{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T23:04:29Z","timestamp":1784070269991,"version":"3.55.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004179","name":"Ningxia Medical University","doi-asserted-by":"publisher","award":["XT2024038"],"award-info":[{"award-number":["XT2024038"]}],"id":[{"id":"10.13039\/501100004179","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004772","name":"Natural Science Foundation of Ningxia Province","doi-asserted-by":"publisher","award":["2021AAC03368"],"award-info":[{"award-number":["2021AAC03368"]}],"id":[{"id":"10.13039\/501100004772","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004772","name":"Natural Science Foundation of Ningxia Province","doi-asserted-by":"publisher","award":["2021A0648"],"award-info":[{"award-number":["2021A0648"]}],"id":[{"id":"10.13039\/501100004772","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.tice.2026.103518","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T17:28:33Z","timestamp":1775755713000},"page":"103518","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Glutaredoxin 1 promotes sorafenib resistance in renal cell carcinoma through ferroptosis suppression: Integrative bioinformatics analysis and experimental validation"],"prefix":"10.1016","volume":"102","author":[{"given":"Lingdong","family":"Lv","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianghong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"37","key":"10.1016\/j.tice.2026.103518_bib1","doi-asserted-by":"crossref","first-page":"eadi5192","DOI":"10.1126\/sciadv.adi5192","article-title":"Glutaredoxin attenuates glutathione levels via deglutathionylation of Otub1 and subsequent destabilization of system x(C)","volume":"9","author":"Aboushousha","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.tice.2026.103518_bib2","doi-asserted-by":"crossref","DOI":"10.1177\/11795549241298541","article-title":"Cancer biomarkers and precision oncology: a review of recent trends and innovations","volume":"18","author":"AlDoughaim","year":"2024","journal-title":"Clin. Med. Insights Oncol."},{"issue":"3","key":"10.1016\/j.tice.2026.103518_bib3","article-title":"RCC an overview of the epidemiology, diagnosis, and treatment","volume":"39","author":"Bahadoram","year":"2022","journal-title":"G Ital. Nefrol."},{"key":"10.1016\/j.tice.2026.103518_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.coi.2023.102369","article-title":"Tissue-specific macrophage immunometabolism","volume":"84","author":"Ben-Arosh","year":"2023","journal-title":"Curr. Opin. Immunol."},{"issue":"23","key":"10.1016\/j.tice.2026.103518_bib5","doi-asserted-by":"crossref","first-page":"3940","DOI":"10.1158\/0008-5472.CAN-22-4001","article-title":"DPP9 stabilizes NRF2 to suppress ferroptosis and induce sorafenib resistance in clear cell renal cell carcinoma","volume":"83","author":"Chang","year":"2023","journal-title":"Cancer Res."},{"issue":"6","key":"10.1016\/j.tice.2026.103518_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.115774","article-title":"GCLM lactylation mediated by ACAT2 promotes ferroptosis resistance in KRAS(G12D)-mutant cancer","volume":"44","author":"Chen","year":"2025","journal-title":"Cell Rep."},{"issue":"9","key":"10.1016\/j.tice.2026.103518_bib7","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1056\/NEJMoa2026982","article-title":"Nivolumab plus Cabozantinib versus Sunitinib for advanced renal-cell carcinoma","volume":"384","author":"Choueiri","year":"2021","journal-title":"N. Engl. J. Med."},{"issue":"23","key":"10.1016\/j.tice.2026.103518_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13235896","article-title":"Antiangiogenic therapy in clear cell renal carcinoma (CCRC): pharmacological basis and clinical results","volume":"13","author":"Comandone","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.tice.2026.103518_bib9","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.02523","article-title":"Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis","volume":"3","author":"Dixon","year":"2014","journal-title":"Elife"},{"issue":"2","key":"10.1016\/j.tice.2026.103518_bib10","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-001369","article-title":"Vaccination with early ferroptotic cancer cells induces efficient antitumor immunity","volume":"8","author":"Efimova","year":"2020","journal-title":"J. Immunother. Cancer"},{"issue":"2","key":"10.1016\/j.tice.2026.103518_bib11","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1056\/NEJMoa060655","article-title":"Sorafenib in advanced clear-cell renal-cell carcinoma","volume":"356","author":"Escudier","year":"2007","journal-title":"N. Engl. J. Med"},{"issue":"20","key":"10.1016\/j.tice.2026.103518_bib12","doi-asserted-by":"crossref","first-page":"3312","DOI":"10.1200\/JCO.2008.19.5511","article-title":"Sorafenib for treatment of renal cell carcinoma: final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial","volume":"27","author":"Escudier","year":"2009","journal-title":"J. Clin. Oncol."