{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T22:47:35Z","timestamp":1787611655847,"version":"build-2736575974"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009392","name":"Prince Sattam bin Abdulaziz University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019725","name":"Prince Sattam bin Abdulaziz University Deanship of Scientific Research","doi-asserted-by":"publisher","award":["PSAU\/2026\/R\/1447"],"award-info":[{"award-number":["PSAU\/2026\/R\/1447"]}],"id":[{"id":"10.13039\/100019725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.tice.2026.103520","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T16:32:38Z","timestamp":1775665958000},"page":"103520","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Hepatoprotective effect of engeletin against risperidone-induced liver injury in rats involvement of TGF-\u03b21\/Smad and NF-\u03baB pathways"],"prefix":"10.1016","volume":"102","author":[{"given":"Mohammed A.","family":"Alshehri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Alghamdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulkarim S.","family":"Binshaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tawfiq N.","family":"Juraybi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adil","family":"Abalkhail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4045-0810","authenticated-orcid":false,"given":"Mohammed","family":"Alissa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.tice.2026.103520_bib1","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/clpt.2011.58","article-title":"Case definition and phenotype standardization in drug-induced liver injury","volume":"89","author":"Aithal","year":"2011","journal-title":"Clin. Pharmacol. & Ther."},{"key":"10.1016\/j.tice.2026.103520_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2024.105936","article-title":"Risperidone-induced bioenergetic disruption in the isolated human peripheral blood monocytes","volume":"101","author":"Alenazi","year":"2024","journal-title":"Toxicol. Vitr."},{"issue":"2","key":"10.1016\/j.tice.2026.103520_bib3","doi-asserted-by":"crossref","first-page":"431","DOI":"10.4103\/MJBL.MJBL_1510_23","article-title":"Hepatoprotective Activity of Ezetimibe Against Risperidone-Induced Liver Injury in Rats","volume":"21","author":"Al-Juhaishi","year":"2024","journal-title":"Med. J. Babylon."},{"key":"10.1016\/j.tice.2026.103520_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2025.117275","article-title":"Afzelechin alleviates deltamethrin induced hepatic dysfunction via regulating TLR4\/MyD88, HMGB1\/RAGE and NF-\u03baB pathway","volume":"497","author":"Alzahrani","year":"2025","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"6","key":"10.1016\/j.tice.2026.103520_bib5","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.jhep.2019.02.014","article-title":"EASL clinical practice guidelines: drug-induced liver injury","volume":"70","author":"Andrade","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.tice.2026.103520_bib6","first-page":"184","article-title":"Quercetin and Catechin Protects Leptin-Deficient Lepob\/Ob Mice Against Alloxan-Induced Diabetes and Hepatotoxicity via Suppression of Oxidative Stress and Inflammation","author":"Badiee","year":"2024","journal-title":"Rep. Biochem. Mol. Biol."},{"issue":"1","key":"10.1016\/j.tice.2026.103520_bib7","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/8709521","article-title":"Risperidone-induced renal damage and metabolic side effects: the protective effect of resveratrol","volume":"2017","author":"Bilgi\u00e7","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.tice.2026.103520_bib8","first-page":"484","article-title":"[59] Glutathione reductase","volume":"113","author":"Carlberg","year":"1985"},{"issue":"3","key":"10.1016\/j.tice.2026.103520_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2020.12.017","article-title":"Dietary squalene supplementation alleviates diquat-induced oxidative stress and liver damage of broiler chickens","volume":"100","author":"Chen","year":"2021","journal-title":"Poult. Sci."},{"issue":"1","key":"10.1016\/j.tice.2026.103520_bib10","first-page":"54","article-title":"Risperidone and hepatotoxicity in children and adolescent: a literature review","volume":"2","author":"\u00c7\u00f6p\u00fcr","year":"2020","journal-title":"K. \u0131Br. \u0131S. T\u00fcrk Psikiyatr. ve Psikol. Derg."