{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:59:25Z","timestamp":1785301165757,"version":"3.55.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100014970","name":"jiangxisheng shui xinxi xietong ganzhi yu zhineng chuli zhongdian shiyanshi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.tice.2025.103162","type":"journal-article","created":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T07:29:19Z","timestamp":1759044559000},"page":"103162","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Purinergic ion channel-type P2X7 receptor regulates SK3 channel to promote the progression of gastric cancer"],"prefix":"10.1016","volume":"98","author":[{"given":"Pin","family":"Wan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-bing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2025.103162_bib1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3892\/ijo.2017.4000","article-title":"Gastric cancer: metabolic and metabolomics perspectives (Review)","volume":"51","author":"Xiao","year":"2017","journal-title":"Int J. Oncol."},{"key":"10.1016\/j.tice.2025.103162_bib2","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.3748\/wjg.v22.i8.2403","article-title":"Wagner AD. Advanced gastric cancer: current treatment landscape and future perspectives","volume":"22","author":"Digklia","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.tice.2025.103162_bib3","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41388-018-0426-6","article-title":"ATP in the tumour microenvironment drives expression of nfP2X7, a key mediator of cancer cell survival","volume":"38","author":"Gilbert","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.tice.2025.103162_bib4","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.brainresbull.2019.11.006","article-title":"The role and pharmacological properties of the P2X7 receptor in neuropathic pain","volume":"155","author":"Zhang","year":"2020","journal-title":"Brain Res Bull."},{"key":"10.1016\/j.tice.2025.103162_bib5","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s41568-018-0037-0","article-title":"Extracellular ATP and P2 purinergic signalling in the tumour microenvironment","volume":"18","author":"Di Virgilio","year":"2018","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.tice.2025.103162_bib6","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/onc.2016.206","article-title":"Extracellular purines, purinergic receptors and tumor growth","volume":"36","author":"Di Virgilio","year":"2017","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.tice.2025.103162_bib7","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s11302-021-09834-2","article-title":"P2X7 receptor: the regulator of glioma tumor development and survival","volume":"18","author":"Maty\u015bniak","year":"2022","journal-title":"Purinergic Signal"},{"issue":"4","key":"10.1016\/j.tice.2025.103162_bib8","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s11302-023-09928-z","article-title":"P2X7 receptor promotes migration and invasion of non-small cell lung cancer A549 cells through the PI3K\/Akt pathways","volume":"19","author":"Bai","year":"2023","journal-title":"Purinergic Signal"},{"issue":"1","key":"10.1016\/j.tice.2025.103162_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-81515-7","article-title":"Role of P2X7 receptor in the progression and clinicopathological characteristics of gastric cancer","volume":"14","author":"Zhang","year":"2024","journal-title":"Sci. Rep."},{"issue":"41","key":"10.1016\/j.tice.2025.103162_bib10","doi-asserted-by":"crossref","first-page":"5240","DOI":"10.1038\/onc.2014.444","article-title":"The P2X7 receptor is a key modulator of the PI3K\/GSK3\u03b2\/VEGF signaling network: evidence in experimental neuroblastoma","volume":"34","author":"Amoroso","year":"2015","journal-title":"Oncogene"},{"issue":"18","key":"10.1016\/j.tice.2025.103162_bib11","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1038\/onc.2010.593","article-title":"P2X(7) receptor activation enhances SK3 channels- and cystein cathepsin-dependent cancer cells invasiveness","volume":"30","author":"Jelassi","year":"2011","journal-title":"Oncogene"},{"key":"10.1016\/j.tice.2025.103162_bib12","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.1038\/onc.2016.501","article-title":"The SigmaR1 chaperone drives breast and colorectal cancer cell migration by tuning SK3-dependent Ca2+homeostasis","volume":"36","author":"Gueguinou","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.tice.2025.103162_bib13","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1007\/s00424-013-1435-5","article-title":"cAMP-PKA inhibition of SK3 channel reduced both Ca2+ entry and cancer cell migration by regulation of SK3-Orai1 complex","volume":"466","author":"Clarysse","year":"2014","journal-title":"Pflug. Arch."},{"key":"10.1016\/j.tice.2025.103162_bib14","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1093\/carcin\/bgr101","article-title":"Hypoxia-increased RAGE and P2X7R expression regulates tumor cell invasion through phosphorylation of Erk1\/2 and akt and nuclear translocation of NF-{kappa}B","volume":"32","author":"Tafani","year":"2011","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.tice.2025.103162_bib15","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s12029-018-00186-6","article-title":"Curcumin and gastric cancer: a review on mechanisms of action","volume":"50","author":"Hassanalilou","year":"2019","journal-title":"J. Gastrointest. Cancer"},{"key":"10.1016\/j.tice.2025.103162_bib16","first-page":"188","article-title":"P2X7 receptor as an independent prognostic indicator in gastric cancer","volume":"20","author":"Calik","year":"2020","journal-title":"Bosn. J. Basic Med Sci."},{"key":"10.1016\/j.tice.2025.103162_bib17","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s11302-015-9483-2","article-title":"Extracellular ATP and other nucleotides-ubiquitous triggers of intercellular messenger release","volume":"12","author":"Zimmermann","year":"2016","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.tice.2025.103162_bib18","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/bs.mie.2019.10.006","article-title":"Luciferase-assisted detection of extracellular ATP and ATP metabolites during immunogenic death of cancer cells","volume":"629","author":"Dubyak","year":"2019","journal-title":"Methods Enzym."