{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T14:44:54Z","timestamp":1792853094222,"version":"4.5.0"},"reference-count":86,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.tice.2026.103373","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T16:25:50Z","timestamp":1770395150000},"page":"103373","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["The effects of sofosbuvir on the colon of adult male albino rats and the potential protective role of propolis: A histological and immunohistochemical study"],"prefix":"10.1016","volume":"100","author":[{"given":"Eman S.","family":"El-Roghy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7946-5756","authenticated-orcid":false,"given":"Eman A.","family":"Eissa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"23","key":"10.1016\/j.tice.2026.103373_bib1","doi-asserted-by":"crossref","first-page":"4101","DOI":"10.3889\/oamjms.2019.868","article-title":"Effect of Sofosbuvir Administration and Its Withdrawal on the Submandibular Salivary Gland of Adult Male Albino Rats: A Histological and Ultra-Structural Study","volume":"7","author":"Abdeen","year":"2019","journal-title":"Open Access Maced. J. Med. Sci."},{"issue":"1","key":"10.1016\/j.tice.2026.103373_bib2","first-page":"71","article-title":"Direct-acting antivirals sofosbuvir and daclatasvir attenuate carbon tetrachloride-induced liver fibrosis in mice","volume":"7","author":"Abdelsalam","year":"2023","journal-title":"Liver Res. (Beijing China)"},{"issue":"1","key":"10.1016\/j.tice.2026.103373_bib3","first-page":"325","article-title":"Extra hepatic effects of sofosbuvir on a serous model of major and minor salivary glands in albino rats","volume":"43","author":"Adel Saad","year":"2020","journal-title":"Egypt. J. Histol."},{"issue":"5","key":"10.1016\/j.tice.2026.103373_bib4","first-page":"150","article-title":"Iraqi Propolis is effective in avoiding deviations of gut rats\u2019 homeostasis exposed to AFB-1","volume":"4","author":"AJAlqayim","year":"2017","journal-title":"J. Kerbala Agric. Sci."},{"issue":"1","key":"10.1016\/j.tice.2026.103373_bib5","article-title":"The deleterious effects of sofosbuvir and ribavirin (antiviral drugs against hepatitis C virus) on different body systems in male albino rats regarding reproductive, hematological, biochemical, hepatic, and renal profiles and histopathological changes","volume":"14","author":"Ali","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2026.103373_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2025.102767","article-title":"Taxifolin mitigates cisplatin-induced testicular damage by reducing inflammation, oxidative stress, and apoptosis in mice","volume":"93","author":"Al-Khawalde","year":"2025","journal-title":"Tissue Cell"},{"issue":"5","key":"10.1016\/j.tice.2026.103373_bib7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.21315\/mjms2017.24.5.11","article-title":"Sample Size Calculation in Animal Studies Using Resource Equation Approach","volume":"24","author":"Arifin","year":"2017","journal-title":"Malays. J. Med Sci."},{"issue":"9","key":"10.1016\/j.tice.2026.103373_bib8","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.53350\/pjmhs211592867","article-title":"Hepatoprotective Role of Propolis Extract to Prevent Hepatotoxic Effects of ATT in Patients with Tuberculosis","volume":"15","author":"Arshad","year":"2021","journal-title":"Pak. J. Med. Health Sci."},{"key":"10.1016\/j.tice.2026.103373_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.1126579","article-title":"Recent updates on correlation between reactive oxygen species and synbiotics for effective management of ulcerative colitis","volume":"10","author":"Ashique","year":"2023","journal-title":"Front. Nutr."},{"issue":"1","key":"10.1016\/j.tice.2026.103373_bib10","doi-asserted-by":"crossref","first-page":"158","DOI":"10.5603\/FM.a2020.0021","article-title":"Effect of vitamin B17 on experimentally induced colon cancer in adult male albino rat","volume":"80","author":"Badr El-Kholy","year":"2021","journal-title":"Folia Morphol. (Pol. )"},{"issue":"1","key":"10.1016\/j.tice.2026.103373_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.21608\/bbj.2024.325405.1045","article-title":"Histological and Immunohistochemical Study of the Effect of Sofosbuvir and its withdrawal on the Submandibular salivary glands and Tongue of Adult Male Albino Rats","volume":"3","author":"Badr","year":"2025","journal-title":"Biol. Biomed. J."