{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T15:44:29Z","timestamp":1782056669799,"version":"3.54.5"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.tice.2025.103306","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:56:01Z","timestamp":1767167761000},"page":"103306","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Phytochemicals in ethanolic extract of Cinnamomum tamala induce cell cycle arrest, DNA damage and apoptosis in human breast cancer cell lines MDA-MB-231 and MCF-7"],"prefix":"10.1016","volume":"100","author":[{"given":"Ishrat","family":"Husain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anu","family":"Chandra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mrinal Ranjan","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzana","family":"Mahdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4804-9925","authenticated-orcid":false,"given":"Rumana","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2025.103306_bib1","first-page":"2","article-title":"Evaluation of the volatile oil composition and antiproliferative activity of Laurus nobilis L. (Lauraceae) on breast cancer cell line models","volume":"8","author":"Abu-Dahab","year":"2014","journal-title":"Record Nat. Prod."},{"key":"10.1016\/j.tice.2025.103306_bib2","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1038\/s12276-022-00863-4","article-title":"DNA damage response revisited: the p53 family and its regulators provide endless cancer therapy opportunities","volume":"54","author":"Abuetabh","year":"2022","journal-title":"Exp. Mol. Med"},{"issue":"2","key":"10.1016\/j.tice.2025.103306_bib3","doi-asserted-by":"crossref","first-page":"122","DOI":"10.2174\/1871520619666191015103712","article-title":"Anticancer potential of dietary natural products: a comprehensive review","volume":"20","author":"Ahmad","year":"2020","journal-title":"AntiCancer Agent. Med. Chem."},{"issue":"4","key":"10.1016\/j.tice.2025.103306_bib4","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.nutres.2010.04.001","article-title":"Volatile oil composition and antiproliferative activity of Laurus nobilis, Origanum syriacum, Origanum vulgare, and Salvia triloba against human breast adenocarcinoma cells","volume":"30","author":"Al-Kalaldeh","year":"2010","journal-title":"Nutr. Res."},{"issue":"1","key":"10.1016\/j.tice.2025.103306_bib5","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-43573-1","article-title":"Phytocompound screening, antioxidant activity and molecular docking studies of pomegranate seed: a preventive approach for SARS-CoV-2 pathogenesis","volume":"13","author":"Ashfaq","year":"2023","journal-title":"Sci. Rep."},{"issue":"23","key":"10.1016\/j.tice.2025.103306_bib6","doi-asserted-by":"crossref","first-page":"6845","DOI":"10.1093\/emboj\/18.23.6845","article-title":"Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation","volume":"18","author":"Bulavin","year":"1999","journal-title":"EMBO J."},{"issue":"5","key":"10.1016\/j.tice.2025.103306_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0020174","article-title":"Two naturally occurring terpenes, dehydrocostuslactone and costunolide, decrease intracellular GSH content and inhibit STAT3 activation","volume":"6","author":"Butturini","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.tice.2025.103306_bib8","first-page":"3","article-title":"Isolation of endophytic fungi and actinomycetes taxane producers","volume":"50","author":"Caruso","year":"2000","journal-title":"Ann. Microbiol"},{"issue":"11","key":"10.1016\/j.tice.2025.103306_bib9","doi-asserted-by":"crossref","first-page":"4935","DOI":"10.7150\/thno.73223","article-title":"Histone acetyltransferases CBP\/p300 in tumorigenesis and CBP\/p300 inhibitors as promising novel anticancer agents","volume":"12","author":"Chen","year":"2022","journal-title":"Theranostics"},{"issue":"11","key":"10.1016\/j.tice.2025.103306_bib10","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3390\/toxins8110319","article-title":"Tenuifolide B from Cinnamomum tenuifolium stem selectively inhibits proliferation of oral cancer cells via apoptosis, ROS generation, mitochondrial depolarization, and DNA damage","volume":"8","author":"Chen","year":"2016","journal-title":"Toxins"},{"key":"10.1016\/j.tice.2025.103306_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.775507","article-title":"The Cross Talk Between p53 and mTOR pathways in response to physiological and genotoxic stresses","volume":"9","author":"Cui","year":"2021","journal-title":"Front Cell Dev. Biol."},{"issue":"4","key":"10.1016\/j.tice.2025.103306_bib12","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.3390\/molecules26041109","article-title":"Plant-derived anticancer compounds as new perspectives in drug discovery and alternative therapy","volume":"26","author":"Dehelean","year":"2021","journal-title":"Mol"},{"issue":"1","key":"10.1016\/j.tice.2025.103306_bib13","article-title":"Two-dimensional PCA highlights the differentiated antitumor and antimicrobial activity of methanolic and aqueous extracts of Laurus nobilis L. from Different Origins","author":"Dias","year":"2014","journal-title":"BioMed. Res. Int."