{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:11:58Z","timestamp":1791267118132,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274588"],"award-info":[{"award-number":["82274588"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.tice.2025.103234","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T10:59:57Z","timestamp":1763636397000},"page":"103234","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Scutellarin reduces apoptosis in R28 cells induced by continuous hydrostatic pressure combined with oxygen-glucose deprivation through the Keap1\/Nrf2\/NF-\u03baB pathway"],"prefix":"10.1016","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5498-4762","authenticated-orcid":false,"given":"Hongda","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.tice.2025.103234_bib1","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.3390\/antiox12071465","article-title":"Oxidative Stress: A Suitable Therapeutic Target for Optic Nerve Diseases","volume":"12","author":"Buonfiglio","year":"2023","journal-title":"Antioxid. (Basel)"},{"issue":"11","key":"10.1016\/j.tice.2025.103234_bib2","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.3390\/antiox12112011","article-title":"Targeting Mitochondrial Dysfunction and Oxidative Stress to Prevent the Neurodegeneration of Retinal Ganglion Cells","volume":"12","author":"Catalani","year":"2023","journal-title":"Antioxid. (Basel)"},{"key":"10.1016\/j.tice.2025.103234_bib3","doi-asserted-by":"crossref","DOI":"10.1007\/s12035-025-04933-2","article-title":"Scutellarin Modulates Astrocyte-Microglia-Neuron Crosstalk to Mitigate Neuroinflammation and Apoptosis in Cerebral Ischemia","author":"Chen","year":"2025","journal-title":"Mol. Neurobiol."},{"issue":"8","key":"10.1016\/j.tice.2025.103234_bib4","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1111\/nep.14069","article-title":"Scutellarin protects the kidney from ischemia\/reperfusion injury by targeting Nrf2","volume":"27","author":"Dai","year":"2022","journal-title":"Nephrol. (Carlton)"},{"issue":"Pt A","key":"10.1016\/j.tice.2025.103234_bib5","article-title":"Qingguang'An II decoction attenuates retinal ganglion cell pyroptosis in glaucoma via inhibition of the TRPV4\/NF-\u03baB signaling pathway","volume":"355","author":"Huang","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.tice.2025.103234_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2022.101136","article-title":"Glaucomatous optic neuropathy: Mitochondrial dynamics, dysfunction and protection in retinal ganglion cells","volume":"95","author":"Ju","year":"2023","journal-title":"Prog. Retin Eye Res"},{"issue":"1","key":"10.1016\/j.tice.2025.103234_bib7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00056-016-0061-1","article-title":"Continuous hydrostatic pressure induces differentiation phenomena in chondrocytes mediated by changes in polycystins, SOX9, and RUNX2","volume":"78","author":"Karamesinis","year":"2017","journal-title":"J. Orofac. Orthop."},{"issue":"6","key":"10.1016\/j.tice.2025.103234_bib8","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.3390\/antiox12061211","article-title":"Mammalian Animal and Human Retinal Organ Culture as Pre-Clinical Model to Evaluate Oxidative Stress and Antioxidant Intraocular Therapeutics","volume":"12","author":"Kropp","year":"2023","journal-title":"Antioxid. (Basel)"},{"key":"10.1016\/j.tice.2025.103234_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.114253","article-title":"Harnessing engineered adaptive nanoparticles to modulate macrophages for treating corneal alkali burns","volume":"387","author":"Qin","year":"2025","journal-title":"J. Control Release"},{"issue":"1","key":"10.1016\/j.tice.2025.103234_bib10","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s40104-025-01255-0","article-title":"LAPTM4B as a key regulator in the copper-induced endoplasmic reticulum-lysosome interplay disorder in duck liver and the protective role of baicalin","volume":"16","author":"Shang","year":"2025","journal-title":"J. Anim. Sci. Biotechnol."},{"issue":"32","key":"10.1016\/j.tice.2025.103234_bib11","article-title":"Scutellarin Rescued Mitochondrial Damage through Ameliorating Mitochondrial Glucose Oxidation via the Pdk-Pdc Axis","volume":"10","author":"Sheng","year":"2023","journal-title":"Adv. Sci. (Weinh. )"},{"issue":"1","key":"10.1016\/j.tice.2025.103234_bib12","doi-asserted-by":"crossref","first-page":"211","DOI":"10.7150\/ijbs.103222","article-title":"The role of RGC degeneration in the pathogenesis of glaucoma","volume":"21","author":"Si","year":"2025","journal-title":"Int J. Biol. Sci."},{"key":"10.1016\/j.tice.2025.103234_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.118052","article-title":"Synthesis and evaluation of lansiumamide B analogues to ameliorate acute lung injury by reducing oxidative stress and inflammation via Keap1\/Nrf2\/NF-\u03baB pathway","volume":"299","author":"Song","year":"2025","journal-title":"Eur. J. Med Chem."