{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T03:14:02Z","timestamp":1778728442145,"version":"3.51.4"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100017534","name":"Inner Mongolia Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017534","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004763","name":"Natural Science Foundation of Inner Mongolia Autonomous Region","doi-asserted-by":"publisher","award":["2022MS08049"],"award-info":[{"award-number":["2022MS08049"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020788","name":"Science and Technology Major Project of Inner Mongolia Autonomous Region of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020788","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.tice.2026.103512","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T06:44:48Z","timestamp":1774939488000},"page":"103512","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A novel AGTPBP1-ERK\/MYLK network mediates pancreatic cancer progression"],"prefix":"10.1016","volume":"101","author":[{"given":"Zhe-yu","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-rui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-dong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-le","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-yu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8395-1041","authenticated-orcid":false,"given":"Rui","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-jun","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2026.103512_bib1","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/s41392-023-01705-z","article-title":"Targeting the RAS\/RAF\/MAPK pathway for cancer therapy: from mechanism to clinical studies","volume":"8","author":"Bahar","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.tice.2026.103512_bib2","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.3390\/biomedicines9091157","article-title":"The childhood-onset neurodegeneration with cerebellar atrophy (CONDCA) disease caused by AGTPBP1 gene mutations: the purkinje cell degeneration mouse as an animal model for the study of this human disease","volume":"9","author":"Baltan\u00e1s","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.tice.2026.103512_bib3","doi-asserted-by":"crossref","first-page":"4257","DOI":"10.3390\/cancers14174257","article-title":"Pancreatic cancer: challenges and opportunities in locoregional therapies","volume":"14","author":"Bazeed","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.tice.2026.103512_bib4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/bs.acr.2021.07.008","article-title":"Targeting the ERK mitogen-activated protein kinase cascade for the treatment of KRAS-mutant pancreatic cancer","volume":"153","author":"Diehl","year":"2022","journal-title":"Adv. Cancer Res."},{"key":"10.1016\/j.tice.2026.103512_bib5","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1159\/000521631","article-title":"Pancreatic cancer: current multimodality treatment options and the future impact of molecular biological profiling","volume":"38","author":"Ettrich","year":"2022","journal-title":"Visc. Med."},{"key":"10.1016\/j.tice.2026.103512_bib6","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1126\/science.1068912","article-title":"Purkinje cell degeneration (pcd) phenotypes caused by mutations in the axotomy-induced gene, Nna1","volume":"295","author":"Fernandez-Gonzalez","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.tice.2026.103512_bib7","doi-asserted-by":"crossref","first-page":"8615","DOI":"10.2147\/OTT.S258715","article-title":"Circular RNA MYLK promotes hepatocellular carcinoma progression through the miR29a\/KMT5C signaling pathway","volume":"13","author":"Gao","year":"2020","journal-title":"Onco Targets Ther."},{"key":"10.1016\/j.tice.2026.103512_bib8","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s12264-010-0933-0","article-title":"Modulation of M4 muscarinic acetylcholine receptors by interacting proteins","volume":"26","author":"Guo","year":"2010","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.tice.2026.103512_bib9","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/j.cell.2023.02.014","article-title":"Pancreatic cancer: advances and challenges","volume":"186","author":"Halbrook","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.tice.2026.103512_bib10","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/s41575-024-00951-y","article-title":"Unlocking the promise of RAS inhibition in pancreatic cancer","volume":"21","author":"Haldar","year":"2024","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.tice.2026.103512_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2021.106058","article-title":"Nonmuscle Myosin II in cancer cell migration and mechanotransduction","volume":"139","author":"Halder","year":"2021","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.tice.2026.103512_bib12","doi-asserted-by":"crossref","first-page":"7465","DOI":"10.1038\/ncomms8465","article-title":"Targeted inhibition of fascin function blocks tumour invasion and metastatic colonization","volume":"6","author":"Huang","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tice.2026.103512_bib13","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.clon.2014.06.002","article-title":"Locally advanced pancreatic cancer: the role of definitive chemoradiotherapy","volume":"26","author":"Huguet","year":"2014","journal-title":"Clin. Oncol."