},{"key":"10.1016\/j.tice.2026.103373_bib12","series-title":"Theory and Practice of Histological Techniques","article-title":"Theory and Practice of Histological Techniques, Sixth Edition","author":"Bancroft","year":"2007"},{"key":"10.1016\/j.tice.2026.103373_bib13","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/0003-2697(71)90370-8","article-title":"Superoxide Dismutase: Improved Assays and an Assay Applicable to Acrylamide Gels","volume":"44","author":"Beauchamp","year":"1971","journal-title":"Anal. Biochem"},{"key":"10.1016\/j.tice.2026.103373_bib14","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1053\/gast.2000.16497","article-title":"Mechanisms of NSAID-induced gastrointestinal injury defined using mutant mice","volume":"119","author":"Beck","year":"2000","journal-title":"Gastroenterology"},{"issue":"8","key":"10.1016\/j.tice.2026.103373_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/nu13082528","article-title":"Experimental Evidence for Therapeutic Potentials of Propolis","volume":"13","author":"Bhargava","year":"2021","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.tice.2026.103373_bib16","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.3390\/cells9041003","article-title":"Sofosbuvir Activates EGFR-Dependent Pathways in Hepatoma Cells with Implications for Liver-Related Pathological Processes","volume":"9","author":"Bojkova","year":"2020","journal-title":"Cells"},{"issue":"11","key":"10.1016\/j.tice.2026.103373_bib17","first-page":"1990","article-title":"Prophylactic Coloprotective Effect of Urtica dioica Leaves against Dextran Sulfate Sodium (DSS)-Induced Ulcerative Colitis in Rats","volume":"59","author":"Dakhli","year":"2023","journal-title":"Med. (Kaunas. Lith. )"},{"key":"10.1016\/j.tice.2026.103373_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.amsu.2021.103231","article-title":"Malondialdehyde value as radical oxidative marker and endogenous antioxidant value analysis in brain tumor","volume":"77","author":"Dharmajaya","year":"2022","journal-title":"Ann. Med. Surg."},{"key":"10.1016\/j.tice.2026.103373_bib19","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.jff.2016.06.025","article-title":"Oat products modulate the gut microbiota and produce anti-obesity effects in obese rats","volume":"25","author":"Dong","year":"2016","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.tice.2026.103373_bib20","first-page":"526","article-title":"Effect of Sofosbuvir on rats\u2019 ovaries and the possible protective role of vitamin E: biochemical and immunohistochemical study","volume":"56","author":"Ebrahim","year":"2023"},{"issue":"3","key":"10.1016\/j.tice.2026.103373_bib21","first-page":"289","article-title":"The protective efficacy of propolis against multi-heavy metals-induced oxidative stress and hepato-renal damage in the males of albino rats","volume":"66","author":"El-Amawy","year":"2023","journal-title":"Egypt. J. Chem."},{"issue":"3","key":"10.1016\/j.tice.2026.103373_bib22","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.21608\/edj.2022.132962.2069","article-title":"The Effect of Sofosbuvir Administration on Albino Rats\u2019 Buccal Mucosa (Histological and immunochemical study)","volume":"68","author":"Elbatrick","year":"2022","journal-title":"Egypt. Dent. J."},{"key":"10.1016\/j.tice.2026.103373_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2025.102791","article-title":"Dihydroartemisinin attenuates acetic acid-induced ulcerative colitis in rats: Suppression of inflammation and modulation of NF\u03ba\u03b2\/TNF-\u03b1\/RIPK1-mediated necroptosis and apoptosis","volume":"94","author":"Eldesoqui","year":"2025","journal-title":"Tissue Cell"},{"issue":"12","key":"10.1016\/j.tice.2026.103373_bib24","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.14202\/vetworld.2021.3076-3083","article-title":"Antioxidant activity and protective effect of propolis against carbon tetrachloride-induced liver and kidney injury by modulation of oxidative parameters","volume":"14","author":"El-Haskoury","year":"2021","journal-title":"Vet. World"},{"issue":"September","key":"10.1016\/j.tice.2026.103373_bib25","first-page":"2565","article-title":"Histological Study of the Possible Protective Effect of Royal Jelly on Ulcerative Colitis Induced by Dextran Sodium Sulfate in Adult Male Albino Rat","volume":"86","author":"El-Hoda","year":"2018","journal-title":"Med. J. Cairo Univ."