},{"key":"10.1016\/j.tice.2025.103234_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.132917","article-title":"Scutellarin targets Wnt5a against zearalenone-induced apoptosis in mouse granulosa cells in vitro and in vivo","volume":"464","author":"Sun","year":"2024","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.tice.2025.103234_bib15","first-page":"428","article-title":"Photothermal therapy with regulated Nrf2\/NF-\u03baB signaling pathway for treating bacteria-induced periodontitis","volume":"9","author":"Tian","year":"2022","journal-title":"Bioact. Mater."},{"issue":"4","key":"10.1016\/j.tice.2025.103234_bib16","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3892\/ijmm.2025.5504","article-title":"The molecular mechanisms underlying retinal ganglion cell apoptosis and optic nerve regeneration in glaucoma (Review)","volume":"55","author":"Wang","year":"2025","journal-title":"Int J. Mol. Med"},{"issue":"1","key":"10.1016\/j.tice.2025.103234_bib17","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13024-022-00524-0","article-title":"Solving neurodegeneration: common mechanisms and strategies for new treatments","volume":"17","author":"Wareham","year":"2022","journal-title":"Mol. Neurodegener."},{"issue":"11","key":"10.1016\/j.tice.2025.103234_bib18","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20192501","article-title":"Scutellarin attenuates hypoxia\/reoxygenation injury in hepatocytes by inhibiting apoptosis and oxidative stress through regulating Keap1\/Nrf2\/ARE signaling","volume":"39","author":"Wu","year":"2019","journal-title":"Biosci. Rep."},{"issue":"1","key":"10.1016\/j.tice.2025.103234_bib19","doi-asserted-by":"crossref","first-page":"9057","DOI":"10.1038\/s41598-019-45510-7","article-title":"An in vitro pressure model towards studying the response of primary retinal ganglion cells to elevated hydrostatic pressures","volume":"9","author":"Wu","year":"2019","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.tice.2025.103234_bib20","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3892\/mmr.2024.13207","article-title":"Apoptosis in glaucoma: A new direction for the treatment of glaucoma (Review)","volume":"29","author":"Xia","year":"2024","journal-title":"Mol. Med Rep."},{"key":"10.1016\/j.tice.2025.103234_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175979","article-title":"Scutellarin attenuates oxidative stress and neuroinflammation in cerebral ischemia\/reperfusion injury through PI3K\/Akt-mediated Nrf2 signaling pathways","volume":"957","author":"Xie","year":"2023","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.tice.2025.103234_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113781","article-title":"Scutellarin ameliorates osteoarthritis by protecting chondrocytes and subchondral bone microstructure by inactivating NF-\u03baB\/MAPK signal transduction","volume":"155","author":"Yang","year":"2022","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.tice.2025.103234_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117340","article-title":"Scutellarin ameliorates mitochondrial dysfunction and apoptosis in OGD\/R-insulted HT22 cells through mitophagy induction","volume":"179","author":"Yang","year":"2024","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.tice.2025.103234_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102687","article-title":"Pathologically high intraocular pressure induces mitochondrial dysfunction through Drp1 and leads to retinal ganglion cell PANoptosis in glaucoma","volume":"62","author":"Zeng","year":"2023","journal-title":"Redox Biol."},{"issue":"7","key":"10.1016\/j.tice.2025.103234_bib25","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1631\/jzus.B2200612","article-title":"Scutellarin prevents acute alcohol-induced liver injury via inhibiting oxidative stress by regulating the Nrf2\/HO-1 pathway and inhibiting inflammation by regulating the AKT, p38 MAPK\/NF-\u03baB pathways","volume":"24","author":"Zhang","year":"2023","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"10.1016\/j.tice.2025.103234_bib26","article-title":"Oral Scutellarin Treatment Ameliorates Retinal Thinning and Visual Deficits in Experimental Glaucoma","volume":"8","author":"Zhu","year":"2021","journal-title":"Front Med (Lausanne)"}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625005166?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625005166?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T14:00:05Z","timestamp":1773324005000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816625005166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":26,"alternative-id":["S0040816625005166"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2025.103234","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Scutellarin reduces apoptosis in R28 cells induced by continuous hydrostatic pressure combined with oxygen-glucose deprivation through the Keap1\/Nrf2\/NF-\u03baB pathway","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2025.103234","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103234"}}