{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T03:11:03Z","timestamp":1778728263478,"version":"3.51.4"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007480","name":"University of Castilla-La Mancha","doi-asserted-by":"publisher","award":["2025-GRIN-38362"],"award-info":[{"award-number":["2025-GRIN-38362"]}],"id":[{"id":"10.13039\/501100007480","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["SBPLY\/24\/180225\/000007"],"award-info":[{"award-number":["SBPLY\/24\/180225\/000007"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["SBPLY\/21\/180501\/000064"],"award-info":[{"award-number":["SBPLY\/21\/180501\/000064"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Gobierno de Espana Ministerio de Ciencia e Innovacion","doi-asserted-by":"publisher","award":["PID2024-155887OB-I00"],"award-info":[{"award-number":["PID2024-155887OB-I00"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Gobierno de Espana Ministerio de Ciencia e Innovacion","doi-asserted-by":"publisher","award":["PID2021-125875OB-I00"],"award-info":[{"award-number":["PID2021-125875OB-I00"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011698","name":"Regional Government of Castilla-La Mancha","doi-asserted-by":"publisher","award":["SBPLY\/24\/180225\/000007"],"award-info":[{"award-number":["SBPLY\/24\/180225\/000007"]}],"id":[{"id":"10.13039\/501100011698","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011698","name":"Regional Government of Castilla-La Mancha","doi-asserted-by":"publisher","award":["SBPLY\/21\/180501\/000064"],"award-info":[{"award-number":["SBPLY\/21\/180501\/000064"]}],"id":[{"id":"10.13039\/501100011698","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.tice.2026.103436","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T16:52:05Z","timestamp":1773161525000},"page":"103436","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Amyloid-\u03b2 and tau pathology induce a reduction of the G-protein G\u03b1o subunit in the mouse hippocampus"],"prefix":"10.1016","volume":"101","author":[{"given":"Carolina","family":"Aguado","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda de los Llanos","family":"Mart\u00ednez-Poyato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Mart\u00edn-Belmonte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roc\u00edo","family":"Alfaro-Ruiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Esther","family":"Moreno-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Luj\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2026.103436_bib1","first-page":"1967","article-title":"Developmental regulation of GABAB receptors and downstream molecules in the mouse brain","volume":"40","author":"Aguado","year":"2025","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.tice.2026.103436_bib2","first-page":"725","article-title":"Histoblot: A sensitive method to quantify the expression of proteins in normal and pathological conditions","volume":"38","author":"Aguado","year":"2023","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.tice.2026.103436_bib3","doi-asserted-by":"crossref","first-page":"16601","DOI":"10.1096\/fj.202001113R","article-title":"GNAO1 organizes the cytoskeletal remodeling and firing of developing neurons","volume":"34","author":"Akamine","year":"2020","journal-title":"FASEB J."},{"key":"10.1016\/j.tice.2026.103436_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222011106","article-title":"The Expression and Localisation of G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channels Is Differentially Altered in the Hippocampus of Two Mouse Models of Alzheimer\u2019s Disease","volume":"22","author":"Alfaro-Ruiz","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2026.103436_bib5","doi-asserted-by":"crossref","first-page":"506","DOI":"10.3390\/cells9020506","article-title":"G-Protein-Coupled Receptors in CNS: A Potential Therapeutic Target for Intervention in Neurodegenerative Disorders and Associated Cognitive Deficits","volume":"9","author":"Azam","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.tice.2026.103436_bib6","doi-asserted-by":"crossref","DOI":"10.1152\/physrev.00036.2003","article-title":"Molecular structure and physiological functions of GABAB receptors","author":"Bettler","year":"2004","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.tice.2026.103436_bib7","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.neurobiolaging.2017.12.013","article-title":"APP\/Go protein G\u03b2\u03b3-complex signaling mediates A\u03b2 degeneration and cognitive impairment in Alzheimer\u2019s disease models","volume":"64","author":"Bignante","year":"2018","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.tice.2026.103436_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2017.00037","article-title":"Understanding the Role of GPCR Heteroreceptor Complexes in Modulating the Brain Networks in Health and Disease","volume":"11","author":"Borroto-Escuela","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.tice.2026.103436_bib9","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0014-5793(87)80218-1","article-title":"Localization of mRNAs encoding the alpha-subunits of signal-transducing G-proteins within rat brain and among peripheral tissues","volume":"222","author":"Brann","year":"1987","journal-title":"FEBS Lett."