{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T03:13:24Z","timestamp":1778728404742,"version":"3.51.4"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013262","name":"UiTM Institute of Research Management & Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013262","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.tice.2026.103474","type":"journal-article","created":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T03:00:57Z","timestamp":1773457257000},"page":"103474","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Maternal tocotrienol supplementation protects early embryo mitochondria from allergic asthma stress"],"prefix":"10.1016","volume":"101","author":[{"given":"Che Ismail","family":"Wafriy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhaniza Shafinie","family":"Kamsani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhaila Abd","family":"Muid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mimi Sophia","family":"Sarbandi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Noor Khan","family":"Nor-Ashikin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2026.103474_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15252\/embj.2022111699","article-title":"Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies","volume":"42","author":"Acin-Perez","year":"2023","journal-title":"EMBO J."},{"key":"10.1016\/j.tice.2026.103474_bib2","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.humimm.2019.04.018","article-title":"Relationship between various cytokines implicated in asthma","volume":"80","author":"Ayakannu","year":"2019","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.tice.2026.103474_bib3","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.cmet.2018.03.003","article-title":"Mitochondria bound to lipid droplets have unique bioenergetics, composition, and dynamics that support lipid droplet expansion","volume":"27","author":"Benador","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.tice.2026.103474_bib4","doi-asserted-by":"crossref","first-page":"7644","DOI":"10.1096\/fj.201901761R","article-title":"Mitofusin 1 is required for oocyte growth and communication with follicular somatic cells","volume":"34","author":"Carvalho","year":"2020","journal-title":"FASEB J."},{"key":"10.1016\/j.tice.2026.103474_bib5","doi-asserted-by":"crossref","DOI":"10.7150\/ijbs.102424","article-title":"Targeting mitochondria by lipid-selenium conjugate drug results in malate \/ fumarate exhaustion and induces mitophagy-mediated necroptosis suppression","volume":"20","author":"Chang","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.tice.2026.103474_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117084","article-title":"New insights into the role of mitochondrial dynamics in oxidative stress-induced diseases","volume":"178","author":"Chen","year":"2024","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.tice.2026.103474_bib7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.devcel.2020.02.015","article-title":"Glycolysis independent glucose metabolism distinguishes TE from ICM fate during mammalian embryogenesis","volume":"53","author":"Chi","year":"2020","journal-title":"Dev. Cell"},{"key":"10.1016\/j.tice.2026.103474_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/jcm13133724","article-title":"The Impacts of Inflammatory and Autoimmune Conditions on the Endometrium and Reproductive Outcomes","volume":"13","author":"Cuadrado-torroglosa","year":"2024","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.tice.2026.103474_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.618322","article-title":"Two types of contact between lipid droplets and mitochondria","volume":"8","author":"Cui","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.tice.2026.103474_bib10","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3390\/cells10020369","article-title":"Loss of COX4I1 leads to combined respiratory chain deficiency and impaired mitochondrial protein synthesis","volume":"10","author":"\u010cun\u00e1tov\u00e1","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.tice.2026.103474_bib11","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.1007\/s13197-022-05402-7","article-title":"Separation of tocol (tocopherol & tocotrienol) and phytosterols from palm fatty acid distillate by saponification and purification by low temperature solvent crystallization","volume":"59","author":"Gore","year":"2022","journal-title":"J. Food Sci. Technol."},{"key":"10.1016\/j.tice.2026.103474_bib12","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3390\/antiox10030337","article-title":"Mitochondrial dysfunction and oxidative stress caused by cryopreservation in reproductive cells","volume":"10","author":"Gualtieri","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.tice.2026.103474_bib13","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.3390\/jcm8071070","article-title":"ATP synthase subunit epsilon overexpression promotes metastasis by modulating AMPK signaling to induce epithelial-to-mesenchymal transition and is a poor prognostic marker in colorectal cancer patients","volume":"8","author":"Huang","year":"2019","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.tice.2026.103474_bib14","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/bs.ctdb.2016.04.010","article-title":"Metabolism of preimplantation embryo development: a bystander or an active participant?","volume":"120","author":"Kaneko","year":"2016","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.tice.2026.103474_bib15","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1534\/genetics.104.037648","article-title":"The \u03b5-subunit of mitochondrial ATP synthase is required for normal spindle orientation during the drosophila embryonic divisions","volume":"170","author":"Kidd","year":"2005","journal-title":"Genetics"},{"key":"10.1016\/j.tice.2026.103474_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1187832","article-title":"Species and embryo genome origin affect lipid droplets in preimplantation embryos","volume":"11","author":"Lipinska","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.tice.2026.103474_bib17","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1038\/s41467-022-31323-2","article-title":"Dynamic enlargement and mobilization of lipid droplets in pluripotent cells coordinate morphogenesis during mouse peri-implantation