},{"issue":"7","key":"10.1016\/j.tice.2026.103518_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1333","article-title":"Glutaredoxin-1 promotes lymphangioleiomyomatosis progression through inhibiting Bim-mediated apoptosis via COX2\/PGE2\/ERK pathway","volume":"13","author":"Feng","year":"2023","journal-title":"Clin. Transl. Med."},{"issue":"5","key":"10.1016\/j.tice.2026.103518_bib14","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1089\/ars.2008.2291","article-title":"Mechanistic and kinetic details of catalysis of thiol-disulfide exchange by glutaredoxins and potential mechanisms of regulation","volume":"11","author":"Gallogly","year":"2009","journal-title":"Antioxid. Redox Signal"},{"issue":"12","key":"10.1016\/j.tice.2026.103518_bib15","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202114351","article-title":"YAP\/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis","volume":"13","author":"Gao","year":"2021","journal-title":"EMBO Mol. Med."},{"issue":"5","key":"10.1016\/j.tice.2026.103518_bib16","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.tim.2022.11.006","article-title":"When ferroptosis meets pathogenic infections","volume":"31","author":"Gao","year":"2023","journal-title":"Trends Microbiol."},{"issue":"23","key":"10.1016\/j.tice.2026.103518_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252312557","article-title":"Oxidative DNA damage and arterial hypertension in light of current ESC guidelines","volume":"25","author":"Hazukova","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"13","key":"10.1016\/j.tice.2026.103518_bib18","doi-asserted-by":"crossref","first-page":"6503","DOI":"10.18632\/aging.204867","article-title":"Galectin-1-mediated MET\/AXL signaling enhances sorafenib resistance in hepatocellular carcinoma by escaping ferroptosis","volume":"15","author":"Hsu","year":"2023","journal-title":"Aging"},{"issue":"1","key":"10.1016\/j.tice.2026.103518_bib19","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/s41467-025-56344-5","article-title":"Palmitoylation-dependent regulation of GPX4 suppresses ferroptosis","volume":"16","author":"Huang","year":"2025","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.tice.2026.103518_bib20","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1111\/cas.15378","article-title":"Ferroptosis is induced by lenvatinib through fibroblast growth factor receptor-4 inhibition in hepatocellular carcinoma","volume":"113","author":"Iseda","year":"2022","journal-title":"Cancer Sci."},{"issue":"4","key":"10.1016\/j.tice.2026.103518_bib21","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41581-020-00359-2","article-title":"Clear cell renal cell carcinoma ontogeny and mechanisms of lethality","volume":"17","author":"Jonasch","year":"2021","journal-title":"Nat. Rev. Nephrol."},{"issue":"1","key":"10.1016\/j.tice.2026.103518_bib22","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1038\/s41598-020-59656-2","article-title":"Assessment of modelling strategies for drug response prediction in cell lines and xenografts","volume":"10","author":"Kurilov","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2026.103518_bib23","article-title":"Tissue-specific approaches reveal diverse metabolic functions of Rho-Kinase 1","volume":"11","author":"Landry","year":"2020","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.tice.2026.103518_bib24","article-title":"Meta-analysis of ERCC1 protein expression and platinum chemosensitivity in non-small-cell lung cancer","volume":"2020","author":"Li","year":"2020","journal-title":"Evid. Based Compl. Altern. Med."},{"issue":"4","key":"10.1016\/j.tice.2026.103518_bib25","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.ccell.2022.02.003","article-title":"CD8(+) T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4","volume":"40","author":"Liao","year":"2022","journal-title":"Cancer Cell"},{"issue":"13","key":"10.1016\/j.tice.2026.103518_bib26","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1089\/ars.2012.5007","article-title":"Glutaredoxins in thiol\/disulfide exchange","volume":"18","author":"Lillig","year":"2013","journal-title":"Antioxid. Redox Signal"},{"issue":"7","key":"10.1016\/j.tice.2026.103518_bib27","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1002\/ijc.28159","article-title":"Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib","volume":"133","author":"Louandre","year":"2013","journal-title":"Int J. Cancer"},{"issue":"2","key":"10.1016\/j.tice.2026.103518_bib28","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJMoa065044","article-title":"Sunitinib versus interferon alfa in metastatic renal-cell carcinoma","volume":"356","author":"Motzer","year":"2007","journal-title":"N. Engl. J. Med"},{"issue":"14","key":"10.1016\/j.tice.2026.103518_bib29","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1056\/NEJMoa2035716","article-title":"Lenvatinib plus Pembrolizumab or Everolimus for advanced renal cell carcinoma","volume":"384","author":"Motzer","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tice.2026.103518_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101975","article-title":"Glutaredoxin: discovery, redox defense and much more","volume":"43","author":"Ogata","year":"2021","journal-title":"Redox Biol."