},{"issue":"2","key":"10.1016\/j.tice.2025.103306_bib14","first-page":"127","article-title":"Inhibitory effects by ayurvedic plants on prostate enlargement induced in rats","volume":"6","author":"Dumbre","year":"2014","journal-title":"Pharm. Res."},{"key":"10.1016\/j.tice.2025.103306_bib15","doi-asserted-by":"crossref","first-page":"799","DOI":"10.3389\/fpls.2015.00799","article-title":"Plant derived substances with anti-cancer activity: from folklore to practice","volume":"6","author":"Fridlender","year":"2015","journal-title":"Front. Plant Sci."},{"issue":"17","key":"10.1016\/j.tice.2025.103306_bib16","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1101\/gad.12.17.2658","article-title":"JNK targets p53 ubiquitination and degradation in nonstressed cells","volume":"12","author":"Fuchs","year":"1998","journal-title":"Genes Dev."},{"issue":"5","key":"10.1016\/j.tice.2025.103306_bib17","volume":"6","author":"Geetika","year":"2014","journal-title":"Exploring anticancer potential methanolic extract laurusnobilis breast cancer vitro silico studies"},{"key":"10.1016\/j.tice.2025.103306_bib18","first-page":"1","article-title":"Cinnamon and chronic diseases. Drug discovery from mother nature","author":"Hariri","year":"2016","journal-title":"Afr. J. Biol. Sci."},{"issue":"3","key":"10.1016\/j.tice.2025.103306_bib19","doi-asserted-by":"crossref","first-page":"591","DOI":"10.53555\/AJBR.v27i3.2523","article-title":"Cytotoxic effect of Laurus nobilis leave extracts on bacterial growth and MCF-7 cancer cell line in vitro","volume":"27","author":"Hassan","year":"2024","journal-title":"Afr. J. Biomed. Res."},{"issue":"2","key":"10.1016\/j.tice.2025.103306_bib20","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1124\/jpet.108.148395","article-title":"Dehydrocostuslactone, a medicinal plant-derived sesquiterpene lactone, induces apoptosis coupled to endoplasmic reticulum stress in liver cancer cells","volume":"329","author":"Hsu","year":"2009","journal-title":"J. Pharm. Exp. Ther."},{"issue":"12","key":"10.1016\/j.tice.2025.103306_bib21","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jep.2018.02.001","article-title":"Phytochemical characterization and biological activity evaluation of ethanolic extract of Cinnamomum zeylanicum","volume":"219","author":"Husain","year":"2018","journal-title":"J. Ethnopharmacol."},{"issue":"10","key":"10.1016\/j.tice.2025.103306_bib22","doi-asserted-by":"crossref","DOI":"10.1111\/jfbc.14262","article-title":"Structural interactions of phytoconstituent(s) from cinnamon, bay leaf, oregano, and parsley with SARS-CoV-2 nucleocapsid protein: A comparative assessment for development of potential antiviral nutraceuticals","volume":"46","author":"Husain","year":"2022","journal-title":"J Food Biochem"},{"key":"10.1016\/j.tice.2025.103306_bib23","unstructured":"International Agency for Research on Cancer & World Health Organization. (2024). GLOBOCAN 2022: World cancer statistics \u2014 World fact sheet. IARC. https:\/\/gco.iarc.who.int\/media\/globocan\/factsheets\/populations\/900-world-fact-sheet.pdf."},{"issue":"12","key":"10.1016\/j.tice.2025.103306_bib24","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.apjtb.2017.10.016","article-title":"Plant-derived anticancer agents: A green anticancer approach","volume":"7","author":"Iqbal","year":"2017","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"10.1016\/j.tice.2025.103306_bib25","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.phytochem.2012.05.013","article-title":"Sesquiterpenes from the leaves of Laurus nobilis L","volume":"80","author":"Julianti","year":"2012","journal-title":"Phytochem"},{"issue":"3","key":"10.1016\/j.tice.2025.103306_bib26","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.jep.2007.07.008","article-title":"Screening of indigenous Palestinian medicinal plants for potential anti-inflammatory and cytotoxic activity","volume":"113","author":"Kaileh","year":"2007","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.tice.2025.103306_bib27","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12906-022-03533-0","article-title":"Anticancer potential of Phoenix dactylifera L. seed extract in human cancer cells and pro-apoptotic effects mediated through caspase-3 dependent pathway in human breast cancer MDA-MB-231 cells: an in vitro and in silico investigation","volume":"22","author":"Khan","year":"2022","journal-title":"BMC Complement. Med. Ther."},{"issue":"5","key":"10.1016\/j.tice.2025.103306_bib28","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1158\/1535-7163.MCT-08-0914","article-title":"Dehydrocostuslactone disrupts signal transducers and activators of transcription 3 through up-regulation of suppressor of cytokine signaling in breast cancer cells","volume":"8","author":"Kuo","year":"2009","journal-title":"Mol. Cancer Ther."