix":"10.1016","volume":"96","author":[{"given":"Dana","family":"Koishybayeva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adilet","family":"Amirashov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saule","family":"Balmagambetova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadiar M.","family":"Mussin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0222-3035","authenticated-orcid":false,"given":"Amin","family":"Tamadon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.tice.2025.103043_bib1","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1007\/s10787-023-01255-4","article-title":"The potential effect of metformin on fibroblast growth factor 21 in type 2 diabetes mellitus (T2DM)","volume":"31","author":"Al-Kuraishy","year":"2023","journal-title":"Inflammopharmacology"},{"issue":"4","key":"10.1016\/j.tice.2025.103043_bib2","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1007\/s43440-023-00500-5","article-title":"DPP-4 inhibitors and type 2 diabetes mellitus in Parkinson's disease: a mutual relationship","volume":"75","author":"Alrouji","year":"2023","journal-title":"Pharm. Rep."},{"issue":"13","key":"10.1016\/j.tice.2025.103043_bib3","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1111\/jcmm.17784","article-title":"NF-\u03baB\/NLRP3 inflammasome axis and risk of Parkinson's disease in Type 2 diabetes mellitus: A narrative review and new perspective","volume":"27","author":"Alrouji","year":"2023","journal-title":"J. Cell Mol. Med"},{"issue":"1","key":"10.1016\/j.tice.2025.103043_bib4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s13098-023-01082-1","article-title":"The potential role of human islet amyloid polypeptide in type 2 diabetes mellitus and Alzheimer's diseases","volume":"15","author":"Alrouji","year":"2023","journal-title":"Diabetol. Metab. Syndr."},{"issue":"7","key":"10.1016\/j.tice.2025.103043_bib5","doi-asserted-by":"crossref","DOI":"10.4252\/wjsc.v17.i7.108202","article-title":"Autologous and Allogeneic MSC-Based Therapies for Diabetes Mellitus: A Systematic Review and Meta-Analysis","volume":"17","author":"Aringazina","year":"2025","journal-title":"World J. Stem Cells"},{"issue":"4","key":"10.1016\/j.tice.2025.103043_bib6","doi-asserted-by":"crossref","first-page":"174","DOI":"10.4103\/ajm.ajm_53_20","article-title":"Pathophysiology of diabetes: An overview","volume":"10","author":"Banday","year":"2020","journal-title":"Avicenna J. Med"},{"key":"10.1016\/j.tice.2025.103043_bib7","article-title":"Engineering Islets From Stem Cells: The Optimal Solution for the Treatment of Diabetes?","volume":"13","author":"Du","year":"2022","journal-title":"Front Immunol."},{"issue":"4","key":"10.1016\/j.tice.2025.103043_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0151938","article-title":"Clinical Efficacy of Stem Cell Therapy for Diabetes Mellitus: A Meta-Analysis","volume":"11","author":"El-Badawy","year":"2016","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.tice.2025.103043_bib9","doi-asserted-by":"crossref","first-page":"587","DOI":"10.2337\/db14-0656","article-title":"Preserved \u03b2-cell function in type 1 diabetes by mesenchymal stromal cells","volume":"64","author":"Carlsson","year":"2015","journal-title":"Diabetes"},{"issue":"S1","key":"10.1016\/j.tice.2025.103043_bib10","first-page":"226","article-title":"Therapeutic Effects of Stem Cells for the Treatment of Diabetes Mellitus","volume":"84","author":"Fei","year":"2022","journal-title":"Indian J. Pharm. Sci."},{"issue":"1","key":"10.1016\/j.tice.2025.103043_bib11","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1464-5491.2011.03433.x","article-title":"Stem cell-based treatments for Type 1 diabetes mellitus: bone marrow, embryonic, hepatic, pancreatic and induced pluripotent stem cells","volume":"29","author":"Godfrey","year":"2012","journal-title":"Diabet. Med"},{"issue":"2","key":"10.1016\/j.tice.2025.103043_bib12","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s13300-019-0578-6","article-title":"Efficacy of Autologous Bone Marrow Mononuclear Cell Transplantation Therapy for Type 2 Diabetes Mellitus: An Updated Meta-Analysis","volume":"10","author":"Guo","year":"2019","journal-title":"Diabetes Ther."