{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:52:34Z","timestamp":1788187954945,"version":"build-2803163510"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004242","name":"Princess Nourah bint Abdulrahman University","doi-asserted-by":"publisher","award":["PNURSP2026R141"],"award-info":[{"award-number":["PNURSP2026R141"]}],"id":[{"id":"10.13039\/501100004242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.tice.2026.103475","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T16:38:47Z","timestamp":1773851927000},"page":"103475","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Molecular docking and experimental validation for the protective effect of betanin against capecitabine-induced myocardial injury: Binding to TLR4 and downregulation of MyD88\/NF\u03baB signaling"],"prefix":"10.1016","volume":"101","author":[{"given":"Tahani A.","family":"Saeedi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fady T.","family":"Hakem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Helal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa Hussein","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba W.Z.","family":"Khella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed H.","family":"Elbassiouny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein M.","family":"Ismail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma M.","family":"Alshahrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abir S.","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa","family":"Saleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noura Moustafa","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9688-7683","authenticated-orcid":false,"given":"Sawsan A.","family":"Zaitone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2026.103475_bib1","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/3281670","article-title":"Diosmin attenuates methotrexate-induced hepatic, renal, and cardiac injury: a biochemical and histopathological study in mice","volume":"2017","author":"Abdel-Daim","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.tice.2026.103475_bib2","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.biopha.2017.05.049","article-title":"Cardiotoxic effect of levofloxacin and ciprofloxacin in rats with\/without acute myocardial infarction: impact on cardiac rhythm and cardiac expression of Kv4.3, Kv1.2 and Nav1.5 channels","volume":"92","author":"Abdelrady","year":"2017","journal-title":"Biomed. & Pharmacother."},{"key":"10.1016\/j.tice.2026.103475_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1362739","article-title":"Chemotherapeutic potential of betanin\/capecitabine combination targeting colon cancer: experimental and bioinformatic studies exploring NF\u03baB and cyclin D1 interplay","volume":"15","author":"Ahmed","year":"2024","journal-title":"Front. Pharm."},{"key":"10.1016\/j.tice.2026.103475_bib4","article-title":"Betanin mitigates vancomycin-induced acute kidney injury in mice and molecular docking indicated inhibition of STAT3 phosphorylation","author":"Alrshedi","year":"2025","journal-title":"Tissue Cell"},{"key":"10.1016\/j.tice.2026.103475_bib5","doi-asserted-by":"crossref","first-page":"39","DOI":"10.9734\/jpri\/2021\/v33i731200","article-title":"Betanin and allicin ameliorate adriamycin-induced cardiotoxicity in rats by ameliorating cardiac ischemia and improving antioxidant efficiency","author":"Al-Thubiani","year":"2021","journal-title":"JPRI"},{"key":"10.1016\/j.tice.2026.103475_bib6","doi-asserted-by":"crossref","DOI":"10.1177\/2050312120965752","article-title":"Inflammatory cytokines in the pathogenesis of cardiovascular disease and cancer","volume":"8","author":"Amin","year":"2020","journal-title":"SAGE Open Med."},{"key":"10.1016\/j.tice.2026.103475_bib7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3747\/co.v17i1.437","article-title":"Capecitabine-induced cardiotoxicity: case report and review of the literature","volume":"17","author":"Ang","year":"2010","journal-title":"Curr. Oncol."},{"key":"10.1016\/j.tice.2026.103475_bib8","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.2147\/OTT.S65653","article-title":"Capecitabine-induced cardiotoxicity: more evidence or clinical approaches to protect the patients' heart?","author":"Aprile","year":"2014","journal-title":"OTT"},{"key":"10.1016\/j.tice.2026.103475_bib9","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1089\/ars.2010.3728","article-title":"Toll-like receptor 4 stimulation initiates an inflammatory response that decreases cardiomyocyte contractility","volume":"15","author":"Avlas","year":"2011","journal-title":"Antioxid. & Redox Signal."},{"key":"10.1016\/j.tice.2026.103475_bib10","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.lfs.2015.10.003","article-title":"Chemopreventive effect of leflunomide against Ehrlich\u2019s solid tumor grown in mice: effect on EGF and EGFR expression and tumor proliferation","volume":"141","author":"Bahr","year":"2015","journal-title":"Life Sci."},{"key":"10.1016\/j.tice.2026.103475_bib11","doi-asserted-by":"crossref","DOI":"10.1590\/s0102-865020190110000004","article-title":"Biochanin A attenuates myocardial ischemia\/reperfusion injury through the TLR4\/NF-\u03baB\/NLRP3 signaling pathway","volume":"34","author":"Bai","year":"2019","journal-title":"Acta Cir. Bras."