},{"key":"10.1016\/j.tice.2026.103436_bib10","doi-asserted-by":"crossref","first-page":"8740","DOI":"10.1073\/pnas.1206171109","article-title":"Critical role of soluble amyloid-\u03b2 for early hippocampal hyperactivity in a mouse model of Alzheimer\u2019s disease","volume":"109","author":"Busche","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tice.2026.103436_bib11","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1074\/jbc.275.3.1565","article-title":"Degradation of heterotrimeric G\u03b1(o) subunits via the proteosome pathway is induced by the hsp90-specific compound geldanamycin","volume":"275","author":"Busconi","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tice.2026.103436_bib12","doi-asserted-by":"crossref","DOI":"10.1186\/s13041-019-0477-9","article-title":"Deletion of the \u03b1 subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice","volume":"12","author":"Cha","year":"2019","journal-title":"Mol. Brain"},{"key":"10.1016\/j.tice.2026.103436_bib13","doi-asserted-by":"crossref","first-page":"10974","DOI":"10.1073\/pnas.1613026113","article-title":"Development of the main olfactory system and main olfactory epithelium-dependent male mating behavior are altered in G o -deficient mice","volume":"113","author":"Choi","year":"2016","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.tice.2026.103436_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2017.00003","article-title":"Role of APP Interactions with Heterotrimeric G Proteins: Physiological Functions and Pathological Consequences","volume":"10","author":"Copenhaver","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.tice.2026.103436_bib15","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1042\/bss0670163","article-title":"Receptor-G-protein signalling in Alzheimer\u2019s disease","volume":"67","author":"Cowburn","year":"2001","journal-title":"Biochem. Soc. Symp."},{"key":"10.1016\/j.tice.2026.103436_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2019.00089","article-title":"Gi\/o-Protein Coupled Receptors in the Aging Brain","volume":"11","author":"de Oliveira","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.tice.2026.103436_bib17","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1002\/hipo.22161","article-title":"Association of Rgs7\/G\u03b25 complexes with girk channels and GABA B receptors in hippocampal CA1 pyramidal neurons","volume":"23","author":"Fajardo-Serrano","year":"2013","journal-title":"Hippocampus"},{"key":"10.1016\/j.tice.2026.103436_bib18","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/jnr.10125","article-title":"Loss of stimulatory effect of guanosine triphosphate on [(35)S]GTPgammaS binding correlates with Alzheimer\u2019s disease neurofibrillary pathology in entorhinal cortex and CA1 hippocampal subfield","volume":"67","author":"Garca-Jimnez","year":"2002","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.tice.2026.103436_bib19","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.nbd.2006.08.017","article-title":"Characterization of amyloid deposition in the APPswe\/PS1dE9 mouse model of Alzheimer disease","volume":"24","author":"Garcia-Alloza","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.tice.2026.103436_bib20","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1097\/00001756-200308060-00025","article-title":"G-protein alpha-subunit levels in hippocampus and entorhinal cortex of brains staged for Alzheimer\u2019s disease neurofibrillary and amyloid pathologies","volume":"14","author":"Garc\u00eda-Jim\u00e9nez","year":"2003","journal-title":"Neuroreport"},{"key":"10.1016\/j.tice.2026.103436_bib21","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0167-4889(91)90008-L","article-title":"Analysis by mRNA levels of the expression of six G protein alpha-subunit genes in mammalian cells and tissues","volume":"1094","author":"Garibay","year":"1991","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.tice.2026.103436_bib22","doi-asserted-by":"crossref","first-page":"6367","DOI":"10.1523\/JNEUROSCI.0395-10.2010","article-title":"Memory impairment in transgenic alzheimer mice requires cellular prion protein","volume":"30","author":"Gimbel","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tice.2026.103436_bib23","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1111\/nan.12742","article-title":"G protein-coupled