},{"issue":"5","key":"10.1016\/j.tice.2026.103373_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0302795","article-title":"In vitro and in vivo burn healing study of standardized propolis: Unveiling its antibacterial, antioxidant and anti-inflammatory actions in relation to its phytochemical profiling","volume":"19","author":"El-Kersh","year":"2024","journal-title":"PloS One"},{"key":"10.1016\/j.tice.2026.103373_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/srep41453","article-title":"Characteristics, chemical compositions and biological activities of propolis from Al-Bahah, Saudi Arabia","volume":"7","author":"Elnakady","year":"2017","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.tice.2026.103373_bib28","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/ar.24942","article-title":"Saffron extract attenuates Sofosbuvir-induced retinal neurodegeneration in albino rat","volume":"306","author":"Elseady","year":"2023","journal-title":"Anat. Rec."},{"key":"10.1016\/j.tice.2026.103373_bib29","article-title":"Potential Anti-Fibrotic Effect of Direct-Acting Antiviral Drugs on CCl4-Induced Hepatic Fibrosis in Rats","volume":"9","author":"El-Sisi","year":"2019","journal-title":"Egypt. J. Basic Clin. Pharmacol."},{"issue":"2","key":"10.1016\/j.tice.2026.103373_bib30","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1128\/AAC.01922-15","article-title":"Role of mitochondrial RNA polymerase in the toxicity of nucleotide inhibitors of hepatitis C virus","volume":"60","author":"Feng","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"issue":"10","key":"10.1016\/j.tice.2026.103373_bib31","doi-asserted-by":"crossref","first-page":"416","DOI":"10.3390\/toxins16100416","article-title":"Effects of Propolis Supplementation on Gut Microbiota and Uremic Toxin Profiles of Patients Undergoing Hemodialysis","volume":"16","author":"Fonseca","year":"2024","journal-title":"Toxins (Basel)"},{"issue":"16","key":"10.1016\/j.tice.2026.103373_bib32","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.3390\/foods13162474","article-title":"Ex Vivo Study of Colon Health, Contractility, and Innervation in Male and Female Rats after Regular Exposure to Instant Cascara Beverage","volume":"13","author":"Gallego-Barcel\u00f3","year":"2024","journal-title":"Foods"},{"issue":"3","key":"10.1016\/j.tice.2026.103373_bib33","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1007\/s11033-009-9508-4","article-title":"Antioxidant defense of betaine against isoprenaline-induced myocardial infarction in rats","volume":"37","author":"Ganesan","year":"2010","journal-title":"Mol. Biol. Rep."},{"issue":"21","key":"10.1016\/j.tice.2026.103373_bib34","doi-asserted-by":"crossref","first-page":"15844","DOI":"10.3390\/ijms242115844","article-title":"Direct-Acting Antiviral Drug Modulates the Mitochondrial Biogenesis in Different Tissues of Young Female Rats","volume":"24","author":"Hafez","year":"2023","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.tice.2026.103373_bib35","first-page":"81","article-title":"Selective inhibition of T2AA for human PCNA over PCNA homolog in Trypanosoma brucei","volume":"56","author":"Haggag","year":"2018","journal-title":"Alex. J. Vet. Sci."},{"issue":"2","key":"10.1016\/j.tice.2026.103373_bib36","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1097\/01.EHX.0000446578.43207.90","article-title":"Possible protective effect of dietary extra-virgin olive oil on experimentally induced acute colitis in adult male albino rats: A histological and immunohistochemical study","volume":"37","author":"Hamam","year":"2014","journal-title":"Egypt. J. Histol."