{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:05:26Z","timestamp":1789589126258,"version":"build-2803163510"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.tice.2025.103141","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T03:54:15Z","timestamp":1758513255000},"page":"103141","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Formononetin enhances angiogenesis in diabetic wounds by inhibiting ferroptosis through suppression of mtROS-mediated xCT\/GPX4 upregulation"],"prefix":"10.1016","volume":"98","author":[{"given":"Xinying","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanguo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanqi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuangang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2025.103141_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115453","article-title":"Berberis dictyophylla F. Inhibits angiogenesis and apoptosis of diabetic retinopathy via suppressing HIF-1alpha\/VEGF\/DLL-4\/Notch-1 pathway","volume":"296","author":"Ai","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.tice.2025.103141_bib2","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-01512-y","article-title":"Blocked O-GlcNAc cycling alters mitochondrial morphology, function, and mass","volume":"11","author":"Akinbiyi","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2025.103141_bib3","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/848272","article-title":"Diabetes, endothelial dysfunction, and vascular repair: what should a diabetologist keep his eye on?","volume":"2015","author":"Altabas","year":"2015","journal-title":"Int. J. Endocrinol."},{"key":"10.1016\/j.tice.2025.103141_bib4","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.jid.2017.01.027","article-title":"Protective role of mitochondrial peroxiredoxin III against UVB-Induced apoptosis of epidermal keratinocytes","volume":"137","author":"Baek","year":"2017","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.tice.2025.103141_bib5","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.cardiores.2004.08.007","article-title":"Vascular NADPH oxidases: molecular mechanisms of activation","volume":"65","author":"Brandes","year":"2005","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.tice.2025.103141_bib6","doi-asserted-by":"crossref","first-page":"6408278","DOI":"10.1155\/2017\/6408278","article-title":"Mitochondria-Targeted antioxidant SkQ1 improves dermal wound healing in genetically diabetic mice","volume":"2017","author":"Demyanenko","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.tice.2025.103141_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1368765","article-title":"Potential mechanisms of formononetin against inflammation and oxidative stress: a review","volume":"15","author":"Ding","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.tice.2025.103141_bib8","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/nyas.13569","article-title":"Update on management of diabetic foot ulcers","volume":"1411","author":"Everett","year":"2018","journal-title":"Ann. N. Y Acad. Sci."},{"key":"10.1016\/j.tice.2025.103141_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103388","article-title":"Lipid peroxidation triggered by the degradation of xCT contributes to gasdermin D-mediated pyroptosis in COPD","volume":"77","author":"Hou","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.tice.2025.103141_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23407","article-title":"Mitochondrial dysfunction and oxidative stress in diabetic wound","volume":"37","author":"Jiang","year":"2023","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.tice.2025.103141_bib11","doi-asserted-by":"crossref","first-page":"94","DOI":"10.4103\/0976-500X.72351","article-title":"Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research","volume":"1","author":"Kilkenny","year":"2010","journal-title":"J. Pharmacol. Pharmacother."},{"key":"10.1016\/j.tice.2025.103141_bib12","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202407802","article-title":"Metformin syncs CeO(2) to recover intra- and extra-cellular ROS homeostasis in diabetic wound healing","volume":"20","author":"Li","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.tice.2025.103141_bib13","doi-asserted-by":"crossref","first-page":"E509","DOI":"10.1152\/ajpendo.00042.2021","article-title":"Diabetic ferroptosis plays an important role in triggering on inflammation in diabetic wound","volume":"321","author":"Li","year":"2021","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tice.2025.103141_bib14","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/iwj.13540","article-title":"Clinical and economic burden of diabetic foot ulcers: a 5-year longitudinal multi-ethnic cohort study from the tropics","volume":"18","author":"Lo","year":"2021","journal-title":"Int. Wound J."