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Impact of maternal microplastic exposure on offspring lung structure and function: Insights into transcriptional misregulation and the TGF-\u03b2\/\u03b1-SMA pathway. 299, 118397.","DOI":"10.1016\/j.ecoenv.2025.118397"},{"key":"10.1016\/j.tice.2026.103313_bib70","doi-asserted-by":"crossref","first-page":"3743","DOI":"10.1007\/s00216-019-01763-9","article-title":"Promising techniques and open challenges for microplastic identification and quantification in environmental matrices","volume":"411","author":"Zarfl","year":"2019","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.tice.2026.103313_bib71","doi-asserted-by":"crossref","unstructured":"Zhilong, Z., Yimeng, C., Kaiyue, H., Dongdong, L., Zhiying, G., Xiwu, Y., Zhongming, H., Yanjie, Q.J.A.R., 2025. 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