{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:04:23Z","timestamp":1779894263853,"version":"3.53.1"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.tice.2025.103052","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T15:51:01Z","timestamp":1753372261000},"page":"103052","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Ultrastructural markers of human liver cryptococcosis in an immunocompetent patient: Lipid droplets, multilamellar bodies, megamitochondria, and syncytia"],"prefix":"10.1016","volume":"97","author":[{"given":"Chul Jong","family":"Yoon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Je Geun","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7010-0336","authenticated-orcid":false,"given":"Ki Woo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2025.103052_bib1","first-page":"478","article-title":"Frequency of gastroesophageal reflux in patients with liver cirrhosis","volume":"40","author":"Ahmed","year":"1993","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.tice.2025.103052_bib2","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/ar.1091630401","article-title":"Fine structure of canine Kupffer cells and their microtubule-containing cytosomes","volume":"163","author":"Boler","year":"1969","journal-title":"Anat. Rec."},{"key":"10.1016\/j.tice.2025.103052_bib3","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3390\/jof3040057","article-title":"Global and multi-national prevalence of fungal diseases\u2014estimate precision","volume":"3","author":"Bongomin","year":"2017","journal-title":"J. Fungi"},{"key":"10.1016\/j.tice.2025.103052_bib4","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s10024-002-1201-8","article-title":"Bile acid synthetic defects and liver disease: a comprehensive review","volume":"7","author":"Bove","year":"2004","journal-title":"Pediatr. Dev. Pathol."},{"key":"10.1016\/j.tice.2025.103052_bib5","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/S0016-5085(85)80028-7","article-title":"Cholangitis associated with Cryptococcus neoformans","volume":"88","author":"Bucuvalas","year":"1985","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tice.2025.103052_bib6","doi-asserted-by":"crossref","first-page":"200","DOI":"10.7150\/ijms.3810","article-title":"Isolated biliary cryptococcosis manifesting as obstructive jaundice in an immunocompetent adult","volume":"9","author":"Cai","year":"2012","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.tice.2025.103052_bib7","doi-asserted-by":"crossref","first-page":"512","DOI":"10.14411\/fp.2014.063","article-title":"Bile canalicular changes and defective bile secretion in Opisthorchis viverrini-infected hamsters","volume":"61","author":"Charoensuk","year":"2014","journal-title":"Folia Parasitol. (Praha)"},{"key":"10.1016\/j.tice.2025.103052_bib8","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41392-023-01547-9","article-title":"Mitochondrial dynamics in health and disease: mechanisms and potential targets","volume":"8","author":"Chen","year":"2023","journal-title":"Sig. Transduct. Target Ther."},{"key":"10.1016\/j.tice.2025.103052_bib9","article-title":"Disseminated cryptococcosis in an HIV-negative patient with liver cirrhosis and asplenia: a rare but dreadful disease","volume":"15","author":"Chippa","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.tice.2025.103052_bib10","first-page":"34","article-title":"Giant mitochondria in the myocardium of aging and endurance-trained mice","volume":"33","author":"Coleman","year":"1987","journal-title":"Gerontology"},{"key":"10.1016\/j.tice.2025.103052_bib11","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s12072-013-9490-8","article-title":"Advancements in in vitro hepatic models: application for drug screening and therapeutics","volume":"8","author":"Damania","year":"2014","journal-title":"Hepatol. Int."},{"key":"10.1016\/j.tice.2025.103052_bib12","doi-asserted-by":"crossref","first-page":"253","DOI":"10.4254\/wjh.v12.i5.253","article-title":"Transmission of cryptococcosis by liver transplantation: a case report and review of literature","volume":"12","author":"Ferreira","year":"2020","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.tice.2025.103052_bib13","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1152\/physrev.00013.2007","article-title":"Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver","volume":"88","author":"Friedman","year":"2008","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.tice.2025.103052_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2022.108480","article-title":"Ultrastructural evidence of four types of lipofuscins in the melanomacrophagic centers in hepatocytes of zebrafish (Denio rerio)","volume":"132","author":"Gandahi","year":"2023","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.tice.2025.103052_bib15","article-title":"Navigating the horizon: the world health organization reporting system for liver cytopathology","volume":"36","author":"Gao","year":"2024","journal-title":"Hum. Pathol. Rep."