{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:14:57Z","timestamp":1790741697849,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.tice.2026.103433","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:27:38Z","timestamp":1772497658000},"page":"103433","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["The effects of withaferin A-conjugated mesoporous silica nanoparticles on sciatic nerve regeneration in male wistar rats"],"prefix":"10.1016","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9353-6900","authenticated-orcid":false,"given":"Azad Hasan","family":"Kheder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.tice.2026.103433_bib1","article-title":"Incidence, risk factors, and outcomes of recurrent laryngeal nerve injury and dysphonia following anterior cervical spine surgery: a systematic review and meta-analysis","volume":"17","author":"Abu-Gameh","year":"2025","journal-title":"Cureus"},{"key":"10.1016\/j.tice.2026.103433_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.111114","article-title":"Withaferin A alleviates inflammation in animal models of arthritis by inhibiting the NF-\u03baB pathway and cytokine release","volume":"398","author":"Alenazi","year":"2024","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.tice.2026.103433_bib3","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.reth.2025.04.016","article-title":"Advances in sciatic nerve regeneration: a review of contemporary techniques","volume":"29","author":"Ali","year":"2025","journal-title":"Regen. Ther."},{"issue":"4","key":"10.1016\/j.tice.2026.103433_bib4","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s11064-015-1771-2","article-title":"Neuroprotective effect of natural products on peripheral nerve degeneration: a systematic review","volume":"41","author":"Ara\u00fajo-Filho","year":"2016","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.tice.2026.103433_bib5","doi-asserted-by":"crossref","unstructured":"Baghirov H., Karaman D., Viitala T., Duchanoy A., Lou Y.-R., Mamaeva V., et al. Feasibility study of the permeability and uptake of mesoporous silica nanoparticles across the blood-brain barrier. 2016;11(8):e0160705.","DOI":"10.1371\/journal.pone.0160705"},{"key":"10.1016\/j.tice.2026.103433_bib6","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1039\/c8pp00143j","article-title":"Mesoporous silica nanoparticles in recent photodynamic therapy applications","volume":"17","author":"Bayir","year":"2018","journal-title":"Photochem. Photobiol. Sci."},{"issue":"2","key":"10.1016\/j.tice.2026.103433_bib7","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1006\/exnr.1994.1104","article-title":"Nerve crush injuries\u2014a model for axonotmesis","volume":"127","author":"Bridge","year":"1994","journal-title":"Exp. Neurol."},{"issue":"4","key":"10.1016\/j.tice.2026.103433_bib8","first-page":"303","article-title":"How to calculate sample size in animal studies?","volume":"4","author":"Charan","year":"2013","journal-title":"J. Pharm. Pharm."},{"issue":"2","key":"10.1016\/j.tice.2026.103433_bib9","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1529-8027.2010.00260.x","article-title":"Traumatic peripheral nerve injuries: epidemiological findings, neuropathic pain and quality of life in 158 patients","volume":"15","author":"Ciaramitaro","year":"2010","journal-title":"J. Peripher. Nerv. Syst."},{"issue":"1","key":"10.1016\/j.tice.2026.103433_bib10","doi-asserted-by":"crossref","first-page":"40","DOI":"10.53771\/ijlsra.2024.7.1.0060","article-title":"Revolutionizing drug delivery systems: nanotechnology-based approaches for targeted therapy","volume":"7","author":"Emeihe","year":"2024","journal-title":"Int J. Life Sci. Res Arch."},{"issue":"6","key":"10.1016\/j.tice.2026.103433_bib11","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.neuron.2017.02.005","article-title":"New horizons in diabetic neuropathy: mechanisms, bioenergetics, and pain","volume":"93","author":"Feldman","year":"2017","journal-title":"Neuron"},{"issue":"40","key":"10.1016\/j.tice.2026.103433_bib12","doi-asserted-by":"crossref","first-page":"15252","DOI":"10.1039\/C7NR05762H","article-title":"Evaluation of mesoporous silica nanoparticles for oral drug delivery\u2013current status and perspective of MSNs drug carriers","volume":"9","author":"Florek","year":"2017","journal-title":"Nanoscale"},{"issue":"3","key":"10.1016\/j.tice.2026.103433_bib13","doi-asserted-by":"crossref","first-page":"756","DOI":"10.3390\/biomedicines11030756","article-title":"Differentiating lumbar spinal etiology from peripheral plexopathies","volume":"11","author":"Foreman","year":"2023","journal-title":"Biomedicines"},{"issue":"40","key":"10.1016\/j.tice.2026.103433_bib14","first-page":"13850","article-title":"Mesoporous-silica-functionalized nanoparticles for drug delivery","volume":"21","author":"Giret","year":"2015"},{"key":"10.1016\/j.tice.2026.103433_bib15","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.actbio.2021.07.023","article-title":"Carboxyl-functionalized mesoporous silica nanoparticles for the controlled delivery of poorly water-soluble non-steroidal anti-inflammatory drugs","volume":"134","author":"Gou","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.tice.2026.103433_bib16","doi-asserted-by":"crossref","unstructured":"Guzman-Ruiz M.A., de La Mora M.B., Torres X., Meza C., Garc\u00eda E., Chavarr\u00eda A.. Oral silica nanoparticles lack of neurotoxic effects in a Parkinson\u2019s disease model: a possible nanocarrier? 