},{"key":"10.1016\/j.tice.2026.103512_bib14","doi-asserted-by":"crossref","first-page":"7526","DOI":"10.3892\/mmr.2015.4404","article-title":"Rho\u2011associated kinase inhibitor, Y\u201127632, inhibits the invasion and proliferation of T24 and 5367 bladder cancer cells","volume":"12","author":"Jiang","year":"2015","journal-title":"Mol. Med Rep."},{"key":"10.1016\/j.tice.2026.103512_bib15","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/00006676-200201000-00005","article-title":"Myosin light chain kinase inhibitors can block invasion and adhesion of human pancreatic cancer cell lines","volume":"24","author":"Kaneko","year":"2002","journal-title":"Pancreas"},{"key":"10.1016\/j.tice.2026.103512_bib16","doi-asserted-by":"crossref","first-page":"4495","DOI":"10.1038\/onc.2015.508","article-title":"Loss of MYLK leads to disruption of cell-cell adhesion and invasive behavior of breast epithelial cells via increased expression of EGFR and ERK\/JNK signaling","volume":"35","author":"Kim","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.tice.2026.103512_bib17","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s10059-011-0002-1","article-title":"Abnormal sperm development in pcd(3J)-\/- mice: the importance of Agtpbp1 in spermatogenesis","volume":"31","author":"Kim","year":"2011","journal-title":"Mol. Cells"},{"key":"10.1016\/j.tice.2026.103512_bib18","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1083\/jcb.137.2.481","article-title":"Regulation of cell motility by mitogen-activated protein kinase","volume":"137","author":"Klemke","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.tice.2026.103512_bib19","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3390\/jpm10040263","article-title":"Expression of ATP\/GTP binding protein 1 Has prognostic value for the clinical outcomes in non-small cell lung carcinoma","volume":"10","author":"Kwak","year":"2020","journal-title":"J. Pers. Med."},{"key":"10.1016\/j.tice.2026.103512_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2021.146001","article-title":"The AGTPBP1 gene in neurobiology","volume":"809","author":"Lalonde","year":"2022","journal-title":"Gene"},{"key":"10.1016\/j.tice.2026.103512_bib21","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s10020-024-00892-x","article-title":"Targeting AGTPBP1 inhibits pancreatic cancer progression via regulating microtubules and ERK signaling pathway","volume":"30","author":"Li","year":"2024","journal-title":"Mol. Med."},{"key":"10.1016\/j.tice.2026.103512_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2022.1049136","article-title":"Recent estimates and predictions of 5-year survival rate in patients with pancreatic cancer: a model-based period analysis","volume":"9","author":"Li","year":"2022","journal-title":"Front. Med."},{"key":"10.1016\/j.tice.2026.103512_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117936","article-title":"The Ras-ERK1\/2 signaling pathway regulates H3K9ac through PCAF to promote the development of pancreatic cancer","volume":"256","author":"Li","year":"2020","journal-title":"LIFE Sci."},{"key":"10.1016\/j.tice.2026.103512_bib24","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/s12935-019-0926-7","article-title":"Circular RNA MYLK promotes hepatocellular carcinoma progression by increasing Rab23 expression by sponging miR-362-3p","volume":"19","author":"Li","year":"2019","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.tice.2026.103512_bib25","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s10238-018-0509-2","article-title":"MYLK promotes hepatocellular carcinoma progression through regulating cytoskeleton to enhance epithelial-mesenchymal transition","volume":"18","author":"Lin","year":"2018","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.tice.2026.103512_bib26","doi-asserted-by":"crossref","first-page":"809","DOI":"10.3389\/fonc.2020.00809","article-title":"Identification of potential key genes for pathogenesis and prognosis in prostate cancer by integrated analysis of gene expression profiles and the cancer genome Atlas","volume":"10","author":"Liu","year":"2020","journal-title":"Front Oncol."},{"key":"10.1016\/j.tice.2026.103512_bib27","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.tice.2026.103512_bib28","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/j.cub.2011.08.049","article-title":"The tubulin deglutamylase CCPP-1 regulates the function and stability of sensory cilia in C. elegans","volume":"21","author":"O'Hagan","year":"2011","journal-title":"Curr. Biol."},{"key":"10.1016\/j.tice.2026.103512_bib29","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.3390\/ijms20122885","article-title":"Extracellular-signal regulated kinase: a central molecule driving epithelial-mesenchymal transition in cancer","volume":"20","author":"Olea-Flores","year":"2019","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.tice.2026.103512_bib30","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s10585-008-9174-2","article-title":"The actin cytoskeleton in cancer cell motility","volume":"26","author":"Olson","year":"2009","journal-title":"Clin. Exp. Metastas-.-."},{"key":"10.1016\/j.tice.2026.103512_bib31","doi-asserted-by":"crossref","first-page":"5335","DOI":"10.3390\/ijms24065335","article-title":"CCP1, a regulator of tubulin post-translational modifications, potentially plays an essential role in cerebellar development","volume":"24","author":"Pang","year":"2023","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.tice.2026.103512_bib32","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/s41568-024-00679-6","article-title":"Combinatorial strategies to target RAS-driven cancers","volume":"24","author":"Perurena","year":"2024","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.tice.2026.103512_bib33","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1096\/fj.12-209080","article-title":"Functional segregation and emerging role of cilia-related cytosolic carboxypeptidases (CCPs)","volume":"27","author":"Rodr\u00edguez de la Vega Otazo","year":"2013","journal-title":"FASEB J."