{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T06:23:39Z","timestamp":1777703019148,"version":"3.51.4"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32371169"],"award-info":[{"award-number":["32371169"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016305","name":"First Affiliated Hospital of Zhengzhou University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016305","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.tice.2026.103381","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:37:55Z","timestamp":1770741475000},"page":"103381","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Cordycepin inhibits human extravillous trophoblast invasion by suppressing snail-mediated MMP2 expression"],"prefix":"10.1016","volume":"100","author":[{"given":"Manman","family":"Guo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siwei","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beibei","family":"Bi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Chien","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8725-895X","authenticated-orcid":false,"given":"Lanlan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2026.103381_bib1","doi-asserted-by":"crossref","first-page":"715","DOI":"10.3389\/fphar.2019.00715","article-title":"Natural Plants Compounds as Modulators of Epithelial-to-Mesenchymal Transition","volume":"10","author":"Avila-Carrasco","year":"2019","journal-title":"Front Pharm."},{"key":"10.1016\/j.tice.2026.103381_bib2","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1016\/j.jds.2022.03.002","article-title":"Cordycepin attenuates migration and invasion of HSC-4 oral squamous carcinoma cells through autophagy-dependent FAK\/Akt and MMP2\/MMP9 suppression","volume":"17","author":"Binlateh","year":"2022","journal-title":"J. Dent. Sci."},{"key":"10.1016\/j.tice.2026.103381_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2026.108092","article-title":"Benefits and risks of herbal medicine use during pregnancy on offspring outcomes: A systematic review and meta-analysis of randomized controlled trials and observational studies","volume":"224","author":"Chen","year":"2026","journal-title":"Pharm. Res"},{"key":"10.1016\/j.tice.2026.103381_bib4","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s12964-023-01107-2","article-title":"Snail mediates GDF-8-stimulated human extravillous trophoblast cell invasion by upregulating MMP2 expression","volume":"21","author":"Chen","year":"2023","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.tice.2026.103381_bib5","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/s42003-021-02816-5","article-title":"G protein-coupled estrogen receptor stimulates human trophoblast cell invasion via YAP-mediated ANGPTL4 expression","volume":"4","author":"Cheng","year":"2021","journal-title":"Commun. Biol."},{"key":"10.1016\/j.tice.2026.103381_bib6","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/166949a0","article-title":"Cordycepin, a metabolic product isolated from cultures of Cordyceps militaris (Linn.) Link","volume":"166","author":"Cunningham","year":"1950","journal-title":"Nature"},{"key":"10.1016\/j.tice.2026.103381_bib7","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.placenta.2014.06.369","article-title":"Activation of adenosine A2B receptor impairs properties of trophoblast cells and involves mitogen-activated protein (MAP) kinase signaling","volume":"35","author":"Darashchonak","year":"2014","journal-title":"Placenta"},{"key":"10.1016\/j.tice.2026.103381_bib8","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1016\/j.placenta.2015.10.013","article-title":"Differentiation of first trimester cytotrophoblast to extravillous trophoblast involves an epithelial-mesenchymal transition","volume":"36","author":"DaSilva-Arnold","year":"2015","journal-title":"Placenta"},{"key":"10.1016\/j.tice.2026.103381_bib9","doi-asserted-by":"crossref","first-page":"717","DOI":"10.2741\/4915","article-title":"EMTiness in pseudo-malignant behavior of trophoblasts during embryo implantation","volume":"26","author":"Dhar","year":"2021","journal-title":"Front Biosci. (Landmark Ed. )"},{"key":"10.1016\/j.tice.2026.103381_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/cells9030785","article-title":"Focusing on Adenosine Receptors as a Potential Targeted Therapy in Human Diseases","volume":"9","author":"Effendi","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.tice.2026.103381_bib11","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.placenta.2020.02.007","article-title":"Trophoblast lineage-specific differentiation and associated alterations in preeclampsia and fetal growth restriction","volume":"102","author":"Farah","year":"2020","journal-title":"Placenta"},{"key":"10.1016\/j.tice.2026.103381_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/pr.110.003285","article-title":"International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors--an update","volume":"63","author":"Fredholm","year":"2011","journal-title":"Pharm. Rev."},{"key":"10.1016\/j.tice.2026.103381_bib13","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1006\/excr.1993.1139","article-title":"Establishment and characterization of first trimester human trophoblast cells with extended lifespan","volume":"206","author":"Graham","year":"1993","journal-title":"Exp. Cell Res"},{"key":"10.1016\/j.tice.2026.103381_bib14","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/jog.15066","article-title":"Role of adenosine signaling in preeclampsia","volume":"48","author":"Iriyama","year":"2022","journal-title":"J. Obstet. Gynaecol. Res"},{"key":"10.1016\/j.tice.2026.103381_bib15","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1080\/19336918.2016.1170258","article-title":"Epithelial-mesenchymal transition during extravillous trophoblast differentiation","volume":"10","author":"J","year":"2016","journal-title":"Cell Adh Migr."