},{"key":"10.1016\/j.tice.2026.103520_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153746","article-title":"A characterized saponin extract of Panax japonicus suppresses hepatocyte EMT and HSC activation in vitro and CCl4-provoked liver fibrosis in mice: Roles of its modulatory effects on the Akt\/GSK3\u03b2\/Nrf2 cascade","volume":"93","author":"Dai","year":"2021","journal-title":"Phytomedicine"},{"issue":"6958","key":"10.1016\/j.tice.2026.103520_bib12","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nature02006","article-title":"Smad-dependent and Smad-independent pathways in TGF-\u03b2 family signalling","volume":"425","author":"Derynck","year":"2003","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.tice.2026.103520_bib13","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1080\/15376516.2016.1204641","article-title":"vitro\/vivo studies towards mechanisms of risperidone-induced oxidative stress and the protective role of coenzyme Q10 and N-acetylcysteine","volume":"26","author":"Eftekhari","year":"2016","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.tice.2026.103520_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111670","article-title":"Captopril downregulates expression of Bax\/cytochrome C\/caspase-3 apoptotic pathway, reduces inflammation, and oxidative stress in cisplatin-induced acute hepatic injury","volume":"139","author":"Eid","year":"2021","journal-title":"Biomed. & Pharmacother."},{"key":"10.1016\/j.tice.2026.103520_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2024.127567","article-title":"Pharmacotherapeutic potential of bilobetin to combat chromium induced hepatotoxicity via regulating TLR-4, Nrf-2\/Keap-1, JAK1\/STAT3 and NF-\u03baB pathway: A pharmacokinetic and molecular dynamic approach","volume":"86","author":"El Safadi","year":"2024","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"1","key":"10.1016\/j.tice.2026.103520_bib16","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/4139117","article-title":"A comprehensive review of the pharmacological importance of dietary flavonoids as hepatoprotective agents","volume":"2023","author":"Gajender","year":"2023","journal-title":"Evid. -Based Complement. Altern. Med."},{"issue":"1","key":"10.1016\/j.tice.2026.103520_bib17","doi-asserted-by":"crossref","DOI":"10.1111\/and.13813","article-title":"Risperidone induced reproductive toxicity in male rats targeting leydig cells and hypothalamic\u2013pituitary\u2013gonadal axis by inducing oxidative stress","volume":"53","author":"G\u00f6rm\u00fc\u015f","year":"2021","journal-title":"Andrologia"},{"key":"10.1016\/j.tice.2026.103520_bib18","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.dib.2015.12.012","article-title":"Data supporting the spectrophotometric method for the estimation of catalase activity","volume":"6","author":"Hadwan","year":"2016","journal-title":"Data Brief."},{"issue":"1","key":"10.1016\/j.tice.2026.103520_bib19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.mrgentox.2007.04.006","article-title":"High-throughput spectrophotometric assay of reactive oxygen species in serum","volume":"631","author":"Hayashi","year":"2007","journal-title":"Mutat. Res. \/Genet. Toxicol. Environ. Mutagen."},{"key":"10.1016\/j.tice.2026.103520_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2024.127445","article-title":"Ameliorative potential of eriocitrin against cadmium instigated hepatotoxicity in rats via regulating Nrf2\/keap1 pathway","volume":"84","author":"Hayat","year":"2024","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"1","key":"10.1016\/j.tice.2026.103520_bib21","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/SLA.0b013e31825d5d47","article-title":"Physiological and biochemical basis of clinical liver function tests: a review","volume":"257","author":"Hoekstra","year":"2013","journal-title":"Ann. Surg."},{"key":"10.1016\/j.tice.2026.103520_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113275","article-title":"Forsythiae Fructuse water extract attenuates liver fibrosis via TLR4\/MyD88\/NF-\u03baB and TGF-\u03b2\/smads signaling pathways","volume":"262","author":"Hu","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.tice.2026.103520_bib23","first-page":"74","article-title":"Comparative study of serum levels of gamma-glutamyl transferase, Aspartate aminotransferase (AST), Alanine Transaminase (ALT), AST: ALT, and bilirubin in patients with chronic hepatitis","volume":"26","author":"Jain","year":"2022","journal-title":"Indian J. Med. Biochem"},{"issue":"6","key":"10.1016\/j.tice.2026.103520_bib24","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/neup.12905","article-title":"Engeletin ameliorates sevoflurane-induced cognitive impairment by activating PPAR-gamma in neonatal mice","volume":"43","author":"Jiang","year":"2023","journal-title":"Neuropathology"},{"issue":"3","key":"10.1016\/j.tice.2026.103520_bib25","first-page":"151","article-title":"Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3, 4-bromobenzene oxide as the hepatotoxic metabolite","volume":"11","author":"Jollow","year":"1974","journal-title":"Pharmacology"},{"issue":"19","key":"10.1016\/j.tice.2026.103520_bib26","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1093\/ajhp\/zxaa224","article-title":"Risperidone-and paliperidone-induced hepatotoxicity: Case report and review of literature","volume":"77","author":"Khorassani","year":"2020","journal-title":"Am. J. Health-Syst. Pharm."},{"issue":"1","key":"10.1016\/j.tice.2026.103520_bib27","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2174\/1566524018666180608084947","article-title":"Hesperetin mitigates bile duct ligation-induced liver fibrosis by inhibiting extracellular matrix and cell apoptosis via the TGF-\u03b21\/Smad pathway","volume":"18","author":"Kong","year":"2018","journal-title":"Curr. Mol. Med."