{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T05:00:41Z","timestamp":1785301241611,"version":"3.55.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003454","name":"Guangxi Zhuang Autonomous Region Health Department","doi-asserted-by":"publisher","award":["Z-A20231248"],"award-info":[{"award-number":["Z-A20231248"]}],"id":[{"id":"10.13039\/501100003454","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2704803"],"award-info":[{"award-number":["2022YFC2704803"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.tice.2025.103198","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T22:57:21Z","timestamp":1761433041000},"page":"103198","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The effect of Klotho protein on biological behavior of JEG-3 cells"],"prefix":"10.1016","volume":"98","author":[{"given":"Guixiang","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.tice.2025.103198_bib1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13045-018-0616-2","article-title":"Randomized, phase I\/II study of gemcitabine plus IGF-1R antagonist (MK-0646) versus gemcitabine plus erlotinib with and without MK-0646 for advanced pancreatic adenocarcinoma","volume":"11","author":"Abdel-Wahab","year":"2018","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.tice.2025.103198_bib2","doi-asserted-by":"crossref","first-page":"579","DOI":"10.3892\/mmr.2014.2258","article-title":"Insulin-like growth factors in embryonic and fetal growth and skeletal development M. Kanbay et al. | 1581","volume":"10","author":"Agrogiannis","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.tice.2025.103198_bib3","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41390-020-0803-z","article-title":"Effects of Klotho supplementation on hyperoxia-induced renal injury in a rodent model of postnatal nephrogenesis","volume":"88","author":"Ali","year":"2020","journal-title":"Pedia Res."},{"issue":"1","key":"10.1016\/j.tice.2025.103198_bib4","first-page":"91","article-title":"Relationship between insulin-like growth factor type 1 and intrauterine growth","volume":"59","author":"Banjac","year":"2020","journal-title":"Acta Clin. Croat."},{"key":"10.1016\/j.tice.2025.103198_bib5","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.placenta.2024.11.005","article-title":"Understanding the impact of placental oxidative and nitrative stress in pregnancies complicated by fetal growth restriction","volume":"158","author":"Brooker","year":"2024","journal-title":"Placenta"},{"key":"10.1016\/j.tice.2025.103198_bib6","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s12013-015-0710-9","article-title":"Potential role of placental klotho in the pathogenesis of preeclampsia","volume":"74","author":"Cecati","year":"2016","journal-title":"Cell Biochem Biophys."},{"issue":"5","key":"10.1016\/j.tice.2025.103198_bib7","first-page":"789","article-title":"Dysregulated GH\/IGF-1 axis in preeclampsia: a meta-analysis","volume":"108","author":"Chen","year":"2023","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.tice.2025.103198_bib8","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCRESAHA.120.317348","article-title":"Klotho deficiency causes heart aging via impairing the Nrf2-GR pathway","volume":"128","author":"Chen","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.tice.2025.103198_bib9","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.cmet.2016.12.004","article-title":"FGF21 is an exocrine pancreas secretagogue","volume":"25","author":"Coate","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.tice.2025.103198_bib10","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1113\/JP281647","article-title":"KLB dysregulation mediates disrupted muscle development in intrauterine growth restriction","volume":"600","author":"Cortes-Araya","year":"2022","journal-title":"J. Physiol."},{"key":"10.1016\/j.tice.2025.103198_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.636403","article-title":"The complex world of regulation of pituitary growth hormone secretion: the role of Ghrelin, Klotho, and Nesfatins in it","volume":"12","author":"Devesa","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.tice.2025.103198_bib12","doi-asserted-by":"crossref","first-page":"369","DOI":"10.4103\/1735-5362.263627","article-title":"Klotho induces insulin resistance possibly through interference with GLUT4 translocation and activation of Akt, GSK3beta, and PFKfbeta3 in 3T3-L1 adipocyte cells","volume":"14","author":"Hasannejad","year":"2019","journal-title":"Res. Pharm. Sci."