},{"issue":"1","key":"10.1016\/j.tice.2026.103373_bib37","first-page":"188","article-title":"Antioxidant ameliorating effect of setria (reduced glutathione) on experimentally induced colitis in adult male albino rats","volume":"44","author":"Hashem","year":"2021","journal-title":"Egypt. J. Histol."},{"key":"10.1016\/j.tice.2026.103373_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2024.102327","article-title":"Modulatory effects of Moringa oleifera leaf extract on sodium nitrate-induced experimental colitis via regulation of P53, Ki-67 and PCNA biomarkers","volume":"88","author":"Hassan","year":"2024","journal-title":"Tissue Cell"},{"key":"10.1016\/j.tice.2026.103373_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2025.107036","article-title":"Effects of Propolis supplementation on inflammation and oxidative stress markers: A GRADE-assessed systematic review and Meta-analysis of clinical trials","volume":"134","author":"Heshmatipour","year":"2025","journal-title":"J. Funct. Foods"},{"issue":"29","key":"10.1016\/j.tice.2026.103373_bib40","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.2174\/092986708786848587","article-title":"Regeneration of the Gastric Mucosa and its Glands from Stem Cells","volume":"15","author":"Hoffmann","year":"2008","journal-title":"Curr. Med. Chem."},{"issue":"1","key":"10.1016\/j.tice.2026.103373_bib41","doi-asserted-by":"crossref","first-page":"119","DOI":"10.21608\/jmh.2020.33529.1077","article-title":"A Histological Study on the Possible Adverse Effect of Sofosbuvir on Lungs of Adult Male Albino Rats","volume":"4","author":"Hosny","year":"2020","journal-title":"J. Med. Histol."},{"issue":"4","key":"10.1016\/j.tice.2026.103373_bib42","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1177\/29.4.6166661","article-title":"Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures","volume":"29","author":"Hsu","year":"1981","journal-title":"Journal Histochemistry Cytochemistry Official Journal Histochemistry Society"},{"issue":"1","key":"10.1016\/j.tice.2026.103373_bib43","first-page":"33","article-title":"Assessment of the Prophylactic Effect of Probiotics in an Experimental Model of Ulcerative Colitis in Male Albino Rat: Histological and Immunohistochemical Study","volume":"46","author":"Hussein","year":"2023","journal-title":"Egypt. J. Histol."},{"issue":"2","key":"10.1016\/j.tice.2026.103373_bib44","doi-asserted-by":"crossref","first-page":"192","DOI":"10.21608\/EJH.2018.13841","article-title":"Royal jelly protects against experimentally-induced ulcerative colitis in adult male albino rats: A histological study","volume":"41","author":"Ismail","year":"2018","journal-title":"Egypt. J. Histol."},{"issue":"4","key":"10.1016\/j.tice.2026.103373_bib45","first-page":"79","article-title":"Light and electronic histological studies on the effect of Sofosbuvir on the visual cerebral cortex of adult male albino rats","volume":"13","author":"Issa","year":"2017","journal-title":"J. Am. Sci."},{"issue":"1","key":"10.1016\/j.tice.2026.103373_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13027-017-0158-1","article-title":"Outcomes after sofosbuvir-containing regimens for hepatitis C virus in patients with decompensated cirrhosis: A real-world study, Dr Stefano Vella","volume":"12","author":"Ji","year":"2017","journal-title":"Infect. Agents Cancer"},{"key":"10.1016\/j.tice.2026.103373_bib47","first-page":"135","article-title":"Connective Tissues and Stains","author":"Jones","year":"2008","journal-title":"Theory Pract. Histol. Tech."},{"issue":"4","key":"10.1016\/j.tice.2026.103373_bib48","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1097\/01.EHX.0000407699.63226.2a","article-title":"Light and electron microscopic study on the effect of topically applied hyaluronic acid on experimentally induced corneal alkali burn in albino rats","volume":"34","author":"Kalleny","year":"2011","journal-title":"Egypt. J. Histol."},{"issue":"6","key":"10.1016\/j.tice.2026.103373_bib49","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.22246\/jikm.2023.44.6.1139","article-title":"Effects of <italic>Mannyeon-hwan<\/italic> on Acetic Acid-induced Colitis in Rats","volume":"44","author":"Kong","year":"2023","journal-title":"J. Intern. Korean Med."