{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T17:11:45Z","timestamp":1769620305272,"version":"3.49.0"},"reference-count":91,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.tice.2025.103295","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T16:32:58Z","timestamp":1766766778000},"page":"103295","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Adipose tissue- derived mesenchymal stem cells versus puerarin for ameliorating nicotine- induced pancreatic fibrosis in rats"],"prefix":"10.1016","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4479-4802","authenticated-orcid":false,"given":"Heba F.","family":"Ibrahim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eman H.","family":"Thabet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Assem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basma","family":"Mady","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soha","family":"Elatrebi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manal Ahmed","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiman I.","family":"Zaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2025.103295_bib1","article-title":"Omega 3 fish oil-based lipid nanocapsules augment the therapeutic effects of vitamin D3 in a rat model of doxorubicin-induced cardiotoxicity","volume":"104","author":"Abd El Mottelib","year":"2025","journal-title":"J. Drug Deliv. Sci. Technol."},{"issue":"6","key":"10.1016\/j.tice.2025.103295_bib2","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1080\/01913123.2024.2407330","article-title":"The possible effects of chronic administration of amiodarone hydrochloride on the seminiferous tubules of adult male albino rats: histological and biochemical study","volume":"48","author":"Abo-Ouf","year":"2024","journal-title":"Ultrastruct. Pathol."},{"issue":"10","key":"10.1016\/j.tice.2025.103295_bib3","doi-asserted-by":"crossref","first-page":"7767","DOI":"10.1007\/s00210-024-03120-9","article-title":"Nicotine exacerbates liver damage in a mice model of Ehrlich ascites carcinoma through shifting SOD\/NF-\u03baB\/caspase-3 pathways: ameliorating role of Chlorella vulgaris","volume":"397","author":"Abu-Zeid","year":"2024","journal-title":"Naunyn. Schmiede Arch. Pharm."},{"issue":"12","key":"10.1016\/j.tice.2025.103295_bib4","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1111\/exd.13787","article-title":"Effect of oral isotretinoin on the nucleo-cytoplasmic distribution of FoxO1 and FoxO3 proteins in sebaceous glands of patients with acne vulgaris","volume":"27","author":"Agamia","year":"2018","journal-title":"Exp. Dermatol."},{"issue":"6","key":"10.1016\/j.tice.2025.103295_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0197362","article-title":"Cigarette toxin 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces experimental pancreatitis through \u03b17 nicotinic acetylcholine receptors (nAChRs) in mice","volume":"13","author":"Alahmari","year":"2018","journal-title":"Plos One"},{"issue":"1","key":"10.1016\/j.tice.2025.103295_bib6","doi-asserted-by":"crossref","first-page":"79","DOI":"10.21608\/jmh.2020.23716.1073","article-title":"The Possible Effects of Caffeine and Nicotine on the Pathogenesis of Experimentally Induced Alcoholic Pancreatitis: A Histological and Immunohistochemical Study","volume":"4","author":"Alazouny","year":"2020","journal-title":"J. Med. Histol."},{"issue":"6","key":"10.1016\/j.tice.2025.103295_bib7","doi-asserted-by":"crossref","first-page":"E1323","DOI":"10.1152\/ajpendo.90617.2008","article-title":"Evaluating the glucose tolerance test in mice","volume":"295","author":"Andrikopoulos","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"8","key":"10.1016\/j.tice.2025.103295_bib8","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.pan.2019.09.004","article-title":"Tobacco smoking and the risk of pancreatitis: A systematic review and meta-analysis of prospective studies","volume":"19","author":"Aune","year":"2019","journal-title":"Pancreatology"},{"key":"10.1016\/j.tice.2025.103295_bib9","article-title":"Molecular Mechanism of Puerarin Against Diabetes and its Complications","volume":"12","author":"Bai","year":"2021","journal-title":"Front. Pharm."