},{"issue":"7","key":"10.1016\/j.tice.2025.103162_bib19","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1111\/cas.15375","article-title":"Extracellular ATP promotes angiogenesis and adhesion of TNBC cells to endothelial cells via upregulation of CTGF","volume":"113","author":"Zhou","year":"2022","journal-title":"Cancer Sci."},{"issue":"13","key":"10.1016\/j.tice.2025.103162_bib20","doi-asserted-by":"crossref","first-page":"7165","DOI":"10.3390\/ijms25137165","article-title":"KLF4 suppresses the progression of hepatocellular carcinoma by reducing tumor ATP synthesis through targeting the Mir-206\/RICTOR axis","volume":"25","author":"Wang","year":"2024","journal-title":"Int J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.tice.2025.103162_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0304062","article-title":"Extracellular ATP\/P2X7 receptor, a regulatory axis of migration in ovarian carcinoma-derived cells","volume":"19","author":"Nu\u00f1ez-R\u00edos","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.tice.2025.103162_bib22","doi-asserted-by":"crossref","first-page":"48972","DOI":"10.18632\/oncotarget.16903","article-title":"P2X7 receptor and NLRP3 inflammasome activation in head and neck cancer","volume":"8","author":"Bae","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.tice.2025.103162_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11302-017-9593-0","article-title":"The potential of P2X7 receptors as a therapeutic target, including inflammation and tumour progression","volume":"14","author":"Burnstock","year":"2018","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.tice.2025.103162_bib24","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/s12943-015-0472-4","article-title":"The P2X7 receptor regulates cell survival, migration and invasion of pancreatic ductal adenocarcinoma cells","volume":"14","author":"Giannuzzo","year":"2015","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.tice.2025.103162_bib25","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1093\/carcin\/bgu019","article-title":"Atorvastatin prevents ATP-driven invasiveness via P2X7 and EHBP1 signaling in PTEN-expressing prostate cancer cells","volume":"35","author":"Ghalali","year":"2014","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.tice.2025.103162_bib26","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1477-5751-13-16","article-title":"P2X7 protein expression and polymorphism in non-small cell lung cancer (NSCLC)","volume":"13","author":"Boldrini","year":"2014","journal-title":"J. Negat. Results Biomed."},{"key":"10.1016\/j.tice.2025.103162_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.109844","article-title":"Effect of P2X7 receptor on tumorigenesis and its pharmacological properties","volume":"125","author":"Zhang","year":"2020","journal-title":"Biomed. Pharm."},{"issue":"12","key":"10.1016\/j.tice.2025.103162_bib28","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s41419-021-04378-0","article-title":"P2X7 promotes metastatic spreading and triggers release of miRNA-containing exosomes and microvesicles from melanoma cells","volume":"12","author":"Pegoraro","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.tice.2025.103162_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174041","article-title":"PI3K\/Akt\/GSK-3\u03b2 signal pathway is involved in P2X7 receptor-induced proliferation and EMT of colorectal cancer cells","volume":"899","author":"Zhang","year":"2021","journal-title":"Eur. J. Pharm."},{"issue":"8","key":"10.1016\/j.tice.2025.103162_bib30","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/s12032-025-02932-w","article-title":"Blocking or knockdown of P2X7 receptor inhibits invasion and migration of mouse breast cancer cells via PI3K\/Akt\/GSK-3\u03b2 pathways and EMT","volume":"42","author":"Zhao","year":"2025","journal-title":"Med Oncol."},{"issue":"6","key":"10.1016\/j.tice.2025.103162_bib31","doi-asserted-by":"crossref","first-page":"3752","DOI":"10.1097\/JS9.0000000000002406","article-title":"P2X7 receptor promotes the growth and metastasis of gastric cancer by activating P13\/AKT\/GSK-3 beta signaling (experimental research)","volume":"111","author":"Zhang","year":"2025","journal-title":"Int J. Surg."},{"key":"10.1016\/j.tice.2025.103162_bib32","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1158\/0008-5472.CAN-14-1259","article-title":"Accelerated tumor progression in mice lacking the ATP receptor P2X7","volume":"75","author":"Adinolfi","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.tice.2025.103162_bib33","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.2174\/156800911798073069","article-title":"New alkyl-lipid blockers of SK3 channels reduce cancer cell migration and occurrence of metastasis","volume":"11","author":"Gourv\u00e8s","year":"2011","journal-title":"Curr. Cancer Drug Targets"},{"key":"10.1016\/j.tice.2025.103162_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111854","article-title":"Lipidic synthetic alkaloids as SK3 channel modulators. Synthesis and biological evaluation of 2-substituted tetrahydropyridine derivatives with potential anti-metastatic activity","volume":"186","author":"Kouba","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.tice.2025.103162_bib35","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.1038\/onc.2016.501","article-title":"The SigmaR1 chaperone drives breast and colorectal cancer cell migration by tuning SK3-dependent Ca2+homeostasis","volume":"36","author":"Gueguinou","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.tice.2025.103162_bib36","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1038\/onc.2010.593","article-title":"P2X(7) receptor activation enhances SK3 channels- and cystein cathepsin-dependent cancer cells invasiveness","volume":"30","author":"Baroja-Mazo","year":"2011","journal-title":"Oncogene"}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625004446?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625004446?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:07:16Z","timestamp":1785298036000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816625004446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":36,"alternative-id":["S0040816625004446"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2025.103162","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Purinergic ion channel-type P2X7 receptor regulates SK3 channel to promote the progression of gastric cancer","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2025.103162","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103162"}}