receptor kinases are associated with Alzheimer\u2019s disease pathology","volume":"47","author":"Guimar\u00e3es","year":"2021","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.tice.2026.103436_bib24","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/380258a0","article-title":"Modulation of Ca2+ channels by G-protein beta gamma subunits","volume":"380","author":"Herlitze","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.tice.2026.103436_bib25","doi-asserted-by":"crossref","DOI":"10.1111\/jnc.16248","article-title":"G\u03b1o1 and G\u03b1o1\/G\u03b1o2 deletion differentially affect hippocampal mossy fiber tract anatomy and neuronal morphogenesis","volume":"169","author":"H\u00f6ltje","year":"2025","journal-title":"J. Neurochem."},{"key":"10.1016\/j.tice.2026.103436_bib26","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1002\/j.1460-2075.1996.tb00604.x","article-title":"Negative transactivation of cAMP response element by familial Alzheimer\u2019s mutants of APP","volume":"15","author":"Ikezu","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/j.tice.2026.103436_bib27","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/hmg\/ddh019","article-title":"Mutant presenilins specifically elevate the levels of the 42 residue \u03b2-amyloid peptide in vivo: Evidence for augmentation of a 42-specific \u03b3 secretase","volume":"13","author":"Jankowsky","year":"2004","journal-title":"Hum. Mol. Genet"},{"key":"10.1016\/j.tice.2026.103436_bib28","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1389-0344(01)00067-3","article-title":"Co-expression of multiple transgenes in mouse CNS: A comparison of strategies","volume":"17","author":"Jankowsky","year":"2001","journal-title":"Biomol. Eng."},{"key":"10.1016\/j.tice.2026.103436_bib29","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1073\/pnas.95.6.3269","article-title":"Multiple neurological abnormalities in mice deficient in the G protein Go","volume":"95","author":"Jiang","year":"1998","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.tice.2026.103436_bib30","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.4103\/NRR.NRR-D-24-01550","article-title":"Molecular biomarkers in GNAO1 encephalopathies","volume":"21","author":"Katanaev","year":"2026","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.tice.2026.103436_bib31","doi-asserted-by":"crossref","first-page":"4544","DOI":"10.1523\/JNEUROSCI.19-11-04544.1999","article-title":"Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons","volume":"19","author":"Katona","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tice.2026.103436_bib32","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.nbd.2008.10.006","article-title":"Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model","volume":"33","author":"Kimura","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.tice.2026.103436_bib33","doi-asserted-by":"crossref","first-page":"6542","DOI":"10.1073\/pnas.92.14.6542","article-title":"Evidence that neuronal G-protein-gated inwardly rectifying K+ channels are activated by G beta gamma subunits and function as heteromultimers","volume":"92","author":"Kofuji","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tice.2026.103436_bib34","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1111\/j.1471-4159.2008.05712.x","article-title":"Pre-synaptic GABA receptors inhibit glutamate release through GIRK channels in rat cerebral cortex","volume":"107","author":"Ladera","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.tice.2026.103436_bib35","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.molmed.2005.02.009","article-title":"Alzheimer\u2019s disease: A\u03b2, tau and synaptic dysfunction","volume":"11","author":"LaFerla","year":"2005","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.tice.2026.103436_bib36","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1002\/mds.29881","article-title":"Clinical and Molecular Profiling in GNAO1 Permits Phenotype-Genotype Correlation","volume":"39","author":"Lasa-Aranzasti","year":"2024","journal-title":"Mov. Disord."},{"key":"10.1016\/j.tice.2026.103436_bib37","doi-asserted-by":"crossref","first-page":"12523","DOI":"10.1523\/JNEUROSCI.1527-11.2011","article-title":"Compartmentalization of the GABAB receptor signaling complex is required for presynaptic inhibition at hippocampal synapses","volume":"31","author":"Laviv","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tice.2026.103436_bib38","doi-asserted-by":"crossref","first-page":"5651","DOI":"10.1073\/pnas.080572297","article-title":"The role of members of the pertussis toxin-sensitive family of G proteins in coupling receptors to the activation of the G protein-gated inwardly rectifying potassium