},{"key":"10.1016\/j.tice.2025.103295_bib10","series-title":"Bancroft\u2019s Theory and Practice of Histological Techniques","first-page":"25","article-title":"Light microscopy","author":"Bancroft","year":"2019"},{"issue":"10249","key":"10.1016\/j.tice.2025.103295_bib11","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0140-6736(20)31318-0","article-title":"Chronic pancreatitis","volume":"396","author":"Beyer","year":"2020","journal-title":"Lancet (Lond. Engl. )"},{"issue":"14","key":"10.1016\/j.tice.2025.103295_bib12","doi-asserted-by":"crossref","first-page":"5586","DOI":"10.3390\/molecules28145586","article-title":"Pancreatic Stellate Cells and the Targeted Therapeutic Strategies in Chronic Pancreatitis","volume":"28","author":"Chang","year":"2023","journal-title":"Mol. (Basel Switz. )"},{"issue":"4","key":"10.1016\/j.tice.2025.103295_bib13","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/s41419-024-06620-x","article-title":"The dual role of mesenchymal stem cells in apoptosis regulation","volume":"15","author":"Chen","year":"2024","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.tice.2025.103295_bib14","doi-asserted-by":"crossref","first-page":"R834","DOI":"10.1152\/ajpregu.00270.2017","article-title":"Chronic inhalation of e-cigarette vapor containing nicotine disrupts airway barrier function and induces systemic inflammation and multiorgan fibrosis in mice","volume":"314","author":"Crotty Alexander","year":"2018","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"1","key":"10.1016\/j.tice.2025.103295_bib15","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s12967-021-02822-5","article-title":"Chemokines and their receptors: predictors of the therapeutic potential of mesenchymal stromal cells","volume":"19","author":"Cuesta-Gomez","year":"2021","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.tice.2025.103295_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110541","article-title":"S1P\/S1PR2 promote pancreatic stellate cell activation and pancreatic fibrosis in chronic pancreatitis by regulating autophagy and the NLRP3 inflammasome","volume":"380","author":"Cui","year":"2023","journal-title":"Chem. Biol. Inter."},{"issue":"4","key":"10.1016\/j.tice.2025.103295_bib17","doi-asserted-by":"crossref","first-page":"3888","DOI":"10.3390\/ijms24043888","article-title":"Adipose-Derived Mesenchymal Stromal Cells in Basic Research and Clinical Applications","volume":"24","author":"Czerwiec","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2025.103295_bib18","series-title":"A Manual of applied techniques for biological electron microscopy","first-page":"1","article-title":"Specimen preparation In","author":"Dykstra","year":"2017"},{"issue":"4","key":"10.1016\/j.tice.2025.103295_bib19","doi-asserted-by":"crossref","first-page":"931","DOI":"10.5603\/FM.a2021.0093","article-title":"The role of the adipose tissue-derived mesenchymal stem cells enriched with melatonin in pancreatic cellular regeneration","volume":"81","author":"El Aasar","year":"2022","journal-title":"Folia Morpho"},{"issue":"11","key":"10.1016\/j.tice.2025.103295_bib20","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1113\/JP281135","article-title":"When healing turns into killing\u2013the pathophysiology of pancreatic and hepatic fibrosis","volume":"600","author":"Ferdek","year":"2022","journal-title":"J. Physiol."},{"key":"10.1016\/j.tice.2025.103295_bib21","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/bs.mcb.2022.04.011","article-title":"Methods to isolate adipose tissue-derived stem cells","volume":"171","author":"Ferroni","year":"2022","journal-title":"Methods Cell Biol."},{"issue":"3","key":"10.1016\/j.tice.2025.103295_bib22","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s11938-015-0056-9","article-title":"Epidemiologic and Mechanistic Associations Between Smoking and Pancreatitis","volume":"13","author":"Greer","year":"2015","journal-title":"Curr. Treat. Options Gastroenterol."},{"key":"10.1016\/j.tice.2025.103295_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2023.111989","article-title":"Nicotine promotes renal interstitial fibrosis via upregulation of XIAP in an alpha7-nAChR-dependent manner","volume":"576","author":"Guo","year":"2023","journal-title":"Mol. Cell Endocrinol."},{"issue":"1","key":"10.1016\/j.tice.2025.103295_bib24","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s10654-022-00945-7","article-title":"Smoking as the most important risk factor for chronic pancreatitis in the general population","volume":"38","author":"Hansen","year":"2023","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.tice.2025.103295_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.939910","article-title":"Clinical characteristics of smoking-related chronic pancreatitis","volume":"12","author":"Hao","year":"2022","journal-title":"Front. Cell Infect. Microbiol"},{"issue":"6","key":"10.1016\/j.tice.2025.103295_bib26","first-page":"5956","article-title":"Comparison of bone marrow-vs. adipose tissue-derived mesenchymal stem cells for attenuating liver fibrosis","volume":"14","author":"Hao","year":"2017","journal-title":"Exp. Ther. Med."