},{"key":"10.1016\/j.tice.2026.103475_bib12","doi-asserted-by":"crossref","first-page":"87","DOI":"10.4103\/1735-5362.278718","article-title":"Cardioprotective effect of vanillic acid against doxorubicin-induced cardiotoxicity in rat","volume":"15","author":"Baniahmad","year":"2020","journal-title":"Res Pharma Sci."},{"issue":"1","key":"10.1016\/j.tice.2026.103475_bib13","doi-asserted-by":"crossref","DOI":"10.1136\/vr.119.1.22-a","article-title":"Animals (Scientific Procedures) Act 1986","volume":"119","author":"Bleby","year":"1986","journal-title":"Vet. rec."},{"key":"10.1016\/j.tice.2026.103475_bib14","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23540","article-title":"Beta vulgaris -derived exosome-like nanovesicles alleviate chronic doxorubicin-induced cardiotoxicity by inhibiting ferroptosis","volume":"38","author":"Cai","year":"2024","journal-title":"J. Biochem &amp Mol. Tox"},{"key":"10.1016\/j.tice.2026.103475_bib15","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0008-6363(03)00348-1","article-title":"Toll-like receptors in cardiovascular diseases","volume":"60","author":"Dekleijn","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.tice.2026.103475_bib16","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1080\/0284186X.2019.1711164","article-title":"Incidence and risk markers of 5-fluorouracil and capecitabine cardiotoxicity in patients with colorectal cancer","volume":"59","author":"Dyhl-Polk","year":"2020","journal-title":"Acta Oncol."},{"key":"10.1016\/j.tice.2026.103475_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114917","article-title":"Betanin improves motor function and alleviates experimental Parkinsonism via downregulation of TLR4\/MyD88\/NF-\u03baB pathway: Molecular docking and biological investigations","volume":"164","author":"ElSayed","year":"2023","journal-title":"Biomed. & Pharmacother."},{"key":"10.1016\/j.tice.2026.103475_bib18","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/mnfr.201400484","article-title":"Betanin\u2014A food colorant with biological activity","volume":"59","author":"Esatbeyoglu","year":"2015","journal-title":"Mol. Nutr. & Food Res."},{"key":"10.1016\/j.tice.2026.103475_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbrc.2022.10.061","article-title":"Baicalin regulates TLR4\/I\u03baB\u03b1\/NF\u03baB signaling pathway to alleviate inflammation in Doxorubicin related cardiotoxicity","volume":"637","author":"Feng","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tice.2026.103475_bib20","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1177\/09603271211027933","article-title":"Betalain exerts cardioprotective and anti-inflammatory effects against the experimental model of heart failure","volume":"40","author":"Gao","year":"2021","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.tice.2026.103475_bib21","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1093\/bioinformatics\/btz931","article-title":"ShinyGO: a graphical gene-set enrichment tool for animals and plants","volume":"36","author":"Ge","year":"2020","journal-title":"Bioinformatics"},{"key":"10.1016\/j.tice.2026.103475_bib22","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1080\/02652030600986032","article-title":"Betanin, the main pigment of red beet: molecular origin of its exceptionally high free radical-scavenging activity","volume":"23","author":"Gliszczy\u0144ska-\u015awig\u0142o","year":"2006","journal-title":"Food Addit. & Contam."},{"key":"10.1016\/j.tice.2026.103475_bib23","first-page":"1","article-title":"Natural antioxidant betanin protects rats from paraquat-induced acute lung injury interstitial pneumonia","volume":"2015","author":"Han","year":"2015","journal-title":"BioMed. Res. Int."},{"key":"10.1016\/j.tice.2026.103475_bib24","doi-asserted-by":"crossref","first-page":"77","DOI":"10.4103\/RPS.RPS_204_24","article-title":"Dietary silymarin supplementation enhances chemotherapy efficacy of capecitabine and irinotecan and mitigates hepatotoxicity in a mouse model of colon cancer","volume":"20","author":"Hassani","year":"2025","journal-title":"Res. Pharm. Sci."},{"key":"10.1016\/j.tice.2026.103475_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121523","article-title":"Baicalein prevents capecitabine-induced heart damage in female Wistar rats and enhances its anticancer potential in MCF-7 breast cancer cells","volume":"319","author":"Ibrahim","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.tice.2026.103475_bib26","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tice.2026.103475_bib27","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ejca.2017.02.009","article-title":"Incidence of capecitabine-related cardiotoxicity in different treatment schedules of metastatic colorectal cancer: a retrospective analysis of the CAIRO studies of the Dutch Colorectal Cancer Group","volume":"76","author":"Kwakman","year":"2017","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.tice.2026.103475_bib28","doi-asserted-by":"crossref","first-page":"e158","DOI":"10.1093\/oncolo\/oyab035","article-title":"Cardiotoxicity from capecitabine chemotherapy: prospective study of incidence at rest and during physical exercise","volume":"27","author":"Lestuzzi","year":"2022","journal-title":"Oncologist"},{"key":"10.1016\/j.tice.2026.103475_bib29","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1536\/ihj.20-809","article-title":"Circ-SKA3 Enhances Doxorubicin Toxicity in AC16 Cells Through miR-1303\/TLR4 Axis","volume":"62","author":"Li","year":"2021","journal-title":"Int. Heart J."