},{"key":"10.1016\/j.tice.2025.103141_bib15","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.bbrc.2023.05.081","article-title":"High glucose-induced endothelial STING activation inhibits diabetic wound healing through impairment of angiogenesis","volume":"668","author":"Luo","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tice.2025.103141_bib16","article-title":"MCL attenuates atherosclerosis by suppressing macrophage ferroptosis via targeting KEAP1\/NRF2 interaction","volume":"69","author":"Luo","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.tice.2025.103141_bib17","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.freeradbiomed.2018.11.003","article-title":"17beta-Estradiol protects mesenchymal stem cells against high glucose-induced mitochondrial oxidants production via Nrf2\/Sirt3\/MnSOD signaling","volume":"130","author":"Oh","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.tice.2025.103141_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18071419","article-title":"Diabetes and wound angiogenesis","volume":"18","author":"Okonkwo","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2025.103141_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.116000","article-title":"Formononetin ameliorates isoproterenol induced cardiac fibrosis through improving mitochondrial dysfunction","volume":"170","author":"Qian","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.tice.2025.103141_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2025.125727","article-title":"ROS-responsive nanocomposite hydrogel dressing accelerates diabetic wound healing through modulation of the inflammatory microenvironment","volume":"678","author":"Qin","year":"2025","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.tice.2025.103141_bib21","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.3390\/ijms12053133","article-title":"Impaired mitochondrial respiratory functions and oxidative stress in streptozotocin-induced diabetic rats","volume":"12","author":"Raza","year":"2011","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2025.103141_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.117148","article-title":"High glucose augments ROS generation regulates mitochondrial dysfunction and apoptosis via stress signalling cascades in keratinocytes","volume":"241","author":"Rizwan","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.tice.2025.103141_bib23","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1161\/CIRCULATIONAHA.110.014506","article-title":"Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus","volume":"124","author":"Shenouda","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.tice.2025.103141_bib24","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"key":"10.1016\/j.tice.2025.103141_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.116112","article-title":"The mechanisms of ferroptosis and its role in atherosclerosis","volume":"171","author":"Xu","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.tice.2025.103141_bib26","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1080\/10717544.2021.2023699","article-title":"Milk exosomes-mediated miR-31-5p delivery accelerates diabetic wound healing through promoting angiogenesis","volume":"29","author":"Yan","year":"2022","journal-title":"Drug Deliv."},{"key":"10.1016\/j.tice.2025.103141_bib27","article-title":"Endothelial dysfunction in vascular complications of diabetes: a comprehensive review of mechanisms and implications","volume":"15","author":"Yang","year":"2024","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.tice.2025.103141_bib28","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.toxlet.2022.08.007","article-title":"Acrylamide induces ferroptosis in HSC-T6 cells by causing antioxidant imbalance of the XCT-GSH-GPX4 signaling and mitochondrial dysfunction","volume":"368","author":"Yuan","year":"2022","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tice.2025.103141_bib29","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1210\/en.2011-1442","article-title":"Protection from palmitate-induced mitochondrial DNA damage prevents from mitochondrial oxidative stress, mitochondrial dysfunction, apoptosis, and impaired insulin signaling in rat L6 skeletal muscle cells","volume":"153","author":"Yuzefovych","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.tice.2025.103141_bib30","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.redox.2017.12.019","article-title":"Empagliflozin rescues diabetic myocardial microvascular injury via AMPK-mediated inhibition of mitochondrial fission","volume":"15","author":"Zhou","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.tice.2025.103141_bib31","doi-asserted-by":"crossref","DOI":"10.1177\/03946320221111117","article-title":"Formononetin regulates endothelial nitric oxide synthase to protect vascular endothelium in deep vein thrombosis rats","volume":"36","author":"Zhou","year":"2022","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.tice.2025.103141_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.121331","article-title":"Formononetin ameliorates ferroptosis-associated fibrosis in renal tubular epithelial cells and in mice with chronic kidney disease by suppressing the Smad3\/ATF3\/SLC7A11 signaling","volume":"315","author":"Zhu","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.tice.2025.103141_bib33","article-title":"Formononetin activates the Nrf2\/ARE signaling pathway via Sirt1 to improve diabetic renal fibrosis","volume":"11","author":"Zhuang","year":"2020","journal-title":"Front. Pharmacol."}],"updated-by":[{"DOI":"10.1016\/j.tice.2025.103275","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000}},{"DOI":"10.1016\/j.tice.2025.103275","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000}}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625004239?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625004239?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:17:52Z","timestamp":1785298672000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816625004239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":33,"alternative-id":["S0040816625004239"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2025.103141","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Formononetin enhances angiogenesis in diabetic wounds by inhibiting ferroptosis through suppression of mtROS-mediated xCT\/GPX4 upregulation","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2025.103141","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103141"}}