},{"issue":"1","key":"10.1016\/j.tice.2025.103295_bib27","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s13287-025-04236-2","article-title":"Donor age and breed determine mesenchymal stromal cell characteristics","volume":"16","author":"Heyman","year":"2025","journal-title":"Stem. Cell. Res. Ther."},{"key":"10.1016\/j.tice.2025.103295_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155813","article-title":"Puerarin suppresses macrophage M1 polarization to alleviate renal inflammatory injury through antagonizing TLR4\/MyD88-mediated NF-\u03baB p65 and JNK\/FoxO1 activation","volume":"132","author":"Hu","year":"2024","journal-title":"Phytomedicine"},{"issue":"3","key":"10.1016\/j.tice.2025.103295_bib29","doi-asserted-by":"crossref","first-page":"189","DOI":"10.2174\/0118715303287050240223073217","article-title":"PUERARIN: A Potential Supplement for Diabetes and its Complications","volume":"25","author":"Huai","year":"2025","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"issue":"2","key":"10.1016\/j.tice.2025.103295_bib30","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s13770-020-00309-w","article-title":"The Therapeutic Potential of Amniotic Fluid-Derived Stem Cells on Busulfan-Induced Azoospermia in Adult Rats","volume":"18","author":"Ibrahim","year":"2021","journal-title":"Tissue Eng. Regen. Med."},{"issue":"2","key":"10.1016\/j.tice.2025.103295_bib31","first-page":"518","article-title":"The Protective Impact of Lycopene and Folic Acid Supplementation Against Nicotine Toxicity on Pancreatic Islets in Adult Male Albino Rats: Biochemical and Immuno-Histochemical Study","volume":"46","author":"Ibrahim","year":"2023","journal-title":"Egypt. J. Histol."},{"issue":"2","key":"10.1016\/j.tice.2025.103295_bib32","first-page":"215","article-title":"Effects of Cigarette Smoke and Electronic Cigarette Vapors on Lung Histomorphology: A Comparative Study in Rats","volume":"29","author":"Jadoon","year":"2023","journal-title":"Pak. J. Chest Med."},{"key":"10.1016\/j.tice.2025.103295_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176996","article-title":"Mesenchymal stem cells alleviate inflammatory responses through regulation of T-cell subsets","volume":"983","author":"Ji","year":"2024","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.tice.2025.103295_bib34","doi-asserted-by":"crossref","DOI":"10.1590\/acb382523","article-title":"Puerarin alleviated oxidative stress and ferroptosis during renal fibrosis induced by ischemia\/reperfusion injury via TLR4\/Nox4 pathway in rats","volume":"38","author":"Jian","year":"2023","journal-title":"Acta Cir. Bras."},{"key":"10.1016\/j.tice.2025.103295_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112655","article-title":"Roles and mechanisms of puerarin on cardiovascular disease\uff1aA review","volume":"147","author":"Jiang","year":"2022","journal-title":"Biomed. Pharm."},{"issue":"4","key":"10.1016\/j.tice.2025.103295_bib36","doi-asserted-by":"crossref","first-page":"539","DOI":"10.4142\/jvs.2016.17.4.539","article-title":"Canine adipose tissue-derived mesenchymal stem cells ameliorate severe acute pancreatitis by regulating T cells in rats","volume":"17","author":"Kim","year":"2016","journal-title":"J. Vet. Sci."},{"issue":"8","key":"10.1016\/j.tice.2025.103295_bib37","doi-asserted-by":"crossref","first-page":"6216","DOI":"10.3390\/cimb45080392","article-title":"Regeneration of Pancreatic Beta Cells by Modulation of Molecular Targets Using Plant-Derived Compounds: Pharmacological Mechanisms and Clinical Potential","volume":"45","author":"Kimani","year":"2023","journal-title":"Curr. Issues Mol. Biol."},{"issue":"3","key":"10.1016\/j.tice.2025.103295_bib38","first-page":"3","article-title":"Effect of ghrelin in alleviating nicotine induced oxidative stress in BALB\/C mice","volume":"18","author":"Kiyani","year":"2022","journal-title":"Paki. J. Physiol."