{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T03:13:51Z","timestamp":1778728431360,"version":"3.51.4"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.tice.2026.103457","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T16:42:55Z","timestamp":1773074575000},"page":"103457","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Key signaling pathways in the development and progression of prostate cancer: The crosstalk between inflammation, autophagy, and pyroptosis"],"prefix":"10.1016","volume":"101","author":[{"given":"Yong","family":"Cai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Bo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Mai","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2026.103457_bib1","article-title":"Polygenic anti-cancer activity of Indigofera macrophylla in prostate cancer induced animal model","volume":"13","author":"Alabi","year":"2024","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.tice.2026.103457_bib2","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.clnesp.2021.12.030","article-title":"The possible role of ursolic acid in Covid-19: A real game changer","volume":"47","author":"Al-Kuraishy","year":"2022","journal-title":"Clin. Nutr. ESPEN"},{"issue":"4","key":"10.1016\/j.tice.2026.103457_bib3","doi-asserted-by":"crossref","first-page":"496","DOI":"10.4103\/jnrp.jnrp_97_18","article-title":"Lipoprotein-associated phospholipase A2 is linked with poor cardio-metabolic profile in patients with ischemic stroke: a study of effects of statins","volume":"9","author":"Alkuraishy","year":"2018","journal-title":"J. Neurosci. Rural Pr."},{"key":"10.1016\/j.tice.2026.103457_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112193","article-title":"Arginine vasopressin and pathophysiology of COVID-19: An innovative perspective","volume":"143","author":"Al-Kuraishy","year":"2021","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.tice.2026.103457_bib5","article-title":"Case report: hyperbilirubinemia in gilbert syndrome attenuates covid-19-induced metabolic disturbances","volume":"8","author":"Al-Kuraishy","year":"2021","journal-title":"Front. Cardiovasc Med."},{"issue":"2","key":"10.1016\/j.tice.2026.103457_bib6","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.1063","article-title":"Pros and cons for statins use and risk of Parkinson's disease: An updated perspective","volume":"11","author":"Al-Kuraishy","year":"2023","journal-title":"Pharm. Res. Perspect."},{"issue":"4","key":"10.1016\/j.tice.2026.103457_bib7","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1007\/s11010-023-04771-7","article-title":"Metformin role in Parkinson's disease: a double-sword effect","volume":"479","author":"Alrouji","year":"2024","journal-title":"Mol. Cell Biochem."},{"issue":"9","key":"10.1016\/j.tice.2026.103457_bib8","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1158\/2159-8290.CD-19-0292","article-title":"Targeting autophagy in cancer: recent advances and future directions","volume":"9","author":"Amaravadi","year":"2019","journal-title":"Cancer Discov."},{"issue":"10","key":"10.1016\/j.tice.2026.103457_bib9","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1101\/gad.1653708","article-title":"Role of platelet-derived growth factors in physiology and medicine","volume":"22","author":"Andrae","year":"2008","journal-title":"Genes Dev."},{"issue":"1","key":"10.1016\/j.tice.2026.103457_bib10","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s13046-022-02293-6","article-title":"Targeting autophagy in prostate cancer: preclinical and clinical evidence for therapeutic response","volume":"41","author":"Ashrafizadeh","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"10013","key":"10.1016\/j.tice.2026.103457_bib11","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0140-6736(14)61947-4","article-title":"Prostate cancer","volume":"387","author":"Attard","year":"2016","journal-title":"Lancet"},{"issue":"24","key":"10.1016\/j.tice.2026.103457_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14246164","article-title":"Antagonistic functions of androgen receptor and NF-\u03baB in Prostate Cancer-Experimental and Computational Analyses","volume":"14","author":"Bas\u00edlio","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"Pt 2","key":"10.1016\/j.tice.2026.103457_bib13","article-title":"The pyroptotic role of Caspase-3\/GSDME signalling pathway among various cancer: a review","volume":"242","author":"Bhat","year":"2023","journal-title":"Int J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.tice.2026.103457_bib14","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.tips.2023.11.005","article-title":"Pharmacological targets at the lysosomal autophagy-NLRP3 inflammasome crossroads","volume":"45","author":"Bonam","year":"2024","journal-title":"Trends Pharm. Sci."