{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:06:20Z","timestamp":1785888380114,"version":"3.56.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["232300420016"],"award-info":[{"award-number":["232300420016"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["222300420431"],"award-info":[{"award-number":["222300420431"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.tice.2025.103099","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T15:10:02Z","timestamp":1755875402000},"page":"103099","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Resveratrol-pretreated ADSC-CM alleviates liver oxidative damage in mice by mediating the Sirt1\/Nrf2 axis"],"prefix":"10.1016","volume":"98","author":[{"given":"Jingwen","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenhao","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyao","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanni","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiongxia","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongliu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"S279","key":"10.1016\/j.tice.2025.103099_bib1","doi-asserted-by":"crossref","DOI":"10.1111\/aos.15935","article-title":"Comparative analysis of the effects of limbal and adipose-derived mesenchymal stem cell conditioned media on oxidative stress-induced damage in retinal pigment epithelial cells","volume":"102","author":"Aydemir","year":"2024","journal-title":"Acta Ophthalmol."},{"issue":"12","key":"10.1016\/j.tice.2025.103099_bib2","doi-asserted-by":"crossref","first-page":"947","DOI":"10.2174\/1381612829666230403133322","article-title":"Resveratrol attenuates hydrogen peroxide-induced injury of rat ovarian granulosa-lutein cells by resisting oxidative stress via the SIRT1\/Nrf2\/ARE signaling pathway","volume":"29","author":"Cai","year":"2023","journal-title":"Curr. Pharm. Des."},{"issue":"9","key":"10.1016\/j.tice.2025.103099_bib3","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1002\/term.2917","article-title":"Protective effect of autologous transplantation of resveratrol preconditioned adipose-derived stem cells in the treatment of diabetic liver dysfunction in rat model","volume":"13","author":"Chen","year":"2019","journal-title":"J. Tissue Eng. Regen. Med."},{"issue":"5","key":"10.1016\/j.tice.2025.103099_bib4","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1159\/000374009","article-title":"Sonic hedgehog signaling mediates resveratrol to increase proliferation of neural stem cells after oxygen-glucose deprivation\/reoxygenation injury in vitro","volume":"35","author":"Cheng","year":"2015","journal-title":"Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol."},{"key":"10.1016\/j.tice.2025.103099_bib5","article-title":"A characterized saponin extract of panax japonicus suppresses hepatocyte EMT and HSC activation in vitro and CCl4-provoked liver fibrosis in mice: roles of its modulatory effects on the Akt\/GSK3\u03b2\/Nrf2 cascade","volume":"93","author":"Dai","year":"2021","journal-title":"Phytomedicine Int. J. Phytother. Phytopharm."},{"issue":"1","key":"10.1016\/j.tice.2025.103099_bib6","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s13287-020-01680-0","article-title":"Human adipose-derived mesenchymal stem cell-conditioned medium ameliorates polyneuropathy and foot ulceration in diabetic BKS db\/db mice","volume":"11","author":"De Gregorio","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.tice.2025.103099_bib7","article-title":"New insights into the molecular basis of alcohol abstinence and relapse in alcohol-associated liver disease","author":"Diaz","year":"2023","journal-title":"Hepatology (Baltimore, Md.)"},{"key":"10.1016\/j.tice.2025.103099_bib8","unstructured":"Different effects of resveratrol on early and late passage mesenchymal stem cells through \u03b2-catenin regulation - PubMed[EB\/OL]. [2025a-04-14].\u3008https:\/\/pubmed.ncbi.nlm.nih.gov\/26456654\/\u3009."},{"key":"10.1016\/j.tice.2025.103099_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120615","article-title":"Liver cirrhosis: an overview of experimental models in rodents","volume":"301","author":"Faccioli","year":"2022","journal-title":"Life Sci."},{"issue":"7","key":"10.1016\/j.tice.2025.103099_bib10","doi-asserted-by":"crossref","first-page":"855","DOI":"10.3390\/nu10070855","article-title":"Curcumin in liver diseases: a systematic review of the cellular mechanisms of oxidative stress and clinical perspective","volume":"10","author":"Farzaei","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.tice.2025.103099_bib11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.neulet.2013.02.057","article-title":"Adipose stromal cells-conditioned medium blocks 6-hydroxydopamine-induced neurotoxicity and reactive oxygen species","volume":"544","author":"Gu","year":"2013","journal-title":"Neurosci. Lett."