},{"key":"10.1016\/j.tice.2026.103475_bib30","doi-asserted-by":"crossref","first-page":"8009","DOI":"10.2147\/JIR.S484919","article-title":"Arctiin alleviates atopic dermatitis against inflammation and pyroptosis through suppressing TLR4\/MyD88\/NF-\u03baB and NLRP3\/Caspase-1\/GSDMD signaling pathways","volume":"17","author":"Li","year":"2024","journal-title":"JIR"},{"key":"10.1016\/j.tice.2026.103475_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/e82f77a8-3d29-44be-a9ef-7abc6c7e584a","article-title":"Toll-Like Receptor (TLR) 2 and TLR4 differentially regulate doxorubicin induced cardiomyopathy in mice","volume":"7","author":"Ma","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tice.2026.103475_bib32","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1021\/ci100436p","article-title":"FRED pose prediction and virtual screening accuracy","volume":"51","author":"McGann","year":"2011","journal-title":"J. Chem. Inf. Model"},{"key":"10.1016\/j.tice.2026.103475_bib33","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/S0959-8049(98)00058-6","article-title":"Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue","volume":"34","author":"Miwa","year":"1998","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.tice.2026.103475_bib34","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s43094-025-00844-0","article-title":"Ameliorative effect of betanin on monosodium glutamate-induced mouse ADHD and modulation of Nrf2 and TLR4\/NF\u03baB\/p53 interplay","volume":"11","author":"Mokhtar","year":"2025","journal-title":"Futur J. Pharm. Sci."},{"key":"10.1016\/j.tice.2026.103475_bib35","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.tice.2026.103475_bib36","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3390\/medicines4040078","article-title":"Ameliorative effect of caffeic acid on capecitabine-induced hepatic and renal dysfunction: involvement of the antioxidant defence system","volume":"4","author":"Olayinka","year":"2017","journal-title":"Medicines"},{"key":"10.1016\/j.tice.2026.103475_bib37","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/nature07830","article-title":"The structural basis of lipopolysaccharide recognition by the TLR4\u2013MD-2 complex","volume":"458","author":"Park","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.tice.2026.103475_bib38","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2016-012798","article-title":"Incidence and risk factors for capecitabine-induced symptomatic cardiotoxicity: a retrospective study of 452 consecutive patients with metastatic breast cancer","volume":"6","author":"Polk","year":"2016","journal-title":"BMJ Open"},{"key":"10.1016\/j.tice.2026.103475_bib39","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.ctrv.2013.03.005","article-title":"Cardiotoxicity in cancer patients treated with 5-fluorouracil or capecitabine: a systematic review of incidence, manifestations and predisposing factors","volume":"39","author":"Polk","year":"2013","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.tice.2026.103475_bib40","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/cgt.2017.4","article-title":"Customized laboratory TLR4 and TLR2 detection method from peripheral human blood for early detection of doxorubicin-induced cardiotoxicity","volume":"24","author":"Pop-Moldovan","year":"2017","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.tice.2026.103475_bib41","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1080\/15376516.2024.2322666","article-title":"Leflunomide-induced cardiac injury in adult male mice and bioinformatic approach identifying Nrf2\/NF-\u03bab signaling interplay","volume":"34","author":"Rahman","year":"2024","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.tice.2026.103475_bib42","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ejheart.2008.01.004","article-title":"Toll-like receptor-4 deficiency attenuates doxorubicin-induced cardiomyopathy in mice","volume":"10","author":"Riad","year":"2008","journal-title":"Eur. J. Heart Fail"},{"key":"10.1016\/j.tice.2026.103475_bib43","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1253\/circj.71.70","article-title":"Histopathological features of the resected left atrial appendage as predictors of recurrence after surgery for atrial fibrillation in valvular heart disease","volume":"71","author":"Saito","year":"2007","journal-title":"Circ. J."},{"key":"10.1016\/j.tice.2026.103475_bib44","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1080\/10408398.2020.1822277","article-title":"Betanin as a multipath oxidative stress and inflammation modulator: a beetroot pigment with protective effects on cardiovascular disease pathogenesis","volume":"62","author":"Silva","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.tice.2026.103475_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/181394","article-title":"The emerging role of TLR and innate immunity in cardiovascular disease","volume":"2012","author":"Spirig","year":"2012","journal-title":"Cardiol. Res. Pract."