development","volume":"13","author":"Mau","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tice.2026.103474_bib18","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3390\/antiox10020139","article-title":"Embryo and its mitochondria","volume":"10","author":"May-Panloup","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.tice.2026.103474_bib19","doi-asserted-by":"crossref","first-page":"9232","DOI":"10.1038\/s41598-023-36441-5","article-title":"Oxidative damage contributes to bisphenol S-induced development block at 2-cell stage preimplantation embryos in mice through inhibiting of embryonic genome activation","volume":"13","author":"Ning","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2026.103474_bib20","first-page":"893","article-title":"Mitochondrial fission and fusion: molecular mechanisms, biological functions, and related disorders","volume":"12","author":"Ojaimi","year":"2022","journal-title":"Membr. (Basel)"},{"key":"10.1016\/j.tice.2026.103474_bib21","doi-asserted-by":"crossref","first-page":"75","DOI":"10.4168\/aair.2014.6.1.75","article-title":"A quantitative study of airway changes on Micro-CT in a mouse asthma model: comparison with histopathological findings","volume":"6","author":"Paik","year":"2014","journal-title":"Allergy Asthma Immunol. Res."},{"key":"10.1016\/j.tice.2026.103474_bib22","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s10456-024-09938-4","article-title":"Emerging insights into the pathogenesis and therapeutic strategies for vascular endothelial injury-associated diseases: focus on mitochondrial dysfunction","volume":"27","author":"Pang","year":"2024","journal-title":"Angiogenesis"},{"key":"10.1016\/j.tice.2026.103474_bib23","first-page":"1","article-title":"Advances in pathogenesis and treatment of vascular endothelial injury-related diseases mediated by mitochondrial abnormality","author":"Pang","year":"2024","journal-title":"Front. Pharm."},{"key":"10.1016\/j.tice.2026.103474_bib24","doi-asserted-by":"crossref","unstructured":"Parisi, F., Milazzo, R., Savasi, V.M., 2021. Maternal Low-Grade Chronic Inflammation and Intrauterine Programming of Health and Disease.","DOI":"10.3390\/ijms22041732"},{"key":"10.1016\/j.tice.2026.103474_bib25","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3390\/ijms21010220","article-title":"Alpha-tocotrienol prevents oxidative stress-mediated post-translational cleavage of Bcl-xL in primary hippocampal neurons","volume":"21","author":"Park","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2026.103474_bib26","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/8416763","article-title":"Oxidative stress: harms and benefits for human health","volume":"2017","author":"Pizzino","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.tice.2026.103474_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0059218","article-title":"Opa1 Is Required for Proper Mitochondrial Metabolism in Early Development","volume":"8","author":"Rahn","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.tice.2026.103474_bib28","first-page":"1","article-title":"The role of oocyte organelles in determining developmental competence","volume":"6","author":"Reader","year":"2017","journal-title":"Biol. (Basel)"},{"key":"10.1016\/j.tice.2026.103474_bib29","doi-asserted-by":"crossref","first-page":"608","DOI":"10.3390\/metabo12070608","article-title":"Antioxidant and neuroprotective activity of vitamin E homologues: in vitro study","volume":"12","author":"Trela-makowej","year":"2022","journal-title":"Metabolites"},{"key":"10.1016\/j.tice.2026.103474_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cdev.2023.203864","article-title":"Inflammation and oxidative stress impair preimplantation embryonic morphogenesis in allergic asthma model","volume":"175","author":"Wafriy","year":"2023","journal-title":"Cells Dev."},{"key":"10.1016\/j.tice.2026.103474_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2024.106650","article-title":"Microtubules and cardiovascular diseases: insights into pathology and therapeutic strategies","volume":"175","author":"Wu","year":"2024","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.tice.2026.103474_bib32","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.semcdb.2024.01.007","article-title":"The role of mitochondrial dynamics in oocyte and early embryo development","volume":"159\u2013160","author":"Yildirim","year":"2024","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.tice.2026.103474_bib33","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/s41574-023-00845-0","article-title":"Lipid droplet biogenesis and functions in health and disease","volume":"19","author":"Zadoorian","year":"2023","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.tice.2026.103474_bib34","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.3390\/ijms20071764","article-title":"Effects of palm oil tocotrienol-rich fraction (TRF) and carotenes in ovalbumin (OVA)-challenged asthmatic brown norway rats","volume":"20","author":"Zainal","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2026.103474_bib35","article-title":"Mfn2 affects embryo development via mitochondrial dysfunction and apoptosis","volume":"10","author":"Zhao","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.tice.2026.103474_bib36","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41392-024-01839-8","article-title":"Mitochondrial dysfunction: mechanisms and advances in therapy","volume":"9","author":"Zong","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.tice.2026.103474_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.717328","article-title":"Players in mitochondrial dynamics and female reproduction","volume":"8","author":"Zou","year":"2021","journal-title":"Front. Mol. Biosci."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626001679?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626001679?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T02:53:10Z","timestamp":1778727190000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816626001679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":37,"alternative-id":["S0040816626001679"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2026.103474","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal tocotrienol supplementation protects early embryo mitochondria from allergic asthma stress","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2026.103474","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103474"}}