},{"issue":"5","key":"10.1016\/j.tice.2026.103457_bib15","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.it.2025.03.001","article-title":"IL-1\u03b2(+) macrophages and the control of pathogenic inflammation in cancer","volume":"46","author":"Caronni","year":"2025","journal-title":"Trends Immunol."},{"issue":"1","key":"10.1016\/j.tice.2026.103457_bib16","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/s12943-024-02137-1","article-title":"Prostate cancer microenvironment: multidimensional regulation of immune cells, vascular system, stromal cells, and microbiota","volume":"23","author":"Chen","year":"2024","journal-title":"Mol. Cancer"},{"issue":"8","key":"10.1016\/j.tice.2026.103457_bib17","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00262-024-03723-4","article-title":"Evaluation of the clinical application value of cytokine expression profiles in the differential diagnosis of prostate cancer","volume":"73","author":"Chen","year":"2024","journal-title":"Cancer Immunol. Immunother."},{"issue":"3","key":"10.1016\/j.tice.2026.103457_bib18","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.ajpath.2011.11.021","article-title":"PTEN regulates PDGF ligand switch for \u03b2-PDGFR signaling in prostate cancer","volume":"180","author":"Conley-LaComb","year":"2012","journal-title":"Am. J. Pathol."},{"issue":"6917","key":"10.1016\/j.tice.2026.103457_bib19","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature01322","article-title":"Inflammation and cancer","volume":"420","author":"Coussens","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.tice.2026.103457_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1195572","article-title":"The roles of inflammasomes in cancer","volume":"14","author":"Deng","year":"2023","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.tice.2026.103457_bib21","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S0302-2838(02)00548-1","article-title":"Distribution of inflammation, pre-malignant lesions, incidental carcinoma in histologically confirmed benign prostatic hyperplasia: a retrospective analysis","volume":"43","author":"Di Silverio","year":"2003","journal-title":"Eur. Urol."},{"issue":"8","key":"10.1016\/j.tice.2026.103457_bib22","doi-asserted-by":"crossref","first-page":"7112","DOI":"10.3390\/curroncol30080516","article-title":"Nanoparticle-based treatment approaches for skin cancer: a systematic review","volume":"30","author":"Diaz","year":"2023","journal-title":"Curr. Oncol."},{"key":"10.1016\/j.tice.2026.103457_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117572","article-title":"Modulation of inflammatory mediators underlies the antitumor effect of the combination of morusin and docetaxel on prostate cancer cells","volume":"180","author":"Fadil","year":"2024","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.tice.2026.103457_bib24","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1155\/2014\/480941","article-title":"Role of Fractalkine\/CX3CL1 and Its Receptor in the Pathogenesis of Inflammatory and Malignant Diseases with Emphasis on B Cell Malignancies","volume":"2014","author":"Ferretti","year":"2014","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.tice.2026.103457_bib25","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-immunol-081022-021207","article-title":"Structural mechanisms of NLRP3 inflammasome assembly and activation","volume":"41","author":"Fu","year":"2023","journal-title":"Annu Rev. Immunol."},{"issue":"6","key":"10.1016\/j.tice.2026.103457_bib26","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1038\/s41590-022-01220-3","article-title":"NLRP3 licenses NLRP11 for inflammasome activation in human macrophages","volume":"23","author":"Gangopadhyay","year":"2022","journal-title":"Nat. Immunol."