},{"issue":"1","key":"10.1016\/j.tice.2026.103373_bib50","doi-asserted-by":"crossref","first-page":"27","DOI":"10.15430\/JCP.2020.25.1.27","article-title":"Effects of Genetic and Pharmacologic Inhibition of COX-2 on Colitis-associated Carcinogenesis in Mice","volume":"25","author":"Lee","year":"2020","journal-title":"J. Cancer Prev."},{"issue":"1","key":"10.1016\/j.tice.2026.103373_bib51","article-title":"Sodium butyrate alleviates DSS-induced inflammatory bowel disease by inhibiting ferroptosis and modulating ERK\/STAT3 signaling and intestinal flora","volume":"57","author":"Liu","year":"2025","journal-title":"Ann. Med"},{"issue":"1","key":"10.1016\/j.tice.2026.103373_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s41936-022-00281-y","article-title":"The possible ameliorative role of Moringa oleifera seed oil on sofosbuvir-induced nephrotoxicity in albino rats; histopathological, immunohistochemical, and biochemical studies","volume":"83","author":"Mahran","year":"2022","journal-title":"J. Basic Appl. Zool."},{"key":"10.1016\/j.tice.2026.103373_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2019.105184","article-title":"Amino-decorated mesoporous silica nanoparticles for controlled sofosbuvir delivery","volume":"143","author":"Mehmood","year":"2020","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.tice.2026.103373_bib54","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.ejphar.2014.11.016","article-title":"Evaluation of anti-colitic effect of fluvoxamine against acetic acid-induced colitis in normal and reserpinized depressed rats","volume":"746","author":"Minaiyan","year":"2015","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.tice.2026.103373_bib55","first-page":"496","article-title":"Histological study on the effect of adipose mesenchymal stem cells-derived microvesicles and the role of its RNA content on experimentally induced ulcerative colitis in albino rats","volume":"42","author":"Mohsen","year":"2019","journal-title":"Egypt. J. Histol."},{"issue":"1","key":"10.1016\/j.tice.2026.103373_bib56","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s40199-021-00429-1","article-title":"Investigation of the effect of verapamil on the regional absorption of sofosbuvir from rabbit intestine in situ","volume":"30","author":"Mohsen","year":"2022","journal-title":"DARU J. Pharm. Sci."},{"issue":"1","key":"10.1016\/j.tice.2026.103373_bib57","first-page":"366","article-title":"Effect of Red Bull energy drink on Rats\u2019 Submandibular salivary glands (Light and Electron microscopic Study)","volume":"8","author":"Mubarak","year":"2012","journal-title":"J. Am. Sci."},{"issue":"2","key":"10.1016\/j.tice.2026.103373_bib58","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem"},{"key":"10.1016\/j.tice.2026.103373_bib59","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12986-020-00485-5","article-title":"Molecular and cellular mechanisms of the effects of Propolis in inflammation, oxidative stress and glycemic control in chronic diseases","volume":"17","author":"Pahlavani","year":"2020","journal-title":"Nutr. Metab."},{"key":"10.1016\/j.tice.2026.103373_bib60","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/8917804","article-title":"Macrophage Polarization in Chronic Inflammatory Diseases: Killers or Builders?","volume":"2018","author":"Parisi","year":"2018","journal-title":"J. Immunol. Res."},{"issue":"1","key":"10.1016\/j.tice.2026.103373_bib61","first-page":"1","article-title":"About the absolute need to keep active research on the efficacy of direct-acting antiviral drugs against the hepatitis C virus","volume":"73","author":"Pawlotsky","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.tice.2026.103373_bib62","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/3824509","article-title":"Antioxidant, Anti-Inflammatory, and Microbial-Modulating Activities of Nutraceuticals and Functional Foods 2018","volume":"2018","author":"Peluso","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.tice.2026.103373_bib63","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0294169","article-title":"Propolis alleviates ulcerative colitis injury by inhibiting the protein kinase C-transient receptor potential cation channel subfamily