2019;18(4):535-41.","DOI":"10.1109\/TNB.2019.2934074"},{"issue":"2","key":"10.1016\/j.tice.2026.103433_bib17","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/00006534-199202000-00009","article-title":"Walking track analysis: a long-term assessment of peripheral nerve recovery","volume":"89","author":"Hare","year":"1992","journal-title":"Plast. Reconstr. Surg."},{"issue":"4","key":"10.1016\/j.tice.2026.103433_bib18","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.bcp.2014.08.004","article-title":"Withaferin A inhibits NF-kappaB activation by targeting cysteine 179 in IKK\u03b2","volume":"91","author":"Heyninck","year":"2014","journal-title":"Biochem. Pharmacol."},{"issue":"3","key":"10.1016\/j.tice.2026.103433_bib19","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.biomaterials.2009.09.060","article-title":"The effect of the shape of mesoporous silica nanoparticles on cellular uptake and cell function","volume":"31","author":"Huang","year":"2010","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.tice.2026.103433_bib20","first-page":"77","article-title":"Hydrophobic drug release studies from the core\/shell magnetic mesoporous silica nanoparticles and their anticancer application: drug release studies from magnetic mesoporous nanoparticles and their anticancer application","volume":"58","author":"Hussain","year":"2021","journal-title":"Proc. Pak. Acad. Sci. B Life Environ. Sci."},{"issue":"3","key":"10.1016\/j.tice.2026.103433_bib21","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.mporth.2020.03.011","article-title":"Peripheral nerve injury: an update","volume":"34","author":"Khan","year":"2020","journal-title":"Orthop. Trauma"},{"issue":"10","key":"10.1016\/j.tice.2026.103433_bib22","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.3390\/molecules21101322","article-title":"Natural and synthetic coumarins with effects on inflammation","volume":"21","author":"Kirsch","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.tice.2026.103433_bib23","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.mehy.2016.04.034","article-title":"Exploring neuroprotective potential of Withania somnifera phytochemicals by inhibition of GluN2B-containing NMDA receptors: an in silico study","volume":"92","author":"Kumar","year":"2016","journal-title":"Med. Hypotheses"},{"issue":"2","key":"10.1016\/j.tice.2026.103433_bib24","doi-asserted-by":"crossref","first-page":"918","DOI":"10.3390\/ijms23020918","article-title":"Peripheral nerve injury treatments and advances: one health perspective","volume":"23","author":"Lopes","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.tice.2026.103433_bib25","article-title":"Withaferin A inhibits nuclear factor-\u03baB-dependent pro-inflammatory and stress response pathways in the astrocytes","volume":"2015","author":"Martorana","year":"2015","journal-title":"Neural Plast."},{"key":"10.1016\/j.tice.2026.103433_bib26","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.wneu.2022.09.094","article-title":"Outcomes after minimally invasive sacroiliac joint fusion: a scoping review","volume":"168","author":"Mehkri","year":"2022","journal-title":"World Neurosurg."},{"issue":"9","key":"10.1016\/j.tice.2026.103433_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/ppsc.201900195","article-title":"Multidisciplinary role of mesoporous silica nanoparticles in brain regeneration and cancers: from crossing the blood\u2013brain barrier to treatment","volume":"36","author":"Mendiratta","year":"2019","journal-title":"Part. Part. Syst. Charact."},{"issue":"12","key":"10.1016\/j.tice.2026.103433_bib28","doi-asserted-by":"crossref","first-page":"5167","DOI":"10.1039\/c3nr00357d","article-title":"Mesoporous silica nanoparticles as antigen carriers and adjuvants for vaccine delivery","volume":"5","author":"Mody","year":"2013","journal-title":"Nanoscale"},{"issue":"1","key":"10.1016\/j.tice.2026.103433_bib29","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/6565396","article-title":"Natural products and their bioactive compounds: neuroprotective potentials against neurodegenerative diseases","volume":"2020","author":"Mohd Sairazi","year":"2020","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.tice.2026.103433_bib30","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.micromeso.2016.08.038","article-title":"Stimuli-responsive mesoporous silica nanoparticles for cancer therapy: a review","volume":"236","author":"Moreira","year":"2016","journal-title":"Microporous Mesoporous Mater."