},{"issue":"5","key":"10.1016\/j.tice.2026.103457_bib27","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1158\/1055-9965.EPI-13-1126","article-title":"Chronic inflammation in benign prostate tissue is associated with high-grade prostate cancer in the placebo arm of the prostate cancer prevention trial","volume":"23","author":"Gurel","year":"2014","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"issue":"12","key":"10.1016\/j.tice.2026.103457_bib28","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1158\/1541-7786.MCR-19-0540","article-title":"Prostate Tumor Cell-Derived IL1\u03b2 Induces an Inflammatory Phenotype in Bone Marrow Adipocytes and Reduces Sensitivity to Docetaxel via Lipolysis-Dependent Mechanisms","volume":"17","author":"Herroon","year":"2019","journal-title":"Mol. Cancer Res"},{"issue":"12","key":"10.1016\/j.tice.2026.103457_bib29","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/s41419-023-06382-y","article-title":"The multifaceted roles of GSDME-mediated pyroptosis in cancer: therapeutic strategies and persisting obstacles","volume":"14","author":"Hu","year":"2023","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.tice.2026.103457_bib30","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00262-011-1181-5","article-title":"Immune suppression in the tumor microenvironment: a role for dendritic cell-mediated tolerization of T cells","volume":"61","author":"Hurwitz","year":"2012","journal-title":"Cancer Immunol. Immunother."},{"issue":"6","key":"10.1016\/j.tice.2026.103457_bib31","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1245\/s10434-008-9876-3","article-title":"Increased expression of fractalkine is correlated with a better prognosis and an increased number of both CD8+ T cells and natural killer cells in gastric adenocarcinoma","volume":"15","author":"Hyakudomi","year":"2008","journal-title":"Ann. Surg. Oncol."},{"issue":"2","key":"10.1016\/j.tice.2026.103457_bib32","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1042\/BST20230549","article-title":"New insights into Gasdermin D pore formation","volume":"52","author":"Kappelhoff","year":"2024","journal-title":"Biochem Soc. Trans."},{"issue":"12","key":"10.1016\/j.tice.2026.103457_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/biom11121806","article-title":"Inhibition of Autophagy Promotes Hemistepsin A-Induced Apoptosis via Reactive Oxygen Species-Mediated AMPK-Dependent Signaling in Human Prostate Cancer Cells","volume":"11","author":"Kim","year":"2021","journal-title":"Biomolecules"},{"issue":"2","key":"10.1016\/j.tice.2026.103457_bib34","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.canlet.2013.10.003","article-title":"Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K\/Akt\/mTOR signaling pathway","volume":"343","author":"Kumar","year":"2014","journal-title":"Cancer Lett."},{"key":"10.1016\/j.tice.2026.103457_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1419806","article-title":"To eat or not to eat: a critical review on the role of autophagy in prostate carcinogenesis and prostate cancer therapeutics","volume":"15","author":"Kurganovs","year":"2024","journal-title":"Front Pharm."},{"issue":"10","key":"10.1016\/j.tice.2026.103457_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0205242","article-title":"NLRP3\/Caspase-1 inflammasome activation is decreased in alveolar macrophages in patients with lung cancer","volume":"13","author":"Lasithiotaki","year":"2018","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.tice.2026.103457_bib37","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/s41391-024-00793-4","article-title":"The role of autophagy in prostate cancer and prostatic diseases: a new therapeutic strategy","volume":"27","author":"Lemos","year":"2024","journal-title":"Prostate Cancer Prostatic Dis."},{"issue":"10","key":"10.1016\/j.tice.2026.103457_bib38","doi-asserted-by":"crossref","first-page":"3979","DOI":"10.1111\/cas.15059","article-title":"Pyroptosis, a new bridge to tumor immunity","volume":"112","author":"Li","year":"2021","journal-title":"Cancer Sci."