},{"issue":"1","key":"10.1016\/j.tice.2025.103099_bib12","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s13287-022-02760-z","article-title":"Adipose-derived stem cells alleviate liver injury induced by type 1 diabetes mellitus by inhibiting mitochondrial stress and attenuating inflammation","volume":"13","author":"Hou","year":"2022","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.tice.2025.103099_bib13","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-45354-2","article-title":"Skimmianine attenuates liver ischemia\/reperfusion injury by regulating PI3K-AKT signaling pathway-mediated inflammation, apoptosis and oxidative stress","volume":"13","author":"Huo","year":"2023","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.tice.2025.103099_bib14","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1080\/01480545.2022.2135007","article-title":"Effect of curcumin on lipid profile, fibrosis, and apoptosis in liver tissue in abemaciclib-administered rats","volume":"46","author":"Huyut","year":"2023","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.tice.2025.103099_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2020.108573","article-title":"Sulforaphane ameliorates ethanol plus carbon tetrachloride-induced liver fibrosis in mice through the Nrf2-mediated antioxidant response and acetaldehyde metabolization with inhibition of the LPS\/TLR4 signaling pathway","volume":"89","author":"Ishida","year":"2021","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.tice.2025.103099_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2019.134372","article-title":"Amelioration of postoperative cognitive dysfunction in mice by mesenchymal stem cell-conditioned medium treatments is associated with reduced inflammation, oxidative stress and increased BDNF expression in brain tissues","volume":"709","author":"Jiang","year":"2019","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.tice.2025.103099_bib17","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3389\/fcell.2020.00177","article-title":"Adipose-derived stem cells protect ischemia-reperfusion and partial hepatectomy by attenuating endoplasmic reticulum stress","volume":"8","author":"Jiao","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"2","key":"10.1016\/j.tice.2025.103099_bib18","first-page":"112","article-title":"Role of stem cells transplantation in tissue regeneration after acute or chronic acetaminophen induced liver Injury","volume":"29","author":"Katselis","year":"2016","journal-title":"J. Invest. Surg. Off. J. Acad. Surg. Res."},{"issue":"2","key":"10.1016\/j.tice.2025.103099_bib19","doi-asserted-by":"crossref","first-page":"168","DOI":"10.15283\/ijsc22137","article-title":"Therapeutic effect of three-dimensional cultured adipose-derived stem cell-conditioned medium in renal ischemia-reperfusion Injury","volume":"16","author":"Kim","year":"2023","journal-title":"Int. J. Stem Cells"},{"issue":"6","key":"10.1016\/j.tice.2025.103099_bib20","first-page":"1203","article-title":"Resveratrol attenuates senescence of adipose-derived mesenchymal stem cells and restores their paracrine effects on promoting insulin secretion of INS-1 cells through Pim-1","volume":"20","author":"Lei","year":"2016","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.tice.2025.103099_bib21","article-title":"Zinc oxide nanoparticles induce human multiple myeloma cell death via reactive oxygen species and Cyt-C\/Apaf-1\/Caspase-9\/Caspase-3 signaling pathway in vitro","volume":"122","author":"Li","year":"2020","journal-title":"Biomed. Pharmacother. = Biomedecine Pharmacother."},{"key":"10.1016\/j.tice.2025.103099_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119986","article-title":"Optimal intervention time of ADSCs for hepatic ischemia-reperfusion combined with partial resection injury in rats","volume":"285","author":"Piao","year":"2021","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.tice.2025.103099_bib23","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1080\/21691401.2020.1817057","article-title":"Resveratrol promotes secretion of wound healing related growth factors of mesenchymal stem cells originated from adult and fetal tissues","volume":"48","author":"Prakoeswa","year":"2020","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"issue":"1","key":"10.1016\/j.tice.2025.103099_bib24","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1080\/21691401.2020.1817057","article-title":"Resveratrol promotes secretion of wound healing related growth factors of mesenchymal stem cells originated from adult and fetal tissues","volume":"48","author":"Prakoeswa","year":"2020","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"10.1016\/j.tice.2025.103099_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2022.109600","article-title":"Treatment effects of phosphorylated chrysanthemum indicum polysaccharides on duck viral hepatitis by protecting mitochondrial function from oxidative damage","volume":"275","author":"Qiu","year":"2022","journal-title":"Vet. Microbiol."