},{"key":"10.1016\/j.tice.2026.103381_bib16","first-page":"1697","article-title":"Inhibition of migration and invasion of LNCaP human prostate carcinoma cells by cordycepin through inactivation of Akt","volume":"40","author":"Jeong","year":"2012","journal-title":"Int J. Oncol."},{"key":"10.1016\/j.tice.2026.103381_bib17","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1080\/08820139.2024.2418572","article-title":"Cordycepin Alleviates Lipopolysaccharides-Induced Preeclampsia-Like Impairments in Rats","volume":"54","author":"Jian","year":"2025","journal-title":"Immunol. Invest"},{"key":"10.1016\/j.tice.2026.103381_bib18","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/0006-291X(64)90086-5","article-title":"Identification of cordycepin, a metabolite of Cordyceps militaris, as 3\u2032-deoxyadenosine","volume":"14","author":"Kaczka","year":"1964","journal-title":"Biochem Biophys. Res Commun."},{"key":"10.1016\/j.tice.2026.103381_bib19","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1177\/1933719108322431","article-title":"Modulation of matrix metalloproteinase secretion by adenosine A3 receptor in preeclamptic villous explants","volume":"15","author":"Kim","year":"2008","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.tice.2026.103381_bib20","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0378-4320(02)00131-8","article-title":"In vitro maturation of bovine oocytes requires polyadenylation of mRNAs coding proteins for chromatin condensation, spindle assembly, MPF and MAP kinase activation","volume":"73","author":"Krischek","year":"2002","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.tice.2026.103381_bib21","first-page":"1","article-title":"Bioactive compounds from Cordyceps and their therapeutic potential","author":"Krishna","year":"2023","journal-title":"Crit. Rev. Biotechnol."},{"key":"10.1016\/j.tice.2026.103381_bib22","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nrm3758","article-title":"Molecular mechanisms of epithelial-mesenchymal transition","volume":"15","author":"Lamouille","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.tice.2026.103381_bib23","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/s00018-023-05030-0","article-title":"Cordycepin delays postovulatory aging of oocytes through inhibition of maternal mRNAs degradation via DCP1A polyadenylation suppression","volume":"80","author":"Li","year":"2023","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.tice.2026.103381_bib24","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1039\/C9FO02879J","article-title":"Natural cordycepin induces apoptosis and suppresses metastasis in breast cancer cells by inhibiting the Hedgehog pathway","volume":"11","author":"Liu","year":"2020","journal-title":"Food Funct."},{"key":"10.1016\/j.tice.2026.103381_bib25","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1038\/sj.bjc.6601685","article-title":"Snail and SIP1 increase cancer invasion by upregulating MMP family in hepatocellular carcinoma cells","volume":"90","author":"Miyoshi","year":"2004","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.tice.2026.103381_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118425","article-title":"TBBPA-BDBPE induces ferroptosis in trophoblasts through chaperone-mediated autophagy of GPX4","volume":"299","author":"Mu","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.tice.2026.103381_bib27","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jphs.2014.09.001","article-title":"Anticancer and antimetastatic effects of cordycepin, an active component of Cordyceps sinensis","volume":"127","author":"Nakamura","year":"2015","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.tice.2026.103381_bib28","first-page":"365","article-title":"Early stimulation of human chorionic gonadotropin secretion by dibutyryl cyclic AMP and theophylline in human malignant trophoblast cells in vitro: inhibition by actinomycin D, alpha-amanitin, and cordycepin. Gynecol Invest","volume":"6","author":"Pattillo","year":"1975"},{"key":"10.1016\/j.tice.2026.103381_bib29","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1210\/en.2007-1282","article-title":"Human chorionic gonadotropin stimulates trophoblast invasion through extracellularly regulated kinase and AKT signaling","volume":"149","author":"Prast","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.tice.2026.103381_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26195886","article-title":"A Systematic Review of the Biological Effects of Cordycepin","volume":"26","author":"Radhi","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.tice.2026.103381_bib31","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1124\/mol.62.5.1137","article-title":"Signaling pathway from the human adenosine A(3) receptor expressed in Chinese hamster ovary cells to the extracellular signal-regulated kinase 1\/2","volume":"62","author":"Schulte","year":"2002","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.tice.2026.103381_bib32","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/1477-7827-2-59","article-title":"Expression and importance of matrix metalloproteinase 2 and 9 (MMP-2 and -9) in human trophoblast invasion","volume":"2","author":"Staun-Ram","year":"2004","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.tice.2026.103381_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/molecules22040629","article-title":"Metronomic Cordycepin Therapy Prolongs Survival of Oral Cancer-Bearing Mice and Inhibits Epithelial-Mesenchymal