},{"key":"10.1016\/j.tice.2026.103457_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.122951","article-title":"Igniting hope: Harnessing NLRP3 inflammasome-GSDMD-mediated pyroptosis for cancer immunotherapy","volume":"354","author":"Li","year":"2024","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.tice.2026.103457_bib40","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s10238-025-01944-0","article-title":"Tumor microenvironment-mediated immune evasion and resistance in prostate cancer: mechanisms, cross-talk, and therapeutic opportunities","volume":"26","author":"Li","year":"2025","journal-title":"Clin. Exp. Med"},{"issue":"11","key":"10.1016\/j.tice.2026.103457_bib41","first-page":"1276","article-title":"Role of non-canonical pyroptosis in sepsis and other inflammatory diseases","volume":"46","author":"Liang","year":"2021","journal-title":"Zhong Nan Da Xue Xue Bao Yi Xue Ban."},{"issue":"4","key":"10.1016\/j.tice.2026.103457_bib42","first-page":"1544","article-title":"CX3CL1\/fractalkine enhances prostate cancer spinal metastasis by activating the Src\/FAK pathway","volume":"53","author":"Liu","year":"2018","journal-title":"Int J. Oncol."},{"issue":"7","key":"10.1016\/j.tice.2026.103457_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23073826","article-title":"Novel insights into autophagy and prostate cancer: a comprehensive review","volume":"23","author":"Loizzo","year":"2022","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.tice.2026.103457_bib44","article-title":"Prostate cancer immunotherapy-based strategies: an updated review emphasizing immune checkpoint inhibitors","volume":"16","author":"Lu","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tice.2026.103457_bib45","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/5925817","article-title":"Identification of ZDHHC1 as a Pyroptosis Inducer and Potential Target in the Establishment of Pyroptosis-Related Signature in Localized Prostate Cancer","volume":"2022","author":"Luo","year":"2022","journal-title":"Oxid. Med. Cell Longev."},{"issue":"1","key":"10.1016\/j.tice.2026.103457_bib46","first-page":"293","article-title":"Immune checkpoint inhibitors and prostate cancer: a new frontier?","volume":"10","author":"Modena","year":"2016","journal-title":"Oncol. Rev."},{"issue":"5","key":"10.1016\/j.tice.2026.103457_bib47","doi-asserted-by":"crossref","first-page":"693","DOI":"10.3390\/tomography10050054","article-title":"Advancements in neurosurgical intraoperative histology","volume":"10","author":"Mohamed","year":"2024","journal-title":"Tomography"},{"issue":"1","key":"10.1016\/j.tice.2026.103457_bib48","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/s12943-018-0900-3","article-title":"Role of the NLRP3 inflammasome in cancer","volume":"17","author":"Moossavi","year":"2018","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.tice.2026.103457_bib49","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1600-065X.2008.00706.x","article-title":"Interleukin-10: new perspectives on an old cytokine","volume":"226","author":"Mosser","year":"2008","journal-title":"Immunol. Rev."},{"issue":"Pt 3","key":"10.1016\/j.tice.2026.103457_bib50","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.semcancer.2022.02.017","article-title":"Chemokines and cytokines: axis and allies in prostate cancer pathogenesis","volume":"86","author":"Mughees","year":"2022","journal-title":"Semin Cancer Biol."},{"key":"10.1016\/j.tice.2026.103457_bib51","first-page":"98","article-title":"Chronic inflammation in cancer development","volume":"2","author":"Multhoff","year":"2011","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.tice.2026.103457_bib52","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1158\/1541-7786.MCR-12-0071","article-title":"Differential tumorigenic potential and matriptase activation between PDGF B versus PDGF D in prostate cancer","volume":"10","author":"Najy","year":"2012","journal-title":"Mol. Cancer Res"},{"issue":"12","key":"10.1016\/j.tice.2026.103457_bib53","doi-asserted-by":"crossref","first-page":"6649","DOI":"10.21873\/anticanres.14689","article-title":"Mir-139 Regulates Autophagy in Prostate Cancer Cells Through Beclin-1 and mTOR Signaling Proteins","volume":"40","author":"Nam","year":"2020","journal-title":"Anticancer Res"},{"issue":"6","key":"10.1016\/j.tice.2026.103457_bib54","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1111\/bju.12452","article-title":"Inflammation and prostate cancer: the role of interleukin 6 (IL-6)","volume":"113","author":"Nguyen","year":"2014","journal-title":"BJU Int"},{"issue":"2","key":"10.1016\/j.tice.2026.103457_bib55","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1158\/2159-8290.CD-20-0805","article-title":"Fueling the fire: inflammatory forms of cell death and implications for cancer immunotherapy","volume":"11","author":"Rosenbaum","year":"2021","journal-title":"Cancer Discov."