},{"issue":"1","key":"10.1016\/j.tice.2025.103295_bib39","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3390\/biomedicines12010108","article-title":"Activation and Regulation of Pancreatic Stellate Cells in Chronic Pancreatic Fibrosis: A Potential Therapeutic Approach for Chronic Pancreatitis","volume":"12","author":"Kong","year":"2024","journal-title":"Biomedicines"},{"issue":"8","key":"10.1016\/j.tice.2025.103295_bib40","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.3390\/cells10081908","article-title":"Processing and Ex Vivo Expansion of Adipose Tissue-Derived Mesenchymal Stem\/Stromal Cells for the Development of an Advanced Therapy Medicinal Product for use in Humans","volume":"10","author":"Labedz-Maslowska","year":"2021","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.tice.2025.103295_bib41","doi-asserted-by":"crossref","first-page":"8515","DOI":"10.1080\/21655979.2022.2051838","article-title":"Exosomes from human adipose-derived mesenchymal stem cells inhibit production of extracellular matrix in keloid fibroblasts via downregulating transforming growth factor-\u03b22 and Notch-1 expression","volume":"13","author":"Li","year":"2022","journal-title":"Bioengineered"},{"key":"10.1016\/j.tice.2025.103295_bib42","article-title":"A dose-response correlation between smoking and severity of acute pancreatitis: a propensity score-matched study","volume":"11","author":"Li","year":"2024","journal-title":"Front. Med."},{"issue":"1","key":"10.1016\/j.tice.2025.103295_bib43","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1186\/s12876-024-03481-8","article-title":"Global and regional burden of pancreatitis: epidemiological trends, risk factors, and projections to 2050 from the global burden of disease study 2021","volume":"24","author":"Li","year":"2024","journal-title":"Bmc. Gastroenterol."},{"key":"10.1016\/j.tice.2025.103295_bib44","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.toxlet.2021.06.012","article-title":"Nicotine facilitates pancreatic fibrosis by promoting activation of pancreatic stellate cells via \u03b17nAChR-mediated JAK2\/STAT3 signaling pathway in rats","volume":"349","author":"Li","year":"2021","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tice.2025.103295_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117301","article-title":"Nicotine promotes activation of human pancreatic stellate cells through inducing autophagy via \u03b17nAChR-mediated JAK2\/STAT3 signaling pathway","volume":"243","author":"Li","year":"2020","journal-title":"Life Sci."},{"issue":"10","key":"10.1016\/j.tice.2025.103295_bib46","doi-asserted-by":"crossref","first-page":"5222","DOI":"10.3390\/ijms25105222","article-title":"Puerarin-A Promising Flavonoid: Biosynthesis, Extraction Methods, Analytical Techniques, and Biological Effects","volume":"25","author":"Liga","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2025.103295_bib47","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.12659\/MSM.902227","article-title":"The Effects and Possible Mechanisms of Puerarin to Treat Uterine Fibrosis Induced by Ischemia-Reperfusion Injury in Rats","volume":"23","author":"Lin","year":"2017","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.tice.2025.103295_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114721","article-title":"Puerarin exerts an inhibitory effect on inflammatory infiltration in the cardiac tissue of EAM mice by regulation of the TNF-\u03b1\/CCL2\/CCR2 signal pathway","volume":"157","author":"Liu","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"10.1016\/j.tice.2025.103295_bib49","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1002\/med.21801","article-title":"Mesenchymal stromal cell therapy for pancreatitis: Progress and challenges","volume":"41","author":"Ma","year":"2021","journal-title":"Med. Res. Rev."},{"issue":"1","key":"10.1016\/j.tice.2025.103295_bib50","doi-asserted-by":"crossref","first-page":"127","DOI":"10.47836\/pjst.32.1.08","article-title":"Chromatography and Spectroscopy Methods for the Analysis of Nicotine and Other Chemical Ingredients in E-Liquid Formulation: A Review","volume":"32","author":"Manap","year":"2024","journal-title":"Pertanika J. Sci. Technol."},{"issue":"6","key":"10.1016\/j.tice.2025.103295_bib51","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000457","article-title":"Nicotine aggravates liver fibrosis via \u03b17 nicotinic acetylcholine receptor expressed on activated hepatic stellate cells in mice","volume":"8","author":"Mihara","year":"2024","journal-title":"Hepatol. Commun."