channel","volume":"97","author":"Leaney","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tice.2026.103436_bib39","doi-asserted-by":"crossref","first-page":"5013","DOI":"10.1021\/acs.jmedchem.9b01452","article-title":"Heterotrimeric G Proteins as Therapeutic Targets in Drug Discovery","volume":"63","author":"Li","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.tice.2026.103436_bib40","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1111\/j.1460-9568.1996.tb01611.x","article-title":"Perisynaptic Location of Metabotropic Glutamate Receptors mGluR1 and mGluR5 on Dendrites and Dendritic Spines in the Rat Hippocampus","volume":"8","author":"Luj\u00e1n","year":"1996","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.tice.2026.103436_bib41","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0896-6273(00)80381-5","article-title":"G Protein-Coupled Inwardly Rectifying K+ Channels (GIRKs) Mediate Postsynaptic but Not Presynaptic Transmitter Actions in Hippocampal Neurons","volume":"19","author":"L\u00fcscher","year":"1997","journal-title":"Neuron"},{"key":"10.1016\/j.tice.2026.103436_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22115867","article-title":"The Density of Group I mGlu5 Receptors Is Reduced along the Neuronal Surface of Hippocampal Cells in a Mouse Model of Alzheimer\u2019s Disease","volume":"22","author":"Mart\u00edn-Belmonte","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2026.103436_bib43","doi-asserted-by":"crossref","DOI":"10.1186\/s13195-022-01078-5","article-title":"Nanoscale alterations in GABAB receptors and GIRK channel organization on the hippocampus of APP\/PS1 mice","volume":"14","author":"Mart\u00edn-Belmonte","year":"2022","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.tice.2026.103436_bib44","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/bpa.12802","article-title":"Reduction in the neuronal surface of post and presynaptic GABAB receptors in the hippocampus in a mouse model of Alzheimer\u2019s disease","volume":"30","author":"Mart\u00edn-Belmonte","year":"2020","journal-title":"Brain Pathol."},{"key":"10.1016\/j.tice.2026.103436_bib45","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0306-4522(00)00496-6","article-title":"Total number and distribution of inhibitory and excitatory synapses on hippocampal CA1 pyramidal cells","volume":"102","author":"Meg\u00edas","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.tice.2026.103436_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.108718","article-title":"G\u03b1o is a major determinant of cAMP signaling in the pathophysiology of movement disorders","volume":"34","author":"Muntean","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.tice.2026.103436_bib47","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1007\/s00429-014-0848-z","article-title":"Evidence for Alzheimer\u2019s disease-linked synapse loss and compensation in mouse and human hippocampal CA1 pyramidal neurons","volume":"220","author":"Neuman","year":"2015","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.tice.2026.103436_bib48","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/362075a0","article-title":"Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o)","volume":"362","author":"Nishimoto","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.tice.2026.103436_bib49","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","article-title":"Intraneuronal \u03b2-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer\u2019s disease mutations: Potential factors in amyloid plaque formation","volume":"26","author":"Oakley","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tice.2026.103436_bib50","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.713726","article-title":"Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study","volume":"13","author":"Oblak","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.tice.2026.103436_bib51","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/nrm2299","article-title":"Heterotrimeric G protein activation by G-protein-coupled receptors","volume":"9","author":"Oldham","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.tice.2026.103436_bib52","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0006-8993(94)91017-0","article-title":"Regionally selective alterations in G protein subunit levels in the Alzheimer\u2019s disease brain","volume":"636","author":"O\u2019Neill","year":"1994","journal-title":"Brain Res"},{"key":"10.1016\/j.tice.2026.103436_bib53","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.02053","article-title":"RGS7\/G\u03b25\/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABABR-GIRK signaling","volume":"3","author":"Ostrovskaya","year":"2014","journal-title":"Elife"},{"key":"10.1016\/j.tice.2026.103436_bib54","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.neuron.2007.11.023","article-title":"Adenosine A2A Receptors Are Essential for