},{"key":"10.1016\/j.tice.2026.103457_bib56","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1398109","article-title":"Immunome profiling in prostate cancer: a guide for clinicians","volume":"15","author":"San-Jose Manso","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tice.2026.103457_bib57","article-title":"Re: EAU-EANM-ESTRO-ESUR-ISUP-SIOG Guidelines on Prostate Cancer","author":"Santiago","year":"2025","journal-title":"Eur. Urol."},{"issue":"5","key":"10.1016\/j.tice.2026.103457_bib58","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/s41590-021-00886-5","article-title":"NLRP3 inflammasome in cancer and metabolic diseases","volume":"22","author":"Sharma","year":"2021","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.tice.2026.103457_bib59","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s12672-025-01829-4","article-title":"The heat of the battle: inflammation's role in prostate cancer development and inflammation-targeted therapies","volume":"16","author":"Sharma","year":"2025","journal-title":"Discov. Oncol."},{"issue":"12","key":"10.1016\/j.tice.2026.103457_bib60","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21124507","article-title":"The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling","volume":"21","author":"Shorning","year":"2020","journal-title":"Int J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.tice.2026.103457_bib61","doi-asserted-by":"crossref","DOI":"10.3390\/cells10123509","article-title":"Pyroptosis: Mechanisms and Links with Fibrosis","volume":"10","author":"Song","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.tice.2026.103457_bib62","article-title":"The NLRP3 inflammasome in urogenital cancers: structure, dual function, and therapeutic potential","volume":"15","author":"Sun","year":"2025","journal-title":"Front Oncol."},{"issue":"3","key":"10.1016\/j.tice.2026.103457_bib63","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.tice.2026.103457_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107538","article-title":"NF-\u03baB signaling promotes castration-resistant prostate cancer initiation and progression","volume":"211","author":"Thomas-Jardin","year":"2020","journal-title":"Pharm. Ther."},{"issue":"6","key":"10.1016\/j.tice.2026.103457_bib65","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1007\/s13402-023-00860-3","article-title":"Triggering pyroptosis enhances the antitumor efficacy of PARP inhibitors in prostate cancer","volume":"46","author":"Tian","year":"2023","journal-title":"Cell Oncol (Dordr)"},{"issue":"11","key":"10.1016\/j.tice.2026.103457_bib66","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1002\/pros.23842","article-title":"Circulating inflammation markers and prostate cancer","volume":"79","author":"Ugge","year":"2019","journal-title":"Prostate"},{"key":"10.1016\/j.tice.2026.103457_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107213","article-title":"Pro-inflammatory cytokines and CXC chemokines as game-changer in age-associated prostate cancer and ovarian cancer: Insights from preclinical and clinical studies' outcomes","volume":"204","author":"Ullah","year":"2024","journal-title":"Pharm. Res"},{"key":"10.1016\/j.tice.2026.103457_bib68","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.molimm.2023.03.016","article-title":"ALK-JNK signaling promotes NLRP3 inflammasome activation and pyroptosis via NEK7 during Streptococcus pneumoniae infection","volume":"157","author":"Wang","year":"2023","journal-title":"Mol. Immunol."