{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:03:54Z","timestamp":1779894234036,"version":"3.53.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2014\/22689\\u20133"],"award-info":[{"award-number":["2014\/22689\\u20133"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/08888\\u20139"],"award-info":[{"award-number":["2016\/08888\\u20139"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/21807\\u20136"],"award-info":[{"award-number":["2019\/21807\\u20136"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.tice.2025.103101","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T15:52:01Z","timestamp":1756137121000},"page":"103101","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Aqueous extracts of propolis modulate ECM remodeling and calcium levels during pre-osteoblast differentiation"],"prefix":"10.1016","volume":"97","author":[{"given":"Paula Bertin","family":"de Morais","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerson Santos","family":"de Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo de Oliveira","family":"Orsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willian Fernando","family":"Zambuzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9lio Jr. Da Costa","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2025.103101_bib1","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S0955-0674(96)80081-0","article-title":"The retinoblastoma protein pathway and the restriction point","volume":"8","author":"Bartek","year":"1996","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.tice.2025.103101_bib2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.colsurfb.2010.02.027","article-title":"Hydroxyapatite surface solubility and effect on cell adhesion","volume":"78","author":"Bertazzo","year":"2010","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.tice.2025.103101_bib3","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1002\/bit.26310","article-title":"Nano hydroxyapatite-blasted titanium surface affects pre-osteoblast morphology by modulating critical intracellular pathways","volume":"114","author":"Bezerra","year":"2017","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.tice.2025.103101_bib4","doi-asserted-by":"crossref","first-page":"9021","DOI":"10.1073\/pnas.0812690106","article-title":"The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1","volume":"106","author":"Cayrol","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.tice.2025.103101_bib5","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s00223-013-9759-x","article-title":"A 12-year ecological study of hip fracture rates among older Taiwanese adults","volume":"93","author":"Chan","year":"2013","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.tice.2025.103101_bib6","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.dental.2014.10.007","article-title":"Osseointegration: hierarchical designing encompassing the macrometer, micrometer, and nanometer length scales","volume":"31","author":"Coelho","year":"2015","journal-title":"Dent. Mater."},{"key":"10.1016\/j.tice.2025.103101_bib7","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s11010-017-3083-0","article-title":"Fibroblast contributes for osteoblastic phenotype in a MAPK-ERK and sonic hedgehog signaling-independent manner","volume":"436","author":"da Costa Fernandes","year":"2017","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.tice.2025.103101_bib8","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1089\/ten.teb.2014.0419","article-title":"Endochondral ossification for enhancing bone regeneration: converging native extracellular matrix biomaterials and developmental engineering in vivo","volume":"21","author":"Dennis","year":"2015","journal-title":"Tissue Eng. Part B. Rev."},{"key":"10.1016\/j.tice.2025.103101_bib9","doi-asserted-by":"crossref","first-page":"3932","DOI":"10.3760\/cma.j.issn.0366-6999.20141399","article-title":"Anti-catabolic effect of caffeic acid phenethyl ester, an active component of honeybee propolis on bone loss in ovariectomized mice: a micro-computed tomography study and histological analysis","volume":"127","author":"Duan","year":"2014","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.tice.2025.103101_bib10","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/BF00296346","article-title":"Further characterization of interaction between bone sialoprotein (BSP) and collagen","volume":"56","author":"Fujisawa","year":"1995","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.tice.2025.103101_bib11","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1177\/10454411990100010401","article-title":"Bone sialoprotein","volume":"10","author":"Ganss","year":"1999","journal-title":"Crit. Rev. Oral. Biol. Med."},{"key":"10.1016\/j.tice.2025.103101_bib12","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.abb.2014.06.019","article-title":"Cellular behavior as a dynamic field for exploring bone bioengineering: a closer look at cell-biomaterial interface","volume":"561","author":"Gemini-Piperni","year":"2014","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.tice.2025.103101_bib13","doi-asserted-by":"crossref","first-page":"8954","DOI":"10.1073\/pnas.1302927110","article-title":"Essential role for Cdk2 inhibitory phosphorylation during replication stress revealed by a human Cdk2 knockin mutation","volume":"110","author":"Hughes","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.tice.2025.103101_bib14","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1101\/gad.851100","article-title":"Structural basis of inhibition of CDK\u2013cyclin complexes by INK4 inhibitors","volume":"14","author":"Jeffrey","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.tice.2025.103101_bib15","doi-asserted-by":"crossref","first-page":"6483","DOI":"10.2147\/DDDT.S97797","article-title":"Effect of caffeic acid phenethyl ester on bone formation in the expanded inter-premaxillary suture","volume":"9","author":"Kazancioglu","year":"2015","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.tice.2025.103101_bib16","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1097\/BOR.0000000000000400","article-title":"Osteoporosis in premenopausal women","volume":"29","author":"Langdahl","year":"2017","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.tice.2025.103101_bib17","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/BF01621856","article-title":"Epidemiology and prevention of osteoporosis in urbanized asian