},{"issue":"8","key":"10.1016\/j.tice.2025.103099_bib26","first-page":"1414","article-title":"Anti-Oxidative effects of human adipose stem cell conditioned medium with different basal medium during mouse embryo in vitro culture","volume":"10","author":"Ra","year":"2020","journal-title":"Anim. Open Access J. MDPI"},{"key":"10.1016\/j.tice.2025.103099_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1234300","article-title":"Development of a novel human triculture model of non-alcoholic fatty liver disease and identification of berberine as ameliorating steatosis, oxidative stress and fibrosis","volume":"14","author":"Rafiei","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.tice.2025.103099_bib28","unstructured":"Resveratrol Attenuates Sepsis-Induced Cardiomyopathy in Rats through Anti-Ferroptosis via the Sirt1\/Nrf2 Pathway - PubMed[EB\/OL]. [2025b-04-14].\u3008https:\/\/pubmed.ncbi.nlm.nih.gov\/36576230\/\u3009."},{"issue":"23","key":"10.1016\/j.tice.2025.103099_bib29","doi-asserted-by":"crossref","first-page":"9262","DOI":"10.3390\/ijms21239262","article-title":"The crosstalk of adipose-derived stem cells (ADSC), oxidative stress, and inflammation in protective and adaptive responses","volume":"21","author":"Rochette","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.tice.2025.103099_bib30","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.3390\/ijms20071656","article-title":"Conditioned medium from human mesenchymal stromal cells: towards the clinical Translation","volume":"20","author":"Sagaradze","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"28","key":"10.1016\/j.tice.2025.103099_bib31","doi-asserted-by":"crossref","first-page":"4850","DOI":"10.2174\/092986712803341520","article-title":"Role of oxidative stress and molecular changes in liver fibrosis: a review","volume":"19","author":"S\u00e1nchez-Valle","year":"2012","journal-title":"Curr. Med. Chem."},{"issue":"6","key":"10.1016\/j.tice.2025.103099_bib32","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.tiv.2006.01.016","article-title":"Resveratrol prevents CsA inhibition of proliferation and osteoblastic differentiation of mouse bone marrow-derived mesenchymal stem cells through an ER\/NO\/cGMP pathway","volume":"20","author":"Song","year":"2006","journal-title":"Toxicol. Vit."},{"issue":"1","key":"10.1016\/j.tice.2025.103099_bib33","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.devcel.2007.12.002","article-title":"Keap1\/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila","volume":"14","author":"Sykiotis","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.tice.2025.103099_bib34","article-title":"Veronica persica ameliorates acetaminophen-induced murine hepatotoxicity via attenuating oxidative stress and inflammation","volume":"169","author":"Tian","year":"2023","journal-title":"Biomed. Pharmacother. = Biomedecine Pharmacother."},{"issue":"21","key":"10.1016\/j.tice.2025.103099_bib35","doi-asserted-by":"crossref","first-page":"R1147","DOI":"10.1016\/j.cub.2017.09.019","article-title":"The liver","volume":"27","author":"Trefts","year":"2017","journal-title":"Curr. Biol."},{"issue":"2","key":"10.1016\/j.tice.2025.103099_bib36","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.niox.2011.02.007","article-title":"The Keap1-Nrf2 system as an in vivo sensor for electrophiles","volume":"25","author":"Uruno","year":"2011","journal-title":"Nitric Oxide Biol. Chem."},{"key":"10.1016\/j.tice.2025.103099_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.911757","article-title":"New insights into the persistent effects of acute exposure to AFB1 on rat liver","volume":"13","author":"Yan","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.tice.2025.103099_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174201","article-title":"Alpha lipoic acid priming enhances the hepatoprotective effect of adipose derived stem cells in CCl4 induced hepatic injury in-vitro","volume":"906","author":"Yaqub","year":"2021","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.tice.2025.103099_bib39","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jfma.2012.12.002","article-title":"Adipose-derived mesenchymal stem cells inhibit activation of hepatic stellate cells in vitro and ameliorate rat liver fibrosis in vivo","volume":"114","author":"Yu","year":"2015","journal-title":"J. Formos. Med. Assoc. = Taiwan Yi Zhi"},{"issue":"1","key":"10.1016\/j.tice.2025.103099_bib40","doi-asserted-by":"crossref","first-page":"4172","DOI":"10.1038\/s41598-023-30582-3","article-title":"Mangiferin relieves CCl4-induced liver fibrosis in mice","volume":"13","author":"Zhang","year":"2023","journal-title":"Sci. Rep."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625003817?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625003817?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:17:11Z","timestamp":1785298631000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816625003817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":40,"alternative-id":["S0040816625003817"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2025.103099","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Resveratrol-pretreated ADSC-CM alleviates liver oxidative damage in mice by mediating the Sirt1\/Nrf2 axis","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2025.103099","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103099"}}