},{"issue":"11","key":"10.1016\/j.tice.2025.103198_bib13","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1055\/s-0036-1586109","article-title":"Role of insulinlike growth factor 1 in fetal development and in the early postnatal life of premature infants","volume":"33","author":"Hellstr\u00f6m","year":"2016","journal-title":"Am. J. Perinatol."},{"key":"10.1016\/j.tice.2025.103198_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118644","article-title":"Epigenetic and nonepigenetic regulation of Klotho in kidney disease","volume":"264","author":"Kale","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.tice.2025.103198_bib15","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1093\/ndt\/gfae066","article-title":"Klotho in pregnancy and intrauterine development\u2014potential clinical implications: a review from the European Renal Association CKD-MBD Working Group","volume":"39","author":"Kanbay","year":"2024","journal-title":"Nephrol. Dial. Transpl."},{"key":"10.1016\/j.tice.2025.103198_bib16","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202301916","article-title":"Feto-maternal cholesterol transport regulated by \u03b2-Klotho-FGF15 axis is essential for fetal growth","volume":"6","author":"Kobayashi","year":"2023","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.tice.2025.103198_bib17","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41581-018-0078-3","article-title":"The Klotho proteins in health and disease","volume":"15","author":"Kuro-O","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.tice.2025.103198_bib18","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s00424-009-0722-7","article-title":"Klotho flugers Arch","volume":"459","author":"Kuro-o","year":"2010","journal-title":"Eur. J. Physiol."},{"key":"10.1016\/j.tice.2025.103198_bib19","first-page":"1","article-title":"Upregulation of Klotho aggravates insulin resistance in gestational diabetes mellitus trophoblast cells","volume":"2022","author":"Lin","year":"2022","journal-title":"Genet. Res."},{"key":"10.1016\/j.tice.2025.103198_bib20","doi-asserted-by":"crossref","first-page":"449","DOI":"10.3109\/14767058.2013.818652","article-title":"The anti-aging factor \u03b1-klotho during human pregnancy and its expression in pregnancies complicated by small-for-gestational-age neonates and\/or preeclampsia","volume":"27","author":"Miranda","year":"2014","journal-title":"J. Matern Fetal Neonatal Med."},{"key":"10.1016\/j.tice.2025.103198_bib21","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.tem.2014.10.002","article-title":"Tissue-specific actions of the metabolic hormones FGF15\/19 and FGF21","volume":"26","author":"Owen","year":"2015","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.tice.2025.103198_bib22","article-title":"Pathobiology of the Klotho antiaging protein and therapeutic considerations","volume":"3","author":"Prud'homme","year":"2022","journal-title":"Front. Aging"},{"key":"10.1016\/j.tice.2025.103198_bib23","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1530\/EJE-12-0476","article-title":"Plasma soluble \u03b1-klotho protein levels in premature and term neonates: correlations with growth and metabolic parameters","volume":"167","author":"Siahanidou","year":"2012","journal-title":"Eur. J. Endocrinol."},{"issue":"2","key":"10.1016\/j.tice.2025.103198_bib24","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3892\/br.2017.930","article-title":"Human placental growth hormone in normal and abnormal fetal growth","volume":"7","author":"Velegrakis","year":"2017","journal-title":"Biomed. Rep."},{"key":"10.1016\/j.tice.2025.103198_bib25","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1210\/er.2013-1079","article-title":"Molecular basis of Klotho: from gene to function in aging","volume":"36","author":"Xu","year":"2015","journal-title":"Endocr. Rev."},{"issue":"2","key":"10.1016\/j.tice.2025.103198_bib26","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/s41420-024-01888-6","article-title":"Klotho suppresses tumor growth via IGF-1R signaling in placental carcinomas","volume":"15","author":"Zhang","year":"2024","journal-title":"Cell Death Dis."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004081662500480X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004081662500480X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:19:32Z","timestamp":1785298772000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004081662500480X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":26,"alternative-id":["S004081662500480X"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2025.103198","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of Klotho protein on biological behavior of JEG-3 cells","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2025.103198","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103198"}}