},{"issue":"8","key":"10.1016\/j.tice.2025.103295_bib52","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1210\/clinem\/dgad142","article-title":"Adipose-derived Mesenchymal Stem Cells Therapy as a new Treatment Option for Diabetes Mellitus","volume":"108","author":"Mik\u0142osz","year":"2023","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tice.2025.103295_bib53","author":"Molecular Probes","year":"2005","journal-title":"DiI Deriv. Long. Term. Cell. Labeling."},{"issue":"3","key":"10.1016\/j.tice.2025.103295_bib54","first-page":"991","article-title":"Evaluation of the Probable Alleviating Effect of Luteolin on Acrylamide Mediated Toxicity of the Caput Epididymal Lining Epithelium in Adult Rats: Histological and Biochemical Study","volume":"47","author":"Nabil","year":"2024","journal-title":"Egypt. J. Histol."},{"issue":"2","key":"10.1016\/j.tice.2025.103295_bib55","first-page":"120","article-title":"Influence of Prenatal Administration of Nicotine\/Thiocyanate on the Morphology of Exocrine Pancreas of 1-Month-Old Rat Offspring","volume":"42","author":"Othman","year":"2020","journal-title":"Bahrain Med. Bull."},{"key":"10.1016\/j.tice.2025.103295_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2025.106453","article-title":"Exploring kudzu: Extraction, quantification, and health impacts of bioactive compounds","volume":"182","author":"Patil","year":"2025","journal-title":"Fitoterapia"},{"issue":"1","key":"10.1016\/j.tice.2025.103295_bib57","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s13287-023-03381-w","article-title":"MSCs' conditioned media cytokine and growth factor profiles and their impact on macrophage polarization","volume":"14","author":"Peshkova","year":"2023","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.tice.2025.103295_bib58","first-page":"83","article-title":"Colony forming unit assays for MSCs","volume":"449","author":"Pochampally","year":"2008","journal-title":"Methods Mol. Biol."},{"issue":"20","key":"10.1016\/j.tice.2025.103295_bib59","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202207334","article-title":"An Update on Adipose-Derived Stem Cells for Regenerative Medicine: Where Challenge Meets Opportunity","volume":"10","author":"Qin","year":"2023","journal-title":"Adv. Sci."},{"issue":"3","key":"10.1016\/j.tice.2025.103295_bib60","first-page":"71","article-title":"An improvement of the 2\u02c6(-delta delta CT) method for quantitative real-time polymerase chain reaction data analysis","volume":"3","author":"Rao","year":"2013","journal-title":"Biostat. Bioinforma. Biomath."},{"issue":"2","key":"10.1016\/j.tice.2025.103295_bib61","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/MPA.0000000000000721","article-title":"Pancreatic Insufficiency Secondary to Tobacco Exposure: A Controlled Cross-Sectional Evaluation","volume":"46","author":"Raphael","year":"2017","journal-title":"Pancreas"},{"key":"10.1016\/j.tice.2025.103295_bib62","article-title":"Therapeutic potential and mechanisms of puerarin in liver disease: A comprehensive review of pharmacological effects and drug delivery innovations","volume":"14","author":"Ravikumar","year":"2025","journal-title":"Pharmacol. Res."},{"issue":"21","key":"10.1016\/j.tice.2025.103295_bib63","doi-asserted-by":"crossref","first-page":"8366","DOI":"10.3390\/ijms21218366","article-title":"Application of Mesenchymal Stem Cells in Inflammatory and Fibrotic Diseases","volume":"21","author":"Ryu","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.tice.2025.103295_bib64","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1093\/stcltm\/szae045","article-title":"Exploring mesenchymal stem cells homing mechanisms and improvement strategies","volume":"13","author":"Sajjad","year":"2024","journal-title":"Stem Cells Transl. Med."},{"issue":"19","key":"10.1016\/j.tice.2025.103295_bib65","doi-asserted-by":"crossref","first-page":"14570","DOI":"10.3390\/ijms241914570","article-title":"Nicotine: From Discovery to Biological Effects","volume":"24","author":"Sansone","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2025.103295_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2024.109959","article-title":"Acute nicotine activates orectic and inhibits anorectic brain regions in rats exposed to chronic nicotine","volume":"253","author":"Shankar","year":"2024","journal-title":"Neuropharmacology"},{"issue":"7","key":"10.1016\/j.tice.2025.103295_bib67","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.1016\/j.ymthe.2025.03.028","article-title":"AAT-MSC-EVs: Novel implications for suppressing ferroptosis, fibrosis and pain associated with chronic pancreatitis","volume":"33","author":"Shoeibi","year":"2025","journal-title":"Mol. Ther."