populations","volume":"3","author":"Lau","year":"1993","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.tice.2025.103101_bib18","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/0167-4889(91)90020-X","article-title":"Production of gelatin-degrading matrix metalloproteinases ('type IV collagenases\u2019) and inhibitors by articular chondrocytes during their dedifferentiation by serial subcultures and under stimulation by interleukin-1 and tumor necrosis factor alpha","volume":"1094","author":"Lefebvre","year":"1991","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.tice.2025.103101_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11010-013-1775-7","article-title":"Identification of miR-1293 potential target gene: TIMP-1","volume":"384","author":"Li","year":"2013","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.tice.2025.103101_bib20","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folin phenol reagent","volume":"193","author":"LOWRY","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tice.2025.103101_bib21","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.tibs.2005.09.005","article-title":"Mammalian cyclin-dependent kinases","volume":"30","author":"Malumbres","year":"2005","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.tice.2025.103101_bib22","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1093\/intimm\/dxr077","article-title":"IL-1\u03b2 and TNF\u03b1-initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis","volume":"23","author":"Mori","year":"2011","journal-title":"Int. Immunol."},{"key":"10.1016\/j.tice.2025.103101_bib23","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/bs.pmbts.2017.05.001","article-title":"Matrix metalloproteinases in bone resorption, remodeling, and repair","volume":"148","author":"Paiva","year":"2017","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.tice.2025.103101_bib24","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.3892\/ijo.2016.3739","article-title":"Comparative gene expression profiling of ADAMs, MMPs, TIMPs, EMMPRIN, EGF-R and VEGFA in low grade meningioma","volume":"49","author":"Rooprai","year":"2016","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.tice.2025.103101_bib25","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.1002\/jbm.a.36150","article-title":"Titanium-released from dental implant enhances pre-osteoblast adhesion by ROS modulating crucial intracellular pathways","volume":"105","author":"Rossi","year":"2017","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"10.1016\/j.tice.2025.103101_bib26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S1098-3597(06)80061-X","article-title":"Osteoporosis diagnosis and screening","volume":"8","author":"Singer","year":"2006","journal-title":"Clin. Cornerstone"},{"key":"10.1016\/j.tice.2025.103101_bib27","first-page":"35","article-title":"Biological properties and clinical application of propolis. Viii. experimental observation on the influence of ethanol extract of propolis (EEP) on the regeneration of bone tissue","volume":"28","author":"Stojko","year":"1978","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.tice.2025.103101_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2022.116350","article-title":"The multifaced role of HtrA1 in the development of joint and skeletal disorders","volume":"157","author":"Tossetta","year":"2022","journal-title":"Bone"},{"key":"10.1016\/j.tice.2025.103101_bib29","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.vph.2016.07.003","article-title":"Bone loss and vascular calcification: a bi-directional interplay?","volume":"86","author":"Vassalle","year":"2016","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.tice.2025.103101_bib30","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/S0962-8924(02)02321-8","article-title":"The inner lives of focal adhesions","volume":"12","author":"Wehrle-Haller","year":"2002","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.tice.2025.103101_bib31","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.devcel.2013.02.012","article-title":"Dynamic regulation of the structure and functions of integrin adhesions","volume":"24","author":"Wolfenson","year":"2013","journal-title":"Dev. Cell"},{"key":"10.1016\/j.tice.2025.103101_bib32","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.febslet.2013.11.022","article-title":"HtrA1 is upregulated during RANKL-induced osteoclastogenesis, and negatively regulates osteoblast differentiation and BMP2-induced Smad1\/5\/8, ERK and p38 phosphorylation","volume":"588","author":"Wu","year":"2014","journal-title":"FEBS Lett."},{"key":"10.1016\/j.tice.2025.103101_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095662","article-title":"Nanometer scale titanium surface texturing are detected by signaling pathways involving transient FAK and src activations","volume":"9","author":"Zambuzzi","year":"2014","journal-title":"PLOS One"},{"key":"10.1016\/j.tice.2025.103101_bib34","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/jcb.22236","article-title":"On the road to understanding of the osteoblast adhesion: cytoskeleton organization is rearranged by distinct signaling pathways","volume":"108","author":"Zambuzzi","year":"2009","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.tice.2025.103101_bib35","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s11010-008-9951-x","article-title":"Ascorbate-induced osteoblast differentiation recruits distinct MMP-inhibitors: RECK and TIMP-2","volume":"322","author":"Zambuzzi","year":"2009","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.tice.2025.103101_bib36","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s11914-017-0358-z","article-title":"TNF and bone remodeling","volume":"15","author":"Zhao","year":"2017","journal-title":"Curr. Osteoporos. Rep."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625003830?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625003830?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T14:17:49Z","timestamp":1779891469000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816625003830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":36,"alternative-id":["S0040816625003830"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2025.103101","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aqueous extracts of propolis modulate ECM remodeling and calcium levels during pre-osteoblast differentiation","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2025.103101","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103101"}}