},{"issue":"7","key":"10.1016\/j.tice.2025.103306_bib29","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1002\/tox.22410","article-title":"Cinnamomum cassia extracts reverses TGF-\u03b21-induced epithelial\u2013mesenchymal transition in human lung adenocarcinoma cells and suppresses tumor growth in vivo","volume":"32","author":"Lin","year":"2017","journal-title":"Environ. Toxicol."},{"issue":"5A","key":"10.1016\/j.tice.2025.103306_bib30","first-page":"3293","article-title":"Cytotoxic activity of essential oils from Labiatae and Lauraceae families against in vitro human tumor models","volume":"27","author":"Loizzo","year":"2007","journal-title":"Anticancer Res"},{"issue":"5","key":"10.1016\/j.tice.2025.103306_bib31","article-title":"Cytotoxic, genotoxic, and antibacterial potential of cinnamon oil-in-water nanoemulsion and vitamin D-encapsulated cinnamon oil nanoemulsion on lung carcinoma cells (A549)","volume":"44","author":"Meghani","year":"2018","journal-title":"Drug Dev. Indst. Pharm."},{"issue":"6","key":"10.1016\/j.tice.2025.103306_bib32","article-title":"Elucidating the anti-cancer potential of Cinnamomum tamala essential oil against non-small cell lung cancer: A multifaceted approach involving GC-MS profiling, network pharmacology, and molecular dynamics simulations","volume":"10","author":"Mohanty","year":"2024","journal-title":"Heliy"},{"issue":"3","key":"10.1016\/j.tice.2025.103306_bib33","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s13237-022-00405-3","article-title":"Plant-derived natural products for drug discovery: current approaches and prospects","volume":"65","author":"Nasim","year":"2022","journal-title":"Nucl. (Calcutta)"},{"issue":"1","key":"10.1016\/j.tice.2025.103306_bib34","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nprot.2006.5","article-title":"The comet assay: a method to measure DNA damage in individual cells","volume":"1","author":"Olive","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.tice.2025.103306_bib35","first-page":"2131","article-title":"Antioxidant and cytotoxic potential of acetone and methanolic extracts of fresh and dry barks of Cinnamomum zeylanicum Verum: in vitro study","volume":"10","author":"Priyarani","year":"2010","journal-title":"J. Cell Tissue Res."},{"issue":"1(1","key":"10.1016\/j.tice.2025.103306_bib36","article-title":"Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions","volume":"10","author":"Rasoanaivo","year":"2011","journal-title":"Malar. J."},{"key":"10.1016\/j.tice.2025.103306_bib37","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jep.2016.04.005","article-title":"Cytotoxicity of South-African medicinal plants towards sensitive and multidrug-resistant cancer cells","volume":"186","author":"Saeed","year":"2016","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.tice.2025.103306_bib38","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.foodchem.2012.07.089","article-title":"Cytoprotective and pro-apoptotic activities of native Australian herbs polyphenolic-rich extracts","volume":"136","author":"Sakulnarmrat","year":"2013","journal-title":"Food Chem."},{"issue":"1","key":"10.1016\/j.tice.2025.103306_bib39","first-page":"37","article-title":"Phytochemical study and in-vitro cytotoxic activity of Cinnamomum tammala Linn. Against Ehrlich Ascites carcinoma (EAC) and Dalton's Ascitic Lymphoma (DAL) cell lines","volume":"2","author":"Saluja","year":"2010","journal-title":"Res. J. Pharm. Phytochem"},{"issue":"3","key":"10.1016\/j.tice.2025.103306_bib40","first-page":"969","article-title":"Anticancer activity of Cinnamon tamala leaf constituents towards human ovarian cancer cells","volume":"28","author":"Shahwar","year":"2015","journal-title":"Pak. J. Pharm. Sci."},{"issue":"1","key":"10.1016\/j.tice.2025.103306_bib41","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41598-018-36475-0","article-title":"Cytostatic and anti-tumor potential of Ajwa date pulp against human hepatocellular carcinoma HepG2 cells","volume":"9","author":"Siddiqui","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2025.103306_bib42","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0014-4827(88)90265-0","article-title":"A simple technique for quantitation of low levels of DNA damage in individual cells","volume":"175","author":"Singh","year":"1988","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.tice.2025.103306_bib43","article-title":"Phytochemical characterization, biochemical profiling and evaluation of anticancer potential of methanolic extract of Withania somnifera stem","volume":"20","author":"Srivastava","year":"2024","journal-title":"J. Complement. Integr. Med"},{"issue":"136","key":"10.1016\/j.tice.2025.103306_bib44","article-title":"An update on existing therapeutic options and status of novel anti-metastatic agents in breast cancer: Elucidating the molecular mechanisms underlying the pleiotropic action of Withania somnifera (Indian ginseng) in breast cancer attenuation","volume":"30","author":"Srivastava","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"3","key":"10.1016\/j.tice.2025.103306_bib45","first-page":"70","article-title":"Comparative analysis of cytotoxic and antioxidant potential of edible Cinnamomum verum (bark) and Cinnamomum tamala (Indian bay leaf)","volume":"1","author":"Sudan","year":"2013","journal-title":"Free Rad. Antioxid."