Long-Term Potentiation of NMDA-EPSCs at Hippocampal Mossy Fiber Synapses","volume":"57","author":"Rebola","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.tice.2026.103436_bib55","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1085\/jgp.200709926","article-title":"Antibody-based Validation of CNS Ion Channel Drug Targets","volume":"131","author":"Rhodes","year":"2008","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.tice.2026.103436_bib56","doi-asserted-by":"crossref","DOI":"10.3389\/fnana.2021.686279","article-title":"Cellular Diversity and Differential Subcellular Localization of the G-Protein G\u03b1o Subunit in the Mouse Cerebellum","volume":"15","author":"Rold\u00e1n-Sastre","year":"2021","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.tice.2026.103436_bib57","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1177\/1073858405284672","article-title":"Ca2+-dependent mechanisms of presynaptic control at central synapses","volume":"12","author":"Rusakov","year":"2006","journal-title":"Neuroscientist"},{"key":"10.1016\/j.tice.2026.103436_bib58","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/0896-6273(92)90244-8","article-title":"Presynaptic inhibition of miniature excitatory synaptic currents by baclofen and adenosine in the hippocampus","volume":"9","author":"Scanziani","year":"1992","journal-title":"Neuron"},{"key":"10.1016\/j.tice.2026.103436_bib59","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s004180100303","article-title":"Developmental expression of heterotrimeric G-proteins in the murine cerebellar cortex","volume":"116","author":"Sch\u00fcller","year":"2001","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.tice.2026.103436_bib60","doi-asserted-by":"crossref","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease at 25 years","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.tice.2026.103436_bib61","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1111\/j.1742-4658.2009.06997.x","article-title":"Interactions between the amyloid precursor protein C-terminal domain and G proteins mediate calcium dysregulation and amyloid beta toxicity in Alzheimer\u2019s disease","volume":"276","author":"Shaked","year":"2009","journal-title":"FEBS J."},{"key":"10.1016\/j.tice.2026.103436_bib62","doi-asserted-by":"crossref","first-page":"16281","DOI":"10.1074\/jbc.273.26.16281","article-title":"Regulation of brain G-protein G(o) by Alzheimer\u2019s disease gene presenilin-1","volume":"273","author":"Sminet","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tice.2026.103436_bib63","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.neurobiolaging.2007.11.017","article-title":"Amyloid-\u03b2 precursor protein mediates neuronal toxicity of amyloid \u03b2 through Go protein activation","volume":"30","author":"Sola Vigo","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.tice.2026.103436_bib64","doi-asserted-by":"crossref","DOI":"10.1172\/JCI172057","article-title":"Neomorphic G\u03b1o mutations gain interaction with Ric8 proteins in GNAO1 encephalopathies","volume":"134","author":"Solis","year":"2024","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.tice.2026.103436_bib65","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1046\/j.1460-9568.2003.02697.x","article-title":"High level of mGluR7 in the presynaptic active zones of select populations of GABAergic terminals innervating interneurons in the rat hippocampus","volume":"17","author":"Somogyi","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.tice.2026.103436_bib66","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.neuron.2014.05.004","article-title":"The intersection of amyloid beta and tau at synapses in Alzheimer\u2019s disease","volume":"82","author":"Spires-Jones","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.tice.2026.103436_bib67","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1523\/JNEUROSCI.22-07-02460.2002","article-title":"G-protein alpha subunit isoforms couple differentially to receptors that mediate presynaptic inhibition at rat hippocampal synapses","volume":"22","author":"Straiker","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tice.2026.103436_bib68","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neuron.2012.06.012","article-title":"The presynaptic active zone","volume":"75","author":"S\u00fcdhof","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.tice.2026.103436_bib69","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1146\/annurev-pharmtox-061724-080727","article-title":"G Protein-Coupled Receptor Heteromers in Brain: Functional and Therapeutic Importance in Neuropsychiatric Disorders","volume":"65","author":"Sun","year":"2025","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.tice.2026.103436_bib70","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1016\/S0002-9440(10)64463-X","article-title":"Intraneuronal