},{"key":"10.1016\/j.tice.2026.103475_bib46","doi-asserted-by":"crossref","first-page":"4294","DOI":"10.3390\/molecules28114294","article-title":"Toll-like receptor 4 inflammatory perspective on doxorubicin-induced cardiotoxicity","volume":"28","author":"Sumneang","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.tice.2026.103475_bib47","doi-asserted-by":"crossref","first-page":"D605","DOI":"10.1093\/nar\/gkaa1074","article-title":"The STRING database in 2021: customizable protein\u2013protein networks, and functional characterization of user-uploaded gene\/measurement sets","volume":"49","author":"Szklarczyk","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tice.2026.103475_bib48","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.fct.2015.01.018","article-title":"Betanin attenuates oxidative stress and inflammatory reaction in kidney of paraquat-treated rat","volume":"78","author":"Tan","year":"2015","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tice.2026.103475_bib49","doi-asserted-by":"crossref","DOI":"10.1177\/09603271231223506","article-title":"The effect of melatonin on capecitabine-induced hepatic and renal toxicity in rats","volume":"43","author":"Tavakoli Pirzaman","year":"2024","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.tice.2026.103475_bib50","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1007\/s11011-021-00826-0","article-title":"Benefits of betanin in rotenone-induced Parkinson mice","volume":"36","author":"Thong-asa","year":"2021","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.tice.2026.103475_bib51","first-page":"22","article-title":"Neuroprotective effects of betanin in mice with cerebral ischemia-reperfusion injury","author":"Thong-Asa","year":"2023","journal-title":"Exp. Anim."},{"key":"10.1016\/j.tice.2026.103475_bib52","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-73946-9","article-title":"Toll-like receptor 4 (TLR4) expression is correlated with T2* iron deposition in response to doxorubicin treatment: cardiotoxicity risk assessment","volume":"10","author":"Trofenciuc","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2026.103475_bib53","doi-asserted-by":"crossref","first-page":"211","DOI":"10.4149\/BLL_2020_032","article-title":"The protective effect of betanin and copper on heart and lung in end\u2011organ ischemia reperfusion injury","volume":"121","author":"Tural","year":"2020","journal-title":"BLL"},{"key":"10.1016\/j.tice.2026.103475_bib54","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.intimp.2018.03.002","article-title":"Toll-like receptors in immunity and inflammatory diseases: past, present, and future","volume":"59","author":"Vijay","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.tice.2026.103475_bib55","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s00395-012-0267-3","article-title":"Role of HMGB1 in doxorubicin-induced myocardial apoptosis and its regulation pathway","volume":"107","author":"Yao","year":"2012","journal-title":"Basic Res Cardiol."},{"key":"10.1016\/j.tice.2026.103475_bib56","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s10565-024-09893-2","article-title":"HMGB1 as an extracellular pro-inflammatory cytokine: Implications for drug-induced organic damage","volume":"40","author":"Yuan","year":"2024","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.tice.2026.103475_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2026.110863","article-title":"Betanin protects against diabetic retinal damage via the inhibition of NF-\u03baB\/NLRP3\/VEGF axis: insights from network pharmacology and experimental studies","volume":"264","author":"Zaitone","year":"2026","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.tice.2026.103475_bib58","doi-asserted-by":"crossref","DOI":"10.1080\/15376516.2025.2609605","article-title":"Integrative in silico-in vivo modeling identifies apigenin modulation of TGF-\u03b21\/SMAD2 in methotrexate-induced cardiotoxicity","author":"Zaitone","year":"2026","journal-title":"Toxicol. Mech. Methods 120"},{"key":"10.1016\/j.tice.2026.103475_bib59","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbad518","article-title":"Network pharmacology: towards the artificial intelligence-based precision traditional Chinese medicine","volume":"25","author":"Zhang","year":"2023","journal-title":"Brief. Bioinforma."},{"key":"10.1016\/j.tice.2026.103475_bib60","article-title":"Capecitabine regulates HSP90AB1 expression and induces apoptosis via Akt\/SMARCC1\/AP-1\/ROS Axis in T cells","volume":"2022","author":"Zhang","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.tice.2026.103475_bib61","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/ptr.3649","article-title":"The beetroot component betanin modulates ROS Production, DNA damage and apoptosis in human polymorphonuclear neutrophils","volume":"26","author":"Zieli\u0144ska-Przyjemska","year":"2012","journal-title":"Phytother. Res."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626001680?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626001680?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T02:52:02Z","timestamp":1778727122000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816626001680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":61,"alternative-id":["S0040816626001680"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2026.103475","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular docking and experimental validation for the protective effect of betanin against capecitabine-induced myocardial injury: Binding to TLR4 and downregulation of MyD88\/NF\u03baB signaling","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2026.103475","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103475"}}