},{"key":"10.1016\/j.tice.2025.103043_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1380443","article-title":"Meta-analysis shows that mesenchymal stem cell therapy can be a possible treatment for diabetes","volume":"15","author":"Habiba","year":"2024","journal-title":"Front Endocrinol. (Lausanne)"},{"issue":"3","key":"10.1016\/j.tice.2025.103043_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0247662","article-title":"Clinical efficacy on glycemic control and safety of mesenchymal stem cells in patients with diabetes mellitus: Systematic review and meta-analysis of RCT data","volume":"16","author":"He","year":"2021","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.tice.2025.103043_bib15","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1507\/endocrj.EJ12-0343","article-title":"Long term effects of the implantation of Wharton\u2019s jelly-derived mesenchymal stem cells from the umbilical cord for newly-onset type 1 diabetes mellitus","volume":"60","author":"Hu","year":"2013","journal-title":"Endocr. J."},{"issue":"3","key":"10.1016\/j.tice.2025.103043_bib16","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.3892\/etm.2016.3544","article-title":"Long term effect and safety of Wharton's jelly-derived mesenchymal stem cells on type 2 diabetes","volume":"12","author":"Hu","year":"2016","journal-title":"Exp Ther Med."},{"key":"10.1016\/j.tice.2025.103043_bib17","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3389\/fcell.2020.00016","article-title":"Therapeutic Potential of Wharton's Jelly Mesenchymal Stem Cells for Diabetes: Achievements and Challenges","volume":"8","author":"Kamal","year":"2020","journal-title":"Front Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.tice.2025.103043_bib18","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s13098-025-01619-6","article-title":"Mesenchymal stem cell-based therapy for type 1 & 2 diabetes mellitus patients: a systematic review and meta-analysis of randomized controlled trials","volume":"17","author":"Kashbour","year":"2025","journal-title":"Diabetol. Metab. Syndr."},{"issue":"1","key":"10.1016\/j.tice.2025.103043_bib19","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1186\/s13287-020-01996-x","article-title":"Therapeutic efficacy of umbilical cord-derived stem cells for diabetes mellitus: a meta-analysis study","volume":"11","author":"Kassem","year":"2020","journal-title":"Stem Cell Res Ther."},{"issue":"1","key":"10.1016\/j.tice.2025.103043_bib20","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1186\/s13287-025-04377-4","article-title":"A meta-analysis on application and prospect of cell therapy in the treatment of diabetes mellitus","volume":"16","author":"Li","year":"2025","journal-title":"Stem Cell Res Ther."},{"issue":"1","key":"10.1016\/j.tice.2025.103043_bib21","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1186\/s13287-021-02342-5","article-title":"Efficacy of mesenchymal stem cell transplantation therapy for type 1 and type 2 diabetes mellitus: a meta-analysis","volume":"12","author":"Li","year":"2021","journal-title":"Stem Cell Res Ther."},{"issue":"1","key":"10.1016\/j.tice.2025.103043_bib22","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s13643-022-01950-3","article-title":"Investigating the safety and efficacy of hematopoietic and mesenchymal stem cell transplantation for treatment of T1DM: a systematic review and meta-analysis","volume":"11","author":"Madani","year":"2022","journal-title":"Syst. Rev."},{"issue":"2","key":"10.1016\/j.tice.2025.103043_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.47672\/ejb.409","article-title":"A Modern Overview on Diabetes Mellitus: A Chronic Endocrine Disorder","volume":"5","author":"Mukhtar","year":"2020","journal-title":"Eur. J. Biol."},{"issue":"2","key":"10.1016\/j.tice.2025.103043_bib24","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1080\/17446651.2025.2457474","article-title":"Safety and efficacy of umbilical cord mesenchymal stem cells in the treatment of type 1 and type 2 diabetes mellitus: a systematic review and meta-analysis","volume":"20","author":"Nada","year":"2025","journal-title":"Expert Rev. Endocrinol. Metab."