},{"issue":"6","key":"10.1016\/j.tice.2026.103457_bib69","doi-asserted-by":"crossref","DOI":"10.3390\/biom15060826","article-title":"Role of Tumor Microenvironment in Prostate Cancer Immunometabolism","volume":"15","author":"Wang","year":"2025","journal-title":"Biomolecules"},{"issue":"3 Pt 1","key":"10.1016\/j.tice.2026.103457_bib70","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/S0022-5347(05)67289-8","article-title":"Cytokine variations in patients with hormone treated prostate cancer","volume":"164","author":"Wise","year":"2000","journal-title":"J. Urol."},{"issue":"3","key":"10.1016\/j.tice.2026.103457_bib71","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.3892\/ol.2016.4880","article-title":"Valproic acid induces autophagy by suppressing the Akt\/mTOR pathway in human prostate cancer cells","volume":"12","author":"Xia","year":"2016","journal-title":"Oncol. Lett."},{"issue":"6","key":"10.1016\/j.tice.2026.103457_bib72","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1016\/j.ymthe.2021.04.029","article-title":"The roles of PD-1\/PD-L1 in the prognosis and immunotherapy of prostate cancer","volume":"29","author":"Xu","year":"2021","journal-title":"Mol. Ther."},{"issue":"1","key":"10.1016\/j.tice.2026.103457_bib73","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s41420-021-00766-9","article-title":"NLRP3 inflammasome promoted the malignant progression of prostate cancer via the activation of caspase-1","volume":"7","author":"Xu","year":"2021","journal-title":"Cell Death Discov."},{"issue":"1","key":"10.1016\/j.tice.2026.103457_bib74","first-page":"59","article-title":"Regulated expression of CCL21 in the prostate tumor microenvironment inhibits tumor growth and metastasis in an orthotopic model of prostate cancer","volume":"2","author":"Yousefieh","year":"2009","journal-title":"Cancer Micro"},{"issue":"1","key":"10.1016\/j.tice.2026.103457_bib75","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s11033-023-09132-7","article-title":"Carvedilol induces pyroptosis through NLRP3-caspase1-ASC inflammasome by nuclear migration of NF-\u03baB in prostate cancer models","volume":"51","author":"Zeng","year":"2024","journal-title":"Mol. Biol. Rep."},{"issue":"3","key":"10.1016\/j.tice.2026.103457_bib76","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s10555-023-10152-9","article-title":"Therapeutic importance and diagnostic function of circRNAs in urological cancers: from metastasis to drug resistance","volume":"43","author":"Zhang","year":"2024","journal-title":"Cancer Metastas.. Rev."},{"issue":"11","key":"10.1016\/j.tice.2026.103457_bib77","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202200673RRR","article-title":"Disturbing NLRP3 acetylation and inflammasome assembly inhibits androgen receptor-promoted inflammatory responses and prostate cancer progression","volume":"36","author":"Zhao","year":"2022","journal-title":"Faseb J."},{"key":"10.1016\/j.tice.2026.103457_bib78","article-title":"Relationship between pyroptosis-mediated inflammation and the pathogenesis of prostate disease","volume":"10","author":"Zhao","year":"2023","journal-title":"Front. Med."},{"key":"10.1016\/j.tice.2026.103457_bib79","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/978-1-4939-7519-8_9","article-title":"Inflammatory caspases: activation and cleavage of gasdermin-D in vitro and during pyroptosis","volume":"1714","author":"Zhao","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.tice.2026.103457_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105420","article-title":"The regulation of pyroptosis by post-translational modifications: molecular mechanisms and therapeutic targets","volume":"109","author":"Zhou","year":"2024","journal-title":"EBioMedicine"}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626001503?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626001503?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T03:01:54Z","timestamp":1778727714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816626001503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":80,"alternative-id":["S0040816626001503"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2026.103457","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Key signaling pathways in the development and progression of prostate cancer: The crosstalk between inflammation, autophagy, and pyroptosis","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2026.103457","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103457"}}