},{"issue":"3","key":"10.1016\/j.tice.2026.103518_bib31","doi-asserted-by":"crossref","first-page":"305","DOI":"10.2174\/0115665240271103231127072635","article-title":"Implication of Thioredoxin 1 and Glutaredoxin 1 in H(2)O(2)-induced Phosphorylation of JNK and p38 MAP Kinases","volume":"25","author":"Poulios","year":"2025","journal-title":"Curr. Mol. Med."},{"issue":"9669","key":"10.1016\/j.tice.2026.103518_bib32","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/S0140-6736(09)60229-4","article-title":"Renal cell carcinoma","volume":"373","author":"Rini","year":"2009","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.tice.2026.103518_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24010449","article-title":"Lipid peroxidation and iron metabolism: two corner stones in the homeostasis control of ferroptosis","volume":"24","author":"Rochette","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.tice.2026.103518_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2025.119989","article-title":"Salinomycin inhibits SREBP1 to sensitize ferroptosis and ameliorate sorafenib resistance in clear cell renal cell carcinoma","volume":"1872","author":"Su","year":"2025","journal-title":"Biochim Biophys. Acta Mol. Cell Res."},{"issue":"6","key":"10.1016\/j.tice.2026.103518_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.clgc.2024.102200","article-title":"Serum androgens as predictive biomarkers: results from a randomized clinical trial comparing enzalutamide and abiraterone acetate in men with metastatic castration-resistant prostate cancer","volume":"22","author":"Ternov","year":"2024","journal-title":"Clin. Genitourin. Cancer"},{"issue":"7755","key":"10.1016\/j.tice.2026.103518_bib36","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-019-1170-y","article-title":"CD8(+) T cells regulate tumour ferroptosis during cancer immunotherapy","volume":"569","author":"Wang","year":"2019","journal-title":"Nature"},{"issue":"18","key":"10.1016\/j.tice.2026.103518_bib37","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1097\/CM9.0000000000002675","article-title":"Isoliquiritigenin induces HMOX1 and GPX4-mediated ferroptosis in gallbladder cancer cells","volume":"136","author":"Wang","year":"2023","journal-title":"Chin. Med J. (Engl. )"},{"issue":"18","key":"10.1016\/j.tice.2026.103518_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/cancers17182950","article-title":"Cabozantinib sensitizes NSCLC cells to radiation by inducing ferroptosis via STAT3\/MCL1\/BECN1\/SLC7A11 Axis Suppression","volume":"17","author":"Wang","year":"2025","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.tice.2026.103518_bib39","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.1038\/s41467-022-31218-2","article-title":"Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity","volume":"13","author":"Wiernicki","year":"2022","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.tice.2026.103518_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14010109","article-title":"Comparative analysis of predictive biomarkers for PD-1\/PD-L1 inhibitors in cancers: developments and challenges","volume":"14","author":"Yang","year":"2021","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.tice.2026.103518_bib41","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1186\/s12967-025-06793-9","article-title":"COL6A2 in clear cell renal cell carcinoma: a multifaceted driver of tumor progression, immune evasion, and drug sensitivity","volume":"23","author":"Yang","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.tice.2026.103518_bib42","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.jss.2022.07.041","article-title":"Hypoxia-inducible factor 1alpha stability modified by glutaredoxin-1 in necrotizing enterocolitis","volume":"280","author":"Zhang","year":"2022","journal-title":"J. Surg. Res."},{"issue":"5","key":"10.1016\/j.tice.2026.103518_bib43","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1159\/000209961","article-title":"Sunitinib treatment for patients with advanced clear-cell renal-cell carcinoma after progression on sorafenib","volume":"76","author":"Zimmermann","year":"2009","journal-title":"Oncology"}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626002119?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626002119?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T22:14:12Z","timestamp":1784067252000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816626002119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":43,"alternative-id":["S0040816626002119"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2026.103518","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glutaredoxin 1 promotes sorafenib resistance in renal cell carcinoma through ferroptosis suppression: Integrative bioinformatics analysis and experimental validation","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2026.103518","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103518"}}