},{"issue":"8","key":"10.1016\/j.tice.2025.103295_bib68","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1016\/j.transproceed.2012.07.036","article-title":"Expression of pancreatic endocrine markers by mesenchymal stem cells from human adipose tissue","volume":"44","author":"Silva","year":"2012","journal-title":"Transplant. Proc."},{"issue":"1","key":"10.1016\/j.tice.2025.103295_bib69","doi-asserted-by":"crossref","first-page":"18","DOI":"10.2174\/1574892818666230111152024","article-title":"Puerarin: An Anticancer and Anti-Inflammatory Agent","volume":"19","author":"Singh","year":"2024","journal-title":"Recent Pat. Anticancer Drug Discov."},{"issue":"12","key":"10.1016\/j.tice.2025.103295_bib70","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0143575","article-title":"Chronic Nicotine Exposure In Vivo and In Vitro Inhibits Vitamin B1 (Thiamin) Uptake by Pancreatic Acinar Cells","volume":"10","author":"Srinivasan","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.tice.2025.103295_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2020.152502","article-title":"Nicotine triggers islet \u03b2 cell senescence to facilitate the progression of type 2 diabetes","volume":"441","author":"Sun","year":"2020","journal-title":"Toxicology"},{"issue":"11","key":"10.1016\/j.tice.2025.103295_bib72","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1016\/j.ymthe.2017.06.016","article-title":"Adipose Stem Cell Therapy Mitigates Chronic Pancreatitis via Differentiation into Acinar-like Cells in Mice","volume":"25","author":"Sun","year":"2017","journal-title":"Mol. Ther."},{"key":"10.1016\/j.tice.2025.103295_bib73","doi-asserted-by":"crossref","DOI":"10.1177\/20587384211054036","article-title":"Curative role of mesenchymal stromal cells in chronic pancreatitis: Modulation of MAPK and TGF-\u03b21\/SMAD factors","volume":"35","author":"Taha","year":"2021","journal-title":"Int. J. Immunopathol. Pharm."},{"issue":"2","key":"10.1016\/j.tice.2025.103295_bib74","doi-asserted-by":"crossref","first-page":"723","DOI":"10.3390\/cancers7020723","article-title":"Pathologic cellular events in smoking-related pancreatitis","volume":"7","author":"Thrower","year":"2015","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.tice.2025.103295_bib75","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23622","article-title":"Dexpanthenol exhibits antiapoptotic and anti-inflammatory effects against nicotine-induced liver damage by modulating Bax\/Bcl-xL, Caspase-3\/9, and Akt\/NF-\u03baB pathways","volume":"38","author":"\u00dcremi\u015f","year":"2024","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.tice.2025.103295_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117319","article-title":"Protective effects of puerarin on metabolic diseases: Emphasis on the therapeutical effects and the underlying molecular mechanisms","volume":"179","author":"Wan","year":"2024","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.tice.2025.103295_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153222","article-title":"Puerarin ameliorates hyperglycemia in HFD diabetic mice by promoting \u03b2-cell neogenesis via GLP-1R signaling activation","volume":"70","author":"Wang","year":"2020","journal-title":"Phytomedicine"},{"issue":"11","key":"10.1016\/j.tice.2025.103295_bib78","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.3390\/antiox11112121","article-title":"Pharmacological Activity, Pharmacokinetics, and Clinical Research Progress of Puerarin","volume":"11","author":"Wang","year":"2022","journal-title":"Antioxidants"},{"issue":"1","key":"10.1016\/j.tice.2025.103295_bib79","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1055\/a-1385-8015","article-title":"Berberine Ameliorates Glucose Metabolism in Diabetic Rats through the alpha7 Nicotinic Acetylcholine Receptor-Related Cholinergic Anti-Inflammatory Pathway","volume":"88","author":"Wang","year":"2022","journal-title":"Planta Med"},{"key":"10.1016\/j.tice.2025.103295_bib80","doi-asserted-by":"crossref","first-page":"3697","DOI":"10.2147\/DDDT.S321879","article-title":"Puerarin Alleviates UUO-Induced Inflammation and Fibrosis by Regulating the NF-\u03baB P65\/STAT3 and TGF\u03b21\/Smads Signaling Pathways","volume":"15","author":"Wang","year":"2021","journal-title":"Drug Des. Devel. Ther."