},{"issue":"4","key":"10.1016\/j.tice.2026.103520_bib28","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/0006-291X(76)90747-6","article-title":"Glutathione peroxidase activity in selenium-deficient rat liver","volume":"71","author":"Lawrence","year":"1976","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tice.2026.103520_bib29","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.freeradbiomed.2020.02.015","article-title":"Hepatocyte-specific deficiency of Nrf2 exacerbates carbon tetrachloride-induced liver fibrosis via aggravated hepatocyte injury and subsequent inflammatory and fibrogenic responses","volume":"150","author":"Lyu","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.tice.2026.103520_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.107117","article-title":"Bixin attenuates carbon tetrachloride induced oxidative stress, inflammation and fibrosis in kidney by regulating the Nrf2\/TLR4\/MyD88 and PPAR-\u03b3\/TGF-\u03b21\/Smad3 pathway","volume":"90","author":"Ma","year":"2021","journal-title":"Int. Immunopharmacol."},{"issue":"6","key":"10.1016\/j.tice.2026.103520_bib31","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/9158","article-title":"Dendritic Ih normalizes temporal summation in hippocampal CA1 neurons","volume":"2","author":"Magee","year":"1999","journal-title":"Nat. Neurosci."},{"issue":"2","key":"10.1016\/j.tice.2026.103520_bib32","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3390\/oxygen2020006","article-title":"Free radical properties, source and targets, antioxidant consumption and health","volume":"2","author":"Martemucci","year":"2022","journal-title":"Oxygen"},{"issue":"6","key":"10.1016\/j.tice.2026.103520_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0218937","article-title":"The antipsychotic medication, risperidone, causes global immunosuppression in healthy mice","volume":"14","author":"May","year":"2019","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.tice.2026.103520_bib34","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0304-4165(79)90289-7","article-title":"Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver","volume":"582","author":"Moron","year":"1979","journal-title":"Biochim. Et. Biophys. Acta (BBA)-Gen. Subj."},{"key":"10.1016\/j.tice.2026.103520_bib35","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.bone.2017.07.008","article-title":"A novel role for dopamine signaling in the pathogenesis of bone loss from the atypical antipsychotic drug risperidone in female mice","volume":"103","author":"Motyl","year":"2017","journal-title":"Bone"},{"key":"10.1016\/j.tice.2026.103520_bib36","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/BF02712155","article-title":"Assay of superoxide dismutase activity in animal tissues","volume":"13","author":"Nandi","year":"1988","journal-title":"J. Biosci."},{"issue":"2","key":"10.1016\/j.tice.2026.103520_bib37","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.tice.2026.103520_bib38","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s40801-019-0151-7","article-title":"Adverse events associated with risperidone use in pediatric patients: a retrospective biobank study","volume":"6","author":"Oshikoya","year":"2019","journal-title":"Drugs-Real. World Outcomes"},{"issue":"3","key":"10.1016\/j.tice.2026.103520_bib39","first-page":"273","article-title":"Medicinal importance, pharmacological activities, and analytical aspects of engeletin in medicine: Therapeutic benefit through scientific data analysis","volume":"23","author":"Patel","year":"2023","journal-title":"Endocrine Metabolic & Immune Disorders-Drug Targets (Formerly Current Drug Targets-Immune Endocrine & Metabolic Disorders"},{"issue":"2-3","key":"10.1016\/j.tice.2026.103520_bib40","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ejphar.2006.12.023","article-title":"Silymarin modulates the oxidant\u2013antioxidant imbalance during diethylnitrosamine induced oxidative stress in rats","volume":"560","author":"Pradeep","year":"2007","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.tice.2026.103520_bib41","doi-asserted-by":"crossref","first-page":"152","DOI":"10.2174\/1872208309666140904113615","article-title":"Pharmacogenomics in psychiatry: implications for practice","volume":"8","author":"R Moore","year":"2014","journal-title":"Recent Pat. Biotechnol."