},{"key":"10.1016\/j.tice.2025.103043_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.trim.2022.101740","article-title":"Clinical efficacy of stem-cell therapy on diabetes mellitus: A systematic review and meta-analysis","volume":"75","author":"Pires","year":"2022","journal-title":"Transpl. Immunol."},{"issue":"3","key":"10.1016\/j.tice.2025.103043_bib26","doi-asserted-by":"crossref","first-page":"422","DOI":"10.3390\/jpm13030422","article-title":"Type 1 Diabetes Mellitus and Autoimmune Diseases: A Critical Review of the Association and the Application of Personalized Medicine","volume":"13","author":"Popoviciu","year":"2023","journal-title":"J. Pers. Med"},{"issue":"26","key":"10.1016\/j.tice.2025.103043_bib27","doi-asserted-by":"crossref","first-page":"15","DOI":"10.55529\/jpdmhd.26.15.25","article-title":"Comprehensive Insights into Diabetes Mellitus: Diagnosis, Management, and Emerging Trends","volume":"2","author":"Qadir","year":"2022","journal-title":"J. Prev. Diagn. Manag. Hum. Dis."},{"issue":"0","key":"10.1016\/j.tice.2025.103043_bib28","first-page":"40","article-title":"Stem cell therapy for patients with diabetes: a systematic review and meta-analysis of metabolomics-based risks and benefits","volume":"5","author":"Rahim","year":"2018","journal-title":"Stem Cell Invest."},{"issue":"5","key":"10.1016\/j.tice.2025.103043_bib29","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/jdi.13404","article-title":"Efficacy of mesenchymal stem cell therapy on glucose levels in type 2 diabetes mellitus: A systematic review and meta-analysis","volume":"12","author":"Ranjbaran","year":"2021","journal-title":"J. Diabetes Invest."},{"key":"10.1016\/j.tice.2025.103043_bib30","doi-asserted-by":"crossref","first-page":"j4008","DOI":"10.1136\/bmj.j4008","article-title":"AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both","volume":"358","author":"Shea","year":"2017","journal-title":"BMJ"},{"issue":"22","key":"10.1016\/j.tice.2025.103043_bib31","doi-asserted-by":"crossref","first-page":"12171","DOI":"10.3390\/ijms252212171","article-title":"The Potential of Mesenchymal Stem\/Stromal Cells in Diabetic Wounds and Future Directions for Research and Therapy-Is It Time for Use in Everyday Practice?","volume":"25","author":"Sienko","year":"2024","journal-title":"Int J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.tice.2025.103043_bib32","first-page":"30","article-title":"Evaluation of efficacy and regenerative potential of Wharton\u2019s jelly and bone marrow derived mesenchymal stem cells in diabetic rats","volume":"12","author":"Som","year":"2018","journal-title":"J. PreClin. Clin. Res."},{"issue":"21","key":"10.1016\/j.tice.2025.103043_bib33","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202211897","article-title":"Mesenchymal Stem Cell-Laden Composite \u03b2 Cell Porous Microgel for Diabetes Treatment","volume":"33","author":"Sun","year":"2023","journal-title":"Adv. Funct. Mater."},{"issue":"8","key":"10.1016\/j.tice.2025.103043_bib34","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1507\/endocrj.EJ20-0050","article-title":"Efficacy and safety of stem cells transplantation in patients with type 1 diabetes mellitus-a systematic review and meta-analysis","volume":"67","author":"Wu","year":"2020","journal-title":"Endocr. J."},{"issue":"1","key":"10.1016\/j.tice.2025.103043_bib35","doi-asserted-by":"crossref","first-page":"141","DOI":"10.14336\/AD.2019.0421","article-title":"The Clinical Efficacy and Safety of Stem Cell Therapy for Diabetes Mellitus: A Systematic Review and Meta-Analysis","volume":"11","author":"Zhang","year":"2020","journal-title":"Aging Dis."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625003234?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625003234?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T05:00:33Z","timestamp":1757912433000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816625003234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":35,"alternative-id":["S0040816625003234"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2025.103043","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mesenchymal stem cell therapy for diabetes: An umbrella review","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2025.103043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103043"}}