},{"issue":"9","key":"10.1016\/j.tice.2025.103295_bib81","doi-asserted-by":"crossref","first-page":"8328","DOI":"10.3390\/ijms24098328","article-title":"Puerarin Prevents Cadmium-Induced Neuronal Injury by Alleviating Autophagic Dysfunction in Rat Cerebral Cortical Neurons","volume":"24","author":"Wang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2025.103295_bib82","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.2147\/IJN.S355366","article-title":"Targeted Therapy for Inflammatory Diseases with Mesenchymal Stem Cells and Their Derived Exosomes: From Basic to Clinics","volume":"17","author":"Wang","year":"2022","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.tice.2025.103295_bib83","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/2920530","article-title":"Herbal Medicines Targeting the Improved \u03b2-Cell Functions and \u03b2-Cell Regeneration for the Management of Diabetes Mellitus","volume":"2021","author":"Wickramasinghe","year":"2021","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.tice.2025.103295_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.117882","article-title":"Negative air ions alleviate nicotine-induced renal damage of spontaneously hypertensive rats via inhibiting oxidative stress and TGF-\u03b2\/Smad pathway","volume":"291","author":"Xiao","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"4","key":"10.1016\/j.tice.2025.103295_bib85","first-page":"1833","article-title":"Adipose\u2011derived mesenchymal stem cells ameliorate dibutyltin dichloride\u2011induced chronic pancreatitis by inhibiting the PI3K\/AKT\/mTOR signaling pathway","volume":"21","author":"Xu","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.tice.2025.103295_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176380","article-title":"Mesenchymal stem cells inhibit ferroptosis by activating the Nrf2 antioxidation pathway in severe acute pancreatitis-associated acute lung injury","volume":"967","author":"Yang","year":"2024","journal-title":"Eur. J. Pharm."},{"issue":"4","key":"10.1016\/j.tice.2025.103295_bib87","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.14336\/AD.2021.1205","article-title":"Neuroprotective Mechanisms of Puerarin in Central Nervous System Diseases: Update","volume":"13","author":"Yu","year":"2022","journal-title":"Aging Dis."},{"issue":"1","key":"10.1016\/j.tice.2025.103295_bib88","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1038\/s41598-024-84808-z","article-title":"Puerarin pretreatment provides protection against myocardial ischemia\/reperfusion injury via inhibiting excessive autophagy and apoptosis by modulation of HES1","volume":"15","author":"Yuan","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2025.103295_bib89","doi-asserted-by":"crossref","DOI":"10.1016\/j.trim.2024.102106","article-title":"Adipose tissue-derived mesenchymal stem cells promote the vascularization of pancreatic islets transplanted into decellularized pancreatic skeletons","volume":"86","author":"Zacharovov\u00e1","year":"2024","journal-title":"Transpl. Immunol."},{"key":"10.1016\/j.tice.2025.103295_bib90","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.686992","article-title":"Puerarin Ameliorates Caerulein-Induced Chronic Pancreatitis via Inhibition of MAPK Signaling Pathway","volume":"12","author":"Zeng","year":"2021","journal-title":"Front. Pharm."},{"key":"10.1016\/j.tice.2025.103295_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117101","article-title":"Pharmacological mechanisms of puerarin in the treatment of Parkinson's disease: An overview","volume":"177","author":"Zhang","year":"2024","journal-title":"Biomed. Pharm."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625005774?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625005774?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T05:15:36Z","timestamp":1769577336000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816625005774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":91,"alternative-id":["S0040816625005774"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2025.103295","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adipose tissue- derived mesenchymal stem cells versus puerarin for ameliorating nicotine- induced pancreatic fibrosis in rats","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2025.103295","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103295"}}