},{"key":"10.1016\/j.tice.2026.103520_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155142","article-title":"Drug-induced liver injury and anti-hepatotoxic effect of herbal compounds: A metabolic mechanism perspective","volume":"122","author":"Rani","year":"2024","journal-title":"Phytomedicine"},{"issue":"3","key":"10.1016\/j.tice.2026.103520_bib43","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/s41580-018-0089-8","article-title":"Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins","volume":"20","author":"Singh","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.tice.2026.103520_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1218625","article-title":"Theoretical design for covering Engeletin with functionalized nanostructure-lipid carriers as neuroprotective agents against Huntington\u2019s disease via the nasal-brain route","volume":"14","author":"Smriti","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.tice.2026.103520_bib45","article-title":"Reactive oxygen species-induced lipid peroxidation in apoptosis, autophagy, and ferroptosis","volume":"2019","author":"Su","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"3","key":"10.1016\/j.tice.2026.103520_bib46","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1002\/hep.25711","article-title":"Hepatic activation of IKK\/NF\u03baB signaling induces liver fibrosis via macrophage-mediated chronic inflammation","volume":"56","author":"Sunami","year":"2012","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.tice.2026.103520_bib47","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3390\/ijms22010409","article-title":"Risperidone exacerbates glucose intolerance, nonalcoholic fatty liver disease, and renal impairment in obese mice","volume":"22","author":"Tsai","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2026.103520_bib48","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.redox.2016.01.010","article-title":"Redox homeostasis: The Golden Mean of healthy living","volume":"8","author":"Ursini","year":"2016","journal-title":"Redox Biol."},{"issue":"3","key":"10.1016\/j.tice.2026.103520_bib49","doi-asserted-by":"crossref","first-page":"144","DOI":"10.4254\/wjh.v6.i3.144","article-title":"Hepatoprotective effect of silymarin","volume":"6","author":"Vargas-Mendoza","year":"2014","journal-title":"World J. Hepatol."},{"issue":"4","key":"10.1016\/j.tice.2026.103520_bib50","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1093\/ibd\/izab277","article-title":"Excessive apoptosis in ulcerative colitis: crosstalk between apoptosis, ROS, ER stress, and intestinal homeostasis","volume":"28","author":"Wan","year":"2022","journal-title":"Inflamm. bowel Dis."},{"key":"10.1016\/j.tice.2026.103520_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118733","article-title":"Engeletin attenuates the inflammatory response via inhibiting TLR4-NF\u03baB signaling pathway in Crohn's disease-like colitis","volume":"336","author":"Wei","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"4","key":"10.1016\/j.tice.2026.103520_bib52","doi-asserted-by":"crossref","first-page":"743","DOI":"10.3233\/CBM-170088","article-title":"Rule of changes in serum GGT levels and GGT\/ALT and AST\/ALT ratios in primary hepatic carcinoma patients with different AFP levels","volume":"21","author":"Yang","year":"2018","journal-title":"Cancer Biomark."},{"key":"10.1016\/j.tice.2026.103520_bib53","doi-asserted-by":"crossref","first-page":"596","DOI":"10.3389\/fphar.2020.00596","article-title":"The use of risperidone in behavioral and psychological symptoms of dementia: a review of pharmacology, clinical evidence, regulatory approvals, and off-label use","volume":"11","author":"Yunusa","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.tice.2026.103520_bib54","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1080\/13880209.2020.1834590","article-title":"Engeletin ameliorates pulmonary fibrosis through endoplasmic reticulum stress depending on lnc949-mediated TGF-\u03b21-Smad2\/3 and JNK signalling pathways","volume":"58","author":"Zhang","year":"2020","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.tice.2026.103520_bib55","doi-asserted-by":"crossref","first-page":"3833","DOI":"10.2147\/DDDT.S437703","article-title":"A review on the pharmacological aspects of engeletin as natural compound","author":"Zhong","year":"2023","journal-title":"Drug Des. Dev. Ther."},{"issue":"8","key":"10.1016\/j.tice.2026.103520_bib56","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/j.1872-034X.2012.00996.x","article-title":"Oxidative stress and liver disease","volume":"42","author":"Zhu","year":"2012","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.tice.2026.103520_bib57","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2023.1093030","article-title":"Striatum-related spontaneous coactivation patterns predict treatment response on positive symptoms of drug-naive first-episode schizophrenia with risperidone monotherapy","volume":"14","author":"Zong","year":"2023","journal-title":"Front. Psychiatry"}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626002132?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626002132?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T22:15:13Z","timestamp":1784067313000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816626002132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":57,"alternative-id":["S0040816626002132"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2026.103520","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatoprotective effect of engeletin against risperidone-induced liver injury in rats involvement of TGF-\u03b21\/Smad and NF-\u03baB pathways","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2026.103520","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103520"}}