V member 1-calcitonin gene-related peptide\/substance P (PKC-TRPV1-CGRP\/SP) signaling axis","volume":"19","author":"Qian","year":"2024","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tice.2026.103373_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2025.103085","article-title":"The role of alpha-pinene on the NLRP3-Caspase 1 pathway in the ulcerative colitis model in rats","volume":"97","author":"Rahimi","year":"2025","journal-title":"Tissue Cell"},{"issue":"1","key":"10.1016\/j.tice.2026.103373_bib65","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-07918-2","article-title":"Propolis compound inhibits profibrotic TGF-\u03b21\/SMAD signalling in human fibroblasts","volume":"15","author":"Randall","year":"2025","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.tice.2026.103373_bib66","first-page":"136","article-title":"Effect of Bone Marrow-Derived Mesenchymal Stem Cells versus Probiotics in the Treatment of Experimentally Induced Acute Colitis in Rats: A Histological and an Immunohistochemical Study","volume":"47","author":"Sadek","year":"2024","journal-title":"Egypt. J. Histol."},{"issue":"1","key":"10.1016\/j.tice.2026.103373_bib67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5897\/JCAB2015.0425","article-title":"Light and scanning electron microscopy of the small intestine of goat (Capra hircus)","volume":"9","author":"Said","year":"2015","journal-title":"J. Cell Anim. Biol."},{"key":"10.1016\/j.tice.2026.103373_bib68","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1155\/2022\/8497562","article-title":"Antioxidant and Anticarcinogenic Potentials of Propolis for Dimethylhydrazine-Induced Colorectal Cancer in Wistar Rats","volume":"2022","author":"Salehi","year":"2022","journal-title":"BioMed. Res. Int."},{"issue":"1","key":"10.1016\/j.tice.2026.103373_bib69","doi-asserted-by":"crossref","first-page":"657","DOI":"10.21608\/edj.2017.75014","article-title":"EFFECT OF AN ANTI-HEPATITIS C VIRAL DRUG ON RAT SUBMANDIBULAR SALIVARY GLAND","volume":"63","author":"Salem","year":"2017","journal-title":"Egypt. Dent. J."},{"issue":"9","key":"10.1016\/j.tice.2026.103373_bib70","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1248\/bpb.b18-00325","article-title":"Effect of Royal Jelly and Brazilian Green Propolis on the Signaling for Histamine H1 Receptor and Interleukin-9 Gene Expressions Responsible for the Pathogenesis of the Allergic Rhinitis","volume":"41","author":"Shaha","year":"2018","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.tice.2026.103373_bib71","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1016\/j.jksus.2020.01.003","article-title":"Effect of propolis supplementation on C-reactive protein levels and other inflammatory factors: A systematic review and meta-analysis of randomized controlled trials","volume":"32","author":"Shang","year":"2020","journal-title":"J. King Saud. Univ. Sci."},{"key":"10.1016\/j.tice.2026.103373_bib72","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1051\/apido\/2010016","article-title":"Propolis and Bee Health: The Natural History and Significance of Resin Use by Honeybees","volume":"41","author":"Simone-Finstrom","year":"2010","journal-title":"Apidologie"},{"issue":"3","key":"10.1016\/j.tice.2026.103373_bib73","first-page":"608","article-title":"The protective effect of Ocimum basilicum on the induced diabetic colon of adult male albino rats: A histological, histochemical, and immunohistochemical study. In","volume":"42","author":"Soliman","year":"2019","journal-title":"Egypt. J. Histol."},{"key":"10.1016\/j.tice.2026.103373_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2025.115472","article-title":"Experimental evaluation of favipiravir (T-705)-induced liver and kidney toxicity in rats","volume":"202","author":"\u00dclger","year":"2025","journal-title":"Food Chem. Toxicol."