},{"issue":"1","key":"10.1016\/j.tice.2025.103306_bib46","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/2211-5463.13330","article-title":"Doxorubicin promotes breast cancer cell migration and invasion via DCAF13","volume":"12","author":"Sun","year":"2022","journal-title":"FEBS Open Bio"},{"issue":"1","key":"10.1016\/j.tice.2025.103306_bib47","first-page":"519","article-title":"Evaluation of in vitro cytotoxic activity of petroleum ether, methanol and aqueous extracts of Indian bay leaf, Cinnamomum tamala (Buch.-ham.) T. Nees & eberm. on cancer cells","volume":"3","author":"Thanekar","year":"2013","journal-title":"World J. Pharm. Pharm. Sci."},{"key":"10.1016\/j.tice.2025.103306_bib48","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.sajb.2015.09.014","article-title":"Evaluation of antitumor and anti-angiogenic activity of bioactive compounds from Cinnamomum tamala: In vitro, in vivo and in silico approach","volume":"104","author":"Thanekar","year":"2016","journal-title":"S Afr. J. Bot."},{"issue":"3","key":"10.1016\/j.tice.2025.103306_bib49","first-page":"18","article-title":"Therapeutic and pharmaceutical potential of Cinnamomum tamala","volume":"6","author":"Upadhyay","year":"2017","journal-title":"Res. Rev. Pharm. Pharm. Sci."},{"issue":"8","key":"10.1016\/j.tice.2025.103306_bib50","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.3390\/antibiotics11081014","article-title":"Interactions between medical plant-derived bioactive compounds: focus on antimicrobial combination effects","volume":"11","author":"Vaou","year":"2022","journal-title":"Antibiotics"},{"key":"10.1016\/j.tice.2025.103306_bib51","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s42269-024-01231-0","article-title":"Exploring Ayurveda: principles and their application in modern medicine","volume":"48","author":"Verma","year":"2024","journal-title":"Bull. Natl. Res Cent."},{"key":"10.1016\/j.tice.2025.103306_bib52","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41392-023-01347-1","article-title":"Targeting p53 pathways: mechanisms, structures and advances in therapy","volume":"8","author":"Wang","year":"2023","journal-title":"Sig Transduct. Target Ther."},{"issue":"18","key":"10.1016\/j.tice.2025.103306_bib53","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1091\/mbc.e14-04-0916","article-title":"How taxol\/paclitaxel kills cancer cells","volume":"25","author":"Weaver","year":"2014","journal-title":"Mol. Biol. Cell"},{"issue":"44","key":"10.1016\/j.tice.2025.103306_bib54","doi-asserted-by":"crossref","first-page":"5785","DOI":"10.1038\/onc.2008.192","article-title":"PCAF is an HIF-1alpha cofactor that regulates p53 transcriptional activity in hypoxia","volume":"27","author":"Xenaki","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.tice.2025.103306_bib55","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s13045-024-01631-9","article-title":"RAS signaling in carcinogenesis, cancer therapy and resistance mechanisms","volume":"17","author":"Yang","year":"2024","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.tice.2025.103306_bib56","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.bbrc.2019.12.027","article-title":"Dexrazoxane ameliorates doxorubicin-induced cardiotoxicity by inhibiting both apoptosis and necroptosis in cardiomyocytes","volume":"523","author":"Yu","year":"2020","journal-title":"Biochem Biophys. Res Commun."},{"key":"10.1016\/j.tice.2025.103306_bib57","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/s41418-019-0372-z","article-title":"FNDC5 alleviates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via activating AKT","volume":"27","author":"Zhang","year":"2020","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.tice.2025.103306_bib58","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13020-018-0177-x","article-title":"Techniques for extraction and isolation of natural products: a comprehensive review","volume":"13","author":"Zhang","year":"2018","journal-title":"Chin. Med"}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625005889?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816625005889?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T01:38:27Z","timestamp":1773970707000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816625005889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":58,"alternative-id":["S0040816625005889"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2025.103306","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phytochemicals in ethanolic extract of Cinnamomum tamala induce cell cycle arrest, DNA damage and apoptosis in human breast cancer cell lines MDA-MB-231 and MCF-7","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2025.103306","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103306"}}