Transition","volume":"22","author":"Su","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.tice.2026.103381_bib34","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/nrc822","article-title":"Epithelial-mesenchymal transitions in tumour progression","volume":"2","author":"Thiery","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.tice.2026.103381_bib35","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/mrd.20247","article-title":"Effects of polyadenylation inhibition on meiosis progression in relation to the polyadenylation status of cyclins A2 and B1 during in vitro maturation of bovine oocytes","volume":"71","author":"Traverso","year":"2005","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.tice.2026.103381_bib36","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s11302-022-09883-1","article-title":"Adenosine receptor signalling in Alzheimer's disease","volume":"18","author":"Trinh","year":"2022","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.tice.2026.103381_bib37","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.placenta.2009.02.004","article-title":"Human placental adenosine receptor expression is elevated in preeclampsia and hypoxia increases expression of the A2A receptor","volume":"30","author":"von Versen-Hoynck","year":"2009","journal-title":"Placenta"},{"key":"10.1016\/j.tice.2026.103381_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26199483","article-title":"Molecular Insights into Human Placentation: From Villous Morphogenesis to Pathological Pathways and Translational Biomarkers","volume":"26","author":"Vornic","year":"2025","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.tice.2026.103381_bib39","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.2147\/DDDT.S252401","article-title":"Cordycepin Inhibits Human Gestational Choriocarcinoma Cell Growth by Disrupting Centrosome Homeostasis","volume":"14","author":"Wang","year":"2020","journal-title":"Drug Des. Devel Ther."},{"key":"10.1016\/j.tice.2026.103381_bib40","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s12964-022-00899-z","article-title":"GDF-11 promotes human trophoblast cell invasion by increasing ID2-mediated MMP2 expression","volume":"20","author":"Wu","year":"2022","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.tice.2026.103381_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2024.112190","article-title":"Growth differentiation factor-11 upregulates matrix metalloproteinase 2 expression by inducing Snail in human extravillous trophoblast cells","volume":"585","author":"Wu","year":"2024","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.tice.2026.103381_bib42","article-title":"Effects of beta-Nicotinamide Mononucleotide, Berberine, and Cordycepin on Lipid Droplet Content and Developmental Ability of Vitrified Bovine Oocytes","volume":"12","author":"Xu","year":"2023","journal-title":"Antioxid. (Basel)"},{"key":"10.1016\/j.tice.2026.103381_bib43","first-page":"891","article-title":"Increased invasion and matrix metalloproteinase-2 expression by Snail-induced mesenchymal transition in squamous cell carcinomas","volume":"22","author":"Yokoyama","year":"2003","journal-title":"Int J. Oncol."},{"key":"10.1016\/j.tice.2026.103381_bib44","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19103027","article-title":"The Anticancer Properties of Cordycepin and Their Underlying Mechanisms","volume":"19","author":"Yoon","year":"2018","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.tice.2026.103381_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116899","article-title":"Amphiregulin promotes trophoblast invasion and increases MMP9\/TIMP1 ratio through ERK1\/2 and Akt signal pathways","volume":"236","author":"Yu","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.tice.2026.103381_bib46","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.cellbi.2007.03.023","article-title":"Zinc-finger transcription factor snail accelerates survival, migration and expression of matrix metalloproteinase-2 in human bone mesenchymal stem cells","volume":"31","author":"Zha","year":"2007","journal-title":"Cell Biol. Int"},{"key":"10.1016\/j.tice.2026.103381_bib47","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1002\/mrd.21056","article-title":"Involvement of polyadenylation status on maternal gene expression during in vitro maturation of porcine oocytes","volume":"76","author":"Zhang","year":"2009","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.tice.2026.103381_bib48","article-title":"Structural and pharmacological insights into cordycepin for neoplasms and metabolic disorders","volume":"15","author":"Zhang","year":"2024","journal-title":"Front Pharm."},{"key":"10.1016\/j.tice.2026.103381_bib49","doi-asserted-by":"crossref","DOI":"10.1530\/REP-24-0240","article-title":"Cordycepin suppresses steroidogenic acute regulatory protein expression by reducing SP1 in human granulosa-lutein cells","volume":"168","author":"Zhang","year":"2024","journal-title":"Reproduction"}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004081662600073X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004081662600073X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:37:37Z","timestamp":1777455457000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004081662600073X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":49,"alternative-id":["S004081662600073X"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2026.103381","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cordycepin inhibits human extravillous trophoblast invasion by suppressing snail-mediated MMP2 expression","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2026.103381","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103381"}}