},{"key":"10.1016\/j.tice.2025.103052_bib16","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nrgastro.2017.32","article-title":"Lipid droplets and liver disease: from basic biology to clinical implications","volume":"14","author":"Gluchowski","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.tice.2025.103052_bib17","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1091\/mbc.11.1.255","article-title":"Biogenesis of multilamellar bodies via autophagy","volume":"11","author":"Hariri","year":"2000","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.tice.2025.103052_bib18","series-title":"Liver Biopsy","first-page":"404","article-title":"Electron Microscopy of Liver Biopsies","author":"Iancu","year":"2011"},{"key":"10.1016\/j.tice.2025.103052_bib19","doi-asserted-by":"crossref","first-page":"6851","DOI":"10.1038\/s41598-023-33977-4","article-title":"Distinct features of two lipid droplets types in cell nuclei from patients with liver diseases","volume":"13","author":"Imai","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2025.103052_bib20","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/0014-5793(94)80176-2","article-title":"Direct visualization of lipid aggregates in native human bile by light- and cryo-transmission electron-microscopy","volume":"340","author":"Kaplun","year":"1994","journal-title":"FEBS Lett."},{"key":"10.1016\/j.tice.2025.103052_bib21","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s12890-022-01930-2","article-title":"Clinical characteristics and image features of pulmonary cryptococcosis: a retrospective analysis of 50 cases in a Chinese hospital","volume":"22","author":"Lu","year":"2022","journal-title":"BMC Pulm. Med."},{"key":"10.1016\/j.tice.2025.103052_bib22","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1124\/jpet.104.075051","article-title":"Long-term effect of treating pregnant rats with ursodeoxycholic acid on the congenital impairment of bile secretion induced in the pups by maternal cholestasis","volume":"312","author":"Macias","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tice.2025.103052_bib23","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.idc.2015.10.006","article-title":"Cryptococcosis","volume":"30","author":"Maziarz","year":"2016","journal-title":"Infect. Dis. Clin. North Am."},{"key":"10.1016\/j.tice.2025.103052_bib24","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1111\/liv.14452","article-title":"Cell-type-resolved proteomic analysis of the human liver","volume":"40","author":"\u00d6lander","year":"2020","journal-title":"Liver Int."},{"key":"10.1016\/j.tice.2025.103052_bib25","doi-asserted-by":"crossref","DOI":"10.1128\/mmbr.00196-23","article-title":"Biogenesis, germination, and pathogenesis of Cryptococcus spores","volume":"88","author":"Ortiz","year":"2024","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.tice.2025.103052_bib26","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/MAJ.0b013e3181e99c88","article-title":"Opportunistic fungi: a view to the future","volume":"340","author":"Pappas","year":"2010","journal-title":"Am. J. Med. Sci."},{"key":"10.1016\/j.tice.2025.103052_bib27","doi-asserted-by":"crossref","DOI":"10.1126\/science.abq5202","article-title":"Kupffer cell-like syncytia replenish resident macrophage function in the fibrotic liver","volume":"381","author":"Peiseler","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.tice.2025.103052_bib28","doi-asserted-by":"crossref","first-page":"4419","DOI":"10.1128\/JCM.42.10.4419-4431.2004","article-title":"Rare and emerging opportunistic fungal pathogens: concern for resistance beyond Candida albicans and Aspergillus fumigatus","volume":"42","author":"Pfaller","year":"2004","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.tice.2025.103052_bib29","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S1473-3099(17)30243-8","article-title":"Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis","volume":"17","author":"Rajasingham","year":"2017","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.tice.2025.103052_bib30","article-title":"Early cryptococcosis infection in a liver transplant patient: a case report","volume":"11","author":"Sadeghi Boogar","year":"2023","journal-title":"Clin. Case Rep."},{"key":"10.1016\/j.tice.2025.103052_bib31","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1590\/S0004-28032007000200012","article-title":"Gastroesophageal reflux in cirrhotic patients with esophageal varices without endoscopic treatment","volume":"44","author":"Schechter","year":"2007","journal-title":"Arq. Gastroenterol."