Alzheimer A\u03b242 accumulates in multivesicular bodies and is associated with synaptic pathology","volume":"161","author":"Takahashi","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.tice.2026.103436_bib71","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1046\/j.1460-9568.2000.00959.x","article-title":"Gq protein \u03b1 subunits G\u03b1q and G\u03b111 are localized at postsynaptic extra-junctional membrane of cerebellar Purkinje cells and hippocampal pyramidal cells","volume":"12","author":"Tanaka","year":"2000","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.tice.2026.103436_bib72","doi-asserted-by":"crossref","DOI":"10.1038\/s41398-022-02024-7","article-title":"Neuronal hyperexcitability in Alzheimer\u2019s disease: what are the drivers behind this aberrant phenotype?","volume":"12","author":"Targa Dias Anastacio","year":"2022","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.tice.2026.103436_bib73","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0006-8993(88)91516-8","article-title":"Immunohistochemical analysis of the localization of guanine nucleotide-binding protein in the mouse brain","volume":"442","author":"Terashima","year":"1988","journal-title":"Brain Res"},{"key":"10.1016\/j.tice.2026.103436_bib74","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1749-6632.2000.tb05561.x","article-title":"\u201cFatal attractions\u201d of proteins. A comprehensive hypothetical mechanism underlying Alzheimer\u2019s disease and other neurodegenerative disorders","volume":"924","author":"Trojanowski","year":"2000","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.tice.2026.103436_bib75","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1093\/hmg\/ddab235","article-title":"Genetic modeling of GNAO1 disorder delineates mechanisms of G\u03b1o dysfunction","volume":"31","author":"Wang","year":"2022","journal-title":"Hum. Mol. Genet"},{"key":"10.1016\/j.tice.2026.103436_bib76","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1146\/annurev-biochem-060614-033910","article-title":"The Molecular Basis of G Protein\u2013Coupled Receptor Activation","volume":"87","author":"Weis","year":"2018","journal-title":"Annu. Rev. Biochem"},{"key":"10.1016\/j.tice.2026.103436_bib77","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1152\/physrev.00003.2005","article-title":"Mammalian G Proteins and Their Cell Type Specific Functions","volume":"85","author":"Wettschureck","year":"2005","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.tice.2026.103436_bib78","article-title":"G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders","volume":"8","author":"Wong","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.tice.2026.103436_bib79","doi-asserted-by":"crossref","first-page":"4561","DOI":"10.1073\/pnas.83.12.4561","article-title":"Go, a guanine nucleotide-binding protein: immunohistochemical localization in rat brain resembles distribution of second messenger systems","volume":"83","author":"Worley","year":"1986","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"Pt 3","key":"10.1016\/j.tice.2026.103436_bib80","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1113\/jphysiol.1995.sp020759","article-title":"GABAB receptor-mediated presynaptic inhibition in guinea-pig hippocampus is caused by reduction of presynaptic Ca2+ influx","volume":"485","author":"Wu","year":"1995","journal-title":"J. Physiol."},{"key":"10.1016\/j.tice.2026.103436_bib81","doi-asserted-by":"crossref","DOI":"10.1186\/s40478-024-01720-3","article-title":"The Schwann cell-specific G-protein G\u03b1o (Gnao1) is a cell-intrinsic controller contributing to the regulation of myelination in peripheral nerve system","volume":"12","author":"Xu","year":"2024","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.tice.2026.103436_bib82","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.neuron.2007.01.010","article-title":"Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model","volume":"53","author":"Yoshiyama","year":"2007","journal-title":"Neuron"}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626001291?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626001291?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T02:53:33Z","timestamp":1778727213000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816626001291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":82,"alternative-id":["S0040816626001291"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2026.103436","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amyloid-\u03b2 and tau pathology induce a reduction of the G-protein G\u03b1o subunit in the mouse hippocampus","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2026.103436","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103436"}}