},{"issue":"8","key":"10.1016\/j.tice.2026.103373_bib75","doi-asserted-by":"crossref","first-page":"875","DOI":"10.3390\/nu9080875","article-title":"Dietary Propolis Ameliorates Dextran Sulfate Sodium-Induced Colitis and Modulates the Gut Microbiota in Rats Fed a Western Diet","volume":"9","author":"Wang","year":"2017","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.tice.2026.103373_bib76","article-title":"A cross-sectional study: Relationship between serum oxidative stress levels and arteriovenous fistula maturation in maintenance dialysis patients","volume":"20","author":"Wang","year":"2025","journal-title":"Open Med. (Wars. Pol. )"},{"key":"10.1016\/j.tice.2026.103373_bib77","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.freeradbiomed.2025.04.034","article-title":"Epigenetic silencing of SOD2 exacerbates mitochondrial oxidative stress and promotes pulmonary fibrosis","volume":"235","author":"Wang","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.tice.2026.103373_bib78","series-title":"Basic & Clinical Biostatistics","first-page":"160","author":"White","year":"2020"},{"issue":"16","key":"10.1016\/j.tice.2026.103373_bib79","first-page":"2439","article-title":"The Antioxidant and Anti-Inflammatory Effects of Flavonoids from Propolis via Nrf2 and NF-\u03baB Pathways","volume":"11","author":"Xu","year":"2022","journal-title":"Foods (Basel Switz. )"},{"issue":"1","key":"10.1016\/j.tice.2026.103373_bib80","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-27190-8","article-title":"Propolis impairs cellular proliferation by promoting oxidative damage and disrupting macromolecular composition in a yeast model","volume":"15","author":"Yard\u0131mc\u0131","year":"2025","journal-title":"Sci. Rep."},{"issue":"42","key":"10.1016\/j.tice.2026.103373_bib81","doi-asserted-by":"crossref","first-page":"95660","DOI":"10.1007\/s11356-023-29134-z","article-title":"An insight into the hepatoprotective role of Velpatasvir and Sofosbuvir per se and in combination against carbon tetrachloride-induced hepatic fibrosis in rats","volume":"30","author":"Yasmeen","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"16","key":"10.1016\/j.tice.2026.103373_bib82","article-title":"Clinical significance of high expression of proliferating cell nuclear antigen in non-small cell lung cancer","volume":"99","author":"Ye","year":"2020","journal-title":"Med. (Baltim. )"},{"issue":"6","key":"10.1016\/j.tice.2026.103373_bib83","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.3390\/foods10061383","article-title":"Antioxidant and anti-inflammatory effects of Zingiber officinale Roscoe and Allium subhirsutum: In silico, biochemical and histological study","volume":"10","author":"Zammel","year":"2021","journal-title":"Foods"},{"issue":"1","key":"10.1016\/j.tice.2026.103373_bib84","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s40824-023-00412-8","article-title":"Restoration of dysregulated intestinal barrier and inflammatory regulation through synergistically ameliorating hypoxia and scavenging reactive oxygen species using ceria nanozymes in ulcerative colitis","volume":"27","author":"Zhang","year":"2023","journal-title":"Biomater. Res."},{"issue":"5","key":"10.1016\/j.tice.2026.103373_bib85","first-page":"925","article-title":"Potential protective effects of the water-soluble Chinese propolis on experimental ulcerative colitis","volume":"43","author":"Zhou","year":"2023","journal-title":"J. Tradit. Chin. Med."},{"issue":"23","key":"10.1016\/j.tice.2026.103373_bib86","doi-asserted-by":"crossref","first-page":"8473","DOI":"10.3390\/molecules27238473","article-title":"Recent Update on the Anti-Inflammatory Activities of Propolis","volume":"27","author":"Zulhendri","year":"2022","journal-title":"Molecules"}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626000650?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626000650?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T21:44:17Z","timestamp":1773265457000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816626000650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":86,"alternative-id":["S0040816626000650"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2026.103373","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effects of sofosbuvir on the colon of adult male albino rats and the potential protective role of propolis: A histological and immunohistochemical study","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2026.103373","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103373"}}