},{"key":"10.1016\/j.tice.2026.103512_bib34","first-page":"17","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.tice.2026.103512_bib35","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adg3840","article-title":"The extracellular matrix as hallmark of cancer and metastasis: from biomechanics to therapeutic targets","volume":"16","author":"Sleeboom","year":"2024","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.tice.2026.103512_bib36","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41571-018-0112-1","article-title":"Optimizing the outcomes of pancreatic cancer surgery","volume":"16","author":"Strobel","year":"2019","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.tice.2026.103512_bib37","doi-asserted-by":"crossref","first-page":"27083","DOI":"10.18632\/oncotarget.4807","article-title":"The ZEB1\/miR-200c feedback loop regulates invasion via actin interacting proteins MYLK and TKS5","volume":"6","author":"Sundararajan","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.tice.2026.103512_bib38","doi-asserted-by":"crossref","first-page":"12189","DOI":"10.1007\/s13277-014-2527-3","article-title":"MYLK and MYL9 expression in non-small cell lung cancer identified by bioinformatics analysis of public expression data","volume":"35","author":"Tan","year":"2014","journal-title":"Tumour Biol. J. Int. Soc. Oncodev. Biol. Med."},{"key":"10.1016\/j.tice.2026.103512_bib39","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1074\/mcp.M114.040360","article-title":"C-terminomics screen for natural substrates of cytosolic carboxypeptidase 1 reveals processing of acidic protein C termini","volume":"14","author":"Tanco","year":"2015","journal-title":"Mol. Cell. Proteom."},{"key":"10.1016\/j.tice.2026.103512_bib40","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.semcancer.2021.05.010","article-title":"RAF-MEK-ERK pathway in cancer evolution and treatment","volume":"85","author":"Ullah","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.tice.2026.103512_bib41","doi-asserted-by":"crossref","first-page":"11986","DOI":"10.1007\/s12035-025-05016-y","article-title":"Lacosamide Is a novel drug that improves AGTPBP1 knockout-mediated impairment of neuronal and dopaminergic function","volume":"62","author":"Wang","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.tice.2026.103512_bib42","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s12264-007-0015-0","article-title":"N-methyl-D-aspartate receptors mediate diphosphorylation of extracellular signal-regulated kinases through Src family tyrosine kinases and Ca2+\/calmodulin-dependent protein kinase II in rat hippocampus after cerebral ischemia","volume":"23","author":"Wu","year":"2007","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.tice.2026.103512_bib43","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41586-019-1426-6","article-title":"Intercellular interaction dictates cancer cell ferroptosis via NF2-YAP signalling","volume":"572","author":"Wu","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.tice.2026.103512_bib44","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1097\/CM9.0000000000002108","article-title":"Cancer statistics in China and United States, 2022: profiles, trends, and determinants","volume":"135","author":"Xia","year":"2022","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.tice.2026.103512_bib45","doi-asserted-by":"crossref","first-page":"5469","DOI":"10.2147\/CMAR.S257386","article-title":"Circular RNA MYLK promotes glycolysis and proliferation of non-small cell lung cancer cells by sponging miR-195-5p and increasing glucose transporter member 3 expression","volume":"12","author":"Xiong","year":"2020","journal-title":"Cancer Manag Res."},{"key":"10.1016\/j.tice.2026.103512_bib46","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1158\/1541-7786.MCR-10-0139","article-title":"Mechanisms of motility in metastasizing cells","volume":"8","author":"Yilmaz","year":"2010","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.tice.2026.103512_bib47","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s13045-020-00949-4","article-title":"The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy","volume":"13","author":"Yuan","year":"2020","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.tice.2026.103512_bib48","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.canlet.2017.06.027","article-title":"Circular RNA MYLK as a competing endogenous RNA promotes bladder cancer progression through modulating VEGFA\/VEGFR2 signaling pathway","volume":"403","author":"Zhong","year":"2017","journal-title":"Cancer Lett."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626002053?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626002053?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T03:02:46Z","timestamp":1778727766000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816626002053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":48,"alternative-id":["S0040816626002053"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2026.103512","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel AGTPBP1-ERK\/MYLK network mediates pancreatic cancer progression","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2026.103512","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103512"}}