},{"issue":"5","key":"10.1016\/j.tice.2026.103433_bib31","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.intimp.2009.02.002","article-title":"Withaferin A inhibits tumor necrosis factor-\u03b1-induced expression of cell adhesion molecules by inactivation of Akt and NF-\u03baB in human pulmonary epithelial cells","volume":"9","author":"Oh","year":"2009","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"10.1016\/j.tice.2026.103433_bib32","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1021\/bm501786t","article-title":"A hierarchical porous bowl-like PLA@ MSNs-COOH composite for pH-dominated long-term controlled release of doxorubicin and integrated nanoparticle for potential second treatment","volume":"16","author":"Pan","year":"2015","journal-title":"Biomacromolecules"},{"issue":"1","key":"10.1016\/j.tice.2026.103433_bib33","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s13311-014-0311-0","article-title":"Early-stage treatment with Withaferin A reduces levels of misfolded superoxide dismutase 1 and extends lifespan in a mouse model of amyotrophic lateral sclerosis","volume":"12","author":"Patel","year":"2015","journal-title":"Neurotherapeutics"},{"issue":"1","key":"10.1016\/j.tice.2026.103433_bib34","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1039\/C8AY02215A","article-title":"Amino-functionalized mesoporous silica nanospheres (MSN-NH 2) as sorbent for extraction and concentration of synthetic dyes from foodstuffs prior to HPLC analysis","volume":"11","author":"Qin","year":"2019","journal-title":"Anal. Methods"},{"issue":"2","key":"10.1016\/j.tice.2026.103433_bib35","doi-asserted-by":"crossref","first-page":"304","DOI":"10.4103\/1673-5374.290894","article-title":"Implications of Withaferin A in neurological disorders","volume":"16","author":"Ram","year":"2021","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.tice.2026.103433_bib36","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.biopha.2018.12.133","article-title":"Applications of nanotechnology in drug delivery to the central nervous system","volume":"111","author":"Saeedi","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.tice.2026.103433_bib37","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1158\/1940-6207.CAPR-22-0193","article-title":"Withaferin A inhibits fatty acid synthesis in rat mammary tumors","volume":"16","author":"Singh","year":"2022","journal-title":"Cancer Prev. Res."},{"issue":"12","key":"10.1016\/j.tice.2026.103433_bib38","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1002\/ptr.6200","article-title":"Withaferin A, a novel compound of I ndian ginseng (Withania somnifera), ameliorates C erulein-induced acute pancreatitis: Possible role of oxidative stress and inflammation","volume":"32","author":"Tiruveedi","year":"2018","journal-title":"Phytother. Res."},{"issue":"10","key":"10.1016\/j.tice.2026.103433_bib39","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.bcp.2012.08.027","article-title":"Molecular insight in the multifunctional activities of Withaferin A","volume":"84","author":"Vanden Berghe","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tice.2026.103433_bib40","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/micr.21803","article-title":"Functional assessment of peripheral nerve recovery in the rat: Gait kinematics","volume":"21","author":"Varej\u00e3o","year":"2001","journal-title":"Microsurgery"},{"issue":"2","key":"10.1016\/j.tice.2026.103433_bib41","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s11552-014-9692-0","article-title":"Social impact of peripheral nerve injuries","volume":"10","author":"Wojtkiewicz","year":"2015","journal-title":"Hand"},{"issue":"36","key":"10.1016\/j.tice.2026.103433_bib42","doi-asserted-by":"crossref","first-page":"9972","DOI":"10.1039\/c1cc11760b","article-title":"Mesoporous silica nanoparticles as nanocarriers","volume":"47","author":"Wu","year":"2011","journal-title":"Chem. Commun."},{"key":"10.1016\/j.tice.2026.103433_bib43","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.lfs.2018.09.020","article-title":"Withaferin A inhibits apoptosis via activated Akt-mediated inhibition of oxidative stress","volume":"211","author":"Yan","year":"2018","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.tice.2026.103433_bib44","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1080\/13880209.2017.1288262","article-title":"Withaferin A protects against spinal cord injury by inhibiting apoptosis and inflammation in mice","volume":"55","author":"Yan","year":"2017","journal-title":"Pharm. Biol."},{"issue":"8","key":"10.1016\/j.tice.2026.103433_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0041214","article-title":"Withaferin A inhibits the proteasome activity in mesothelioma in vitro and in vivo","volume":"7","author":"Yang","year":"2012","journal-title":"PLOS ONE"},{"issue":"1","key":"10.1016\/j.tice.2026.103433_bib46","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.advms.2016.09.003","article-title":"Protection against cerebral infarction by Withaferin A involves inhibition of neuronal apoptosis, activation of PI3K\/Akt signaling pathway, and reduced intimal hyperplasia via inhibition of VSMC migration and matrix metalloproteinases","volume":"62","author":"Zhang","year":"2017","journal-title":"Adv. Med. Sci."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626001254?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626001254?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T03:06:50Z","timestamp":1778728010000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816626001254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":46,"alternative-id":["S0040816626001254"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2026.103433","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effects of withaferin A-conjugated mesoporous silica nanoparticles on sciatic nerve regeneration in male wistar rats","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2026.103433","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103433"}}