},{"key":"10.1016\/j.tice.2025.103052_bib32","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1038\/s41598-021-82884-z","article-title":"Three-dimensional ultrastructure of giant mitochondria in human non-alcoholic fatty liver disease","volume":"11","author":"Shami","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2025.103052_bib33","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1021\/bm100074p","article-title":"Nature of alpha and beta particles in glycogen using molecular size distributions","volume":"11","author":"Sullivan","year":"2010","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.tice.2025.103052_bib34","doi-asserted-by":"crossref","first-page":"44507","DOI":"10.1074\/jbc.M207712200","article-title":"The surface of lipid droplets is a phospholipid monolayer with a unique fatty acid composition","volume":"277","author":"Tauchi-Sato","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tice.2025.103052_bib35","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1093\/oxfordjournals.jmicro.a023730","article-title":"Two types of the enlargement of mitochondria related to apoptosis: simple swelling and the formation of megamitochondria","volume":"48","author":"Teranishi","year":"1999","journal-title":"J. Electron Microsc. (Tokyo)"},{"key":"10.1016\/j.tice.2025.103052_bib36","doi-asserted-by":"crossref","first-page":"R1147","DOI":"10.1016\/j.cub.2017.09.019","article-title":"The liver","volume":"27","author":"Trefts","year":"2017","journal-title":"Curr. Biol."},{"key":"10.1016\/j.tice.2025.103052_bib37","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1267\/ahc.18012","article-title":"Electron microscopic study using formalin-fixed, paraffin-embedded material, with special reference to observation of microbial organisms and endocrine granules","volume":"51","author":"Tsutsumi","year":"2018","journal-title":"Acta Histochem. Cytochem."},{"key":"10.1016\/j.tice.2025.103052_bib38","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.pathol.2020.07.018","article-title":"Electron microscopic observations in perfusion-fixed human non-alcoholic fatty liver disease biopsies","volume":"53","author":"Verhaegh","year":"2021","journal-title":"Pathology"},{"key":"10.1016\/j.tice.2025.103052_bib39","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/j.1582-4934.2002.tb00452.x","article-title":"Megamitochondria formation - physiology and pathology","volume":"6","author":"Wakabayashi","year":"2002","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.tice.2025.103052_bib40","unstructured":"World Health Organization. 2022. WHO fungal priority pathogens list to guide research, development and public health action. WHO \u3008https:\/\/www.who.int\/publications\/i\/item\/9789240060241\u3009."},{"key":"10.1016\/j.tice.2025.103052_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.730008","article-title":"Human three-dimensional hepatic models: cell type variety and corresponding applications","volume":"9","author":"Xu","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.tice.2025.103052_bib42","first-page":"478","article-title":"Ultrastructural observation on maturation process of cytomegalovirus i human cells","volume":"28","author":"Yoon","year":"1994","journal-title":"Korean J. Pathol."},{"key":"10.1016\/j.tice.2025.103052_bib43","doi-asserted-by":"crossref","DOI":"10.1093\/jmicro\/dfaf003","article-title":"Encapsulation, vacuolation, and phagocytosis of the opportunistic fungal pathogen Cryptococcus in the liver of an immunocompetent host","author":"Yoon","year":"2025","journal-title":"Microscopy"},{"key":"10.1016\/j.tice.2025.103052_bib44","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1016\/j.clinre.2017.10.004","article-title":"Cryptococcosis manifesting as isolated biliary infection: case report and brief review of literature","volume":"42","author":"Zhou","year":"2018","journal-title":"Clin. Res. Hepatol. Gastroenterol."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625003325?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625003325?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T14:22:36Z","timestamp":1779891756000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816625003325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":44,"alternative-id":["S0040816625003325"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2025.103052","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ultrastructural markers of human liver cryptococcosis in an immunocompetent patient: Lipid droplets, multilamellar bodies, megamitochondria, and syncytia","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2025.103052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103052"}}